STAT+: Pharmalittle: We’re reading about a Maryland law governing 340B discounts, an obesity drug, and more
Good morning, everyone, and welcome to another working week. We hope the weekend respite was relaxing and invigorating, because that oh-so familiar routine of deadlines, online meetings and phone calls has predictably returned. But what can you do? The world, such as it is, continues to spin. So to give it a nudge in a better direction, we are brewing cups of stimulation.
Our choice today is salted caramel, a touch of the Jersey Shore as we say around the Pharmalot campus. Meanwhile, here are a few items of interest to start you on your journey, which we hope is meaningful and productive. Best of luck and do keep in touch…
The largest U.S. pharmaceutical industry trade group and several drug companies lost a bid to block a Maryland law requiring the companies to offer discounts on medicines dispensed by third-party pharmacies that contract with hospitals and clinics serving low-income populations, Reuters notes. U.S. District Judge Matthew Maddox refused to issue a preliminary order blocking the law while he hears a challenge to it by the Pharmaceutical Research and Manufacturers of America, Novartis, AbbVie and AstraZeneca. The case is among numerous similar challenges to state laws around the country dealing with obligations under the 340B program, a federal program under which hospitals and clinics serving low-income populations can receive discounts on prescription drugs. Drugmakers must participate in the 340B program in order to receive funds from government health insurance programs like Medicare and Medicaid.
On Sunday, a small biotech company called Summit Therapeutics won a remarkable victory, saying its experimental drug outperformed Merck’s Keytruda, the world’s best-selling drug, in non-small cell lung cancer, the disease that represents the biggest market for the Merck drug, STAT tells us. By itself, Summit’s victory would be a dramatic story, although not an unheard of one in the unpredictable world of biotechnology. But it’s just the start. Because at the center of it is one of the industry’s most iconoclastic figures: Robert “Bob” Duggan, who became a billionaire after he bought up shares of another biotech company, Pharmacyclics, that was a on the brink of failure, developed a breakthrough cancer drug, and sold the company to AbbVie for $21 billion.
10 months 1 week ago
Pharmalot
Medical News, Health News Latest, Medical News Today - Medical Dialogues |
RG Kar Case: Supreme Court tells protesting doctors to resume work from tomorrow, state to ensure Safety
Kolkata: While considering the suo-motu plea on the rape and murder of a postgraduate trainee at RG Kar Medical College, Kolkata, the Supreme Court bench comprising the Chief Justice of India DY Chandrachud, Justice JB Pardiwala and Manoj Misra asked the protesting resident doctors in Kolkata to return to work by tomorrow.
Asking the State Government to ensure the doctors' safety including making arrangements for separate duty rooms, toilet facilities and installation of CCTV cameras, the bench further asked the counsel for WB Government to state on record that no punitive action would be taken against the protesting doctors if they resumed work.
Meanwhile, regarding the CBI investigation on the death of the Kolkata doctor, the Bench noted that the challan that was required to be filled before sending the deceased's body for Postmortem investigation was missing from record.
The Court has asked to produce a copy of the duly filled form before the bench in the next date of hearing on 17.09.2024.
Supreme Court hearing on 09.09.2024:
Counsel for the State of West Bengal, Advocate Sibal informed the Apex Court bench that they have filed the status report of the investigation. He further informed that 23 people have died since the doctors are still on strike and were not working. Meanwhile, the SG stated that he had not received the report.
CBI submits the status report of the ongoing investigation. Taking note of the report, which was submitted in a sealed envelope, the CJI questioned Solicitor General Tushar Mehta what was the distance between the residence of the Principal of RG Kar Medical College and Hospital. In response, the SG informed the bench that it takes 15-20 minutes maximum.
The CJI sought clarification on two aspects- one regarding the time at which the UD (unnatural death) 861/2024 was registered and what was the GD entry and the time of the GD entry under which GD 861 was registered.
Sibal informed that the death certificate was given at 1:47 PM, entry UD at 2:55 PM at police station. He further informed that the initial GD was 565 which was recorded at 2:55 PM. Although the SG objected to the timing referred to by Advocate Sibal, the latter insisted that it was the certified copy.
Further, Sibal informed that the time of the inquest was 4:20 - 4:40, Judicial Magistrate (JM) arrived at 4:10 and he conducted the inquest from 4:20 - 4:40 and it was videographer. As per Sibal, in between 8:30-10:45 evening, search and seizure was done and once the body was removed for postmortem then photos were taken.
The CJI questioned that if there is a CCTV footage to indicate the entry and exit time of the accused, obviously there should be footage after 4:30 in the morning and if the same footage in entirety was handed over to the CBI. SG submitted that yes it was submitted to the CBI.
Thereafter, the CJI further sought to know if the Calcutta Police handed the entire footage from 8:30 PM to 10:45 PM to CBI. SG submitted that 4 clippings were given, totalling to 27 mints in duration.
Sibal submitted that seizure 8:30 - 10:45 PM was given and in parts videos were given in hard disk, as there was technical glitch and it was stored in part, but given in full.
At this outset, the SG referred to the forensic report and submitted that one thing was admitted that when the girl was found at 9:30, she was in semi nude condition, jeans and undergarment removed, and there were injury marks on her body. He submitted that they took samples and sent to CSFL.
The Solicitor General submitted that the CBI decided to send the samples to the AIIMS and other CFSLs and argued that who took the samples became relevant. He further stated that samples were tested at CFSL in Bengal and pointed out that there were two specimens or two swabs.
The CJI noted in this context that the bench did not want to comment on the line of investigation in open court. Therefore, the bench directed the CJI to submit a status report by Monday and ordered CBI to proceed based on what they are exploring.
The Apex Court bench noted that "Status report has been filed by CBI. Having perused the report, it appears that the investigation is in progress. We direct the CBI to file a fresh Status report by the next date of hearing... We will take it up on Tuesday." Regarding the course of investigation, bench observed that it did not want to guide CBI on its investigation.
Following this, the Court took note of the arguments regarding the accommodation and CISF, which is in charge of ensuring safety and security of doctors at RG Kar Medical College and Hospital. When the CJI questioned what steps were taken by the WB Government for adequate safety measures for the doctor, Advocate Sibal submitted that a status report was filed.
Meanwhile, one senior counsel argued that the postmortem could not have taken place after 6 PM. He further questioned by whom the videographer was conducted, and if it was reiteratable or non-reiterable. He also argued that all the 3 female doctors who were present were part of ther North Bengal lobby and raised the questions regarding the temperature at which the specimen (vaginal swabs) had to be preserved.
The counsel also raised doubts that there were only 10 GD entries between 2:30 noon - 11:30 night and questioned if it was manufactured. Referring to the provisions of the BNS and the time of the FIR, he also argued that there had to be a previous FIR based on which the postmortem officials were called.
During the course of the arguments, Justice Pardiwala referred to the first line of a report and questioned the Solicitor General if they looked into it and if it was in the form of some interpolation or something. The SG submitted that the time difference was a matter of investigation.
