MedCity News

AbbVie Pays $700M for Drug Engineered to Overcome Resistance in Multiple Myeloma

AbbVie has acquired rights to a multispecific antibody that IGI Therapeutics designed to bind to three targets to treat multiple myeloma. Early Phase 1 results showed encouraging responses in a heavily pretreated patient population and a favorable safety profile.

The post AbbVie Pays $700M for Drug Engineered to Overcome Resistance in Multiple Myeloma appeared first on MedCity News.

2 weeks 1 day ago

BioPharma, Daily, Pharma, AbbVie, antibody drug, biopharma nl, Cancer, Clinical trial, deals, multiple myeloma

Health – Dominican Today

Public Health intensifies measles surveillance

Santo Domingo.- The Dominican Republic continues to be free of measles, with no cases of local transmission reported since 2001, according to the Ministry of Public Health. However, in response to rising measles cases across the Americas, as reported by the Pan American Health Organization (PAHO), the country has intensified its epidemiological surveillance.

Santo Domingo.- The Dominican Republic continues to be free of measles, with no cases of local transmission reported since 2001, according to the Ministry of Public Health. However, in response to rising measles cases across the Americas, as reported by the Pan American Health Organization (PAHO), the country has intensified its epidemiological surveillance.

For over two decades, all suspected measles cases have been promptly ruled out through clinical, epidemiological, and laboratory testing—efforts led by the General Directorate of Epidemiology in coordination with technical health bodies. Between 2020 and 2025, over 1.6 million MMR (measles, mumps, and rubella) vaccine doses have been administered to children under two, with a two-dose schedule at 12 and 18 months. The vaccine provides 93% protection after the first dose and up to 97% after the second.

Vaccination coverage has remained high, with first-dose rates above 90% and notable increases in second-dose uptake. During Vaccination Week of the Americas in 2022, the country reached a record 97% coverage among children ages 1 to 5.

So far in 2025, health authorities have reviewed over 1.6 million clinical records and conducted visits to 371 communities with no confirmed measles cases. To maintain this status, the Ministry has implemented a national prevention plan that includes rapid vaccination monitoring, immunization of at-risk individuals, outreach campaigns, and health worker training.

2 weeks 1 day ago

Health

Health – Demerara Waves Online News- Guyana

Caribbean leads in reducing AIDS-related deaths globally

Data from the latest Global AIDS Update Report, released by UNAIDS, shows the Caribbean recorded a 62% reduction in AIDS-related deaths, between 2010 and 2024, the steepest decline among eight regions globally. According to the report—AIDS, Crisis and the Power to Transform—over the last fifteen years, there has been a 54% decline in AIDS-related deaths ...

Data from the latest Global AIDS Update Report, released by UNAIDS, shows the Caribbean recorded a 62% reduction in AIDS-related deaths, between 2010 and 2024, the steepest decline among eight regions globally. According to the report—AIDS, Crisis and the Power to Transform—over the last fifteen years, there has been a 54% decline in AIDS-related deaths ...

2 weeks 1 day ago

Health, News, AIDS-related deaths, Caribbean, hiv, reduction, UNAIDS report

STAT

STAT+: Brawl over Eylea gets biosimilar industry’s attention

Want to stay on top of the science and politics driving biotech today? Sign up to get our biotech newsletter in your inbox.

Hello! Today, we talk about a cool experimental enzyme therapy, observe more patent maneuvers over Eylea, and see an ‘underdog’ startup get a huge seed round to target a common kidney disease.

Want to stay on top of the science and politics driving biotech today? Sign up to get our biotech newsletter in your inbox.

Hello! Today, we talk about a cool experimental enzyme therapy, observe more patent maneuvers over Eylea, and see an ‘underdog’ startup get a huge seed round to target a common kidney disease.

The need-to-know this morning

  • Soleno Therapeutics pre-announced $31-33 million in Vykat XR sales for the second quarter — beating consensus expectations by a wide margin. The drug was approved in late March to treat Prader-Willi syndrome, a rare genetic disease that causes an insatiable desire to eat. Soleno is also raising $200 million in a follow-on stock sale.
  • AbbVie is paying $700 million upfront to acquire licensing rights to a “trispecific antibody” treatment for cancer developed by Ichnos Global Innovation. The drug, called ISB 2001, targets CD38 and BCMA protein receptors on tumor cells and the CD3 receptor on T cells. A Phase 1 study in multiple myeloma is underway.

