Medical News, Health News Latest, Medical News Today - Medical Dialogues |

Albuterol-budesonide combo lowered risk of a severe asthma exacerbation: NEJM

A new study published in The New England Journal of Medicine showed that the participants with asthma who remained uncontrolled despite therapy were less likely to experience a severe asthma exacerbation when albuterol–budesonide was used as required than when albuterol was used alone.

In individuals with moderate-to-severe asthma, as-needed use of albuterol–budesonide has been demonstrated to significantly reduce the likelihood of a severe asthma exacerbation compared to as-needed use of albuterol alone. Under the trade name Airsupra®, albuterol/budesonide is an authorized inhaled corticosteroid (ICS) and short-acting beta2-agonist (SABA) asthma rescue medication.

The patients with asthma who are 18 years of age or older can use the medication to prevent or treat bronchoconstriction as needed and to lower their risk of exacerbations. There is a need for information on albuterol-budesonide in mild asthma. Thus, Craig LaForce and colleagues carried out this investigation to examine the effectiveness of using albuterol/budesonide as needed for moderate asthma.

Those aged 12 and older who had uncontrolled mild asthma despite using SABA and/or low-dose inhaled glucocorticoids or leukotriene-receptor antagonists were the subjects of a completely virtual, multicenter study. For a maximum of 52 weeks, the participants were randomized 1:1 to receive either albuterol (180 μg) + budesonide (160 μg) or albuterol alone (180 μg), administered as two inhaler actuations each dosage.

Time to first severe asthma exacerbation in the population receiving therapy was the main outcome. Systemic glucocorticoid exposure, annualized exacerbation rates, and the intention-to-treat group's delay to first exacerbation were secondary objectives.

Out of the 2516 individuals, 1797 (71.4%) finished the experiment after being randomly assigned. 74.4% of the 2421 people in the complete analytic population used a SABA alone at baseline, and 97.2% of them were 18 years of age or older. After a predetermined interim analysis, the experiment was terminated for effectiveness.

In the on-treatment efficacy population, 5.1% of participants in the albuterol–budesonide group and 9.1% of those in the albuterol group experienced a severe exacerbation, whereas in the intention-to-treat population, the corresponding rates were 5.3% and 9.4%.

Both the mean annualized total dosage of systemic glucocorticoids and the annualized rate of severe asthma exacerbations were lower with albuterol–budesonide than with albuterol. The 2 therapy groups had comparable adverse effects. Overall, when compared to albuterol alone, albuterol/budesonide dramatically decreased the likelihood of severe asthma exacerbations in people with moderate asthma.

Reference:

LaForce, C., Albers, F., Danilewicz, A., Jeynes-Ellis, A., Kraft, M., Panettieri, R. A., Jr, Rees, R., Bardsley, S., Dunsire, L., Harrison, T., Sobande, O., Surujbally, R., Trudo, F., Cappelletti, C., Papi, A., Beasley, R., Chipps, B. E., Israel, E., Pandya, H., … BATURA Investigators. (2025). As-needed albuterol-budesonide in mild asthma. The New England Journal of Medicine. https://doi.org/10.1056/NEJMoa2504544

2 months 1 week ago

Pulmonology,Pulmonology News,Top Medical News

Health – Demerara Waves Online News- Guyana

No spike in COVID cases but publicly-owned health sector on alert for new strain – Health Minister

Health Minister Dr Frank Anthony on Saturday said there was no increase in the number of COVID-19 cases but publicly-owned hospitals have been told to be on alert so that tests could be done to detect a new strain. He said globally, a new COVID-19 strain, NB 1.8.1, was now circulating and causing some hospitalisations ...

Health Minister Dr Frank Anthony on Saturday said there was no increase in the number of COVID-19 cases but publicly-owned hospitals have been told to be on alert so that tests could be done to detect a new strain. He said globally, a new COVID-19 strain, NB 1.8.1, was now circulating and causing some hospitalisations ...

2 months 2 weeks ago

Health, News, alert, COVID response mechanism, COVID-19 strain, Ministry of Health, NB 1.8.1, new strain

Health – Dominican Today

Women face various health situations, challenges

Dominican women usually live in diverse conditions that affect their health. The most frequent are type II diabetes, breast cancer, cervix, mental health disorders, and arterial hypertension.

Addressing these problems requires comprehensive actions aimed at promoting healthy habits, which is the central theme of Bulletin number 20, published by the Ministry of Health.

Dominican women usually live in diverse conditions that affect their health. The most frequent are type II diabetes, breast cancer, cervix, mental health disorders, and arterial hypertension.

Addressing these problems requires comprehensive actions aimed at promoting healthy habits, which is the central theme of Bulletin number 20, published by the Ministry of Health.

Women’s health encompasses that of the entire family environment, which is why it is prioritized.

Health is a fundamental human right, and today, it is recognized that not only biology is related to health, but also social determinants, the socio-economic, environmental, and political decisions, according to the official document.

