STAT

STAT+: Pharmalittle: PBMs are targeted in yet another congressional bill; access to new Alzheimer’s drug may not happen quickly

Rise and shine, another busy day is on the way. However, this is also shaping up as a beautiful day as well, given the clear and sunny skies — and delicious breezes — enveloping the Pharmalot campus this morning. This calls for celebration with a cup of stimulation, and we are opening a new package of salted caramel mocha for the occasion. We can practically taste the Jersey shore.

Meanwhile, our ever-growing to-do list requires attention. Sound familiar? So, here are some items of interest. Have a great day and hope you conquer the world, everyone …

Coherus BioSciences agreed to resolve a dispute over its plans to launch a lower-priced version of AbbVie’s Humira rheumatoid arthritis drug, Reuters writes. Earlier this month, Coherus said it will launch a biosimilar version of the drug at an 85% discount to the $6,922 list price and partnered with Mark Cuban Cost Plus Drug Company to sell it at $569.27. AbbVie alleged it breached an older deal granting Coherus a non-exclusive license to commercialize a biosimilar version in the U.S. as of July 1. AbbVie will not terminate the initial licensing deal based on its notice. It would have to serve another notice and give Coherus time to resolve the breach if it chooses to end the deal.

Expanded access to the Alzheimer’s drug from Eisai and Biogen is unlikely to happen quickly even if the Food and Drug Administration decides follow-up studies confirm the drug helps slow the disease, Bloomberg News explains. Medicare said that “broader” coverage would begin “on the same day the FDA grants traditional approval.” But patients, doctors, and analysts are all doubtful, citing the limited information publicized by the agency on how the registry will work. For the registry to succeed, it must be easy for prescribers to use, they argue. Researchers and others also will need real-time data to show whether the drug is beneficial and safe, they added.

Continue to STAT+ to read the full story…

2 years 1 month ago

Pharma, Pharmalot, Biosimilars, Pharmaceuticals, STAT+

PAHO/WHO | Pan American Health Organization

PAHO Director statement on External Evaluation Report of Organization’s Response to COVID-19

PAHO Director statement on External Evaluation Report of Organization’s Response to COVID-19

Cristina Mitchell

15 Jun 2023

PAHO Director statement on External Evaluation Report of Organization’s Response to COVID-19

Cristina Mitchell

15 Jun 2023

2 years 1 month ago

Health | NOW Grenada

World Blood Donor Day 14 June

We thank all of our unsung heroes who donate blood and encourage more people to become new donors

View the full post World Blood Donor Day 14 June on NOW Grenada.

We thank all of our unsung heroes who donate blood and encourage more people to become new donors

View the full post World Blood Donor Day 14 June on NOW Grenada.

2 years 1 month ago

Health, PRESS RELEASE, ann dufont, carib breweries, friends of the blood bank, nurse jolly, world blood donor day

Irish Medical Times

AbbVie announces European Commission approval of Rinvoq® for the treatment of moderately to severely active Crohn’s disease

RINVOQis the first and only oral JAK inhibitor approved to treat Crohn’s disease in Europe AbbVie, a US-based pharmaceutical company, has announced that its oral Janus Kinase (JAK) inhibitor, RINVOQ® (upadacitinib), has been approved by the European Commission for the treatment of moderately to severely…

2 years 1 month ago

Healthcare, News, AbbVie, Crohn’s disease, Rinvoq, upadacitinib

CNN.com - RSS Channel - Health

In countries where

In countries where magic mushrooms are legal, some people are turning to psilocybin wellness retreats. CNN's David Culver takes us on a mind-altering journey to Oregon and Jamaica on the next episode of "The Whole Story with Anderson Cooper" Sundays at 8 p.m. ET.

In countries where magic mushrooms are legal, some people are turning to psilocybin wellness retreats. CNN's David Culver takes us on a mind-altering journey to Oregon and Jamaica on the next episode of "The Whole Story with Anderson Cooper" Sundays at 8 p.m. ET.

2 years 1 month ago

PAHO/WHO | Pan American Health Organization

Urgent action required to protect SIDS from threat of NCDs and mental health conditions, PAHO Director says.

Urgent action required to protect SIDS from threat of NCDs and mental health conditions, PAHO Director says.