Brawl over Eylea gets biosimilar industry’s attention

A high-stakes legal fight between Regeneron and Amgen over the blockbuster eye drug Eylea is putting the U.S. patent system under a microscope — and is being closely watched by biosimilar makers.

Continue to STAT+ to read the full story…

2 weeks 1 day ago

Biotech, Business, Pharma, The Readout, biotechnology, drug development, drug prices, Research

STAT

STAT+: Pharmalittle: We’re reading about Regeneron’s patent maneuvers, FDA rejection letters, and lots more

Top of the morning to you. And a fine one it is, despite the clouds enveloping the Pharmalot campus. Birds are chirping, neighbors are mulling about, and the official mascots are scurrying across the grounds in search of creatures to annoy. As for us, we are as busy as ever hunting and gathering items of interest. We trust you have your own hectic agendas.

So join us as we hoist the ever-present cup of stimulation — our choice today is maple bourbon — and attack the fast-growing to-do list. Have a grand day, everyone, and do stay in touch. …

A court battle between two of the nation’s largest biotechs — Regeneron Pharmaceuticals and Amgen — is testing the legal limits of how far drugmakers can go in using patents to thwart competition, STAT writes. The case is being closely watched by companies that sell biosimilar medicines amid concerns that the U.S. patent system is being gamed in ways that critics say can maintain high prices for medicines. The saga began early last year when Regeneron filed a lawsuit accusing Amgen of infringing a key patent on its best-selling Eylea injectable drug, which is used to combat such eye diseases as wet age-related macular degeneration, among other ailments. The treatment, with a list price of nearly $1,900 a shot, is at the heart of a multibillion-dollar product line. At the time, Amgen was one of several companies that hoped to sell a biosimilar version, but Amgen’s approach set it apart from the others — and paved its way to the marketplace earlier than Regeneron had hoped.

The U.S. Food and Drug Administration will start publishing the rejection letters that companies until now have mostly kept hidden from investors and the public, Bloomberg News reports. “We had a long set of meetings with our lawyers to determine that we can do this,” FDA Commissioner Marty Makary said in an interview with Bloomberg Television’s Wall Street Week. The agency has historically left it up to drugmakers to disclose when and why their medicines are not approved. But companies often give incomplete or misleading accounts of their interactions with regulators, and that can make an application’s deficiencies seem more minor than they really are, Makary said in the interview airing Friday. “There’s an opportunity for companies to spin the results,” he said. “Now, the decision letters will be public for shareholders and the public to see.” Investors have long asked the FDA to share its reasons for rejecting drugs, arguing that companies can use the agency’s silence on the matter to mislead the market.

Continue to STAT+ to read the full story…

2 weeks 1 day ago

Pharma, Pharmalot, pharmalittle, STAT+

PAHO/WHO | Pan American Health Organization

PAHO and Bloomberg Philanthropies continue partnership to strengthen vital statistics in the Americas

PAHO and Bloomberg Philanthropies continue partnership to strengthen vital statistics in the Americas

Cristina Mitchell

9 Jul 2025

PAHO and Bloomberg Philanthropies continue partnership to strengthen vital statistics in the Americas

Cristina Mitchell

9 Jul 2025

2 weeks 2 days ago

Medical News, Health News Latest, Medical News Today - Medical Dialogues |

Exposure to particulate matter during pregnancy is associated with an increased risk of childhood obesity: Study

Exposure to air pollution during pregnancy, specifically to fine particulate matter (PM2.5), may increase the risk of childhood overweight or obesity.

Exposure to air pollution during pregnancy, specifically to fine particulate matter (PM2.5), may increase the risk of childhood overweight or obesity. This is the conclusion of a large, pan-European meta-analysis study led by the Barcelona Institute for Global Health (ISGlobal), a center supported by the ”la Caixa” Foundation, and recently published in Environment International. The study examined the relationship between exposure to air pollutants during pregnancy and during childhood, and its impact on body mass index (BMI) and the risk of overweight or obesity throughout childhood.

The study is part of the LifeCycle and ATHLETE projects, funded by the European Union, with the aim to evaluate how early life environmental stressors affect health over time. For this research, data were collected from mothers and children from 10 birth cohorts in 8 European countries. In total, 37,111 mother-child pairs participated during the prenatal period and 33,860 during the childhood stage.

