PAHO Deputy Director says Covid cases are more than reported
Dr. Marcos Espinal, deputy director of the Pan American Health Organization/World Health Organization (WHO) in Washington, warned that the rise in COVID-19 cases seen in many countries, including the Dominican Republic, may only represent a fraction of the total number of infections.
The Dominican expert recognizes that by relaxing preventive measures such as mask use, low demand for diagnostic tests, crowding, and fatigue, among others, the true state of the virus in the countries will not be reflected.
As a result, he stressed the importance of countries working on SARS-CoV-2 genomic sequencing, noting that in the Dominican Republic, the sequencing indicates that omicron is the most common variant this year and that vaccines are effective against this variant. Concerning the three circulating respiratory viruses, such as influenza, Covid-19, and respiratory syncytial, the specialist stated that seasonal flu cases in the region are increasing after two years of below-average activity.
He noted that the Dominican Republic also experienced below-average activity during the pandemic’s peak years, owing to the impact of all isolation and distancing measures, which contributed to low circulation, but that the country will resume its normal autumn and winter pattern in 2022.
2 years 4 months ago
Health
COVID-19 daily positivity went from 12.91% to 22.92% in one week
A comparison between the bulletins of the Ministry of Public Health #983 and #990, corresponding to Saturday, November 26, and December 3, shows the increase in cases of COVID-19 in the country, mainly in Greater Santo Domingo. On the last Saturday of November, 1,819 samples were processed, of which 150 were positive for respiratory disease.
While December 3, 1,404 samples were obtained, but more cases were diagnosed, 182, which was reflected in the daily positivity of that day: 22.92% against 12.91% registered on November 26. In the eight days of this analysis, 1,955 new cases were accumulated, raising the number of confirmed cases in the Dominican Republic to 651,671.
The positivity rate for the last four weeks stood at 5.92% this Saturday after having been at 3.05% a week ago. In these eight days, Greater Santo Domingo, followed by the provinces of Santiago and San Pedro de Macorís, registered the most positive cases. Of the 1,955 cases of COVID-19 accumulated in the last eight days, 897 correspond to the National District, 578 to Greater Santo Domingo, 76 to Santiago, and 74 to San Pedro de Macorís.
2 years 4 months ago
Health
Side effects of COVID vaccines often ‘psychosomatic’: Israeli peer-reviewed study - The Times of Israel
- Side effects of COVID vaccines often ‘psychosomatic’: Israeli peer-reviewed study The Times of Israel
- Vaccine hesitancy may predict future COVID-19 vaccine side effects The Jerusalem Post
- Pharmacists Play Unique Role in Addressing Vaccine Hesitancy Pharmacy Times
- New COVID-19 Vaccine Hesitancy Report Launched For Eastern Caribbean States St. Lucia Times Online News
- View Full Coverage on Google News
2 years 4 months ago
Health Archives - Barbados Today
Fight against HIV/AIDS isn’t over, Humphrey says
Bajan men continue to be disproportionately represented in HIV and AIDS statistics. So much so, that Minister of People Empowerment and Elder Affairs Kirk Humphrey is expressing the hope that these, in addition to the overall numbers for testing, will increase over the next few years.
According to Humphrey, this is going to be essential as the country continues its fight to eradicate the virus.
The minister’s comments were made during an HIV/AIDS service at the Church of the Nazarene in Bank Hall, St Michael, this morning. Speaking to the congregation made up of members from the National HIV/AIDS Commission, he noted that beyond prayer there has to be a conversation around prevention and it must be age and culturally appropriate if it is going to make sense and reach the ears of the targeted.
“… A way that does not turn off people because then it becomes about ourselves. We said what we said and we don’t care what you think — no. If it is about the people we are serving it has to be in a way that they can receive it,” he added.
According to statistics, the number of known HIV/AIDS cases stood at 2 493 in 2020. Acknowledging that during the COVID-19 pandemic figures for other scourges such as child abuse and intimate partner violence increased, the minister concluded that people living with HIV/AIDS may have also increased given the realities of society. This is why Humphrey also contended that part of the conversation has to be about early detection and prolonging life, which has been aided by the use of antiretroviral therapy.
“He added: “The doctors would tell you that we haven’t found a way to stop HIV from becoming AIDS but we’ve found a way to reduce the possibility of it happening if you take the medication. The virus, if left untreated, would probably lead to AIDS. That is why we have to make sure that medication is available to all and the theme Putting Ourselves to the Test: Achieving Equity to End HIV symbolizes the idea that all must be able to have access in this country. It means persons with disability, the older population, those who are poor, any particular group … We have to make sure to find a way where all persons have access and people are treated in a way that they could be respected at the end of the day.”