Cristina Mitchell

14 Jun 2023

Urgent action required to protect SIDS from threat of NCDs and mental health conditions, PAHO Director says.

Cristina Mitchell

14 Jun 2023

2 years 1 month ago

Health – Dominican Today

Red Cross: only 1.67% of Dominican blood donors do so voluntarily

Santo Domingo.- Around 30,000 individuals visited the National District Blood Bank in the Dominican Republic during the first five months of this year, intending to donate blood to the Dominican Red Cross. However, only 18,307 individuals were deemed eligible for donation.

Santo Domingo.- Around 30,000 individuals visited the National District Blood Bank in the Dominican Republic during the first five months of this year, intending to donate blood to the Dominican Red Cross. However, only 18,307 individuals were deemed eligible for donation.

Out of the eligible donors, 18,005 were replacement donors, while a mere 302 volunteered altruistically, accounting for only 1.67% of the total number. These statistics were provided by César Matos Moronta, the director of the National Network of Blood Banks, on the occasion of World Blood Donor Day on June 14.

Matos Moronta highlighted the World Health Organization’s recommendation that countries should strive for a minimum of 4% voluntary blood donation from the population. Unfortunately, the Dominican Republic falls short of even 2%.

Miguel Sanz Flores, the president of the Dominican Red Cross, emphasized the urgent need to establish a blood donation culture in the country to address the annual deficit of over 200,000 pints of blood. He expressed concern over the difficulties faced by Dominicans when they require blood transfusions and stressed the importance of societal commitment to saving lives through regular blood donation.

To encourage voluntary blood donation, the Red Cross relaunched the campaign “Save me with your pint, donate blood,” led by Dr. Sanz. He emphasized the importance of action rather than mere reminders on specific days, urging the nation to foster a consistent culture of blood donation.

 

2 years 1 month ago

Health

PAHO/WHO | Pan American Health Organization

PAHO calls for increased blood and plasma donations to ensure a safe and sustainable supply

PAHO calls for increased blood and plasma donations to ensure a safe and sustainable supply

Cristina Mitchell

14 Jun 2023

PAHO calls for increased blood and plasma donations to ensure a safe and sustainable supply

Cristina Mitchell

14 Jun 2023

2 years 1 month ago

Health

General Accident, Chain of Hope partner to save young lives

CHILDREN AWAITING heart surgery at the Bustamante Hospital for Children will see their chances improve as General Accident Jamaica (GenAc), the National Blood Transfusion Service and Chain of Hope join forces to provide life-saving donations of...

CHILDREN AWAITING heart surgery at the Bustamante Hospital for Children will see their chances improve as General Accident Jamaica (GenAc), the National Blood Transfusion Service and Chain of Hope join forces to provide life-saving donations of...

2 years 1 month ago

Health

Improving your memory

MEMORY SLIPS are aggravating, frustrating, and sometimes worrisome. When they happen more than they should, they can trigger fears of looming dementia or Alzheimer’s’s disease. Memory loss is unusual forgetfulness, that you may not be able to...

MEMORY SLIPS are aggravating, frustrating, and sometimes worrisome. When they happen more than they should, they can trigger fears of looming dementia or Alzheimer’s’s disease. Memory loss is unusual forgetfulness, that you may not be able to...

2 years 1 month ago

Health

Memory-enhancing techniques

IF YOU have ever found yourself forgetting where you left your keys or blanking out information on important tests, you have probably wondered how to improve your memory. Fortunately, there are many ways that you can do so to increase memory power...

IF YOU have ever found yourself forgetting where you left your keys or blanking out information on important tests, you have probably wondered how to improve your memory. Fortunately, there are many ways that you can do so to increase memory power...

2 years 1 month ago

Healio News

Stool culture may underperform in detecting new surges of cholera

Stool culture “performed worse than would be expected” in diagnosing cholera during a period of waning cases in Haiti compared with PCR testing, according to the results of a small study.“This finding is important because, as cholera cases wane over the course of a big outbreak, rigorous laboratory-based surveillance must correspondingly increase to identify ongoing transmission, detect outbrea

ks early, and allow public health officials to be on alert for new surges,” wrote Louise C. Ivers, MD, MPH, director of the Harvard Global Health Institute and executive director

2 years 1 month ago

Health – Dominican Today

The Dominican Republic lacks professionals trained to treat people with autism

Santo Domingo.- The Global Institute of Higher Studies in Social Sciences (IGLOBAL) organized a seminar titled “The Autism Spectrum: A Global Look at a Multifactorial Disorder” on Tuesday. The aim of the seminar was to raise awareness and sensitize society, especially educators, about autism.

