VIDEO: COVID adds difficulty in interpreting results of randomized trials
In this video, Jakub Svoboda, MD, discusses the results of the phase 3 Alliance study, pertaining to chronic lymphocytic leukemia, presented at ASCO Annual Meeting.Svoboda, an associate professor of medicine at Hospital of the University of Pennsylvania, highlighted the study, which examined the impact of adding venetoclax (Venclexta; Genentech, AbbVie) to the standard combination therapy of ib
rutinib (Imbruvica; Pharmacyclics, Janssen) and obinutuzumab (Gazyva, Genentech) in older patients with CLL. Svoboda also pondered the effect COVID-19 had on health outcomes in randomized trials.“You
1 year 12 months ago
Medical News, Health News Latest, Medical News Today - Medical Dialogues |
MCC NEET PG, MDS Counselling 2023: Check Out Registration, Counselling Process, Eligibility Criteria Details Here
Delhi: The Medical Counselling Committee (MCC) has released the information bulletin for MD, MS, MDS, and DNB admissions for the academic year 2023-24.
All the concerned candidates are advised to take note of all the below-mentioned details including registration and counselling process, quota-wise eligibility criteria before applying with the MCC for PG medical and dental admissions this year.
PG Counselling conducted by MCC can only be submitted online through the Medical Counselling Committee website www.mcc.nic.in. Registration submitted through any other mode shall be summarily rejected. Candidates are further advised to fill out the application form on their own/self on the MCC website and not through any agent or third party.
Only Qualified/ eligible candidates must register on the MCC website i.e., www.mcc.nic.in to participate in the counseling process for allotment of seats. MCC does not allot any seat either on a nomination basis/ manually or in offline mode.
A candidate can submit the NEET-PG Counselling application/registration form only once. Any candidate found to have submitted more than one application/registration form for NEET-PG Counselling shall be debarred from the NEET-PG Counselling allotment process, his/her candidature shall be canceled and further action as deemed appropriate by the MCC of DGHS, MoHFW shall be taken.
The Security Deposit will be forfeited if a candidate who has been allotted a seat in the Second Round or subsequent rounds does not join the respective institution or surrender the seat due to any unforeseen reason. Also, the Security Deposit will be forfeited if the admission gets canceled due to any reason.
Registering for NEET-PG Counselling does not confer any automatic rights to secure a Post Graduate seat. The selection and admission to Post Graduate seats in any medical Institution recognized for running Post Graduate courses as per Indian Medical Council Act, 1956 is subject to fulfilling the merit, admission criteria, eligibility, and such criteria as may be prescribed by the respective universities, medical institutions, Medical Council of India, State/Central Government.
Candidates should ensure that all the information filled in during the online submission of the application/registration form is correct and factual. Information provided by the candidates in the online application/registration form shall be treated as correct and self-certified and MCC shall not entertain, under any circumstances, any request for change in the information provided by the candidates.
MCC does not change/ edit /modify/alter any information entered by the candidates at the time of online submission of application/registration for counseling under any circumstances. The information regarding Stipend /fee structure/ course duration/bond amount/rendering of service in rural/tribal areas/other conditions etc. has been provided by Medical/Dental Colleges on the MCC website.
Candidates must confirm their eligibility/domicile status before registering on the MCC website for Institutional Quota seats of Central Universities/Institutes/ Deemed Universities before opting for their seats. They must confirm the fee structure/ any other additional fee from the colleges especially Deemed Universities before filling up choices for the same.
Candidates must use the Mobile number/email id used by them during registration on the NBE website for the MCC counseling registration process. The said Email ID and Mobile number shall only be used/pre-populated during the counseling registration process. OTPs etc. will only be sent to the registered mobile number and email ids.
The refund process will commence only after the completion of all the rounds of Counselling. MCC will not entertain any query either through email or phone call with regard to a refund before the completion of all the rounds of counseling.
Candidates note that they will be shown only the Clear-cut Vacancies in Round 1. Also, the vacancy position of the seats will be shown in three categories.
Round 2, which are as follows -
1. Clear-cut vacancies- The seats which have not been allotted in Round 1
2. Virtual Vacancies- Any Candidate who has been allotted a seat in Round 1 and has opted for up-gradation in Round 2, the allotted seats of Round 1 will be shown as virtual vacancies in Round 2 and Candidates can fill the said seat during the choice filling in Round 2. However, such seats will be allotted in Round 2 if the allottee of Round 1 vacates/upgrades in Round 2
Each round of counselling is a separate round and the rules of each round are different. Once any round commences, the rules of that round will apply to all the candidates even if they were allotted/admitted in the previous round(s) of counseling. The rules of round 1 will only apply to the rules of round 1. Once Round 2 commences the rules of Round 2 shall apply and the rules of Round 1 will not apply. Similarly, the rules of the third round will apply only in the third round and the rules of the Stray Vacancy round will apply only in the stray vacancy round.
Candidates should make sure that while taking admission/resignation in the allotted college their admission/resignation is generated through online mode i.e. through the intra-MCC portal by the college authorities. Any other letter of admission/resignation will not be accepted.
Candidates who have an international number must provide an alternative Indian number at the time of registration for the counseling process.
Disability certificate- the Candidates must obtain their online disability certificate from the designated disability board in an online mode generated by the disability Centre as per the NMC norms before the choice filling commences. Only Candidates who have made their disability certificate through online mode from the designated centers will be eligible to fill in the PwD choices. MCC of DGHS does not issue/authenticate/verify and has no role in the generation of online Disability certificates.
INSTRUCTIONS FOR FILLING ONLINE APPLICATION FORM –
Candidates are informed that the e-mail ID and Mobile Number provided in the Online Application Form of NBE will be used for registration on the MCC portal for Counselling. The said fields will be pre-populated in the Application/Registration form of Counselling. All the information/ communication will be sent by MCC of DGHS, MoHFW through email on the registered e-mail address or SMS on the registered Mobile Number only.
Any complaint with regard: to the change of registered mobile number or email address shall not be entertained by the MCC of DGHS, MoHFW.
Candidates are advised to use Laptop or Computer along with the latest registered version of Chrome/Internet Explorer/Firefox/Windows/IOS and a good internet connection during the Registration and Choice-Filling process to avoid any technical complications.
Please note that the registration facilities will be available at the beginning of the first round, second round, third round, and stray vacancy on notified dates. Under no circumstances any request (for any reason) for registration, shall be entertained after the closing of registration.
The seat allotted candidates will have to upload essential certificates after the declaration of results as per the scheduled date. It is mandatory for candidates to carry their original documents during physical reporting to the college/institute for confirmation /joining of the seat.
Candidates are informed that the e-mail ID and Mobile Number provided in the Online Application Form of NBE will be used for registration on the MCC portal for Counselling. The said fields will be pre-populated in the Application/Registration form of Counselling. All the information/ communication will be sent by MCC of DGHS, MoHFW through email on the registered e-mail address or SMS on the registered Mobile Number only.
Any complaint with regard: to the change of registered mobile number or email address shall not be entertained by the MCC of DGHS, MoHFW.
Candidates are advised to use Laptop or Computer along with the latest registered version of Chrome/Internet Explorer/Firefox/Windows/IOS and a good internet connection during the Registration and Choice-Filling process to avoid any technical complications.
Please note that the registration facility will be available at the beginning of the first round, second round, third round, and stray vacancy on notified dates. Under no circumstances any request (for any reason) for registration, shall be entertained after the closing of registration.
The seat allotted candidates will have to upload essential certificates after the declaration of results as per the scheduled date. It is mandatory for candidates to carry their original documents during physical reporting to the college/institute for confirmation /joining of the seat.
The candidates need to refer to a counseling scheme for each below round -
1. ROUND-1 (Start & End)
2. ROUND-2 (Start& End)
3. ROUND-3 (Start& End)
4. STRAY VACANCY ROUND
The details related to each round are mentioned in the notice below.