The research team calculated pregnancy and annual average concentrations of nitrogen dioxide (NO₂) and fine particulate matter (PM2.5) at the family’s place of residence using geospatial models. The study covered air pollution exposures from pregnancy until the children reached 12 years of age. Children's height, weight and age were obtained through clinical assessments or parental reports, and used to calculate BMI. Then, cohort-specific associations between air pollution exposure and childhood obesity outcomes were estimated and pooled together in a meta-analysis of all cohorts.

Higher Risk of Overweight or Obesity in Childhood

Exposure to higher levels of PM2.5 during pregnancy was associated with a 23% increased risk of childhood overweight or obesity. This association was strongest in the 9–12 year age group. However, the study did not observe any associations with exposure to PM2.5 during childhood, nor with NO₂ exposure during pregnancy or childhood.

“Our results indicate that the gestational period may represent a particularly vulnerable window for the risk of childhood obesity. However, further research is needed to precisely identify the critical periods during which exposure to air pollution might influence this risk, and to confirm these findings,” says Sarah Warkentin, an ISGlobal researcher and first author of the study.

“The biological mechanisms that may explain the relationship between exposure to air pollution and weight gain in children are not yet fully understood. In previous studies, exposure to pollution during pregnancy has been linked to reduced fetal growth and low birth weight. This may be due to oxidative stress, inflammation, problems in placental development, or hormonal disruptions. These same processes could also affect growth and increase the risk of obesity during childhood, as shown in animal studies,” explains Martine Vrijheid, director of ISGlobal's Environment and Health over the Lifecourse programme and senior author of the study.

Heterogeneity Among Cohorts

The results showed that the associations between air pollutants and childhood obesity outcomes differed substantially between the different cohorts. For instance, prenatal and postnatal exposure to PM2.5 was associated with a lower BMI at all ages in UK cohorts, whereas childhood exposure to PM2.5 and NO₂ was associated with a higher BMI in a Dutch cohort.

“This heterogeneity could be due to varying levels of air pollution exposure among the cohorts, possible differences in children's lifestyle habits in each country, which could influence their exposure to air pollution and, in turn, their weight, as well as other factors specific to each city's environment,” says Martine Vrijheid.

Reference:

Sarah Warkentin, Serena Fossati, Sandra Marquez, Anne-Marie Nybo Andersen, Sandra Andrusaityte, Demetris Avraam, Ferran Ballester, Tim Cadman, Maribel Casas, Montserrat de Castro, Leda Chatzi, Ahmed Elhakeem, Antonio d’Errico, Mònica Guxens, Regina Grazuleviciene, Jennifer R. Harris, Carmen Iñiguez Hernandez, Barbara Heude,  Ambient air pollution and childhood obesity from infancy to late childhood: An individual participant data meta-analysis of 10 European birth cohorts, Environment International, https://doi.org/10.1016/j.envint.2025.109527.

2 weeks 2 days ago

Obstetrics and Gynaecology,Pediatrics and Neonatology,Obstetrics and Gynaecology News,Pediatrics and Neonatology News,Top Medical News,Latest Medical News

Health Archives - Barbados Today

Classes suspended at Gordon Walters Primary after child hospitalised, others fall ill



A primary school in Christ Church was abruptly closed on Tuesday after a seven-year-old pupil was admitted to intensive care with a suspected infectious illness, leaving parents and teachers demanding answers.

The Barbados Union of Teachers (BUT) has confirmed that a pupil of Gordon Walters Primary School, in St Patrick’s, was being treated in the Intensive Care Unit, and at least six of his 11 classmates have also fallen ill, with high fever the most common symptom reported. 

Teachers are now calling on health authorities to provide answers, as investigations continue into the child’s condition and the cause of the cluster of student absences.

In a statement issued on Tuesday evening, the Ministry of Education said the decision to close the school was made “out of caution for the health and safety of its staff and students” after being notified by the Principal of the hospital admission.

Speaking to Barbados TODAY at the school, BUT Vice-President Julian Pierre, who chairs the union’s health and safety committee, said the incident had left staff deeply concerned.

“There are a number of students in a particular class – I think the class has 12 students – where about seven of the students are out sick. The general symptom of that class, as reported, was high fever,” he disclosed.

“There are also students from other classes who are absent, reasons being unknown. Similar to the case at St Bernard’s Primary School, the staff is concerned as to what it possibly could be.”

Pierre noted that no official diagnosis had yet been made regarding the child in hospital.