Additionally, Humphrey implored the church’s partnership in the fight. He stated that the Government cannot do it alone.
“It is not over yet. Not talking about it does not mean it is over and I commend all who have been doing this work for so long and I trust that together we can continue to serve those who need our help,” Humphrey stressed. (KC)
The post Fight against HIV/AIDS isn’t over, Humphrey says appeared first on Barbados Today.
2 years 4 months ago
A Slider, Health, Local News
How to tell you're diabetic
ONE of the most frequently asked questions in my practice is: How can I tell if I am diabetic? And it is not surprising that people ask this question because some of the symptoms are not visible or are so mild you might think there is no reason to be concerned.
The following is a list of some of the main symptoms of diabetes. When you have finished reading the list, ask yourself if you have any of them. I would recommend that if you do, you should play it safe and see a doctor. This is certainly one situation in which it is better to be safe than sorry.
• Passing your urine frequently: This happens because your body is trying to get rid of the extra blood sugar by passing it out in the urine. This is called polyuria.
• Constant thirst: Your body is trying to rehydrate itself and make up for all the excess urination. The medical term for this is polydipsia.
• Hunger: This is because your body is literally starving for the energy it cannot get from sugar, which is just floating around in the blood and not being taken to the cells. This is known as polyphagia.
• Fatigue: Since the glucose is not getting into your body, it has no fuel.
• Weight loss without any effort on your part: This is because your hungry body has started to use fat and muscle for fuel because it cannot use sugar normally.
• Frequent infections: For example, in the urinary tract and vaginal yeast infections
• Slow-healing sores
• Dry, itchy skin
• Numbness andor tingling in the feet
• Blurred vision
Remember that, although these symptoms give a good indication of the disease, some diabetics may have only a few or even none of these symptoms.
In addition to these symptoms there are also other health problems that can be caused by diabetes. There are many severe long-term complications that are caused by unnoticed and/or untreated diabetes. These include:
• Hardening of the arteries, atherosclerosis: This can cause heart disease, peripheral arterial disease (what we call poor circulation), a stroke, or a heart attack.
• Diabetic retinopathy: A type of eye disease that leads to loss of vision. Unfortunately, some diabetics may have this complication and not know it.
• Diabetic nephropathy: A disease of the kidney that has no early symptoms and can lead to kidney failure.
• Diabetic neuropathy: A family of nerve disorders caused by diabetes. While some persons with nerve damage may have no symptoms, others may experience pain, tingling, or numbness in the feet, legs, hands, and arms. These nerve problems may occur in every organ in the body, including the heart, digestive tract, and sex organs.
• Poor healing of wounds: Particularly of the feet, which can lead to gangrene and limb amputation.
Testing for diabetes
Diabetics need to learn all they can about the disease, and very importantly, about how it is tested and what the measurements mean. This knowledge can literally mean the difference between life and death.
A blood glucose test measures the amount of sugar (glucose) in the blood. Blood glucose is measured in units called milligrams per decilitre (mg/dl) and millimoles per litre (mmol/l). Measurements give an indication of the sugar level in the blood at the time the test is done.
Our blood glucose levels need to be maintained within a certain range to help us keep healthy. Normal glucose levels fall between 3.8 and 7.8 mmol/l (that's the same as 70 and 140 mg/dl ). Generally, blood glucose levels are lower in the mornings and rise after meals are eaten.
Blood sugar levels measuring above 7.8 mmol/l are indicative of high blood sugar or hyperglycemia. Levels that fall below 3.8 mmol/l indicate low blood sugar or hypoglycemia.
Blood tests must be performed to determine whether someone has pre-diabetes or diabetes. Persons who already know they are diabetic need to have regular blood tests performed to check on how well the sugar is being controlled.
There are four main types of blood tests for diabetes:
1. Random blood glucose: This measures your blood sugar regardless of when you had your last meal. A blood glucose level higher than 11 mm/l indicates the possibility of diabetes (11 mm/l means 11 millimoles per litre; this is the same as 200 milligrams per decilitre (200 mg/dl).
2. Fasting blood glucose: This measures your blood sugar when it is at its lowest, that is, at least eight hours after you ate your last meal. If your blood sugar measures more than 6.1 mm/l or 110 mg/dl it indicates the possibility of diabetes or pre-diabetes.