COUNSELLING STAGES –
1. Round 1- AIQ, Deemed, Central Universities & DNB
2. AIQ Round 2-AIQ, Deemed, Central Universities & DNB
3. Third Round- AIQ, Deemed, Central Universities & DNB
4. Stray Vacancy- AIQ, Deemed, Central Universities & DNB. For AIQ and Central Universities/Institutes /Deemed Universities - MCC will conduct the counseling
Result –
The counseling for NEET-PG is conducted by MCC based on the result of qualified candidates sent by NBE. The whole counseling process is completely automated without any manual intervention. MCC uploads the provisional result initially in every round for verification of the candidates/colleges/institute based on their choices, merit, and eligibility.
Once the Candidates are allotted a seat based on their merit, choice & eligibility, in any of the Rounds of counseling conducted by MCC, the Candidates will be required to download their ‘allotment letter’ from the MCC website (www.mcc.nic.in). If the Candidate is satisfied with his/her allotment he/she may approach the allotted college/institute for completing the admission formalities within the reporting time schedule.
Admission –
If the Candidate is satisfied with his/her allotment he/she may approach the allotted college/institute for completing the admission formalities.
Original documents required at the time of joining in allotted Medical/Dental College are as mentioned below -
Allotment Letter issued by MCC (Essential document).
Admit Card issued by NBE.
Result/Rank Letter issued by NBE.
Mark Sheets of MBBS/BDS 1st, 2nd & 3rd Professional Examinations.
MBBS/ BDS Degree Certificate/ Provisional Certificate. (Essential document).
Internship Completion Certificate/Certificate from the Head of Institution or College that the candidate shall complete the Internship by 31st March, of the year of admission/ or if required the date as decided by the Competent Authority.
Permanent / Provisional Registration Certificate issued by MCI/NMC or DCI/State Medical or Dental Council. A provisional Registration Certificate is acceptable only in cases where the candidate is undergoing an internship and likely to complete the same on or before 31st March of the year of admission. (Essential document)
High School/Higher Secondary Certificate/Birth Certificate as proof of date of birth. (Essential document)
Candidates allotted seat must carry one of the identification proofs (ID Proof) to the allotted college at the time of admission (as mentioned in the information Bulletin published by the National Board of Examinations (NBE) for NEET i.e. PAN Card, Driving License, Voter ID, Passport or Aadhaar Card).
The Candidate should also bring the following certificates, if applicable:
SC/ST Certificate issued by the competent authority (in the format specified in the Information Bulletin) should be in English or Hindi. Sub-caste should be clearly mentioned in the certificate. The translated certificate must be certified by a Gazetted Officer. (Essential document)
EWS Certificate as per the Central Govt. Norms (in the format as specified in the Information Bulletin) should be in English or Hindi language. The translated certificate must be certified by a Gazetted Officer. (Essential document)
OBC certificate issued by the competent authority. The sub-caste should tally with the Central List of OBC. The OBC candidates should not belong to Creamy Layer. The OBC certificate must be in the format mentioned in the prospectus. The translated certificate must be certified by a Gazetted Officer. (Essential document).
Disability Certificate issued from a duly constituted and authorized Medical Board for 21 Benchmark Disabilities as per the Rights of Persons with Disability Act,2016, and NMC Norms. No other certificate, issued by any other Authorities/ Hospital will be entertained. The format of the Certificate of Disability is annexed (1,2) in the Information Bulletin. (Essential document)
Details related to quotas -
ALL INDIA QUOTA –
There will be four rounds of AIQ counseling i.e. Round 1, Round 2, A I Q third Round, and AIQ Stray Vacancy Round (SLA(C) No. 10487 of 2021 before the Hon’ble Supreme Court of India). All candidates who have qualified for All India Quota seats on the basis of their rank in NEET PG conducted by the National Board of Examination (NBE) will be eligible for participation in the counseling process. Eligible candidates may download the Rank letter/ Result from the NBE website. The cut-off rank of eligible candidates will also be available on the MCC website (www.mcc.nic.in).
Open seats-domicile free includes -
1. 50% All India Quota seats
2. 50%Seats of BHU
3. 50%Seats of AMU
4. 50% All India Quota seats of DU/Central Institutes (VMMC & SJH, ABVIMS & RML, ESIC-Basaidarapur)
5. 100% DNB
Reservation Policy -
The reservation Policy of the Central Government for the NEET-PGCounselling in All India Quota is as follows –
1. S.C.- 15%
2. S.T.- 7.5%
3. O.B.C.- (Non-Creamy Layer) as per the Central OBC list- 27%
4. EWS- as per Central Government norms- 10%
5. PwD- Horizontal Reservation as per NMC norms- 5%
Candidates who want to avail 5% PwD reservation in PG seats of Govt. /Central medical institutions should obtain a Disability certificate as per 21 Benchmark Disabilities given under RPWD Act 2016 and as per NMC norms, from the designated disability centers as per the list enclosed as Annexure- 2. The certificate issued by any other hospital/ board will not be accepted.
Candidates declared Qualified/Eligible for All India Quota Postgraduate Seats only will be eligible for the online allotment process for All India Quota Seats, which is conducted by the Medical Counseling Committee (MCC), Ministry of Health & Family Welfare, & Government of India. For State Quota, Private medical and dental college seats the candidates are required to contact the appropriate State Government/Admission Authority & Directorate of Medical Education. Medical Counseling Committee (MCC) will not be able to guide candidates in this matter.
Eligibility -
1. The Candidate should have qualified NEET PG
2. Domicile free
DEEMED UNIVERSITY –
There will be four rounds of Counseling i.e., Round 1 & Round 2, third Round & Stray Vacancy Round, and all the rounds will be conducted by MCC. The Medical Counselling Committee (MCC) of DGHS, MoHFW, shall conduct the counseling for the Stray Vacancy Round of 100% (ALL) seats of Deemed Universities.
All the candidates who have qualified for All India Quota seats on the basis of their rank in NEET PG conducted by NBE including candidates from Union Territory of J&K will be eligible. Eligible candidates may download the Rank letter/ Result from the NBE website.
Reservation Policy –
The eligible Indian National Candidates wanting to get converted to sponsored NRI category will have to submit the following documents as and when the same is called for by the MCC -
1. Documents claiming that the sponsorer is an NRI (Passport, Visa of the sponsorer).
2. Relationship of NRI with the candidate as per the court orders of The Hon’ble Supreme Court of India in case W.P.(c) No. 689/2017- Consortium of Deemed Universities in Karnataka (CODEUNIK) & Ans. Vs Union of India & Ors. Dated 22-08- 2017.
3. Affidavit from the sponsorer that he/ she will sponsor the entire course fee of the candidate duly notarized.
4. Embassy Certificate of the Sponsorer (Certificate from the Consulate).
5. NEET Score Card of the candidate.
6. There will be no reservation for OBC/ SC/ ST/ PWD/EWS candidates in Deemed Universities.
Eligibility Condition -
1. The Candidate should have qualified NEET PG
2. Domicile free
Also Read:MBBS, BDS Admissions in Tamil Nadu: Round 1 NEET Counselling to begin tomorrow, check out details
ARMED FORCES MEDICAL SERVICES (AFMS) –
Candidates who desire to participate in AFMS Counseling will be required to register on the MCC portal i.e., www.mcc.nic.in, and may opt for AFMS seats. The list of registered candidates will be sent to AFMS Authorities for conducting counseling at their own end as per the rules and regulations of AFMS Authorities. The role of MCC is limited to the registration of willing Candidates only. MCC shall not be responsible for any allotment made by or on behalf of the AFMS Authorities.