“There has been a report or confirmation from the Chief Medical Officer that there are no cases of scarlet fever,” he said.

News of the hospitalisation began circulating on Monday night, and teachers met with the Principal the following morning. Many expressed discomfort about continuing classes given the uncertainty and the child’s condition.

“Teachers said they were uncomfortable. The level of anxiety was high, especially after what happened at St Bernard’s and the fact that this child had to be hospitalised,” Pierre said. “They’re worried it could be a highly contagious disease.”

The education ministry said in its statement: “The Principal of Gordon Walters Primary conducted a staff briefing this morning to update staff on the student’s welfare. Some teachers communicated feelings of discomfort to the Principal, and choosing to err on the side of caution, [the ministry] closed the school at 11:35 a.m.”

The Ministry of Health was actively investigating the symptoms and circumstances surrounding the child’s admission, the ministry said. 

“As per protocols and best practices, the immediate contacts have been identified and are being appropriately managed,” the statement added.

Despite those assurances, Pierre said the mood among teachers remained tense.

The situation comes just a week after St Bernard’s Primary in St Joseph was forced to close for two days. Several students fell ill at that school, prompting industrial cleaning and a full inspection by health officials. While scarlet fever was ruled out in that instance, two isolated cases of hand, foot and mouth disease were suspected. However, some staff remain unconvinced.

Now, teachers at Gordon Walters are demanding greater transparency from health authorities. Pierre insisted that parents, staff, and the public deserve clear communication.

“There has to be some level of transparency in that if the health officials say it is not a particular thing, there has to be some confirmation to the public as to what it is. This is about the safety of children and those who teach them,” Pierre said. “We need clear, timely information and swift action to prevent panic and protect everyone involved.”

As investigations continue, the BUT is urging parents to be extra cautious.

“We’re asking parents during this time to be vigilant as to the status of their children,” Pierre advised. “Check their skin and so on, make sure that they’re feeling fine. You know that within the school environment, there are many different viruses and bacteria that will pass throughout the school year.

“If you see anything that is irregular, seek medical attention… hopefully it is something that can be treated as soon as possible so there is no further spread of whatever it is that the child may be experiencing.”

The Ministry of Educational Transformation has confirmed that Gordon Walters Primary will remain closed until further notice, pending the outcome of medical investigations and a joint decision with the Ministry of Health.

The current school term ends on Thursday for students.

sheriabrathwaite@barbadostoday.bb

The post Classes suspended at Gordon Walters Primary after child hospitalised, others fall ill appeared first on Barbados Today.

2 weeks 2 days ago

Health, Local News, school

Health | NOW Grenada

Bermuda mulling digital healthcare collaboration with Grenada

Ricky Brathwaite, chief executive of the Bermuda Health Council, said an MOU between Bermuda and Grenada would help ensure the healthcare needs of both communities are better served

2 weeks 2 days ago

External Link, Health, apierion, bermuda, bermuda health council, dickon mitchell, jessie moniz hardy, michael dershem, ricky brathwaite, royal gazette

Health News Today on Fox News

Warding off Alzheimer's might mean making these 11 lifestyle changes, expert says

Research developments in Alzheimer’s disease, including newly approved blood tests for early detection, have helped patients get diagnosed sooner.

With dementia on the rise among younger individuals, the spotlight is on ways to prevent or slow the disease.

Research developments in Alzheimer’s disease, including newly approved blood tests for early detection, have helped patients get diagnosed sooner.

With dementia on the rise among younger individuals, the spotlight is on ways to prevent or slow the disease.

Dr. Daniel Amen, a psychiatrist, brain imaging doctor and founder of Amen Clinics in California, spoke with Fox News Digital in an interview about Alzheimer’s risk and management. (See the video at the top of this article.) 

FIRST BLOOD TEST FOR ALZHEIMER'S DIAGNOSIS CLEARED BY FDA

"Alzheimer's starts in your brain decades before you have any symptoms," he said. "So, a 59-year-old woman I diagnosed with Alzheimer's disease likely had negative changes in her brain in her 20s."

He added, "It's really never too early to think about protecting your brain and your mind."

Amen, author of the book "Change Your Brain Every Day," confirmed that half of Alzheimer’s cases are preventable, according to recent findings.

This can be done through nurturing brain health and treating the 11 major risk factors that "steal your mind," he said.

To remember the factors that can help ward off Alzheimer's, Amen created the acronym "BRIGHTMINDS" as follows.