Where is the Letter when the Body was dispatched for PMR? Questions CJI:
Meanwhile, the CJI sought the letter when the body was dispatched for PMR. When Advocate Sibal submitted that the document could not be found immediately.
"...because when the body is dispatched after the PMR, only the doctors doing the inquest would look at it, where is that filled out challan for the dead body, let the CBI give it to us," the CJI observed at this outset.
When the SG submitted that the challan was not in the file given to the CBI, the CJI asked the counsel for WB Government for the same and also referred to the form having a column with remarks what clothes and other things were seized were sent to the doctors who conducted the PMR.
Seeking time to place the challan on record, Advocate Sibal also submitted that they came to know that the JM came and filled it himself and there was no separate form. Thereafter, the CJI questioned if the PMR was done without the filling of the form?
"...look at the PMR, the constable is supposed to carry this challan...there is no reference of the challan used, you need to explain, tomorrow if this document is missing, you will have to explain why this happened," observed Justice Pardiwala. Thereafter, Advocate Sibal assured to file an affidavit on this.
Advocate Mahesh Jethmalani argued that even after one month of the incident, there is still no clarity regarding the death. At this outset, the CJI observed that there was clarity regarding when the death occurred and the time around the death also that she had a meal before death. Further, the bench observed that there was a delay of 14 hours in filing the FIR.
Regarding the challan, the CJI observed, "SG stated that during the above challan is not part of file handed to CBI for investigation. It is submitted by one of the petitioner before the HC that the form was produced before HC in course of hearings. The form is unavailable with Mr Sibal and Astha Sharma."
"(WB form 5371) the PRB form 54....a copy of the form duly filled in should be produced before the court in the next hearing," ordered the CJI, asking to look at form 5363 and keep it ready for further examination on the next date of hearing.
Safety of Doctors in Kolkata:
During the course of the hearing, Senior Advocate Karuna Nandy requested for a status report on the safety of whistle blowers in the Sandip Ghosh Financial Irregularities Case arguing that these two matters were connected.
Another counsel submitted that she had the names of the miscreants who came and tampered with the evidence. Advocate Luthra pointed out before the Court that people were being allowed inside the hospital without checking their ID cards.
Taking note of this, the CJI observed that the CISF has to ensure and tighten up the measures of who can access the emergency ward and asked the CISF company to ensure that all the necessary safety and precautions were being taken.
Photos of the Victim should be removed from Social Media:
Taking cognisance of the submission that the photographs of the victim doctor were still being circulated on social media, the CJI noted that the damage had already been done in circulation of those photographs and ordered that all photographs of the dead body had to be removed forthwith.
Advocate Sibal submitted that this should also include the seizure list. The CJI noted at this outset that this happened while the State was in charge of it. However, Advocate Sibal denied this and argued that it happened before it.
SC Seeks Report from WB Government to Ensure Doctors' Safety:
Regarding the National Task Force's ongoing consideration, one of the counsels argued that distress calls and CCTV should be installed in all hospitals, management of the hospital should file the complaint and argued that there should be some badge on wrist to ring alarm in case of violent incident.
Meanwhile, the CJI asked the West Bengal Government to file on record the safety measures on site even before the NTF filed its report. When Sibal referred to the State Health Department's report, the Supreme Court bench questioned why the incident took place if 4447 CCTV cameras were installed.
The CJI further questioned about the equipment that had been installed at RG Kar Hospital, not just the funds but what progress took place. "...tell us by next day on what steps on ground are taken. Let the district collectors engage with the heads of the medical colleges and ensure steps are taken by the next week," ordered the CJI.
23 Patients Died due to Doctors' Strike, Claims West Bengal Government:
Referring to the West Bengal Govt's report, Advocate Sibal submitted that 23 patients died since the resident doctors were on strike and not coming back to work. He claimed that 6000 people were affected.
Advocate Sibal referred to the Supreme Court's earlier observations asking the doctors to go back to work and prayed for the Court's order indicating that if the doctors did not go back to work, proceedings should be initiated.
Further, Sibal pointed out that protests were happening all over the place without police permissions. He argued that it was turning into something else as 41 police members were affected and one person permanently lost his eye. He also claimed that police was being denied treatment.
Doctors must go back to work, no punitive action if they return to work by tomorrow: SC
When the CJI questioned of all the doctors would return to work and not abstain, Advocate Luthra submitted that senior doctors were on duty and only junior doctors were not on duty. She also claimed that the doctors were getting threats.
"...we can record that if doctors resume to work, no adverse action but if they do not resume work as doctors then we cannot restrain state govt from taking actions," the CJI noted at this outset.
Advocate Luthra further explained that severe doctors were facing bullying and threats and some of the doctors were giving voluntary treatment outside the hospital. She also submitted that women doctors require toilets, rooms to rest and safety precautions.
Meanwhile, Justice Pardiwala questioned how many resident doctors worked at a time at a given shift. Advocate Sibal submitted that he would find out.
At this outset, the CJI noted, "...during course of hearing grievance made by WB regarding the mass abstention from work of resident doctors of medical colleges across state for 28 days, as consequence of which health care is facing severe disruptions."
Asking the State to create infrastructure to ensure safety of all doctors, the CJI ordered, "State of WB must create steps to create degree of confidence in the minds of the doctors that concerns regarding their safety and duly be catered to . The police shall ensure that necessary conditions are created for ensuring the safety of all doctors including provisions for separate duty rooms; toilet facilities ; installation of CCTV cameras."
Referring to the State's affidavit indicating that funds had been sanctioned for carrying out the safety measures, the CJI further observed, "...this shall be monitored by the District Collectors. In order to create sense of confidence we state that in the event that doctors come to work by 5 PM tomorrow, not adverse actions.....if there is continuous abstention from work despite the facilities given there will be likelihood of action in future."
"...we know what is happening on ground, but doctors must now come back to work, they cannot say senior doctors are working so we will not work, we have put everyone on notice," the CJI further observed, clarifying that if the doctors did not resume work that the bench could not stop the Government from taking disciplinary action.
The Chief Justice of India clarified that the Court wanted to ensure that the doctors resumed work as they were in a system to render service. "We will provide facilities but they have to reciprocate," observed the CJI, further noting on record that Advcate Sibal assured that if the doctors resumed work, no action including punitive transfers would be adopted against the doctors.
When Advocate Sibal raised the issue regarding the protests happening all across the State, the CJI noted that any protests cannot happen at the cost of duress.
Representation of the Dental Association in National Task Force:
One of the counsels urged the bench to consider engaging a dental representative in the composition of the National Task Force (NTF). Taking note of the counsel's submissions, the bench asked to submit an email on behalf of the dental association to the portal.
10 months 1 week ago
Editors pick,State News,News,Health news,Delhi,Doctor News,Medico Legal News,Medical Education,Medical Colleges News,Notifications
'Six-pack surgery' gaining popularity among men, say plastic surgeons
Move over, "Dad bod" — more men are seeking "six-pack abs" with the help of a surgical procedure called high-definition liposuction, according to plastic surgeons.