Santo Domingo.- The Global Institute of Higher Studies in Social Sciences (IGLOBAL) organized a seminar titled “The Autism Spectrum: A Global Look at a Multifactorial Disorder” on Tuesday. The aim of the seminar was to raise awareness and sensitize society, especially educators, about autism. Josefina Pimentel, the rector of IGLOBAL, highlighted the shortage of professionals in the country who are trained to work with individuals with autism. She emphasized the need for understanding the characteristics of this condition in order to support holistic development and tap into the potential of children and adults with autism. Pimentel commended the approval of the autism bill in the Chamber of Deputies, although she also noted that certain aspects may need to be adapted to the current realities of Dominican society. She viewed it as a significant step forward.

The seminar took place at the auditorium of the Global Foundation for Democracy and Development (Funglode). The event brought together medical specialists, teachers, and organizations dedicated to serving individuals with autism, featuring presentations on various aspects of the disorder. The keynote address, titled “A Global Look at a Multifunctional Disorder: Health, Education, and Socialization of People with Autism Spectrum Disorder,” was delivered virtually by Natalia Blanco, the director of the Spanish Federation of Autism, based in Spain.

The seminar covered topics such as the journey from health to well-being for individuals with Autism Spectrum Disorder (ASD), including early detection, neurological perspectives, socio-emotional dimensions, the family and school environment, and holistic behavior therapy.

The second block of the seminar focused on “Education by and for All,” presenting a vision of education that encompassed school inclusion, the role of support teachers, speech therapy approaches, and the Individualized Educational Program (PEI).

The third block, titled “Strengthening the Support Network for People with ASD,” showcased the contributions of both public and private institutions in ensuring the full lives of individuals with ASD. It included presentations from these institutions as well as testimonies and reflections from two families on their experiences.

The closing conference, “Public Policies in Favor of People with ASD: Facilitating the Path Towards Inclusion,” featured three legislators: Deputy Yudelka de la Rosa and Senators Franklin Rodríguez and Dionis Sánchez. They discussed the “Law of Care, Inclusion, and Protection of People with Autism Spectrum Disorder (ASD).”

2 years 1 month ago

Health

Health – Dominican Today

The blood deficit exceeds half of the country’s demand

Santo Domingo.- Despite an increasing number of donors at the National Blood Center, the Dominican Republic continues to face a blood shortage of approximately 150,000 units annually, accounting for around 50% of the national demand of 300,000 units. Dr.

Santo Domingo.- Despite an increasing number of donors at the National Blood Center, the Dominican Republic continues to face a blood shortage of approximately 150,000 units annually, accounting for around 50% of the national demand of 300,000 units. Dr. Pedro Sing, the director of the National Blood Center, highlighted the significance of voluntary donations and emphasized the need to raise awareness about this crucial act.

He assured that the National Blood Center currently fulfills 100% of the emergency blood supply for the Hugo Mendoza Pediatric Hospital, 65-70% for the Robert Reid Cabral Hospital, and close to 50% for the Francisco Moscoso Puello, Salvador B. Gautier, San Lorenzo de Los Mina, and Darío Contreras hospitals.

On the occasion of World Donor Day, which is celebrated on Wednesday, the National Blood Center plans to organize various large-scale blood collection events in Santo Domingo, Santiago, and La Vega. Among these events, there will be a collaboration with the Banco de Reservas Health Insurance (ARS) and the signing of an agreement with the Ministry of Industry and Commerce to further increase blood reserves.

Dr. Sing also announced the opening of the first Node or blood bank at the Vinicio Calventi Hospital this week. This Node operates within a network model, where donor clubs are established to collect blood. The collected blood is then processed at the Hemocentro and returned to the respective hospital.

2 years 1 month ago

Health

STAT

Opinion: How predominantly white hospital leadership teams hurt care for people of color

Last year, my father, a Jamaican immigrant with Medicaid insurance, passed away from a heart attack. He was only 63 years old.