Low blood flow is the No. 1 brain imaging predictor of Alzheimer’s disease, according to the doctor.

Alcohol, marijuana, caffeine, nicotine, sedentary behavior and excess weight or obesity can all decrease blood flow, thus should be avoided.

To promote blood flow, Amen suggests "walking like you’re late," which could entail walking 30 minutes a day — alternating between three minutes of normal walking and three minutes of fast walking.

"Do that five times for 30 minutes, and it increases blood flow to your brain," he said. 

Along with retirement and aging can come a slowdown in learning and cognitive activity, leading to a higher Alzheimer’s risk, Amen said.

'I'M A NEUROLOGIST — HERE'S WHY DEMENTIA IS RISING AND HOW TO REDUCE YOUR RISK’

He encourages retirees to learn something new every day to keep the brain active and healthy.

Inflammation is a "major cause" of psychiatric issues, Amen revealed, as well as conditions like cancer, arthritis and heart disease.

Flossing is an easy way to reduce inflammation in the gums and help prevent gum disease, which is a gateway to brain disease, according to the doctor.

"Genes aren't a death sentence," Amen said. "What they should be is a wake-up call."

The doctor said everyone should take steps to discover which diseases run in the family and then follow a daily prevention program.

STROKE, DEMENTIA AND DEPRESSION SHARE THESE 17 PREVENTABLE RISK FACTORS

"I have heart disease and obesity in my family," he said. "I don't have heart disease, and I'm not overweight. Why? Because I'm on an obesity heart disease prevention program every day of my life."

Concussions and head trauma are a "major cause" of psychiatric problems, Amen described, and should be avoided.

"Don't text and drive," he warned.

Some well-known toxins like alcohol, marijuana and other drugs are known to have negative impacts on overall health.

But some not-so-obvious toxins can include lead, mold, mercury from fish, and even general anesthesia, Amen cautioned.

"You always want to support your organs in detoxification," he said. "Drink more water, as it helps flush things through your kidneys … eat more fiber for your gut, and hold the alcohol."

Amen also suggested eating brassicas, which include vegetables in the cabbage family, as they have a detoxifying effect.

The expert also highlighted the benefits of sauna use as a detox tool.

"The people who take the most saunas have the lowest incidence of Alzheimer's disease," he stated.

A healthy mental state will help support a healthier brain, experts agree.

"Stop believing every stupid thing you think," Amen advised.

Keeping your body healthy and immune from infections is key to overall health, according to Amen.

The doctor suggested optimizing vitamin D intake, which can help support the brain and immune system.

The brain specialist recommends having a hormone balance check done every year, as any imbalances can interfere with the brain and increase Alzheimer’s risk.

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER

"Diabesity," a term referring to the parallel occurrence of obesity and type 2 diabetes, can be a major threat to overall health, the doctor warned.

"You really want to care about your weight," Amen said.

Weight and diet play an important role in brain health, as Amen's research has shown that as weight increases, the size and function of the brain decreases.

"Being overweight, you automatically have 10 of the 11 risk factors, because being overweight lowers blood flow, accelerates aging, increases inflammation and changes your hormones in a negative way," he said.

"Be mindful of only loving food that loves you back."

For more Health articles, visit www.foxnews.com/health

Sleep is crucial for a high-functioning mind, as an adequate night’s slumber "washes" the brain every night, Amen noted.

Better sleep translates to improved memory, energy, blood flow and decision-making, the doctor said, and should be a priority when working to prevent Alzheimer’s. 

2 weeks 2 days ago

Health, alzheimers, brain-health, longevity, nervous-system-health, diet-fitness, geriatric-health, lifestyle, healthy-living

Health News Today on Fox News

Making these 11 lifestyle changes could ward off Alzheimer's, expert says

Research developments in Alzheimer’s disease, including newly approved blood tests for early detection, have helped patients get diagnosed sooner.

Research developments in Alzheimer’s disease, including newly approved blood tests for early detection, have helped patients get diagnosed sooner.

As the common dementia has been on the rise among younger individuals, the spotlight is on ways to prevent or slow the disease.

Dr. Daniel Amen, a psychiatrist, brain imaging doctor and founder of Amen Clinics in California, spoke with Fox News Digital in an interview about Alzheimer’s risk and management.

FIRST BLOOD TEST FOR ALZHEIMER'S DIAGNOSIS CLEARED BY FDA

"Alzheimer's starts in your brain decades before you have any symptoms," he said. "So, a 59-year-old woman I diagnosed with Alzheimer's disease likely had negative changes in her brain in her 20s."