Move over, "Dad bod" — more men are seeking "six-pack abs" with the help of a surgical procedure called high-definition liposuction, according to plastic surgeons.
This type of "ab-etching" technique is gaining popularity among men who can’t get rid of stubborn belly fat with exercise alone, according to members of the American Society of Plastic Surgeons (ASPS).
The method targets removal of stubborn fat much like traditional liposuction, but it also creates defined lines across the stomach muscles to create the illusion of "chiseled" abdominals.
CDC ISSUES HEALTH ADVISORY WARNING OF 'ADVERSE EFFECTS' FROM FAKE BOTOX INJECTIONS
Dr. Josef Hadeed, MD, a board-certified plastic surgeon at the Hadeed Plastic Surgery practice in Beverly Hills, California, and Miami, Florida, described the procedure during an interview with Fox News Digital.
"It is more like creating that six-pack and creating the ‘V lines,’ and giving somebody that more athletic, toned physique that traditional liposuction can't really achieve," he said.
Traditional liposuction focuses on removing fat, volume and bulk, but doesn’t address the specifics of the "underlying anatomy," according to the surgeon.
High-definition liposuction is more detailed, Hadeed said.
"We remove a little more fat from that vertical line above the belly button, and also those horizontal lines above the belly button," he said.
CDC INVESTIGATING FAKE BOTOX INJECTIONS: ‘SERIOUS AND SOMETIMES FATAL’
"We also remove a little more fat in those areas to create the illusion or appearance of somebody having a six-pack."
In some cases, fat is redistributed to other areas to help create a bulkier, more muscular abdominal appearance, the surgeon added.
There has been an uptick in men undergoing this liposuction procedure, according to members of the ASPS.
"I'm definitely seeing an increase in high-definition liposuction requests for men," ASPS member Dr. Joubin Gabbay, MD, the medical director at Gabbay Plastic Surgery in Beverly Hills, California, told Fox News Digital.
"They are coming in with specific requests for a defined, chiseled contour."
Dr. Finny George, MD, a board-certified plastic surgeon and partner at New York Plastic Surgical Group, a division of Long Island Plastic Surgical Group, has also seen more male patients looking to improve their muscle definition.
"There is definitely a growing desire among men [for] alternate means of achieving an athletic physique for two main reasons," George told Fox News Digital.
"First, it is becoming more socially acceptable for men to have plastic surgery — and second, many have already tried and failed with conventional diet and exercise," he added.
High-definition liposuction isn’t the only procedure growing in popularity among men.
There has been a 207% rise in total cosmetic procedures among males since 2019, according to the 2022 ASPS report.
One reason may be that men are looking for a more youthful appearance to "maintain career vitality," the report said.
Social media influencers and male celebrities have also created an open dialogue about male cosmetic surgery, making it more acceptable for men to seek such enhancement treatments, the ASPS also noted.
"It actually has been very common in Brazil and South America for quite some time now, and it's slowly been migrating to the United States," Hadeed told Fox News Digital.
If an individual is considering undergoing high-definition liposuction, they should examine their reasons for doing so, said Hadeed.
"They should do it for themselves, not because their spouse or partner is pressuring them to do it," he advised.
PLASTIC SURGERY DEATHS HAVE SPIKED AMONG US PATIENTS WHO TRAVELED TO DOMINICAN REPUBLIC: CDC REPORT
When a person is seeking those "perfect six-pack abs," Hadeed said, the surgeon will typically look at the individual’s lifestyle behaviors, such as diet and exercise.
For example, if someone is sedentary and eats fast food every day, "maybe this isn't for you," according to the doctor.
Patients should have realistic expectations of what can be achieved rather than trying to look like a certain fitness model or social media influencer, Hadeed cautioned.
In some situations, he said, "we have to lower the expectations a little bit and say, ‘I can't make you look like this other person who's completely ripped and shredded, but I can help you look like a more refined version of yourself.’"
If the individual were to gain or lose a significant amount of weight after the surgery, that could affect the results, leading to the need for a revision or touch-up, Hadeed said — which is why he screens his patients to identify their lifestyle habits and make sure they can maintain the results.
CURE FOR MEN'S HAIR LOSS COULD BE FOUND IN SUGAR STORED IN THE BODY, STUDY SUGGESTS
Gabbay also emphasized the importance of following a good regimen to maintain the benefits of the surgery.
"I think the treatment is certainly effective at helping many achieve the six-pack look, but it requires work and maintenance to maintain," he told Fox News Digital.
"It is important to maintain a healthy, active lifestyle and avoid major weight fluctuations after the procedure," he went on.
"Unintended weight gain after a high-definition procedure can exaggerate the look of the six-pack, making it look a little less natural."
Hadeed, who also serves as chair of the Patient Safety Committee for the ASPS, said it is important for patients to understand the risks involved with the procedure.
"Having elective surgery is a very major decision, and not something that people should take lightly," he said.
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Hadeed agreed that while the surgery is typically safe, there are risks involved.
"In particular, there could be skin necrosis, where some of the skin dies," he warned. "There could also be fat necrosis, where some of the fatty tissue that’s left behind dies."
Other potential complications may include blood clots and intestinal perforation.
It is also important to research the credentials of the plastic surgeon who will perform the procedure and make sure they are certified by the American Board of Plastic Surgery, Hadeed said.
For more Health articles, visit www.foxnews.com/health
The doctor warned, "There are a lot of physicians out there who are not plastic surgeons who are doing these procedures."
10 months 1 week ago
Health, Surgery, cosmetic-surgery, mens-health, healthy-living, weight-loss, lifestyle
STAT+: With a win in lung cancer, biotech’s wealthiest outsider surfs to new heights
On Sunday, a small biotech company called Summit Therapeutics won a remarkable victory, saying its experimental drug outperformed Merck’s Keytruda, the world’s best-selling drug, in non-small cell lung cancer, the disease that represents Keytruda’s biggest market.
On Sunday, a small biotech company called Summit Therapeutics won a remarkable victory, saying its experimental drug outperformed Merck’s Keytruda, the world’s best-selling drug, in non-small cell lung cancer, the disease that represents Keytruda’s biggest market.
By itself, Summit’s victory would be a dramatic story, although not an unheard of one in the unpredictable world of biotechnology. But it’s just the start. Because at the center of it is one of the industry’s most iconoclastic figures: Robert “Bob” Duggan, who became a billionaire after he bought up shares of another biotech company, Pharmacyclics, that was on the brink of failure, developed a breakthrough cancer drug, and sold the company to AbbVie for $21 billion.