Candidates must verify the Eligibility Conditions {especially Medical Eligibility/age conditions (up to 35 years of age)} from the AFMS website before applying for AFMS Counselling. There have been instances of cancellation of admission due to non-fulfillment of Medical Eligibility Conditions. (https://www.mod.gov.in/dod/directorate-general- armed-force medical-services).
Candidates must verify their eligibility conditions well before from the AFMS website before applying for AFMS Counselling. MCC will not entertain any grievance regarding the same.
CENTRAL UNIVERSITY/INSTITUTE –
There will be four rounds of counseling i.e., Round 1, Round 2, third Round & Stray Vacancy Round to be conducted by MCC of DGHS. All the candidates who have qualified for All India Quota seats on the basis of their rank in NEET PG conducted by NBE will be eligible for the Fifty percent (50%) AIQ seats of Central University.
The counseling for 50% AIQ is domicile free. The eligibility conditions for the internal quota are given by the colleges/institutes, MCC has no role to play in determining the eligibility conditions for the internal quota of the Central Universities/Institutes.
The candidates are requested to go through the eligibility conditions before applying for the internal quota of the Central Universities/Institutes and ensure that they meet the prescribed eligibility conditions. If any Candidate at any stage of the counseling process is found to have furnished any incorrect/wrong information with regard to his/her eligibility condition, his/her candidature shall be canceled for the further rounds of counseling and the security deposit shall be forfeited.
Reservation of seats under the PWD Category is 5% in Central Universities and the 21 Benchmark Disabilities as envisaged under the regulations of the Rights of Persons with Disabilities Act 2016 and as per NMC norms. For the range of disabilities included, please see Annexure -1 in the notice below. Candidates who want to avail of 5% PwD reservation in PG seats of Govt./Central medical institutions should obtain a Disability certificate as per 21 Benchmark Disabilities given under RPWD Act 2016 and as per NMC norms, from the designated disability centers as per the list enclosed as Annexure- 2 in the notice below. The certificate issued by any other hospital/ board will not be accepted.
DELHI UNIVERSITY (DU) –
Fifty percent (50%) seats will be contributed by Delhi University to All India Quota. For the remaining 50% of seats, candidates who have completed their MBBS from DU are eligible for an Internal Quota of 50% in Delhi University.
Reservation Policy for AIQ seats and Internal seats of DU -
The reservation policy of the Central Government is followed –
1. S.C.- 15%
2. S.T.- 7.5%
3. O.B.C.- (Non-Creamy Layer) as per the Central OBC list- 27%
4. EWS- as per Central Government norms- 10%
5. PwD- Horizontal Reservation as per NMC norms- 5%
6. Reservation of seats under the PWD Category is 5% in AIQ and the twenty one
(21) Benchmark Disabilities as envisaged under the regulations of the Rights of Persons with Disabilities Act 2016 and as per NMC norms. For the range of disabilities included, please see Annexure 1 in the notice below.
Eligibility –
The candidate must have passed the final MBBS examination (for MD/MS/Diploma Course) and BDS examination (for MDS Course) from the University of Delhi and must have completed satisfactorily one-year compulsory rotating internship as of 31st March of the year of admission and must submit their internship completion certificate at the time of admission.
However, for this academic year, the internship completion date may be treated as 11th August 2023 as approved by the competent authority, MoHFW.
ALIGARH MUSLIM UNIVERSITY (AMU) –
Fifty percent (50%) of Seats will be contributed by the AMU to the All India Quota. For the remaining 50% of seats, candidates who have completed their MBBS from AMU are eligible for internal seats of 50% in AMU.
Reservation Policy for AIQ seats -
The reservation policy of the Central Government is followed -
1. S.C.- 15%
2. S.T.- 7.5%
3. O.B.C.- (Non-Creamy Layer) as per the Central OBC list- 27%
4. EWS- as per Central Government norms- 10%
5. PwD- Horizontal Reservation as per NMC norms- 5%
For the Reservation Policy of 50% Internals seats of AMU, there is no reservation.
Eligibility –
An Institutional (Internal) candidate is one who has passed the qualifying examination (MBBS/BDS as applicable) from AMU and completes his/her internship as per the dates specified by AMU authorities.
BANARAS HINDU UNIVERSITY (BHU) –
Fifty percent (50%) of Seats will be contributed by BHU to the All India Quota. For the remaining 50% of seats, candidates who have completed their MBBS/BDS from BHU are eligible for internal seats of 50% in BHU.
Reservation Policy for AIQ and internal seats of BHU -
The reservation policy of the Central Government is followed -
1. S.C.- 15%
2. S.T.- 7.5%
3. O.B.C.- (Non-Creamy Layer) as per the Central OBC list- 27%
4. EWS- as per Central Government norms- 10%
5. PwD- Horizontal Reservation as per NMC norms- 5%.
Eligibility –
Only those Candidates who have passed MBBS/BDS from the Institute of Medical Sciences, BHU as per the internship dates specified by IMS, BHU will be eligible, provided the Candidates have appeared and qualified in NEET-PG Examination.
CENTRAL INSTITUTE OF PSYCHIATRY, RANCHI –
The Institute contributes a hundred percent ( 100%) seats for NEET-PG Counselling. There are no Internal /State quota seats in this Institute/College.
Reservation Policy -
The reservation policy of the Central Government is followed -
1. S.C.- 15%
2. S.T.- 7.5%
3. O.B.C.- (Non-Creamy Layer) as per the Central OBC list- 27%
4. EWS- as per Central Government norms- 10%
5. PwD- Horizontal Reservation as per NMC norms- 5%
LOKOPRIYA GOPINATH BORDOLOI REGIONAL INSTITUTE OF MENTAL HEALTH, TEZPUR –
The Institute contributes 100% of seats for NEET-PG Counselling.
Reservation Policy -
The reservation policy of the Central Government is followed -
1. S.C.- 15%
2. S.T.- 7.5%
3. O.B.C.- (Non-Creamy Layer) as per the Central OBC list- 27%
4. EWS- as per Central Government norms- 10%
5. PwD- Horizontal Reservation as per NMC norms- 5%
CENTRAL INSTITUTES UNDER IP UNIVERSITY- VMMC & SJH, ABVIMS & RML, ESICBASAIDARAPUR –
Fifty percent (50%) seats will be contributed by the Central Institutes (VMMC & SJH, ABVIMS & RML, ESIC-Basaidarapur) to All India Quota. For the remaining 50% seats, candidates who have completed their MBBS/BDS from I.P. University (VMMC & SJH; ABVIMS & RML; Dr. Baba Saheb Ambedkar Medical College & Hospital, New Delhi; Army College of Medical Sciences, Delhi; North Delhi Municipal Corporation (Medical College) Hindu Rao Hospital) are eligible for Internal seats of 50% in Central Institutes (VMMC & SJH, ABVIMS & RML, ESIC-Basaidarapur).
Reservation Policy for AIQ seats and Internal seats of Central Institutes(VMMC & SJH, ABVIMS & RML, ESIC-Basaidarapur):
The reservation policy of the Central Government is followed -
1. S.C.- 15%
2. S.T.- 7.5%
3. O.B.C.- (Non-Creamy Layer) as per the Central OBC list- 27%
4. EWS- as per Central Government norms- 10%
5. PwD- Horizontal Reservation as per NMC norms- 5%
Eligibility –
The Candidates should have completed their MBBS/BDS from I.P. University (VMMC & SJH; ABVIMS & RML; Dr. Baba Saheb Ambedkar Medical College & Hospital, New Delhi; Army College of Medical Sciences, Delhi; North Delhi Municipal Corporation(Medical College) Hindu Rao Hospital) are eligible for Internal seats of 50% in Central Institutes (VMMC & SJH, ABVIMS & RML, ESIC-Basaidarapur).