3. Two-hour postprandial blood glucose: Postprandial means "after meal". The blood sugar is tested exactly two hours after drinking a glucose-rich drink. If your two-hour blood glucose level is more than 7.8 mm/l or 140 mg/dl and your fasting blood glucose is normal, it means you have pre-diabetes. If your fasting and 2-hour blood glucose levels are above normal, it means you are diabetic. Yes, it's that simple to diagnose.
4. Oral glucose tolerance test: This requires that you fast for at least eight hours before doing the test and for a specific period while the test is being done. After blood is first taken, you are given a glucose-rich drink and asked to wait. Your blood will be taken at hourly intervals after you have this glucose drink. This can be done for up to three hours after you have had the drink. The reason this is done is to chart how your body handles a load of glucose over a specific period. A version of this, the O'Sullivan test, is used to test for gestational diabetes.
5. HbA1c or glycosylated haemoglobin test: This gives your doctor an overall picture of how your diabetes is being controlled. The test measures the amount of sugar that is attached to the red blood cells. The results are given as a percentage. Red blood cells live in the bloodstream for about four months and so the HbA1c test shows the average blood sugar for the past three to four months.
Having diabetes is not a death sentence. Get to know your body, how your body responds to food, exercise, and stress. Live your best life!
Excerpts taken from the book A patient's guide to the treatment of diabetes mellitus. ©Jacqueline Elaine Campbell
Dr Jacqueline E Campbell is a family physician and radio show host. She is the author of the book
2 years 4 months ago
WHO calls on the global community to equalise the HIV response
ON December 1, World AIDS Day 2022, the World Health Organization (WHO) issued a call to global leaders and citizens to recognise and boldly address the inequalities that are holding back progress in attaining the global goal to end AIDS by 2030.
WHO is joining global partners and communities in commemorating World AIDS Day 2022 under the theme 'Equalize' — a message highlighting the need to ensure that essential HIV services reach those who are most at risk and in need, particularly children living with HIV, key populations to HIV, and their partners.
"With global solidarity and bold leadership we can make sure everyone receives the care they need," said Dr Tedros Adhanom Ghebreyesus, WHO director general. "World AIDS Day is an opportunity to reaffirm and refocus on our shared commitment to end AIDS as a public health threat by 2030."
HIV remains a major public health issue that affects millions of people worldwide but our response is at risk of falling behind.
Of the 38 million people living with HIV 5.9 million who know they have HIV are not receiving treatment while a further 4 million people living with HIV have not yet been diagnosed.
While 76 per cent of adults overall were receiving antiretroviral treatment that helps them lead normal and healthy lives only 52 per cent of children living with HIV were accessing this treatment globally in 2021; in addition, 70 per cent of new HIV infections are among people who are marginalised and often criminalised. While transmission has declined overall in Africa, there has been no significant decline among men who have sex with men — a key population group — in the past 10 years.
Overlapping epidemics
Available WHO data show that among people confirmed to have mpox, a high number — 52 per cent — were people living with HIV. Global data reported to WHO suggest that people living with mpox with untreated HIV appear to be at risk for more severe disease than people without HIV.
The current response to mpox shows that transmission can move quickly in sexual networks and within marginalised populations. But it can also be prevented with community-led responses and open attitudes to address stigma, and health and well-being can be improved and lives can be saved.
Delivering for key
This World AIDS Day, WHO recommends a renewed focus to implement WHO's 2022 guidance to reach the HIV and related health needs of key populations and children.
"People must not be denied HIV services — no matter who they are or where they live — if we are to achieve health for all," said Dr Meg Doherty, WHO director of the HIV, hepatitis and STI programmes. "In order to end AIDS we need to end new infections among children, end lack of treatment access to them, and end structural barriers and stigma and discrimination towards key populations in every country as soon as possible."
With only eight years left before the 2030 goal of ending AIDS as a global health threat WHO calls for global solidarity and bold leadership from all sectors to ensure we get back on track to ending AIDS and, with that, end new syndemics such as the recent mpox global outbreak.
2 years 4 months ago
Artificial intelligence and heart care — Pt 1
ARTIFICIAL intelligence (AI) is emerging as crucial component of health care to help improve performance and efficiency of physicians. AI includes deep-learning algorithms, machine learning, computer-aided detection (CAD) systems, and convolutional neural networks.