Duggan, 80, is a living rebuke to a pharmaceutical industry self-image that is increasingly crafted in Cambridge, Mass. and San Francisco. Before Pharmacyclics, he had no drug industry experience, having worked in cookie stores and then surgical robots. He lacks a college degree, and is a practicing scientologist who told STAT in an interview that he reads the works of Scientology founder L. Ron Hubbard every day and who has in the past said he’d given the church more than $360 million. He speaks in long, dramatic arcs, often spelling out words, referencing their roots, or giving itemized lists.
10 months 1 week ago
Biotech, Business, Pharma, biotechnology, Cancer, drug development, Pharmaceuticals, STAT+
Medical News, Health News Latest, Medical News Today - Medical Dialogues |
Olpasiran Shows Prolonged Lipoprotein(a) Reduction: Nearly 50% Drop Maintained for Up to Year After Treatment, Study
USA: In a recent follow-up study of the OCEAN(a)-DOSE clinical trial, new data has revealed the extended benefits of Olpasiran, a promising siRNA therapeutic designed to lower lipoprotein(a) [Lp(a)] levels. This extension period provides significant insights into the drug’s prolonged efficacy and potential for long-term cardiovascular risk management.
The study, published in the Journal of the American College of Cardiology, revealed that participants who received doses of 75 mg or more every 12 weeks maintained a reduction in Lp(a) levels of approximately 40% to 50% nearly a year after their final dose.
Olpasiran, a small interfering RNA (siRNA) medication, has garnered attention for its ability to target and reduce Lp(a), a known risk factor for cardiovascular diseases. It blocks the production of Lp(a) by inhibiting the translation of apolipoprotein(a) mRNA. In Phase 2 trials, higher doses of Olpasiran administered every 12 weeks reduced circulating Lp(a) levels by over 95%.
Against the above background, Michelle L. O’Donoghue, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA, and colleagues aimed to evaluate the timing of return of Lp(a) to baseline after discontinuation of olpasiran, and longer-term safety.
The OCEAN(a)-DOSE (Olpasiran Trials of Cardiovascular Events And LipoproteiN[a] Reduction–DOSE Finding Study) was a Phase 2 trial designed to explore different dosing regimens. It involved 281 participants with atherosclerotic cardiovascular disease and Lp(a) levels exceeding 150 nmol/L.
Participants were randomly assigned to receive one of four Olpasiran doses (10 mg, 75 mg, 225 mg every 12 weeks, or an exploratory 225 mg every 24 weeks) or a placebo. The final dose of Olpasiran was given at week 36, with an additional off-treatment follow-up period extending for at least 24 weeks beyond week 48.
The following were the key findings of the study:
- Two hundred seventy-six participants entered the off-treatment follow-up period. The median study exposure (treatment combined with off-treatment phases) was 86 weeks (Q1-Q3: 79-99 weeks).
- For the 75 mg Q12W dose, the off-treatment placebo-adjusted mean percent change from baseline in Lp(a) was −76.2%, −53.0%, −44.0%, and −27.9% at 60, 72, 84, and 96 weeks, respectively.
- The respective off-treatment changes in Lp(a) for the 225 mg Q12W dose were −84.4%, −61.6%, −52.2%, and −36.4%.
- During the extension follow-up phase, no new safety concerns were identified.
Jared Alexander Spitz from Inova Schar Heart and Vascular in Fairfax, Virginia, USA, commented in his editorial that while the results are promising, no new safety issues emerged during the study. He emphasized that further research, including Phase 3 trials, must validate these findings and explore their broader clinical implications, particularly across diverse patient populations.
"Olpasiran's RNA interference mechanism significantly reduces Lp(a) levels, with its effects remaining robust for several months after treatment cessation. Currently, the drug is demonstrating a favorable safety and tolerance profile. The forthcoming Phase 3 trial results will be crucial in establishing whether lowering Lp(a) with olpasiran provides tangible cardiovascular benefits," the study authors concluded.
Reference:
O'Donoghue ML, Rosenson RS, López JAG, Lepor NE, Baum SJ, Stout E, Gaudet D, Knusel B, Kuder JF, Murphy SA, Wang H, Wu Y, Shah T, Wang J, Wilmanski T, Sohn W, Kassahun H, Sabatine MS; OCEAN(a)-DOSE Trial Investigators. The Off-Treatment Effects of Olpasiran on Lipoprotein(a) Lowering: OCEAN(a)-DOSE Extension Period Results. J Am Coll Cardiol. 2024 Aug 27;84(9):790-797. doi: 10.1016/j.jacc.2024.05.058. PMID: 39168564.
10 months 1 week ago
Cardiology-CTVS,Medicine,Cardiology & CTVS News,Medicine News,Top Medical News,Latest Medical News
Fact check: Bill Gates linked to US encephalitis outbreak? - DW (English)
- Fact check: Bill Gates linked to US encephalitis outbreak? DW (English)
- Maine considering public health emergency over mosquito-borne illnesses as animal cases tick up Press Herald
- How to stay safe during the EEE outbreak, according to a neurologist PBS NewsHour
- Mosquitos in Manchester and Farmington test positive for EEE Eyewitness News 3
- EEE found in mosquito sample from Long Island: What to know about virus NBC New York
10 months 1 week ago
Health Archives - Barbados Today
Vector Control Unit to tackle St Michael and Christ Church
Mosquito breeding sites in St Michael and Christ Church will be targeted by the Vector Control Unit this week.
The team will concentrate its efforts in St Michael for the first three days of the week. On Monday the Unit will visit Hindsbury Road, Tudor Bridge, Dr Kerr Land, Mottley Land, Prescod Bottom, Brathwaite Road, Progressive Road, Field Gap, Country Road, and Laundry Road.
Mosquito breeding sites in St Michael and Christ Church will be targeted by the Vector Control Unit this week.
The team will concentrate its efforts in St Michael for the first three days of the week. On Monday the Unit will visit Hindsbury Road, Tudor Bridge, Dr Kerr Land, Mottley Land, Prescod Bottom, Brathwaite Road, Progressive Road, Field Gap, Country Road, and Laundry Road.
The next day it will be the turn of 2nd Avenue Mannings Land, Peterkins Road, Bamboo Gap, Eagle Hall, Barbarees Hill, Monteith Gardens, Strathclyde, and surrounding areas.
On Wednesday the following districts will be sprayed: Mansion Road, Bank Hall Cross Road, Prince of Wales, Queen Mary Road, King George Road, King Edward Road, Queen Victoria Road, Buckingham Road, 2nd Avenue Sealy Land, Gilkes Road, Powder Road, and Happy Cot.
The Unit will then go into some Christ Church communities on Thursday. They are Fort George Heights, South Ridge, Upton Terrace, Kent Ridge, Little Kent, The Grove, St. David’s, Edey Village, and Staple Grove.
The fogging exercise for the week will conclude in St Michael, on Friday when the Unit goes into Station Hill, Powder Road, Savannah Road, 1st to 3rd Avenue Station Hill, Leinster Road, Waterford, Trainmore Lane, Longford Place,1st to 5th Avenue Park Road and the environs.