"It's really never too early to think about protecting your brain and your mind."

Amen, who also authored the book "Preventing Alzheimer’s," confirmed that half of Alzheimer’s cases are preventable, according to recent findings.

This can be done through nurturing brain health and treating the 11 major risk factors that "steal your mind," he said.

To remember the factors that can help ward off Alzheimer's, Amen created the acronym "BRIGHTMINDS" as follows.

Low blood flow is the No. 1 brain imaging predictor of Alzheimer’s disease, according to the doctor.

Alcohol, marijuana, caffeine, nicotine, sedentary behavior and excess weight or obesity can all decrease blood flow, thus should be avoided.

To promote blood flow, Amen suggests "walking like you’re late," which could entail walking 30 minutes a day — alternating between three minutes of normal walking and three minutes of fast walking.

"Do that five times for 30 minutes, and it increases blood flow to your brain," he said. 

Along with retirement and aging can come a slowdown in learning and cognitive activity, leading to a higher Alzheimer’s risk, Amen said.

'I'M A NEUROLOGIST — HERE'S WHY DEMENTIA IS RISING AND HOW TO REDUCE YOUR RISK’

He encourages retirees to learn something new every day to keep the brain active and healthy.

Inflammation is a "major cause" of psychiatric issues, Amen revealed, as well as conditions like cancer, arthritis and heart disease.

Flossing is an easy way to reduce inflammation in the gums and help prevent gum disease, which is a gateway to brain disease, according to the doctor.

"Genes aren't a death sentence," Amen said. "What they should be is a wake-up call."

The doctor said everyone should take steps to discover which diseases run in the family and then follow a daily prevention program.

STROKE, DEMENTIA AND DEPRESSION SHARE THESE 17 PREVENTABLE RISK FACTORS

"I have heart disease and obesity in my family," he said. "I don't have heart disease, and I'm not overweight. Why? Because I'm on an obesity heart disease prevention program every day of my life."

Concussions and head trauma are a "major cause" of psychiatric problems, Amen described, and should be avoided.

"Don't text and drive," he warned.

Some well-known toxins like alcohol, marijuana and other drugs are known to have negative impacts on overall health.

But some not-so-obvious toxins can include lead, mold, mercury from fish, and even general anesthesia, Amen cautioned.

"You always want to support your organs in detoxification," he said. "Drink more water, as it helps flush things through your kidneys … eat more fiber for your gut, and hold the alcohol."

Amen also suggested eating brassicas, which include vegetables in the cabbage family, as they have a detoxifying effect.

The expert also highlighted the benefits of sauna use as a detox tool.

"The people who take the most saunas have the lowest incidence of Alzheimer's disease," he stated.

A healthy mental state will help support a healthier brain, experts agree.

"Stop believing every stupid thing you think," Amen advised.

Keeping your body healthy and immune from infections is key to overall health, according to Amen.

The doctor suggested optimizing vitamin D intake, which can help support the brain and immune system.

The brain specialist recommends having a hormone balance check done every year, as any imbalances can interfere with the brain and increase Alzheimer’s risk.

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER

"Diabesity," a term referring to the parallel occurrence of obesity and type 2 diabetes, can be a major threat to overall health, the doctor warned.

"You really want to care about your weight," Amen said.

Weight and diet play an important role in brain health, as Amen's research has shown that as weight increases, the size and function of the brain decreases.

"Being overweight, you automatically have 10 of the 11 risk factors, because being overweight lowers blood flow, accelerates aging, increases inflammation and changes your hormones in a negative way," he said.

"Be mindful of only loving food that loves you back."

For more Health articles, visit www.foxnews.com/health

Sleep is crucial for a high-functioning mind, as an adequate night’s slumber "washes" the brain every night, Amen noted.

Better sleep translates to improved memory, energy, blood flow and decision-making, the doctor said, and should be a priority when working to prevent Alzheimer’s. 

2 weeks 2 days ago

Health, alzheimers, brain-health, longevity, nervous-system-health, diet-fitness, geriatric-health, lifestyle, healthy-living

Medical News, Health News Latest, Medical News Today - Medical Dialogues |

JnJ eyes expanded USFDA approval for Caplyta for prevention of relapse in schizophrenia

Titusville: Johnson & Johnson has submitted a supplemental New Drug Application (sNDA) to the U.S.