In medical imaging, and more particularly cardiovascular imaging, AI has become very instrumental in efficiently managing imaging work lists, enabling structured reporting, auto detecting injuries and diseases, and pulling in relevant prior exams and patient data.
In clinical cardiology practice AI helps automate tasks and measurements in imaging and in reporting systems, guides novice diagnostic imaging operators to improve imaging accuracy, and can risk stratify patients.
AI and electrocardiograms (ECG)
An electrocardiogram (ECG) is a primary cardiac diagnostic test that measures the electrical activity in the heart to identify overall heart function, heart rhythm abnormalities, and areas of poor blood circulation and prior heart attack. A standard 12-lead ECG breaks the 3D structure of the heart into 12 zones, each showing the electrical activity in that specific area of the heart. This helps pinpoint areas where there are issues with heart blood vessel blockage or electrical performance. Many home-use heart monitors and consumer grade ECG machines use fewer leads and so are less specific as to cardiac conditions or location of abnormal heart rhythms but they can show areas of concern that may warrant further diagnostic testing or treatment. With AI we are able to expand the utility of the ECG, even when obtained with machines with otherwise limited capability.
AI can be applied to electrocardiogram (ECG) data captured by smart watches for example to identify patients with weak heart pumps, according to a new analysis published in Nature Medicine. These findings were reported in a recent study led by cardiologists from Mayo Clinic exploring ECG data from nearly 2,500 patients. The mean patient age was 53 years old and 56 per cent of the patients were women.
The group applied a 12-lead algorithm for poor heart function to the ECG data and found that AI was able to accurately detect poor heart function in nearly 90 per cent of cases when compared with a cardiac ultrasound. Currently, we diagnose heart dysfunction — a weak heart pump — through an echocardiogram (cardiac ultrasound), CT scan or an MRI but these are expensive, time-consuming and often not routinely accessible, especially in patients in rural areas. Therefore, the ability to diagnose a weak heart pump remotely, from an ECG, could lead to a significant improvement in the care of heart patients as it could allow for a timelier detection of potentially life-threatening disease at massive scale and in a more cost-effective way.
With the advent of consumer grade wearable medical devices the opportunity to extend care to patients remotely is profound. Increasing the capability to accumulate data from wearable consumer electronics and provide analytic capabilities to prevent disease or improve health remotely in the manner demonstrated by this study can transform and expand access to health care.
AI in atrial fibrillation
Atrial fibrillation (Afib) is a common electrical disturbance of the heart manifesting with irregular heart rhythm. Afib is commonly seen in patients with long-standing hypertension and in older persons. There is accumulating evidence that women may be more at risk for Afib than men. Afib over time can cause the clotting of blood inside the heart and may lead to strokes. The economic cost of the complications of Afib on individuals and society can be very significant. Using AI to screen patients for atrial fibrillation can detect new cases that may have otherwise been missed, according to new research published in The Lancet. The application of this work hopefully can play a major role in preventing life-threatening strokes.
Traditional screening programmes select patients based on age (65 or older) or the presence of conditions such as high blood pressure. While these approaches seem reasonable because advanced age is one of the most important risk factors for Afib, it is not feasible to repeatedly conduct intensive heart monitoring in millions of older adults globally.
The investigators aimed to see if AI could provide clinicians with another screening option for identifying Afib patients. In the study involving over 2,000 patients the researchers demonstrated that AI-guided screening was linked to more detected cases of Afib among both high- and low-risk patients, and confirmed that an AI algorithm can select a subgroup of older adults who might benefit from more intensive monitoring. This is particularly valuable in low-resource environments where undetected and untreated Afib can lead to catastrophic consequences and impose additional drain on an already burdened health system.
Use of AI in chest pain evaluation
In the past 25 years cardiac computed tomography (CT) has emerged as a primary cardiovascular imaging modality and has been recommended as a viable tool for chest pain assessment in the hands of experienced and appropriately trained operators. CT plays a key role in evaluation for structural heart disease — especially for heart valves, repair of congenital defects, and left atrial appendage occlusion (LAAO) for both pre-procedure planning and procedural guidance in patients with Afib.
CT calcium scoring is also now used routinely for risk assessment for coronary artery disease and to determine which patients could benefit from the use of cholesterol-lowering and stabilising medications. Coronary CT angiography (CCTA) is used for non-invasive atomical assessment of the heart arteries to determine plaque burden and to identify areas of blockage that may cause ischemia and heart attacks. Additional use of contrast CT perfusion or fractional flow reserve CT (FFR-CT) can offer physiological information on the function of the heart.