Fogging takes place from 4:30 to 8:30 p.m. daily. Householders are reminded to open their windows and doors to allow the spray to enter. Children should not be allowed to play in the spray.
Members of the public are advised that the completion of scheduled fogging activities may be affected by events beyond the Unit’s control. In such circumstances, the Unit will return to communities affected in the soonest possible time. (PR)
The post Vector Control Unit to tackle St Michael and Christ Church appeared first on Barbados Today.
10 months 1 week ago
Health, Local News
Doctor explains: How intense workouts & lifestyle choices trigger heart attacks among youth - Firstpost
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- ‘Average age of people with heart ailments coming down’ | Chandigarh News The Indian Express
- Heart attacks on the rise in young people Trinidad & Tobago Express Newspapers
- Heart ailments creeping fast in young: Dr Bali Babushahi.com
10 months 1 week ago
Traffic jams and chaos stress population; there is deterioration
National Territory, DR – In the Dominican Republic, the indicators that show deterioration of mental health have skyrocketed; one of them, traffic congestion, raises these stressors.
Dr. José Miguel Gómez Montero, psychiatrist and writer, analyzed the topic.
National Territory, DR – In the Dominican Republic, the indicators that show deterioration of mental health have skyrocketed; one of them, traffic congestion, raises these stressors.
Dr. José Miguel Gómez Montero, psychiatrist and writer, analyzed the topic.
“This is a society trapped with a culture of high dangerousness, citizen insecurity, noise and blockage,” said the specialist, explaining that society is macro-stressed and, consequently, mental health indicators are skyrocketing.
Next, he specified: “The streets of the largest cities in the country are crowded with vehicles of various modalities, cars, trucks, vans, motorcycles and scooters. It can be reviewed in any demarcation of the Dominican Republic.”
He referred to the blackouts as an indicator of deterioration in the quality of public services and said that there is a deficit in public and environmental policies aimed at improving people’s quality of life.
The proposal
“The proposal is that the mayors’ offices continue to organize the parks, that the traffic lights work, and that, in Santo Domingo, the transit of high-cylinder trucks is prohibited on the boardwalk,” the doctor and writer said.
The doctor believes that more recreational areas should be built in cities and that the Government should make a greater effort to improve the electricity system. “People get irritated by the heat due to the lack of electricity, which prevents them from sleeping well. Likewise, everything is complicated in large cities with road blockages.”
Noise is highly harmful to mental health, said the professional, specifying that people occupy the sidewalks and that the authorities do not take measures.
He referred to those who use public roads to make sales or wash their windows, an action added to the plugs at intersections.
“It is necessary to develop efficient social policies, which restore peace, tranquility and harmony to the population,” said the doctor.
He said that improving mental health indicators and creating a safer, more spiritual, and comfortable city are necessary. He said that all this was planned.
The reality
In the Dominican Republic, the plugs manifest themselves at any time of the day. A blockage can last for a prolonged period, and people become desperate.
The situation has become complicated with the opening of the school year, which means that tutors take to the streets from the early hours of the morning.
For the public road to be blocked, 10 minutes is enough; it can cost an hour.
Dominicans have experienced anxiety, stress, and a deterioration of mental health in recent years. It would be necessary to expand and adapt important points of the Juan Pablo Duarte highway and the construction of the marginal Los Alcarrizos. Both projects are underway and have been established in traffic studies.
Bus corridors on central routes are initiatives that have a favorable impact.
10 months 1 week ago
Health, Local
New Virus Discovered In China That Can Affect Brain - NDTV
- New Virus Discovered In China That Can Affect Brain NDTV
- Doctors detect first EVER case of new deadly tick-borne virus that 'buries itself in the brain' Daily Mail
- New tick-borne virus discovered in China can affect the brain, scientists report Livescience.com
- Scientists discover novel orthonairovirus in man bitten by tick in China University of Minnesota Twin Cities
- Never-seen-before ‘wetland’ tick virus that ‘buries itself in the brain and switches it off’ infects first... The Sun
10 months 1 week ago
Medical News, Health News Latest, Medical News Today - Medical Dialogues |
Fact Check: Can Entod Pharma's PresVu get rid of reading glasses?
New Delhi: The recent claims made by various media reports based on the press note/conference of ENTOD pharma, stating that its product Presvu and its proprietary formula can get rid of reading glasses is Misleading.
The Claim and its skyrocketing virality
New Delhi: The recent claims made by various media reports based on the press note/conference of ENTOD pharma, stating that its product Presvu and its proprietary formula can get rid of reading glasses is Misleading.
The Claim and its skyrocketing virality
On 3rd September, 2024, pharma company, Entod Pharma organised a press conference where it announced the Drugs Controller General of India (DCGI) approval of the product. The press release that followed was titled " ENTOD Pharmaceuticals’ PresVu Eye Drops Approved by DCGI, Offering a Spectacular Treatment for Presbyopia, making reading possible without Spectacles" and stated that PresVu is the first eye drop in India specifically developed to reduce dependency on reading glasses for individuals affected by presbyopia, a common age-related vision condition that typically impacts those over 40.
"Presvu has also been applied for a patent for this invention in terms of its formulation and the process. The proprietary formula not only gets rid of reading glasses but also helps the patient lubricate their eyes as a side benefit. These eye drops utilise advanced dynamic buffer technology to swiftly adapt to tear pH, ensuring consistent efficacy and safety for extended use, keeping in mind that such drops will be used for years at a stretch," the press release stated
The release went on to add about the incidence and impact of presbyopia, as well as its impact. Presbyopia occurs as a natural consequence of aging when the eye’s ability to focus diminishes, leading to difficulty in focusing on close objects. This condition can significantly impact a person’s quality of life, affecting their ability to perform daily tasks and maintain their lifestyle. The release also contained quotes from Nikkhil K Masurkar, CEO of ENTOD Pharmaceuticals, who stated, “PresVu is the result of years of dedicated research and development. This DCGI approval is a major step forward in our mission to transform eye care in India. PresVu is more than just a product; it's a solution that stands to improve the lives of millions by offering them greater visual independence. We take pride in our commitment to innovation and in providing healthcare solutions that are both accessible and affordable.”
Dr. Dhananjay Bakhle, Scientific Advisor, Entod Pharma commented on the clinical potential of PresVu, stating, “The approval of PresVu is a promising development in the field of ophthalmology. For patients with presbyopia, this eye drop offers a non-invasive option that can enhance near vision without the need for reading glasses. Its rapid efficacy and safety profile, demonstrated in clinical trials, makes it a valuable addition to the treatment arsenal.”
Dr. Aditya Sethi, Ophthalmologist, was quoted in the release as stating, “Presbyopia has long been managed with reading glasses, contact lenses and surgical interventions but PresVu offers an advanced alternative that augments near vision within 15 minutes. This new treatment option is set to greatly improve the quality of life for many, allowing them to perform everyday tasks with newfound ease. It's important to monitor symptoms and seek medical advice if blurry close-up vision interferes with reading, close-up work, or other activities. Immediate medical attention is necessary for sudden blurred vision, flashes of light, or double vision.”