DIPLOMATE OF NATIONAL BOARD (DNB) –
Medical Counseling Committee conducts counseling for the DNB courses which are domicile free and All India in character in compliance of the Judgment dated 26/05/2020 of the Hon’ble Supreme Court of India in W.P. of 2020 (Diary No. 11011 of 2020) in the matter of Alapati Jyotsana & Ors. v/sUoI & Ors. The Counselling for In-service seats of DNB is not conducted by the MCC of DGHS, MoHFW.
There will be four rounds of counseling i.e. Round 1, Round 2, third Round & Stray Vacancy Round which will be conducted by MCC. All the candidates who have qualified for NEET PG conducted by NBE will be eligible. After the allotment of seats by the MCC of DGHS, the admission fee is collected by NBE Authorities. Hence for any query refer to NBE, MCC has no role in the same, hence MCC will not entertain any requests for a refund.
Reservation Policy -
There will be no reservation in Private DNB Colleges/Institutes.
The reservation policy for the Govt. institutes /Colleges seats contributed by DNB of the Central Government is followed -
1. S.C.- 15%
2. S.T.- 7.5%
3. O.B.C.- (Non-Creamy Layer) as per the Central OBC list- 27%
4. EWS- as per Central Government norms- 10%
5. PwD- Horizontal Reservation as per NMC norms- 5%
Reservation of seats under the PWD Category is 5% in AIQ and the 21 Benchmark Disabilities as envisaged under the regulations of the Rights of Persons with Disabilities Act 2016 and as per NMC norms. For the range of disabilities included, please see Annexure- 1 in the notice below.
Eligibility –
Candidate must have qualified NEET-PG.
Candidates who want to avail of 5% PwD reservation in PG seats of Govt./Central medical institutions should obtain a Disability certificate as per 21 Benchmark Disabilities given under RPWD Act 2016 and as per NMC norms, from the designated disability centers as per the list enclosed as Annexure- 2 in the notice below. The certificate issued by any other hospital/ board will not be accepted.
To view the notice, click on the link below -
https://medicaldialogues.in/pdf_upload/pg-214882.pdf
Also Read:MP DME releases NEET PG Counselling schedule, Registrations from July 25th, Check out complete details
1 year 12 months ago
State News,News,Health news,Delhi,Doctor News,Medical Education,Medical Colleges News,Medical Universities News,Dentistry Education News,Medical Admission News,Latest Medical Education News
VIDEO: MOLTO study probes combination therapy in Richter syndrome
In this video, Jakub Svoboda, MD, discusses updated data on the results of the MOLTO study into Richter syndrome presented at ASCO Annual Meeting.Svoboda, an associate professor of medicine at Hospital of the University of Pennsylvaniia, highlighted the study, which examined a combination therapy consisting of venetoclax (Venclexta; Genentech, AbbVie), atezolizumab (Tecentriq, Genentech) and ob
inutuzumab (Gazyva, Genentech) into patients with Richter syndrome, which can be the result of progression from chronic lymphocytic leukemia.“That is a very challenging situation when CLL
1 year 12 months ago
Dengue fever cases could reach near-record highs this year: What to know about the tropical infectious disease
The World Health Organization warned on Friday that cases of dengue fever could reach close to record highs this year, partly due to global warming and the way that climate has helped the mosquitoes that spread it, Reuters reported.
The World Health Organization warned on Friday that cases of dengue fever could reach close to record highs this year, partly due to global warming and the way that climate has helped the mosquitoes that spread it, Reuters reported.
Rates of the disease are climbing worldwide, "with reported cases since 2000 up eight-fold to 4.2 million in 2022," according to the same source.
"Europe has reported a surge in cases and Peru declared a state of emergency in most regions."
LISTERIA OUTBREAK KILLS THREE ADULTS IN WASHINGTON STATE, HEALTH DEPARTMENT CONFIRMS
However, international travelers in the U.S. who are looking for protection against this tropical infectious disease spread by mosquitoes will have to wait a little longer.
On July 11, the Japanese drug-maker Takeda voluntarily withdrew its application to the Food and Drug Administration (FDA) for its dengue vaccine candidate in the U.S. after the agency requested more data that the current trial could not capture, according to a press release.
A dengue vaccine from the company is already approved in multiple endemic and non-endemic areas, such as the European Union, United Kingdom, Brazil, Argentina, Indonesia and Thailand.
There is only one dengue vaccine approved by the FDA in the U.S., but it is indicated only for children and teenagers ages six to 16 living in endemic areas — mainly Puerto Rico — who have previously had the infection.
The World Health Organization listed dengue fever as one of the top 10 threats to global health in 2019.
Roughly half the world’s population, or about 4 billion people, live in places that are at risk for dengue fever, with some 400 million people infected every year.
One country, Peru, is currently battling its worst outbreak in history.
"Dengue is occurring in urban areas where it did not exist before," Dr. Coralith García, associate professor at the school of medicine at Cayetano Heredia University in Lima, Peru, told Fox News Digital.
Experts blame warmer temperatures and increased rainfall, but even in Lima, the second largest desert city in the world, dengue is flourishing because "it’s so crowded that anything can happen," she added.
"But Peru had the highest COVID mortality rate [in] the world and now we have several patients dying of dengue, confirming that the Peruvian health system is very weak."
Most Americans get infected with dengue fever while traveling internationally.
Yet it can spread locally in several states with hot, humid climates, such as Florida, Hawaii, Texas, and Arizona — although this is not common, according to the Centers for Disease Control and Prevention (CDC).
From January to June 1 of this year, there were 129 reported cases in the U.S. and 256 reported cases in Puerto Rico, according to the CDC.
Dengue fever is caused by four viruses: dengue virus 1, 2, 3, and 4.
It is spread primarily by the bite of the Aedes aegypti mosquito, which bites generally during the day, per the CDC.
A person can get infected as many as four times because one virus strain only confers immunity against that specific serotype; people are at higher risk for a life-threatening condition called dengue hemorrhagic fever when they are infected twice, per the CDC.
About one in four people with dengue fever become sick, which can be either a mild or severe illness; but some 40,000 die from severe disease every year, according to the CDC.
Dengue fever is the leading cause of fever among returning travelers to Europe from all continents except Africa, according to a recent study on the tropical disease.
International travelers often complain of a fever with dengue within two weeks after returning home, but symptoms generally resolve within one week.
Dengue has 3 phases of disease: 1) fever phase; 2) critical phase; and 3) recovery phase.
The fever phase, named after its most common symptom, is characterized by severe joint pain and headaches, but most patients recover without complications, Dr. David O. Freedman, professor emeritus of infectious diseases at the University of Alabama at Birmingham, told Fox News Digital.
The disease’s hallmark bone and joint pains have earned it the nickname "breakbone fever."
ARE YOU A MOSQUITO MAGNET? IT MIGHT BE FOR ONE UNPLEASANT REASON
"In a small proportion of patients, just as the fever is resolving, a second critical phase develops where fluid leaks out of the circulation and gets into body spaces, such as the chest and abdominal cavities," he added.
During this phase, the blood pressure drops; severe bleeding may also occur.
Freedman recommends watching for abdominal pain or tenderness; 2) persistent vomiting; 3) fluid in body spaces; 4) bleeding from the mouth or rectum; and 5) lethargy and restlessness.
Any of these combined with a fever increase the likelihood of patients becoming very sick and needing to be hospitalized.
He also reminds people that "a total body rash often develops during the critical or early recovery phase."
Freedman noted, "If the patient survives the critical phase usually with medical intervention, the third phase, recovery, occurs about 3-4 days after that."
A recent paper analyzed nearly 6,000 returning travelers with dengue using the GeoSentinel network surveillance platform.
The network is a collaboration between the CDC and the International Society of Travel Medicine. It monitors infectious diseases in 29 countries on six continents that affect international travelers and migrants.
The researchers looked at the patients with dengue fever, which was relatively mild illness without any complications, or "complicated dengue," which included those who had warning signs or severe illness.
They found only 2% of dengue cases were considered "complicated," but approximately 99% had warning signs, with 31% classified as severe.