Health policies
It is considered essential in life.
Women to have integral health require regular access to medical controls, sexual and reproductive health education, and comprehensive, timely, and humanized services.

Strategies

The official document confirms that the Maternal Child Program has developed strategies aimed at enhancing the health of women.

Official actions
It works to update care protocols during pregnancy, childbirth, and the puerperium, strengthen emergency obstetric care and training for obstetricians and residents, and promote obstetric post-event contraception.

In addition, active monitoring of maternal mortality is conducted through the activation of provincial committees and surveillance of avoidable cases. The Ministry of Health insists that work in education in nutrition and sexual health for pregnant women, alcohol syndrome prevention campaigns Fetal (SAF), and alarm signs during pregnancy.

Accompaniment in the stage of gestation, mainly in the communities of limited economic resources.

Gaps persist
Gaps and challenges persist. In 2023, a consensus was established to prioritize the health of women with actions that involve education, economic development, social protection, and the development of a normative framework. For this, the effort of all sectors of society is required, including women themselves as active protagonists of the change, the Ministry of Health assures in their argument.

The institutional response to women’s health challenges extends to the entire national health system, insists public health

2 months 2 weeks ago

Health, Local

Health |

Rise, Reclaim, Restore: Safe Space Initiative piloted in Carriacou

The Safe Space Initiative emerged from post-hurricane consultations, which exposed that women and girls were unaware of available social protection and Gender Based Violence (GBV) services

2 months 2 weeks ago

Carriacou & Petite Martinique, Health, lifestyle, PRESS RELEASE, Weather, bbe, build back equal project, Canada, dwight logan, gbv, gender based violence, hurricane beryl, leanwall perrotte, loveness nyakujarah, marie george, mcpma, ministry of carriacou & petite martinique affairs and local government, nadina williams, ramona grandison, safe space initiative, un women multi-country office caribbean

PAHO/WHO | Pan American Health Organization

WHO calls for urgent action to ban flavoured tobacco and nicotine products

WHO calls for urgent action to ban flavoured tobacco and nicotine products

Oscar Reyes

30 May 2025

WHO calls for urgent action to ban flavoured tobacco and nicotine products

Oscar Reyes

30 May 2025

2 months 2 weeks ago

Health | NOW Grenada

US$100 million through global philanthropic capital campaign for new hospital

The Government of Grenada is seeking a consultancy firm with a proven record of raising hundreds of millions of dollars through philanthropic campaigns

2 months 2 weeks ago

Business, Health, budget authorisation act, dennis cornwall, eastern caribbean central bank, eccb, fundraising, hope vale, linda straker, mount sinai international, project polaris

Medical News, Health News Latest, Medical News Today - Medical Dialogues |

FDA Approves Genentech's Susvimo for Diabetic Retinopathy

Genentech's ranibizumab injection (Susvimo) has received FDA approval for the treatment of diabetic retinopathy. The continuous delivery system is intended for patients who have previously responded to anti-VEGF injections.

Genentech's ranibizumab injection (Susvimo) has received FDA approval for the treatment of diabetic retinopathy. The continuous delivery system is intended for patients who have previously responded to anti-VEGF injections.

“The approval of Susvimo for diabetic retinopathy expands treatment options for patients, offering predictable and immediate durability after implantation with only one treatment every nine months,” said Levi Garraway, M.D., Ph.D., chief medical officer and head of Global Product Development. “Many patients with common retinal conditions seek alternative treatment options like Susvimo that can help preserve vision with longer intervals between treatments than regular eye injections.”

“Susvimo is a compelling new treatment for patients at risk of vision loss from progression of diabetic retinopathy,” said vitreoretinal surgeon, Carl Awh, M.D., Tennessee Retina, Tennessee. “I am delighted to have this far more durable treatment available for my patients.”

The FDA decision was based on positive one-year results from the Phase III Pavilion study. People with DR who received Susvimo refilled every nine months achieved superior improvements on the Diabetic Retinopathy Severity Scale (DRSS). This means there was a reduction in the severity of eye damage caused by diabetes, compared with those under monthly clinical observation who were treated with anti-VEGF injections as needed based on disease progression. Additionally, none of the participants receiving Susvimo required supplemental treatment at one year. Safety was consistent with the known safety profile for Susvimo.

Susvimo provides continuous delivery of a customized formulation of ranibizumab via the Port Delivery Platform, while other currently approved treatments may require eye injections as often as once per month. The Port Delivery Platform is a refillable eye implant surgically inserted into the eye during a one-time, outpatient procedure, which introduces medicine directly into the eye, addressing certain retinal conditions that can cause vision loss.