Following the press conference, Several media outlets reported about the eye drops claiming it as a spectacular treatment for Presbyopia and the potential to get rid of reading glasses. Times of India report was titled " Say goodbye to reading glasses: DCGI approves vision-correcting eye drops" started by stating" Imagine a world where we no longer need to reach for our reading glasses every time we pick up a book, check our phone, or at a menu. For millions of people over 40, this could soon be a reality....". Similarly, another report in ABP news was titiled," नजर का चश्मा लगाने से मिल जाएगा छुटकारा! DCGI की तरफ से इस आई ड्रॉप को मिली मंजूरी". Another report in NDTV was titled "All About PresVu, New Eye Drops That Can Remove Reading Glasses In 15 Mins. Similarly another news report in in myNation Hindi said "PressVu: गजब! सिर्फ 15 मिनट में हट जाएगा चश्मा, शानदार है ये आई ड्राप.|
Fact check
The claim that Presvu can get rid of reading glasses is Misleading. PresVu eye drops may reduce dependence on reading glasses for certain individuals with presbyopia, but it is unlikely to fully "get rid of" the need for reading glasses in all cases. Presbyopia is a progressive, age-related condition, and while eye drops may improve near vision temporarily, they are not a cure. The phrasing in many of the news reports suggests a complete and permanent solution, which is likely overstated without long-term, conclusive clinical data.
What Is Presbyopia
Presbyopia occurs when the eyes gradually lose the ability to focus on nearby objects. It is a natural part of aging and becomes noticeable after age 40. The word “presbyopia” is derived from Greek, meaning “old eye.” This condition occurs as the lens of the eye, located behind the iris, becomes more rigid and less flexible with age, making it difficult to focus on close-up tasks like reading or threading a needle. While presbyopia cannot be prevented or reversed, it can be managed with eyeglasses, contact lenses, medication, or surgery. Without correction, presbyopia can lead to eye strain and headaches.
What is Presvu
Presvu is a brand name of the ophthalmic drug by Entod Pharma that contains the generic molecule (pilocarpine hydrochloride ophthalmic solution) 1.25%, for topical ophthalmic use. It was initially approved in the United States in 1974 and has been used to treat glaucoma and ocular hypertension by allowing excess fluid to drain from the eye.
It was approved in the US under brand name Vuity for the treatment of Presbyopia, Medical Dialogues team had reported in 2021. In 2023, Entod Pharma got the approval from the CDSCO Panel, DCGI, the drug regulator in India to study Pilocarpine Hydrochloride for Treatment of Presbyopia
Pilocarpine ophthalmic treats presbyopia by reducing the size of the pupils which helps to see objects up close.
Pilocarpine hydrochloride is a cholinergic muscarinic agonist which activates muscarinic receptors located at smooth muscles such as the iris sphincter muscle and ciliary muscle. The drug contracts the iris sphincter muscle, constricting the pupil to improve near and intermediate visual acuity while maintaining some pupillary response to light. It also contracts the ciliary muscle and may shift the eye to a more myopic state.
While the data of Presvu brand is not traceable publicly, the systemic exposure to pilocarpine was evaluated in 22 participants with presbyopia who were administered 1 drop of VUITY in each eye once daily for 30 days. The mean Cmax and AUC0-t,ss values on Day 30 were 1.95 ng/mL and 4.14 ng·hr/mL, respectively. The median Tmax value on Day 30 was 0.3 hours postdose with a range from 0.2 to 0.5 hours postdose.
In a clinical trial published by George O Waring et. al. found the onset effect of AGN-190584 (Allergan, an AbbVie company) which is an optimized topical formulation of pilocarpine hydrochloride, 1.25% was at 15 minutes.
The most common adverse reactions (>5%) of the drug include headache and conjunctival hyperemia, while warning and precautions include the following
- Blurred Vision: Patients should be advised not to drive or operate
machinery if vision is not clear (e.g., blurred vision). Exercise caution in
night driving and other hazardous activities in poor illumination. - Risk of Retinal Detachment: Rare cases of retinal detachment and retinal
tear have been reported with miotics,Individuals with
pre-existing retinal disease are at increased risk. Therefore, examination
of the retina is advised in all patients prior to initiation of therapy.
Patients should be advised to seek immediate medical care with sudden
onset of flashing lights, floaters, or vision loss. - Iritis: Caution is advised in patients with iritis.
The drug is contradicted in patients with known hypersensitivity to the active ingredient or to any of the excipients.
So, is this a breakthrough, Spectacular Drug that gets rid of Reading Glasses?
Based on the analysis of the traceable public data around the molecule, the agent is does not seem to be a breakthrough or revolutionary drug. The molecule was first approved in ophthalmic conditions in 1974 and was particularly approved in the condition of Presbyopia in 2021 by the USFDA.
Regarding the Claim Medical Dialogues Fact check Team, spoke to Dr Ishan Kataria, who informed, "It would be incorrect to classify this drug as a breakthrough treatment for presbyopia. It contains a diluted form of pilocarpine, which provides a temporary 'pinpoint effect' by constricting the pupil and ciliary muscles, similar to looking through a keyhole where light converges to enhance near vision. While this may reduce dependency on reading glasses, it cannot fully eliminate the need for them, as presbyopia is a natural, age-related condition that typically affects those over 40. For individuals above 50, the drops might reduce the need for stronger lenses, e.g- potentially bringing a prescription of +3.0 down to +1.5, but no further. Although the drops work within 15 minutes, their effect is temporary, and without regular use, the benefits will diminish. Additionally, pilocarpine has a known history of side effects, including headaches and, in rare cases, retinal detachment, particularly when used in higher concentrations for glaucoma. Therefore, it may not be suitable for everyone."
The Aftermath of the Viral Claim
With several media reports pointing this as a "breakthrough" or "revolutionary" drug, drug officials came out condemning the reports as false presentation of facts
The claims made by ENTOD Pharmaceuticals about its product PresVU eye drops being approved by DCGI and offering spectacular treatment for Presbyopia are unethical and false presentation of facts, said a top official source to ANI news agency. "This is unethical and false presentation of facts," said the official source. The company has been asked for an explanation for the false representation by the drug regulator, "Explanation has been asked from the company." Said top official sources.
Response of the company
In response to the queries of Medical Dialogues, ENTOD Pharmaceuticals dismissed allegations that it made unethical or false presentation of facts to the media or public about its product, PresVu eye drops.
Nikkhil K Masurkar, CEO, Entod Pharmaceuticals, said in a statement late Thursday evening, "We at ENTOD Pharmaceuticals hereby declare that we have not made any of the unethical or false presentation of facts to the media or public when it comes to PresVu eye drops. All facts disclosed to the media are strictly based on the approved indication for treatment of presbyopia in adults and the Phase 3 clinical trial data generated by us. "
The company further mentioned that the opinions and claims printed in news stories do not represent ENTOD Pharmaceuticals. "Some of the opinions and claims printed in news stories do not represent that of ENTOD Pharmaceuticals or any of its spokespeople. The widespread media interest in such a therapy has been unprecedented and has led to sensationalization of the story."