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"Most of the time it is an uncomplicated course," lead author Ralph Huits, M.D., PhD, department of infectious tropical diseases and microbiology at IRCCS Sacro Cuore Don Calabria Hospital in Negrar, Verona, Italy, told Fox News Digital.
"You can feel very sick, such as [with] a headache, anorexia, but then get better," he added.
"But some 2% of travelers can have a severe dengue," he continued.
"What you should remember is if you have any of the warning signs, then you or the doctor should monitor them very closely, preferably by hospitalization."
1 year 12 months ago
infectious-disease, Health, lifestyle, insects, climate-change, south-america, Europe, Europe, viruses, headaches-and-migraines
The ‘great American switching experiment’: Cyltezo debut ushers in interchangeable era
The hotly debated topic of interchangeability between biologics and biosimilars has officially leapt from the hypothetical realm to clinical practice, ushering in a new era of therapy switching in rheumatology.Cyltezo (adalimumab-adbm, Boehringer Ingelheim), the first biosimilar indicated for certain inflammatory diseases to achieve the interchangeable designation from the FDA, made its U.S.
debut on July 1. This means that it is now possible for a patient being treated with adalimumab (Humira, AbbVie)to be switched to Cyltezo without additional approval from the prescriber.According to the
1 year 12 months ago
Medical News, Health News Latest, Medical News Today - Medical Dialogues |
Cereal bran, especially oat bran useful for controlling BP, cholesterol and blood glucose
Researchers have found in a new study that cereal bran, especially oat bran had a role in controlling BP, cholesterol and blood glucose.
Cardiovascular disease is a prevalent worldwide disease, and cardiometabolic risk factors (CMRFs) include hyperlipidemia, hypertension, diabetes, and adiposity. The researchers conducted the study to investigate the effects of cereal bran consumption on cardiometabolic risk factors.
A study entitled “Effects of cereal bran consumption on cardiometabolic risk factors: A systematic review and meta-analysis” has mentioned that among those with cardiometabolic risk factors or CMRFs, Cereal bran reduces blood pressure, total cholesterol, low-density lipoprotein cholesterol, and fasting blood glucose. Oat bran had the most noticeable effect, they noted.
Cardiovascular disease is highly prevalent. CMRFs include hyperlipidemia, hypertension, diabetes, and adiposity. To control these CMRFs, a healthy diet plays a crucial role in managing CMRFs risks. Cereal bran contains beneficial substances and plays a vital role in this context.
There are still contradictions in the indicators of improving CMRFs by bran from different grain sources or even the same grain source. In this study, researchers investigated the effects of cereal bran consumption on CMRFs using databases like PubMed, Embase, Scopus, the Cochrane Library and Web of Science until February 2023.
The critical points of the study include:
- The present meta-analysis had 22 studies.
- Consuming cereal bran has no significant effect on high-density lipoprotein cholesterol, triglycerides, waist circumference, and BMI compared to the control.
- Cereal bran consumption reduces systolic blood pressure, diastolic blood pressure, total cholesterol, low-density lipoprotein cholesterol and fasting blood glucose with WMD of -1.59, -1.96, -0.19, -0.21 and -0.13, respectively.
- Oat bran reduced blood lipids in individuals with a history of lipid diseases and blood pressure in patients with a history of obesity and hypertension.
Concluding, Cereal bran reduces blood pressure, total cholesterol, low-density lipoprotein cholesterol, and fasting blood glucose in CMRF individuals, while oat bran had the most obvious effect.
Further reading:
https://www.unboundmedicine.com/medline/citation/37482485/full_citation
1 year 12 months ago
Cardiology-CTVS,Diet and Nutrition,Cardiology & CTVS News,Diet and Nutrition News,Top Medical News
STAT+: Gene therapy eyedrops restored a boy’s sight. Similar treatments could help millions
MIAMI — Dr. Alfonso Sabater pulled up two photos of Antonio Vento Carvajal’s eyes. One showed cloudy scars covering both eyeballs. The other, taken after months of gene therapy given through eyedrops, revealed no scarring on either eye.
MIAMI — Dr. Alfonso Sabater pulled up two photos of Antonio Vento Carvajal’s eyes. One showed cloudy scars covering both eyeballs. The other, taken after months of gene therapy given through eyedrops, revealed no scarring on either eye.
Antonio, who’s been legally blind for much of his 14 years, can see again.
The teen was born with dystrophic epidermolysis bullosa, a rare genetic condition that causes blisters all over his body and in his eyes. But his skin improved when he joined a clinical trial to test the world’s first topical gene therapy. That gave Sabater an idea: What if it could be adapted for Antonio’s eyes?
1 year 12 months ago
Biotech, biotechnology
STAT+: Pharmalittle: Three big drugmakers spent less on lobbying after leaving PhRMA; EMA reviews CRO over data concerns
Good morning, everyone, and welcome to another working week. We hope the weekend respite was relaxing and invigorating, because that oh-so familiar routine of online calls, meetings, and deadlines has returned. But what can you do? No matter how hard we try, the world keeps spinning. So time to give it a nudge in a better direction with a cup or three of stimulation.
Our choice today is salted caramel mocha, a touch of the Jersey Shore. Please feel free to join us. Meanwhile, we have assembled a few items of interest for you to peruse as you being your journey. We hope all goes well and that you conquer the world. And of course, do keep in touch. …
The three companies that recently left the Pharmaceutical Research & Manufacturers of America, the industry trade group, all spent less on lobbying following their departures, STAT reports, citing newly released federal disclosures. AbbVie, Teva Pharmaceutical, and AstraZeneca left over a span of five months following the passage of the drug-pricing reform law pushed by Democrats last year. How large members navigate their exits could be instructive to other firms making decisions about their continued membership in the future. Much of PhRMA’s revenue comes from company dues, so exits hurt its bottom line.
Drug companies are systematically funding grassroots patient groups that lobby the U.K. cost-effectiveness watchdog to approve the rollout of their drugs, The Guardian reveals. Of 173 drug appraisals conducted by the National Institute for Health and Care Excellence since April 2021, 138 involved patient groups with a financial link to the maker of the drug being assessed, or have since received funding. Financial interests were often not clearly disclosed in NICE documents. Many of the groups that received payments later made impassioned pleas to NICE for treatments to be approved. Others made submissions appealing NICE decisions when drugs were refused for being too expensive.
1 year 12 months ago
Pharma, Pharmalot, pharmalittle, STAT+
Joy Reid Keto Gummies Reviews [Consumer REVIEWS] - Weight Loss Journey 2023! - Deccan Herald
- Joy Reid Keto Gummies Reviews [Consumer REVIEWS] - Weight Loss Journey 2023! Deccan Herald
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- Active Keto Gummies Reviews Australia (2023) Don’t Buy Active Keto Gummies Canada & Puerto Rico, Check Price First Outlook India
- Bio Pure Keto Gummies Reviews [TRUTH Exposed 2023] Must Watch BioPure Keto Gummies Warning? Deccan Herald
- View Full Coverage on Google News
1 year 12 months ago
STAT+: Lobbying spending dropped for companies that departed PhRMA
WASHINGTON — The three companies that recently left PhRMA all spent less on lobbying following their departures, according to newly released federal disclosures.
PhRMA, the brand-drug industry trade group, lost three members over a span of five months following the passage of Democrats’ drug pricing reform law last year. How large members navigate their exits could be instructive to other firms making decisions about their continued membership in the future. Much of PhRMA’s revenue comes from company dues, so exits hurt the group’s bottom line.