Titusville: Johnson & Johnson has submitted a supplemental New Drug Application (sNDA) to the U.S. Food and Drug Administration (FDA) based upon long-term data evaluating the safety and efficacy of CAPLYTA (lumateperone) for the prevention of relapse in schizophrenia.

CAPLYTA is the newest addition to Johnson & Johnson’s portfolio of schizophrenia therapies, which now offers the broadest range of oral and long-acting injectable treatment options.

“For people living with schizophrenia, relapses can be devastating as they disrupt lives, undo hard-earned treatment progress toward patients’ goals, and increase the risk of hospitalization with each episode,” said Christoph U. Correll, M.D., Clinical Professor of Psychiatry at the Zucker School of Medicine at Hofstra/Northwell, New York. “CAPLYTA substantially lowers the chance of relapse for patients compared to placebo, which is often a major source of anxiety and suffering for them and their families.”

The submission is supported by positive results from a Phase 3, double-blind, multicenter, placebo-controlled, randomized withdrawal trial, which on the primary endpoint found time to relapse during the 26-week double-blind treatment phase was significantly longer in patients receiving CAPLYTA compared to those receiving placebo (p=0.0002). Treatment with CAPLYTA was also associated with a 63 percent reduction in risk of relapse versus placebo (hazard ratio [95% CI] = 0.37, [0.22, 0.65]). The key secondary endpoint showed a significantly delayed time to all-cause discontinuation, including relapse, compared with placebo during the double-blind phase (p=0.0007). The safety profile of CAPLYTA was consistent with the existing body of clinical data, and no new safety concerns were identified. The most commonly reported adverse event that was observed at a rate greater than or equal to 5% and twice the rate of placebo was headache.

Schizophrenia affects up to an estimated 2.8 million adults in the United States, yet it remains insufficiently treated, with approximately 40 percent of people not receiving care. When left untreated, this complex mental health disorder can lead to episodes of psychosis, hallucinations, or other disruptive behaviors, which can damage and interrupt the lives of those living with schizophrenia as well as their loved ones. Relapses, or a recurrence of symptoms, are associated with significant functional decline, increased caregiver burden, and a greater likelihood of hospitalization. On average, an adult with schizophrenia experiences nine relapses in less than six years.

“Relapse prevention is a critical goal for the long-term care and management of this debilitating disorder,” said Bill Martin, Ph.D., Global Therapeutic Area Head, Neuroscience, Johnson & Johnson Innovative Medicine. “These Phase 3 results provide compelling evidence of meaningful relapse prevention, which is critical in preserving long-term patient stability, breaking the cycle of hospitalization, and helping to control symptom progression. We’re committed to building on the decade of research reinforcing the robust efficacy, proven safety, and favorable tolerability of CAPLYTA and providing additional data to support the long-term use of this medicine in neuropsychiatric disorders.”

While its exact mechanism of action is unknown, CAPLYTA is characterized by high serotonin 5-HT2A receptor occupancy and lower amounts of dopamine D2 receptor occupancy at therapeutic doses. In short-term clinical studies, CAPLYTA was similar to placebo in weight change, metabolic effects, and extrapyramidal symptoms, which are often cited as reasons for treatment discontinuation. CAPLYTA can be taken at any time of day with or without food and does not require titration, allowing adult patients to start treatment at the effective dose.

CAPLYTA is FDA approved for the treatment of schizophrenia, as well as depressive episodes associated with bipolar I or II disorder in adults, as monotherapy, and as adjunctive therapy with lithium or valproate. An sNDA for CAPLYTA as an adjunctive treatment for adults with major depressive disorder (MDD) is currently under FDA review. If approved, CAPLYTA has the potential to become a new standard of care to treat some of today’s most prevalent and debilitating mental health disorders.

2 weeks 2 days ago

News,Psychiatry,Psychiatry News,Industry,Pharma News,Latest Industry News

Health

Insulin resistance and how to eat the right food for you

INSULIN IS a hormone that helps regulate your blood sugar by controlling how much glucose your cells can absorb. If your cells do not respond to insulin the way they should, a condition known as insulin resistance can contribute to your risk of...

INSULIN IS a hormone that helps regulate your blood sugar by controlling how much glucose your cells can absorb. If your cells do not respond to insulin the way they should, a condition known as insulin resistance can contribute to your risk of...

2 weeks 2 days ago

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