Final Verdict
The press release and the various reports are misleading as they seem to overstate the role of Pressvu as a breakthrough or a revolutionary drug that can get rid of reading glasses. While there is merit in the use of drugs in improving vision in presbyopia, this improvement is temporary and requires the reuse of drug again and again implying the solution is not permanent. Hence, the claims surrounding Presvu getting rid of reading glasses are misleading
10 months 1 week ago
News,Top Industry News,Fact Check,Eye and ENT Care Fact Check,Latest Fact Check
EEE found in mosquito sample from Long Island: What to know about virus - NBC New York
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10 months 1 week ago
Health Archives - Barbados Today
Trinidad and Tobago records 13 dengue-related deaths
Trinidad and Tobago has recorded its 13th dengue-related death with health authorities saying Friday, that the number of cases had surpassed 1,300.
In a statement, the Ministry of Health said there were 1,315 confirmed cases of dengue fever across the country, with 13 fatalities so far this year.
Trinidad and Tobago has recorded its 13th dengue-related death with health authorities saying Friday, that the number of cases had surpassed 1,300.
In a statement, the Ministry of Health said there were 1,315 confirmed cases of dengue fever across the country, with 13 fatalities so far this year.
It said that as of September 5, health authorities have also issued 914 yellow fever notices to property owners and occupiers, urging them to clean up their surroundings to reduce mosquito breeding sites.
Legal action is being considered against 43 property owners for failing to comply with these directives as the ministry reminds the public that dengue is spread by the bite of an infected Aedes Aegypti mosquito.
It is the same type of mosquito that spreads the Zika and chikungunya viruses.
Trinidad and Tobago recorded its first dengue-related death on June 19, when a 65-year-old succumbed to the virus.
The health ministry said that symptoms appear within five to six days of being bitten (and) last for one to two weeks.
It said the symptoms include fever, headache, pain behind the eyes, muscle and joint pains, skin rash, vomiting and diarrhea and that individuals showing such symptoms should seek immediate medical treatment.
SOURCE: CMC
The post Trinidad and Tobago records 13 dengue-related deaths appeared first on Barbados Today.
10 months 1 week ago
Health, Regional, Trinidad & Tobago
How to stay safe during the EEE outbreak, according to a neurologist - PBS NewsHour
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News Archives - Healthy Caribbean Coalition
2023 CBU Caribbean Media Awards
On August 13, 2024 the 55th Caribbean Broadcasting Union’s Caribbean Media Awards took place in Umaya Hotel, Placencia Belize.
The primary goal of the HCC Communications under the Global Health Advocacy Incubator project remains to tackle childhood obesity and by extension non-communicable diseases (NCDs) through healthy food environments across the Caribbean with a focus on Barbados and Jamaica. This has been achieved through the development and implementation of communication and advocacy campaigns, guided by a strategic plan to reach target audiences including policymakers, the media and lay-persons. Our markers of success have been grounded in regional governments policy readiness and implementation.
The HCC continues to communicate with various target audiences through several channels. These include social media including WhatsApp, Instagram, Facebook, X formerly known as Twitter, YouTube, LinkedIn and digital, including our website, email blasts, RoundUp newsletter, and our webinars. The HCC has engaged both traditional and online media in our efforts to reach our target audiences. The media, being one of our primary audiences we have engaged through our webinars, hang-outs, one-on-one meetings, training sessions, sensitisations and now through the sponsored Caribbean Media Awards.
The Healthy Caribbean Coalition (HCC) expanded its awards this year, to include a Healthy Nutrition Food Policy Award under two (2) themes; Television and Print for the 35th National Gas Company (NGC) Caribbean Media Awards (CMA) of the Caribbean Broadcasting Union (CBU). This activity culminated the 55th Caribbean Broadcasting Union’s Annual General Assembly, which took place in Placencia Belize. The Awards recognizes the work of the media produced and published in 2023. Following the criteria, nominations were released in June 2024. Nestled in the Umaya Hotel, the Awards took place on the night of Tuesday August 13th, 2024. The Nation Publishing Company, having coped its first ever CMA, was awarded in the print category and the Barbados Government Information Service (BGIS) emerged the winner under the television themed category. Special mention was given to RJR Gleaner Communications Group (Print Themed Award).
The event was live telecast hosted by Great Belize Productions Limited – Channel 5. Presentations, Trophies and Certificates were made in fifty-five (55) categories. A record number of these – twenty-four (24) were themed categories supported by category sponsors including:
- UNDP CariSECURE2.0
- Healthy Caribbean Coalition (HCC)
- The Caribbean Community Climate Change Centre
- The Sagicor Financial Company Limited
- The Caribbean Development Bank Basic Needs Trust Fund
- The Nature Conservancy Caribbean Division
- The Partnership Initiative for Sustainable Land Management
- SAEDI Consulting Limited
The organisation with the largest number of wins was RJR Gleaner Communications Group from Jamaica with sixteen (16) awards and four (4) special mentions across its media services. Great Belize Productions – Channel 5 was second with eight (8) wins and two (2) special mentions. Trinidad and Tobago was well represented with Trinidad Express fielding five (5) awards and garnering four (4) special mentions. TTT Limited received four (4) awards and a special mention. The Guardian Group was successful in five (5) categories with two awards for CNC-3; two (2) special mentions for television service and one (1) for the print-arm-Guardian newspaper.
The theme for this year’s Annual General Assembly was the Media and the Environment. This theme, being quite expansive covers key areas of interest of the HCC including the food environment in which a healthy and nutritious environment supported by healthy nutrition food policies allows individuals to grow, live, learn and thrive and climate change; which impacts heavily on the kind of food environment we have at our disposal. Food security relies heavily on and is impacted by climate change.
- The BGIS award – “Grow Green Barbados: Episode 3 – Organic Farming” – Aisha Reid, Mikul Elcock, David Bynoe, Esther Jones, KathyAnn Husbands
- Nation Publishing Company (Barbados) It’s War – Donna Sealy
- Special Mention: RJR Gleaner Communications Group (Jamaica) – “Hungry Belly Children Can’t Learn” – Andre Williams
The HCC will also sponsor two (2) journalists for the 2024 awards (36th CMA) which has been announced will take place in Barbados in August 2025. This will be promoted at the Healthy Food Policy Virtual Sensitisation for Media Managers, Journalists and Partners in October 2024. The HCC was represented by Communications Officer Sheena Warner-Edwards in Belize, throughout the General Assembly. Participants experienced the culture of Belize through the food and the people. Both the Opening Ceremony and the Awards were streamed from Channel 5across HCCs social media channels.