1 year 12 months ago
Politics, Advocacy, Congress, life sciences, Pharmaceuticals, policy, STAT+, White House
Genetic defects in nerve cells of autistic children develop quickly - The Jerusalem Post
- Genetic defects in nerve cells of autistic children develop quickly The Jerusalem Post
- 'Gain-of-function' mutation spawns autism traits | Spectrum Spectrum - Autism Research News
- Stress response in neurons; quantitative bioimaging tutorial Spectrum - Autism Research News
- View Full Coverage on Google News
1 year 12 months ago
World's biggest fruit eaters REVEALED in interactive map (and neither Britain or the US is near the bottom)
Dominica is home to the world's biggest fruit lovers, data shows. People on the Caribbean island eat a whopping 387.18kg of fruit a year. The UK only chomp on 86.4kg of fruit a year.
Dominica is home to the world's biggest fruit lovers, data shows. People on the Caribbean island eat a whopping 387.18kg of fruit a year. The UK only chomp on 86.4kg of fruit a year.
1 year 12 months ago
Preventing heatstroke
Heatstroke
is a condition caused by your body overheating, usually as a result of prolonged exposure to or physical exertion in high temperatures.
This most serious form of heat injury and a heatstroke can occur if your body temperature rises to 104°F (40°C) or higher. The condition is most common in the summer months.
Heatstroke
is a condition caused by your body overheating, usually as a result of prolonged exposure to or physical exertion in high temperatures.
This most serious form of heat injury and a heatstroke can occur if your body temperature rises to 104°F (40°C) or higher. The condition is most common in the summer months.
Heatstroke requires emergency treatment. Untreated heatstroke can quickly damage your brain, heart, kidneys, and muscles. The damage worsens the longer treatment is delayed, increasing your risk of serious complications or death.
Heatstroke signs and symptoms include:
*High body temperature. A core body temperature of 104°F (40°C) or higher, obtained with a rectal thermometer, is the main sign of heatstroke.
*Altered mental state or behaviour. Confusion, agitation, slurred speech, irritability, delirium, seizures, and coma can all result from heatstroke.
*Alteration in sweating. In heatstroke brought on by hot weather, your skin will feel hot and dry to the touch. However, in heatstroke brought on by strenuous exercise, your skin may feel dry or slightly moist.
*Nausea and vomiting. You may feel sick to your stomach or vomit.
*Flushed skin. Your skin may turn red as your body temperature increases.
*Rapid breathing. Your breathing may become rapid and shallow.
*Racing heart rate. Your pulse may significantly increase because heat stress places a tremendous burden on your heart to help cool your body.
*Headache. Your head may throb.
Heatstroke can occur as a result of:
1. Exposure to a hot environment. In a type of heatstroke called non-exertional (classic) heatstroke, being in a hot environment leads to a rise in core body temperature. This type of heatstroke typically occurs after exposure to hot, humid weather, especially for prolonged periods. It occurs most often in older adults and in people with chronic illness.
2. Strenuous activity. Exertional heatstroke is caused by an increase in core body temperature brought on by intense physical activity in hot weather. Anyone exercising or working in hot weather can get exertional heatstroke, but it's most likely to occur if you're not used to high temperatures.
In either type of heatstroke, your condition can be brought on by wearing excess clothing that prevents sweat from evaporating easily and cooling your body; drinking alcohol, which can affect your body's ability to regulate your temperature; and becoming dehydrated by not drinking enough water to replenish fluids lost through sweating.
Risk factors
Anyone can develop heatstroke, but several factors increase your risk:
1. Age. Your ability to cope with extreme heat depends on the strength of your central nervous system. In the very young, the central nervous system is not fully developed, and in adults over 65, the central nervous system begins to deteriorate, which makes your body less able to cope with changes in body temperature. Both age groups usually have difficulty remaining hydrated, which also increases risk.
2. Exertion in hot weather. Military training and participating in sports, such as football or long-distance running events, in hot weather are among the situations that can lead to heatstroke.
3. Sudden exposure to hot weather. You may be more susceptible to heat-related illnesses if you're exposed to a sudden increase in temperature, such as during an early summer heatwave or travel to a hotter climate.
4. A lack of air conditioning. Fans may make you feel better, but during sustained hot weather, air conditioning is the most effective way to cool down and lower humidity.
5. Certain medications. Some medications affect your body's ability to stay hydrated and respond to heat. Be especially careful in hot weather if you take medications that narrow your blood vessels, regulate your blood pressure by blocking adrenaline, rid your body of sodium and water, or reduce psychiatric symptoms.
6. Stimulants for attention-deficit/hyperactivity disorder (ADHD) and illegal stimulants, such as amphetamines and cocaine, also make you more vulnerable to heatstroke.
7. Certain health conditions. Certain chronic illnesses, such as heart or lung disease, might increase your risk of heatstroke. So can being obese, being sedentary, and having a history of previous heatstroke.
Complications
Heatstroke can result in a number of complications depending on how long the body temperature is high. Severe complications include:
1. Vital organ damage. Without a quick response to lower body temperature, heatstroke can cause your brain or other vital organs to swell, possibly resulting in permanent damage.
2. Death. Without prompt and adequate treatment, heatstroke can be fatal.
Prevention
Heatstroke is predictable and preventable. Take these steps to prevent heatstroke during hot weather:
1. Wear loose-fitting, lightweight clothing. Wearing excess clothing or clothing that fits tightly won't allow your body to cool properly.
2. Protect against sunburn. Sunburn affects your body's ability to cool itself, so protect yourself outdoors with a wide-brimmed hat and sunglasses and use a broad-spectrum sunscreen with an SPF of at least 15. Apply sunscreen generously, and reapply every two hours — or more often if you're swimming or sweating.
3. Drink plenty of fluids. Staying hydrated will help your body sweat and maintain a normal body temperature.
4. Take extra precautions with certain medications. Be on the lookout for heat-related problems if you take medications that can affect your body's ability to stay hydrated and dissipate heat.
5. Never leave anyone in a parked car. This is a common cause of heat-related deaths in children. When parked in the sun, the temperature in your car can rise 20° F (more than 11° C) in 10 minutes.
It's not safe to leave a person in a parked car in warm or hot weather, even if the windows are cracked or the car is in shade. When your car is parked, keep it locked to prevent a child from getting inside. Take it easy during the hottest parts of the day. If you can't avoid strenuous activity in hot weather, drink fluids and rest frequently in a cool spot. Try to schedule exercise or physical labour for cooler parts of the day, such as early morning or evening.
6. Get acclimated. Limit time spent working or exercising in heat until you're conditioned to it. People who are not used to hot weather are especially susceptible to heat-related illnesses. It can take several weeks for your body to adjust to hot weather.
7. Be cautious if you're at increased risk. If you take medications or have a condition that increases your risk of heat-related problems, avoid the heat and act quickly if you notice symptoms of overheating. If you participate in a strenuous sporting event or activity in hot weather, make sure there are medical services available in case of a heat emergency.
This article first appeared on Mayo Clinic and can be accessed at the following link: https://www.mayoclinic.org/diseases-conditions/heat-stroke/symptoms-caus...
2 years 28 min ago
Anaesthesia, surgery and your child — Part 1
THE world of medicine is vast and complex. There are several specialities and sub-specialities, then 'sub-sub-specialities'. Anaesthesiology, for example, is a speciality that spans across internal medicine, surgery, paediatrics and emergency medicine.
Anaesthesia is the class of drugs used to make you sleepy as well as relieve and prevent pain during surgeries and procedures. These drugs are further divided into:
1. Local Anaesthesia. This drug numbs a small area of the body. For example, if you need stitches, we inject a local anaesthetic around that area of skin so you don't feel when we stitch (or suture) your wound.
2. Sedation. This medication causes you to relax and sleep during a procedure. Think of when we need to pass a camera down your throat into your stomach to look for ulcers, or you need to have your wisdom tooth pulled. When you wake, you won't remember the procedure.
3. Regional anaesthesia. This drug (temporarily) blocks the nerves of a large area of the body so you can't feel anything. For example, if a mother needs to have a C-section done, the doctor will inject medication into her back causing numbness and no pain everywhere below the waist.