As he received care, he expressed discomfort with the predominantly white teams handling his case. He believed that both clinicians and non-clinical staff discriminated against him because of his racial and ethnic identity, as well as his public insurance status.

Read the rest…

2 years 1 month ago

First Opinion, diversity and inclusion, health care workers, Hospitals

News Archives - Healthy Caribbean Coalition

An NCD Civil Society Response in Support of the 2023 Bridgetown Declaration

This NCD Civil Society Response in Support of the 2023 Bridgetown Declaration to be adopted this week, provides key messages and follow-up recommendations by the Healthy Caribbean Coalition and the NCD Alliance.

This NCD Civil Society Response in Support of the 2023 Bridgetown Declaration to be adopted this week, provides key messages and follow-up recommendations by the Healthy Caribbean Coalition and the NCD Alliance.

It represents civil society’s ongoing contribution to the development of the 2023 Bridgetown Declaration and accompanying Annexes for adoption at the Small Island Developing States (SIDS) Ministerial Conference on Noncommunicable Diseases (NCDs) and Mental Health (14-16 June 2023). The recommendations are the result of NCDA’s and HCC’s involvement in the process so far.

It is hoped that this Conference will be a turning point for SIDS, supported by the global community, to accelerate action on the largely preventable burden of NCDs, including mental, neurological and substance use disorders (MNSDs), that disproportionally impacts SIDS. People living in SIDS are at higher risk of dying prematurely from a major NCD, and SIDS show the highest rates of childhood and adult obesity worldwide.

Read the response document

The post An NCD Civil Society Response in Support of the 2023 Bridgetown Declaration appeared first on Healthy Caribbean Coalition.

2 years 1 month ago

Mental Health, NCDs and Climate Change, News, SIDS, Slider

Medical News, Health News Latest, Medical News Today - Medical Dialogues |

Ultrasonography useful modality for Forearm fracture diagnosis in children: NEJM

A new study published in the New England journal of Medicine suggests that with regard to the result of physical function of the arm at 4 weeks, the use of ultrasonography as the initial diagnostic imaging tool in children and adolescents with a distal forearm injury was noninferior to radiography.

There is minimal information on whether radiography or ultrasonography is non-inferior for the first diagnostic imaging of forearm fractures in children and adolescents. Therefore, Peter Snelling and colleagues undertook this study to evaluate the effectiveness of ultrasonography for diagnostic imaging in fractures.

Participants aged 5 to 15 who presented to the emergency room with an isolated distal forearm injury without a clinically obvious deformity and for whom further imaging evaluation was indicated were recruited for this open-label, non-inferiority, multicenter, randomized trial in Australia. Participants were given a random choice between point-of-care radiography or ultrasonography, and they were then monitored for eight weeks after that. The validated Paediatric Upper Extremity Short Patient-Reported Outcomes Measurement Information System (PROMIS) score was used to evaluate the physical function of the affected arm at 4 weeks; a non-inferiority margin of 5 points was used. Higher scores indicate better function.

The key findings of this study were:

A total of 270 individuals were enrolled, with outcomes for 262 of them (97%) accessible after 4 weeks (with a 3-day interval) as planned. 

At 4 weeks, PROMIS scores in the ultrasonography group were comparable to those in the imaging group (mean, 36.4 and 36.3 points, correspondingly; mean difference, 0.1 point; 95% confidence interval [CI], 1.3 to 1.4). 

Intention-to-treat analyses found comparable results (mean difference, 0.1 point; 95% CI, 1.3 to 1.4) in 266 participants with primary outcome data obtained at any time. 

There were no clinically significant fractures missed, and there were no differences in the prevalence of adverse events across groups.