Applying advanced AI algorithms for CCTA has been shown to provide additional benefits in patients with stable chest pain and suspected coronary artery disease (CAD), according to a late-breaking clinical trial presented at the recently concluded American Heart Association Scientific Sessions held in Chicago in early November 2022.
The Prospective Randomised Trial of the Optimal Evaluation of Cardiac Symptoms and Revascularization (PRECISE) Study reported data on more than 2,000 adult patients who presented with stable chest pain and suspected CAD.
Dr Ernest Madu, MD, FACC and Dr Paul Edwards, MD, FACC are consultant cardiologists for Heart Institute of the Caribbean (HIC) and HIC Heart Hospital. HIC is the regional centre of excellence for cardiovascular care in the English-speaking Caribbean and has pioneered a transformation in the way cardiovascular care is delivered in the region. HIC Heart Hospital is registered by the Ministry of Health and Wellness and is the only heart hospital in Jamaica. Correspondence to info@caribbeanheart.com or call 876-906-2107
2 years 4 months ago
Health Archives - Barbados Today
Pele responding well to treatment for respiratory infection
SOURCE: AP — The Albert Einstein hospital says Brazilian soccer great Pele is responding well to treatment for a respiratory infection and his health condition has not worsened over the latest 24 hours.
The 82-year-old Pele has been at the hospital since Tuesday.
Get well messages have poured in from around the world for the three-time World Cup winner as he also undergoes cancer treatment.
Pele’s daughter posted several pictures on Instagram from Brazil fans in Qatar wishing her father well with flags and banners.
Buildings in the Middle Eastern nation also displayed messages in support of the former soccer great.
The post Pele responding well to treatment for respiratory infection appeared first on Barbados Today.
2 years 4 months ago
A Slider, Health, Sports
Physicians and patients begin to resume the use of face masks
Santo Domingo
Of the 475,000 doses of influenza vaccine acquired by the State to be given free of charge to high-risk groups, 194,568 people have been vaccinated to date, revealed the director of Immunopreventable by Vaccines, Dr. Lucia Vargas.
Santo Domingo
Of the 475,000 doses of influenza vaccine acquired by the State to be given free of charge to high-risk groups, 194,568 people have been vaccinated to date, revealed the director of Immunopreventable by Vaccines, Dr. Lucia Vargas.
Dr. Lucia Vargas said that this vaccine is available in 428 authorized posts. They can also receive the vaccine against Covid-19 to complete their schedules and better protect them against the new circulating subvariants.
She explained that up to mid-week, 16,132,440 COVID-19 vaccines have been applied in the population, corresponding to the first dose, 7,295,993; to the second 6,065,999; to the third, 2 499,887 and with the fourth dose 270, 561 doses.
The director of Immunoprevenibles said that 901,255 people only received the first dose and did not receive the second dose, and that of those who received the double dose, 2,861,622 have not yet received the third dose, for which she urged to complete the scheme.
He urged the population to continue with the vaccination process to be immunized and reduce the effects that may be caused by the different variants that are circulating, which arise due to the non-immunization of the population.
He reminded that the program has 428 vaccinations against Covid and that the country has the Pfizer vaccine for children from 12 to 17 years old and the Sinovac vaccine for children from 5 to 11 years old.
Vargas reminded that the country has availability of the yellow fever vaccine, which is a requirement requested by countries where the disease is endemic, and that 10 thousand new doses are expected to be distributed in the different posts and centers established and to increase the capacity.
In turn, the Vice-Minister of Collective Health, Dr. Eladio Pérez, informed that, during the National Vaccination Day against Rabies, directed by the Center for Prevention and Control of Diseases Transmissible by Vectors and Zoonosis, a total of 162,315 animals were immunized, of which 126,353 were dogs, and 35,962 were cats, to establish an epidemiological blockade to reduce the risks of spreading the virus that causes this disease.
The day will be extended for a few more weeks, so they called on the population to bring their pets to be vaccinated to the provincial health directorates.
Testing posts
The deputy minister of Collective Health of the Ministry of Public Health said that the demand for laboratory tests to diagnose Covid-19 has increased in public and private centers and that the country has sufficient supplies.
2 years 4 months ago
Health, Local
News Archives - Healthy Caribbean Coalition
Caribbean Superheroes – Children and Youth living with Type 1 Diabetes Part 1
What does a 7 year old future scientist from Trinidad and Tobago, an aspiring graphic designer from Antigua and Barbuda and a race car driver fan from Barbados have in common? They all live with type 1 diabetes.