4. General anaesthesia (GA). This is when we say "put to sleep". These drugs will make you totally unconscious and unable to feel pain or any stimuli. We use GA for more invasive procedures like surgeries of the head, chest, abdomen.
Getting news that you or your child needs a procedure or surgery can be one of the most frightening things. The anaesthesiologist will be there to go through what happens before, during, and after surgery.
My colleague, Dr Brittany Smith, who is a resident in the anaesthesiology and intensive care unit (ICU) department at the Bustamante Hospital for Children (BHC), walked me through the ins and outs of what happens when a child comes in for surgery/procedure as a "day case".
Your child may have to come in a few days before the procedure to be reviewed by the surgery doctors as well as the doctors who will "put him or her to sleep". At this visit, the anaesthetist/anaesthesiologist will ask you the parent (or guardian or caregiver) about how healthy your child is. They may ask, "Is there any cough or cold?"; "Any fever or signs of infection?"; etc. The doctor will examine your child's mouth and throat to assess how easy or difficult it will be to intubate (place a breathing tube down the throat) which is required in certain procedures.
If your child is sick with a cold or cough, it decreases the safety of putting your child to sleep, and so it is very important that you tell the doctor if your child has had a cold or cough in the prior two to three weeks before surgery. If so, the surgery must be postponed to a later date. I know this is very annoying and most times inconvenient; however, your child's safety is of utmost priority. We look at blood results (usually done earlier that day or week) to make sure your child's blood count is normal, there is nothing in the blood tests pointing to any signs of infection, if baby has sickle cell disease, plus any other blood tests relevant to that particular surgery.
The doctor will explain what they will do — place an IV (drip) in her hand, and have her inhale a gas to put him or her to sleep. For day cases, inhalation anaesthesia is used to put baby to sleep in 99 per cent of cases, and intubation is rarely done. Towards the end of the procedure, we lower the inhaled gases to allow baby to wake up. We also give pain medications to prevent discomfort when baby wakes up.
Once all this is explained to you, there is a form you must sign giving permission for us to go ahead with the surgery as well as to administer anaesthetic drugs. This is called the Consent for Procedure and Anaesthesia form. (NB only a parent or legal guardian will be able to sign the consent form).
The doctor will explain what to do and what not to do before surgery. These include:
1. Don't give baby any solid food after 12:00 am the morning of surgery
2. Baby is allowed to drink clear fluids (water, apple juice, mint tea) up to 5:30 am the morning of surgery
3. Don't give baby any sweets or candy before surgery
Bring with you:
1. Child's birth and immunisation passport, clinic card, and sheet of paper outlining which surgery is being done
2. A change of clothes, including underwear or diapers
3. A toy, book, blanket, or an electronic device to help child feel comfortable in the waiting area
4. Water or juice for after the surgery
5. Baby wipes or alcohol wipes
6. Face masks for you and child
7. If child is on any medications (like for the heart, or stomach, or any medication taken on a regular basis), please take the medication with you and let the doctors know when the last dose was. If your child has asthma, take the asthma pumps
Next week we will look at what to expect on the morning of the surgery and the possible complications from anaesthesia.
Dr Tal's Tidbit
Knowing your child needs any kind of medical procedure done can be very scary. The anaesthesiologist is the amazing doctor who will ensure you child is sleeping, pain- free and safe before, during and after the procedure or surgery.
Dr Taleya Girvan has over a decade's experience treating children at the Bustamante Hospital for Children, working in the Accident and Emergency Department and Paediatric Cardiology Department. Her goal is to use the knowledge she has gained to improve the lives of patients by increasing knowledge about the health-care system in Jamaica. Dr Tal's Tidbits is a series in which she speaks to patients and caregivers providing practical advice that will improve health care for the general population. Email: dr.talstidbits@gmail.com IG @dr.tals_tidbits
2 years 29 min ago
Reducing heart disease, death in the diabetic patient — Part 2
IN our last article we looked at some of the measures that can be used to improve the outcome of the diabetic patient and noted that cardiac and vascular disease represent the most common cause of death in the diabetics.
The incidence of heart attack, heart failure, and stroke is approximately two to four times that of the general population and cardiovascular disease represent the largest cause of mortality in diabetes.
Insulin was the first drug available to treat diabetes and this was isolated in 1922. The first oral medications for diabetes, the sulfonylureas were discovered in 1942. The management of the diabetic patient for the first 60 to 70 years concentrated on the management of the blood sugar,; however, over the last three to free decades there has been greater emphasis on preventing and managing the complications of diabetes and trying to improve morbidity and mortality. Metformin has for decades been the drug of first choice in the management of Type 2 diabetes in part because of its cardiovascular safety. The last 10 years have seen the emergence of two groups of diabetes medications with robust effects in lowering cardiovascular morbidity and mortality. We will briefly review these medications this week.
Sodium glucose transport 2 (SGLT2) inhibitors
The SGLT2 inhibitors are a class of medications that prevent reabsorption of glucose that has been filtered into the urine. This results in loss of glucose from the body thus lowering the blood sugar level. The presence of high urinary sugar increases the excretion of salt and water from the body. Initial studies of the SGLT2 inhibitors have found that in addition to improving diabetic control, these agents lower the risk of developing heart failure in diabetic patients. These agents also reduce the risk of developing heart failure, being hospitalised with heart failure and the combination of heart failure and death. Further data has found that this benefit extends to patients with heart failure who are not diabetic. Given these findings, SGLT2 inhibitors are currently considered standard treatment for most forms of heart failure. An interesting finding is that the beneficial effects of these agents are noted within weeks of initiation. They have also been demonstrated to significantly decrease the likelihood of diabetic kidney disease and are associated with a small reduction in the risks of heart attack and stroke. The drugs are safe to use with low risk of low blood sugar. The major concern, in terms of complications, is that of infection in the urinary tract, groin, and lower abdominal area.
Glucagon-like peptide receptor 1 agonists (GLP 1 receptor agonists)
These agents have multiple effects which aid in blood sugar control. They stimulate the release of insulin from the pancreas, they prevent the release of glucagon (a hormone which acts in opposition to insulin), slow stomach emptying and decrease appetite. Of most interest to the general population is the fact that these agents produce significant weight loss. The weight loss is 10-15 per cent of body weight on average and many non-diabetics have been using this drug off-label to lose weight. From a cardiac point of view, these agents decrease the risk of disease related to atherosclerosis (cardiovascular death, heart attack and stroke) by up to 24 per cent. In contrast to the SGLT2 inhibitors the effects on cardiac and vascular morbidity and mortality take place over months to years suggesting that ameliorating the effects of cholesterol deposition in vessels is an important part of their effect. The major side effects of these agents are gastrointestinal with nausea, diarrhoea and vomiting being most common. There is also a rare risk of inflammation of the pancreas.
Metformin
Metformin is one of the older agents that is used for treatment of diabetes. It has been used since the late 1950s. It is currently considered a first line medication for the newly diagnosed diabetic patient. It is safe, effective, and results in some weight loss, on average four to seven pounds. The evidence of metformin for improving cardiac outcome in the diabetic patient is mixed. Several studies have shown that it reduces the risk of dying, as well as the risk of heart attack and stroke. Most of these studies; however, are observational and not gold standard large randomised controlled trials. A recent analysis by the Cochrane group in 2020 has concluded that most of the studies demonstrating its protective effect for the heart and vascular system are limited and have suggested further research in this area. While there is some debate as to whether and how much it improves outcome there is no signal of cardiac or vascular harm.
What about aspirin?