2 months 2 weeks ago

Diabetes and Endocrinology,Diabetes and Endocrinology News,Top Medical News,Latest Medical News

Healio News

Updacitinib’s benefits for atopic dermatitis may extend to the heart

Adults with atopic dermatitis treated with upadacitinib had fewer major adverse cardiovascular events compared with background rates in real-world populations, adding to research supporting the drug’s potential cardioprotective benefits.Upadacitinib (Rinvoq, Abbvie) is a systemic anti-inflammatory drug approved by the FDA for treatment of 10 immune-mediated inflammatory disorders, including AD,

rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, non-radiographic axial spondyloarthritis, ulcerative colitis, Crohn’s disease, polyarticular juvenile idiopathic

2 months 2 weeks ago

Health Archives - Barbados Today

Health Ministry investigating suspected cases of infectious skin disease at Geriatric Hospital

The Ministry of Health and Wellness is currently investigating suspected cases of an infectious skin disease in a section of the Geriatric Hospital.

It said in a statement that it is using all available resources at its disposal, both within the public and private sectors to identify, treat and eradicate the problem at the Beckles Road, St Michael facility.

To contain any spread, the ministry has suspended visiting by members of the public to Units 1 and 2 of the hospital until further notice.

The post Health Ministry investigating suspected cases of infectious skin disease at Geriatric Hospital appeared first on Barbados Today.

2 months 2 weeks ago

Health, Local News, News

PAHO/WHO | Pan American Health Organization

Seventy-eighth World Health Assembly concludes: historic outcomes, consequential highlights

Seventy-eighth World Health Assembly concludes: historic outcomes, consequential highlights

Cristina Mitchell

28 May 2025

Seventy-eighth World Health Assembly concludes: historic outcomes, consequential highlights

Cristina Mitchell

28 May 2025

2 months 2 weeks ago

Health

Lupus Foundation, a guiding light for lupus warriors

The Lupus Foundation of Jamaica has dedicated over 40 years of service to improving the lives and outcomes of persons affected by lupus, through information, education, advocacy and support. Dr Desiree Tulloch-Reid, a specialist in internal...

The Lupus Foundation of Jamaica has dedicated over 40 years of service to improving the lives and outcomes of persons affected by lupus, through information, education, advocacy and support. Dr Desiree Tulloch-Reid, a specialist in internal...

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Health

Mental health matters: Breaking the silence in Jamaica

Each May, the world shines a light on a subject that touches us all – mental health awareness. But for Jamaica, this is more than a campaign; it’s a call to action. Mental health is not just about illnesses like depression or anxiety. It’s about...

Each May, the world shines a light on a subject that touches us all – mental health awareness. But for Jamaica, this is more than a campaign; it’s a call to action. Mental health is not just about illnesses like depression or anxiety. It’s about...

2 months 2 weeks ago

Health

Unstable blood pressure or pulse rate?

Have you been experiencing light-headedness, fainting spells, unstable blood pressure especially low blood pressure, (particularly upon standing). Have you been experiencing abnormal heart racing? Then, this information may interest you. When the...

Have you been experiencing light-headedness, fainting spells, unstable blood pressure especially low blood pressure, (particularly upon standing). Have you been experiencing abnormal heart racing? Then, this information may interest you. When the...

2 months 2 weeks ago

Health

Fruits, veggies can contribute to longer lifespan

Certain old lifestyle traditions and traditional medicine practices can be valuable for managing or complementing modern medical treatments for a variety of conditions. These practices, rooted in ancient healing systems, offer holistic approaches...

Certain old lifestyle traditions and traditional medicine practices can be valuable for managing or complementing modern medical treatments for a variety of conditions. These practices, rooted in ancient healing systems, offer holistic approaches...

2 months 2 weeks ago

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Depression + Psilocybin – Pt 2

Dr Piou-Brewer’s holistic retreats are held four times a year in St Ann and St Mary in locations including Boscobel, Tower Isle, Mammee Bay and Ocho Rios. Also championing – monitored psilocybin dosing – is consultant psychiatrist and Government...

Dr Piou-Brewer’s holistic retreats are held four times a year in St Ann and St Mary in locations including Boscobel, Tower Isle, Mammee Bay and Ocho Rios. Also championing – monitored psilocybin dosing – is consultant psychiatrist and Government...

2 months 2 weeks ago

News Archives - Healthy Caribbean Coalition

Webinar: Act on Facts: Lets do it Better for the Children

Webinar: Act on Facts: Lets do it Better for the Children

On Wednesday 28th may 2025, the Healthy Caribbean Coalition (HCC) hosted a regional webinar entitled: Act on Facts: Lets do it Better for the Children.

Webinar: Act on Facts: Lets do it Better for the Children

On Wednesday 28th may 2025, the Healthy Caribbean Coalition (HCC) hosted a regional webinar entitled: Act on Facts: Lets do it Better for the Children.

This webinar discussed the experiences and lessons learned around the implementation of healthy school nutrition policies in the Caribbean and public health experts, policymakers, educators, and civil society advocates shared their experiences, challenges, and best practices in safeguarding children’s health from commercial influences.

Presenters and Panellists

Visit the Lets do it better for the children campaign page.

 

The post Webinar: Act on Facts: Lets do it Better for the Children appeared first on Healthy Caribbean Coalition.

2 months 2 weeks ago

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