Here are some photos from the event.
https://www.youtube.com/watch?v=JOH3Ow9mg_w
CBU Media Monitoring
- https://www.caribroadcastunion.org/cbu-events/cma/
- https://www.caribroadcastunion.org/2024/06/04/ngc-35th-cbu-caribbean-media-awards-announcement-of-nominees/
- https://jamaica-gleaner.com/article/lead-stories/20240817/rjrgleaner-group-continues-caribbean-media-dominance
- https://edition.channel5belize.com/winners-announced-at-record-breaking-35th-caribbean-media-awards/
- https://www.cbc.bb/news/local-news/cbc-cops-regional-media-awards/
- https://emonewsdm.com/sagicor-financial-company-ltd-supports-caribbean-broadcasting-unions-caribbean-media-awards/
- https://www.tv6tnt.com/news/7pmnews/ngc-35th-cbu-caribbean-media-awards/article_ab8b6898-5ab3-11ef-b9a5-9bfe1e50398a.html
- https://www.guardian.co.tt/news/gml-bags-two-cbu-journalism-awards-three-special-mentions-6.2.2082717.e8035f9f03
- https://magneticmediatv.com/2024/08/historic-health-professions-amendment-ordinance-and-regulations-2024-officially-signed-into-law/
- https://climatetrackercaribbean.org/featured/climate-tracker-fellows-shine-at-35th-cbu-awards/
- https://www.ttt.live/cbu-awards-2024/
- https://edition.channel5belize.com/caribbean-journalists-converge-in-belize-for-cbu-agm-media-awards/
- https://caribbean.loopnews.com/content/caribbean-tourism-organization-announces-2024-media-award-winners
The post 2023 CBU Caribbean Media Awards appeared first on Healthy Caribbean Coalition.
10 months 1 week ago
Latest, News
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10 months 1 week ago
Medical News, Health News Latest, Medical News Today - Medical Dialogues |
Can detection of breast Arterial Calcification during mammography help Assess CV Risk in Women?
A recent study published in the American Journal of Preventive Cardiology highlighted a significant challenge in accurately stratifying cardiovascular (CV) risk in females. Traditional models often miss a substantial proportion of at-risk women, particularly the individuals without obvious symptoms or standard risk indicators.
However, breast arterial calcifications (BAC) can be identified during routine mammography and have been emerged as independent prognosticators of cardiovascular risk. The study investigated how BAC interacts with coronary artery disease profiles as assessed by computed tomography (CT) by focusing on the implications of BAC 0 (absence of BAC) and its relationship with coronary artery calcification (CAC) scores, the severity of coronary stenosis, and the presence of high-risk plaques (HRP).
The study included a total of 443 consecutive female patients who underwent both mammography and coronary CT angiography (CTA) for clinical indications within a year. The patients were divided into 3 age groups: under 55 years, 55-65 years, and over 65 years. This research analyzed the prevalence of BAC 0 and its correlation with CAC scores, specifically the individuals greater than 300 Agatston Units (AU), the severity of coronary stenosis (defined as obstructive disease with >50% stenosis) and the presence of high-risk plaques.
The results revealed significant age-related differences in the prevalence of BAC 0. Younger women (under 55 years) with BAC 0 were highly unlikely to have a severe CAC score (>300 AU), with only 0.82% of these women falling into this high-risk category. However, this protective effect of BAC 0 diminishes with age. The prevalence of high CAC scores in the individuals with BAC 0 jumps significantly in women over 65, with a 16.58-fold increase in risk when compared to younger women. Women aged 55-65 also showed a marked increase in high CAC scores, with 12.1% affected.
When examining obstructive coronary disease, the study found that 18.2% of women with BAC 0 had significant coronary stenosis (>50% blockage). Again, this risk was age-dependent: 10.7% in women under 55, 14.7% in those aged 55-65, and 29.9% in women over 65 years. While BAC 0 seemed somewhat protective against severe CAC in younger women, it did not rule out the presence of obstructive coronary disease or high-risk plaques across all age groups. The correlation between BAC, CAC, and CAD-RADS (a scoring system for coronary artery disease severity) was weak, with no significant association between BAC and the presence of high-risk plaques.
The study illuminates that while BAC 0 may help rule out severe coronary calcification in women under 55, it does not reliably predict the absence of obstructive coronary disease or high-risk plaques in older women. Overall, this finding has important implications for primary prevention strategies by suggesting that reliance on BAC 0 alone in cardiovascular risk assessment may leave a significant proportion of women at risk, particularly the women over 55 years old.
Source:
Deeg, J., Swoboda, M., Bilgeri, V., Lacaita, P. G., Scharll, Y., Luger, A., Widmann, G., Gruber, L., & Feuchtner, G. M. (2024). Does the absence of breast arterial calcification (BAC 0) rule out severe coronary artery disease? A computed tomography angiography study. In American Journal of Preventive Cardiology (Vol. 19, p. 100724). Elsevier BV. https://doi.org/10.1016/j.ajpc.2024.100724
10 months 1 week ago
Cardiology-CTVS,Cardiology & CTVS News,Top Medical News
PAHO/WHO | Pan American Health Organization
La OPS y la Oficina Internacional para la Epilepsia buscan elevar la epilepsia como prioridad de salud en las Américas
PAHO and International Bureau for Epilepsy seek to make epilepsy a health priority in the Americas
Oscar Reyes
6 Sep 2024
PAHO and International Bureau for Epilepsy seek to make epilepsy a health priority in the Americas
Oscar Reyes
6 Sep 2024
10 months 1 week ago
Ministry of Health enhances plans for pandemic and respiratory epidemic response
Santo Domingo.- The Ministry of Health, supported by the Pan American Health Organization (PAHO) and other health sector partners, is enhancing the Dominican Republic’s ability to handle health emergencies, particularly those involving respiratory viruses.
Santo Domingo.- The Ministry of Health, supported by the Pan American Health Organization (PAHO) and other health sector partners, is enhancing the Dominican Republic’s ability to handle health emergencies, particularly those involving respiratory viruses.
To achieve this, the Ministry of Health, through its Epidemiology Department, conducted a workshop titled “Framework of National Programs for the Prevention and Control of Diseases Caused by Respiratory Viruses with Epidemic and Pandemic Potential.” The workshop involved collaboration with the National Health Service (SNS), the General Directorate of Livestock, and the General Directorate of Medicines, Food, and Health Products (Digemaps).
The workshop addressed the current status and gaps in the prevention and control of respiratory viruses, aiming to bolster surveillance, expand policy measures, strengthen epidemic response, and improve risk communication and community involvement. It sought to create a unified national strategy for managing influenza and other respiratory viruses with epidemic or pandemic potential.
Key health sector stakeholders, including the Association of Private Clinics (Andeclip), the Dominican Society of Pulmonology, USAID, Promese/Cal, and the National Public Health Laboratory Dr. Fernando A. Defilló, participated in the three-day training, which focused on technical cooperation and response strategies for respiratory diseases.
10 months 1 week ago
Health
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