For several decades, the use of aspirin was considered a routine part of management of the diabetic patient given the considerable risk of cardiac and vascular disease. Studies over the past 30 years have however made clear that there is a difference between aspirin use in a preventative sense i.e., patients who do not yet have vascular disease and in a secondary sense i.e., patients who are using aspirin after developing stroke, heart attack or peripheral vascular disease. There is a much greater risk reduction in the second group of patients. The use of aspirin is associated with a risk of bleeding particularly from the gastrointestinal tract and the brain, and while this risk is low, we do need to consider this risk when prescribing aspirin. In the group of patients who only have diabetes and no vascular disease the risk of bleeding is high enough and the likely benefit low enough that most professional societies have suggested that aspirin use be avoided. In contrast there is robust data that diabetic patients with stroke, heart attack or peripheral vascular disease have improved outcomes on aspirin even when considering the risk of bleeding. A grey area is patients who do not yet have vascular disease but who would be considered extremely high risk. Some experts would suggest the use of low dose aspirin along with medications to protect the stomach.
How do I reduce my cardiac and vascular risk as a diabetic patient?
It is important to remember that medical therapy should take place on a foundation of lifestyle change. Regular aerobic exercise, a heart healthy diet, good sleep hygiene, stress management, avoiding smoking, and illicit drugs, limiting alcohol and weight management are essential for good outcomes. Close attention should be paid to blood pressure as poor hypertension control in diabetic patients is a strong risk factor for heart and vascular disease. ACE inhibitors and angiotensin receptor blockers are considered first line for the management of hypertension in diabetes given the protective effects for the kidneys. Most patients with diabetes will benefit from statin therapy to lower the LDL cholesterol, so that patients should be aware of their cholesterol profile. The use of aspirin should be restricted to patients who have established vascular disease or used selectively in those who are at very high risk for vascular complications. Patients should aim for good glucose control, ideally with a medication regimen that includes a diabetic agent that lowers cardiac and vascular risk as listed above.
Dr Ernest Madu, MD, FACC and Dr Paul Edwards, MD, FACC are consultant cardiologists for the Heart Institute of the Caribbean (HIC) and HIC Heart Hospital. HIC is the regional centre of excellence for cardiovascular care in the English-speaking Caribbean and has pioneered a transformation in the way cardiovascular care is delivered in the region. HIC Heart Hospital is registered by the Ministry of Health and Wellness and is the only heart hospital in Jamaica. Send correspondence to info@caribbeanheart.com or call 876-906-2107.
2 years 30 min ago
Miss Kitty's blood drive yields 95 pints
APPROXIMATELY 285 individuals will benefit from the 95 pints of blood collected at the fourth edition of the Miss Kitty Blood Drive.
The blood drive took place last Friday at itel's headquarters in St Andrew, in partnership with the company's 4Ys Foundation, and was powered by Digicel. Khadine "Miss Kitty" Hylton, attorney-at-law and media personality, was pleased with the turnout for her first post-COVID-19 blood drive.
"I'm really happy that my blood drive returned with a bang, and I extend sincere gratitude to all the donors who participated voluntarily and the sponsors that contributed to the event's success. It's hard to overstate that we need to develop a stronger culture of donating blood voluntarily in Jamaica, and I'm committed to playing an active role in driving positive behaviour change," said Miss Kitty.
Michelle Yeo, executive vice-president - people, resources and culture at itel, underscored that public-private partnerships are critical to improving public health and well-being.
"Miss Kitty, our brand ambassador, has commanded attention as a blood donor advocate over the years. Itel felt compelled to support this important initiative as part of the push by the National Blood Transfusion Service to supply a higher volume of blood requested across the island."
Reshima Kelly Williams, brand marketing manager at Digicel, shared, "As our brand ambassador we were delighted to support Miss Kitty's passion for healing and saving lives. Each donation was a solid expression of solidarity with her cause, and it demonstrated the importance of working better together for the good of our nation and its people."
In addition to itel and Digicel, other sponsors included Brunswick, Complete Sourcing, CVM TV, Deaf Can! Coffee, Krispy Kreme, Maggi, Magnificent Chess Foundation, Main Event, Milo, PriceSmart, Tango's Entertainment, and Wisynco.
The fifth edition of Miss Kitty's Blood Drive is slated for October this year.
Miss Kitty stated, "We need all hands on deck to ensure no one dies due to a shortage of blood or blood products. This will be my first time hosting my blood drive in Montego Bay. I'm very excited about the possibilities of entering a new space to not only mobilise donors, but to help dispel a lot of the misinformation that turns people away from donating."
2 years 31 min ago
Health – Demerara Waves Online News- Guyana
Modern sewage treatment plant for Georgetown
Preparations are underway for the construction of a modern waste water treatment plant for Georgetown and bring an end to the dumping of that type of waste into the Demerara River and Atlantic sea, Minister of Housing and Water Collin Croal said Saturday. He said the US$36 million effluent treatment plant, which would probably be ...
Preparations are underway for the construction of a modern waste water treatment plant for Georgetown and bring an end to the dumping of that type of waste into the Demerara River and Atlantic sea, Minister of Housing and Water Collin Croal said Saturday. He said the US$36 million effluent treatment plant, which would probably be ...
2 years 8 hours ago
Business, Health, News
PAHO/WHO | Pan American Health Organization
Mandeville Comprehensive Health Centre Upgraded and Retrofitted to “Smart” Facility Standard
Mandeville Comprehensive Health Centre Upgraded and Retrofitted to “Smart” Facility Standard
Cristina Mitchell
22 Jul 2023
Mandeville Comprehensive Health Centre Upgraded and Retrofitted to “Smart” Facility Standard
Cristina Mitchell
22 Jul 2023
2 years 11 hours ago
International News: Man loses both arms and parts of feet after a single flea bite - Breaking Belize News
- International News: Man loses both arms and parts of feet after a single flea bite Breaking Belize News
- Flea bite leads man to require amputation of both hands, parts of feet WKRC TV Cincinnati
- Texas man undergoes multiple amputations after bite from insect most have near their homes PennLive
- Doctors share tips on how you can avoid contracting typhus as Houston man recovers from infection KHOU.com
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2 years 11 hours ago
MOH to hire call centre to take patient calls
FORT CHARLOTTE, Hanover — The Ministry of Health and Wellness is currently working on establishing a call centre that will monitor concerns from the public and provide responses.
Health Minister Dr Christopher Tufton said the initiative forms part of the ministry's compassionate care programme. He explained the role that will be played by the call centre, for which the ministry is currently in the process of hiring.
"... When the calls are made, it goes to a central point. It's picked up immediately by the people behind the phone. They log the complaints and the details and then our team will take the responsibility to respond," Tufton explained, noting that calls from across the country will be accepted in a central location.
Dr Tufton, who was responding to questions from the Jamaica Observer during his pop-up tour of the Noel Holmes Hospital in Hanover on Thursday, said the procurement process is underway and the project should be in place at the end of the procurement process later in the year.
"I keep saying about procurement, procurement because it is one of the unfortunate steps that have to be taken. I don't care what anybody says. I think it just takes too much time to get anything done; but it is what it is," he commented.
The minister explained that, over time, the call centre will provide the ministry with a database of complaints, where the complaints are coming from, who is making the complaints and will provide data that will facilitate follow-up communication if warranted.
"What it would do is allow for greater accountability and greater responsiveness of concerns. And I think it's important because I'd much prefer a disgruntled patient call me or my team and we respond to them even if we are wrong — or more so when we are in the wrong — than for them to call TVJ or CVM or mount a demonstration," stated Dr Tufton.
He argued that protests do not help the process and show a lack of confidence in the process.
The call centre will replace a system that, the minister said, has been ineffective.
"In the past, we had a standard and regulation division that responded to concerns or queries that were raised by patients. More often than not, disgruntled patients call a number and someone answers and they respond. I don't think it's working as effectively as I'd like it to work in that people call and they don't get a response. It rings without an answer. In other words, the summarising of the circumstances, the following up and so on [was not being done]," said Dr Tufton.
2 years 1 day ago