What does a 7 year old future scientist from Trinidad and Tobago, an aspiring graphic designer from Antigua and Barbuda and a race car driver fan from Barbados have in common? They all live with type 1 diabetes.
This two-part series (read Part 2 here) aims to educate Caribbean readers about diabetes, particularly type 1 diabetes (which is often misunderstood), through the lived experiences of children and youth with this condition. It details their day-to-day experiences, challenges, successes and solutions to better protect persons living with diabete – one of the most common non-communicable diseases (NCDs) in our region.
Type 1 diabetes, which is often overlooked, traditionally called childhood-onset or juvenile diabetes, occurs when the pancreas does not produce enough insulin, a hormone that regulates blood sugar. A combination of genetic and environmental factors is thought to cause the majority of Type 1 diabetes cases. At present, Type 1 diabetes cannot be prevented and although Type 1 diabetes can be diagnosed at any age it is most common in childhood and adolescence.
Jawan, 7, from Trinidad and Tobago was diagnosed at 3 years. His sister Tiana, 4, was also diagnosed at the same age.
Xarriah, 22, from Barbados, was diagnosed at age 10, the day before her 11th birthday.
Kerro, 20, from Antigua and Barbuda remembers being surrounded by frantic nurses at a school fair when she decided, out of curiosity, to get her blood sugar checked. Kerro, who was 12 when she was diagnosed, remembers the day clearly:
First thing I remember, honestly, was the frantic nurses. Everyone was frantic and I was kinda confused because I felt normal. At the time my sugar was around 382, 383. And everyone was so alarmed, they just kept checking my sugar levels over and over again because they thought there was a malfunction with the machines.
A normal blood sugar reading for children between the ages of 6-12 (before a meal) should range between 90 to 180 mg/dL (5.0 to 10.0 mmol/L). Xarriah, Jawan and Tiana also had abnormal readings.
Once diagnosed, children and young people living with type 1 diabetes and their families must navigate a new reality inclusive of blood sugar checks, taking insulin, homework, play and engaging with peers.
Both Jawan and Tiana shared that they don’t like living with the condition. When asked why, Jawan said “I don’t like taking my sugar and waiting 20 minutes to eat.” Similarly Tiana said, “I don’t like it. I don’t like taking my insulin.”
This is a sentiment that was felt by Kerro and Xarriah as well.
There are a lot of adjustments post-diagnosis. For example, 12 year old newly diagnosed Kerro hated needles but she had to face her fear when she was told she had to inject herself 5-6 times a day (excluding the finger pricks for her sugar checks). She remembers being confronted with this new reality when the nurses at the hospital taught her how to give herself insulin. She “hated it” and recalls it taking a while to get adjusted.
Given that Jawan and Tiana are still quite young, their mom Penelope often wakes up throughout the night to check their sugar levels.
At nights I stay up a few hours because I have to monitor them during the night as well because sometimes their readings are very good just before going to bed but two hours later, if you check them randomly, their levels drop and sometimes they don’t. So you don’t know where they are during the night. And so I do get up some nights, at 1am, well in the morning actually at 1am, I do a random check and sometimes I get up at 3am again. It is very unpredictable.
She also visits their school around lunch time to check in on them. The teachers, whom she is in close contact with, often alert her in the event of any issues/problems.
Although both Kerro and Xarriah recently graduated college and university, their primary and secondary school experiences as recently diagnosed children living with diabetes are easy to remember.
For Kerro, she recalls her peers’ reaction when she had to give herself insulin in class:
At the time I was in grade 6 and it was still new to everyone in the class too. They literally used to run out of the class when they saw the needle. At first I would laugh because I was like “a needle? Ya’ll are running from a needle?” but after a while I was like, why are they running? It started to feel a little lonely in a sense. Only 1 or 2 people would stay back in the class. And at the time my classroom was like 39 students.
She also had to debunk a lot of myths about diabetes while at school. She was stared at while taking insulin and peers asked a lot of questions; one student even asked her if she was taking drugs.
Xarriah also describes her secondary school classmates as being curious but accepting overall.
I have heard some people saying that their classmates tease them but I felt like my classmates were okay. They always had my back. They asked questions and I answered as much as I could but they were pretty accepting. They were very accepting, not pretty accepting, very accepting. They accepted, understood and asked questions and I answered.