Reference: 

Snelling, P. J., Jones, P., Bade, D., Bindra, R., Byrnes, J., Davison, M., George, S., Moore, M., Keijzers, G., & Ware, R. S. (2023). Ultrasonography or Radiography for Suspected Pediatric Distal Forearm Fractures. In New England Journal of Medicine (Vol. 388, Issue 22, pp. 2049–2057). Massachusetts Medical Society. https://doi.org/10.1056/nejmoa2213883

2 years 1 month ago

Pediatrics and Neonatology,Radiology,Pediatrics and Neonatology News,Radiology News,Top Medical News

Medical News, Health News Latest, Medical News Today - Medical Dialogues |

HDL cholesterol and apolipoprotein A ratio linked to diabetic retinopathy in diabetics

High-density lipoprotein cholesterol and apolipoprotein A ratio linked to diabetic retinopathy in diabetics suggests a new study published in the Journal of Diabetes and its Complications

The study is aimed to investigate the relationship between high-density lipoprotein cholesterol to apolipoprotein A ratio (HDL-C/ApoA) and diabetic retinopathy (DR) in subjects with type 2 diabetes mellitus (T2DM).

They retrospect the consecutive medical files of 1058 subjects with T2DM and recorded their clinical information and laboratory findings. Subjects with T2DM were divided into DR group (n = 522) and non-DR group (n = 536). We compared the lipids values of the two groups. Meanwhile we also observed the prevalence of DR at different HDL-C/ApoA levels. Binary logistic regression was used to correct confounding factors. Smooth curve fitting model and subgroup analysis were used to determine the correlation, non-linear relationship and threshold effect between HDL/ApoA and DR.

Results

HDL-C/ApoA value of DR group was significantly higher than non-DR group (0.88 ± 0.17 vs 0.84 ± 0.13, P < 0.05). The prevalence of DR significantly increased as HDL-C/ApoA level increased. There was association between HDL/ApoA levels and DR in the adjusted models (OR 1.55, 95%CI 0.60 to 4.02). After full adjustments for other relevant clinical covariates, patients with HDL/ApoA values in quartile 3 (Q3) had 1.50 times (95 % CI 1.00 to 2.17) and in Q4 had 2.39 times (95%CI 1.65 to 3.47) as high as the risk of DR compared with patients in Q1. HDL/ApoA showed a non-linear relationship with DR, with an inflection point value of 0.759. When HDL/ApoA>0.759, HDL/ApoA was significantly positively associated with DR (HR = 26.508, 95 % CI 7.623–92.174; P < 0.0001). Compared to patients with age < 60, HDL/ApoA was obviously associated with DR when age ≥ 60 (OR = 38.05, 95 % CI 8.06–179.69; P < 0.001).

HDL-C/ApoA was found to be associated with the incidence of DR in patients with T2DM. After adjusting potential related factors HDL-C/ApoA OR value was 1.55 (95%CI 0.60 to 4.02). A non-linear association between HDL/ApoA and DR was observed in T2DM. Subgroup analysis showed that age could alter the relationship between HDL/ApoA and DR.

Reference:

Cong Zhang, Wenjian Lin, Qian Xu, Hongxue Li, Chengye Xu, Xuefei Ma, Ming Hao, Hongyu Kuang. Association between high-density lipoprotein cholesterol to apolipoprotein A ratio and diabetic retinopathy: A cross-sectional study, Journal of Diabetes and its Complications, Volume 37, Issue 6, 2023, 108471,ISSN 1056-8727, https://doi.org/10.1016/j.jdiacomp.2023.108471.

(https://www.sciencedirect.com/science/article/pii/S1056872723000697)

2 years 1 month ago

Diabetes and Endocrinology,Diabetes and Endocrinology News,Top Medical News

PAHO/WHO | Pan American Health Organization

Health and social development top of the agenda at PAHO Director’s meeting with Prime Minister of Barbados

Health and social development top of the agenda at PAHO Director’s meeting with Prime Minister of Barbados

Cristina Mitchell

12 Jun 2023

Health and social development top of the agenda at PAHO Director’s meeting with Prime Minister of Barbados

Cristina Mitchell

12 Jun 2023

2 years 1 month ago

Healio News

FDA approves Linzess as first oral treatment for pediatric functional constipation

The FDA has approved Linzess, the first oral therapy for pediatric functional constipation in patients aged 6 to 17 years, according to an agency release.Previously approved for the treatment of adults with irritable bowel syndrome with constipation or chronic idiopathic constipation, the new drug application for Linzess (linaclotide 72 mcg, AbbVie/Ironwood) was assigned a Prescription Drug Use

r Fee Act date of June 14, 2023 by the FDA — approximately 4 months earlier than the standard review cycle.“Pediatric functional constipation is an all-too-common issue that physicians see

2 years 1 month ago

Pages