In addition to managing curious classmates, children and young people living with type 1 diabetes also have to navigate how, when and what they eat at school.
Given the prevalence of unhealthy foods in schools and the desire to be extra cautious with what Jawan and Tiana eat, Penelope packs lunch for them but wishes the school environment made healthy foods more accessible.
For Xarriah, the timing of university classes, particularly the evening classes, and the ability to eat in class was a challenge as she tries to have her last meal before 9:00PM. Some lecturers allow her to eat during class but others do not.
In addition to school-specific challenges, these superheroes also spoke about dealing with the sugar ‘highs and lows’.
Kerro shared that whenever she gets the lows (low blood sugar), it feels like “you’re on edge, you’re irritated, you just don’t know what’s going on. And then I realized that when I was little I used to experience the same feeling but I didn’t know what it was. I used to feel weak and almost like trembling in a sense. But I just used to think it’s because I didn’t eat or I was tired.”
Jawan, in his few years of living with type 1 has also experienced some scary lows. Penelope recalls that he had 2 seizures which have presented very differently with varying symptoms. During his most recent seizure, he was unresponsive, fell and hit his mouth and burst his lip. It took him quite some time to remember who he was. Penelope recalls that he could hear her but he couldn’t respond. He was aware enough to eat and while she fed him he started to cry. Once he became responsive, Penelope asked him why he was crying and he said “I didn’t know if I was going to make it”.
Living with type 1 diabetes has its ups and downs as described in these real-life accounts. These children and young people have to navigate life while also managing the realities of their condition. Kerro, Xarriah and Penelope mentioned that support from their circle has been critical on their journey.
Both Kerro and Xarriah noted the value of the friendships they made in highschool which followed them into college and beyond. For Kerro, her friends supported her and would step in to answer strangers’ questions when she was too tired. Kerro even taught her friends how to give her insulin if she was ever unable to give it to herself.
Xarriah said that, like Kerro, she has friends from secondary school who “To this day, they still have my back.”
Penelope emphasized the critical role that the Diabetes Association of Trinidad and Tobago has played since the time of Jawan’s diagnosis. She speaks warmly about the community, “the love and support from the association and that type 1 [whatsapp] chat, definitely gives me a lot of support…We say this all the time, we are all in it together. Don’t ever feel like you’re alone. When we all come together, it is very emotional, we can’t help it because of the experiences we have had so far. But it really helps when we have that support.”
Children and young people living with type 1 diabetes are superheroes, there is no doubt about it.
Stay tuned for part 2 of the series where Kerro, Xarriah, Penelope, Jawan and Tiana will share the changes they want to see to better support people living with diabetes.
November is World Diabetes Awareness month and November 14th has been deemed World Diabetes Day. The date was chosen in honour of Canadian Sir Frederick Banting, who, together with Charles Best discovered insulin, 100 years ago.
Danielle Walwyn is the Advocacy Officer at the Healthy Caribbean Coalition (HCC) and helps to coordinate its youth arm, Healthy Caribbean Youth. She is also working alongside Xarriah, superhero and member of the HCC People living with NCDS Advisory Committee, to create a space for young people living with NCDS to connect. Send feedback to danielle.walwyn@healthycaribbean.org
The post Caribbean Superheroes – Children and Youth living with Type 1 Diabetes Part 1 appeared first on Healthy Caribbean Coalition.
2 years 4 months ago
Healthy Caribbean Youth, News
Some 270,561 have received the fourth dose of Covid vaccine.
Santo Domingo
Of the 475,000 doses of influenza vaccine acquired by the State to be given free of charge to high-risk groups, 194,568 people have been vaccinated to date, revealed the director of Immunopreventable by Vaccines, Dr. Lucia Vargas.
Santo Domingo
Of the 475,000 doses of influenza vaccine acquired by the State to be given free of charge to high-risk groups, 194,568 people have been vaccinated to date, revealed the director of Immunopreventable by Vaccines, Dr. Lucia Vargas.
Dr. Lucia Vargas said that this vaccine is available in 428 authorized posts. They can also receive the vaccine against Covid-19 to complete their schedules and better protect them against the new circulating subvariants.
She explained that up to mid-week, 16,132,440 COVID-19 vaccines had been applied in the population, corresponding to the first dose, 7,295,993; to the second, 6,065,999; to the third 2, 499,887 and the fourth dose 270, 561 doses.
The director of Immunoprevenibles said that 901,255 people only received the first dose and did not receive the second dose, and that of those who received the double dose, 2,861,622 have not yet received the third dose, for which she urged to complete the scheme.
He urged the population to continue with the vaccination process to be immunized and reduce the effects that may be caused by the different variants that are circulating, which arise due to the non-immunization of the population.
He reminded that the program has 428 vaccinations against Covid and that the country has the Pfizer vaccine for children from 12 to 17 years old and the Sinovac vaccine for children from 5 to 11 years old.
Vargas reminded that the country has availability of the yellow fever vaccine, which is a requirement requested by countries where the disease is endemic, and that 10 thousand new doses are expected to be distributed in the different posts and centers established and to increase the capacity.
In turn, the Vice-Minister of Collective Health, Dr. Eladio Pérez, informed that, during the National Vaccination Day against Rabies, directed by the Center for Prevention and Control of Diseases Transmissible by Vectors and Zoonosis, a total of 162,315 animals were immunized, of which 126,353 were dogs, and 35,962 were cats, to establish an epidemiological blockade to reduce the risks of spreading the virus that causes this disease.
The day will be extended for a few more weeks, so they called on the population to bring their pets to be vaccinated to the provincial health directorates.
Testing posts
The deputy minister of Collective Health of the Ministry of Public Health said that the demand for laboratory tests to diagnose Covid-19 has increased in public and private centers and that the country has sufficient supplies.
2 years 4 months ago
Health, Local
Medical News, Health News Latest, Medical News Today - Medical Dialogues |
Merck hopes to patent subcutaneous version of blockbuster cancer drug Keytruda
US: U.S. drugmaker Merck & Co hopes to patent a new formulation of its $20 billion cancer immunotherapy Keytruda that can be injected under the skin, allowing it to protect its best-selling drug from competition expected as soon as 2028.
For years Merck has relied on Keytruda to fuel its growth. The treatment, approved in 2014, harnesses the body's own immune system to fight cancers with dramatic results. Against advanced lung cancer, it has led to a five-year survival rate in about one-quarter of people compared to 5% of people historically.But the key patents on Keytruda will begin to expire in 2028, opening the door to biosimilars - near copies of expensive biologic drugs whose complex molecules cultivated inside living cells make it impossible to manufacture exact copies.Merck is testing in clinical trials two versions of the drug that can be injected subcutaneously, a quick alternative to infusions, the current delivery method in which patients receive an intravenous drip in a health office once every three or six weeks. The company reported early data from one of those trials last year.While Merck has disclosed that it is developing subcutaneous versions of Keytruda, it has not previously said that it expects the new formulation to become the most widely used version of the drug after it is rolled out and an engine for growth toward the end of the decade.If successful, Merck could begin marketing the new formulation within a few years, a top Merck executive told Reuters. It expects it to fuel Keytruda's growth as it gains approvals in earlier stage cancers. Keytruda now accounts for more than one-third of Merck's sales."We believe that subcutaneous formulation has the potential to be novel, non-obvious and useful, which means we would get a new patent for it," Merck CFO Caroline Litchfield said in an interview, using the terminology for the criteria under U.S. law to determine what technologies merit a patent."The clock for that patent would start ticking from the time we would get that patent approved."While some patients would likely still receive the original formulation if it is being administered along with chemotherapy or other intravenous drugs, the subcutaneous formulation could replace the IV version for most patients, Merck Chief Medical Officer Eliav Barr told Reuters."In theory it could replace everywhere that Keytruda currently is used," Barr said.Drug patents have a guaranteed term of exclusivity for 20 years after receiving a patent under U.S. law, but sometimes the companies are able to add additional patents that extend their exclusivity.For example, the primary patent on Abbvie's arthritis drug Humira expired in 2016 but the drug will not face U.S. competition until 2023, in part because the company eventually received more than 130 patents that protect the drug.Merck's patents on the subcutaneous version of Keytruda could protect that formulation until at least 2040, according to Tahir Amin, co-founder of drug patents watchdog group Initiative for Medicines, Access & Knowledge (I-MAK)."It's the way the pharmaceutical companies now use that system -- it's all about taking up as much space as possible, making it difficult for anybody to enter," Amin said. "Keytruda is going to be the next Humira by all accounts."Asked whether it was motivated more by patent issues than medical need, Merck said it was continuously focused on improving Keytruda and getting it to more patients.Merck said it may seek patents for innovations in how the drug is used, its formulation, the size and schedule of doses and combinations with other drugs."These patent applications, if granted, may provide varying degrees of protection beyond 2028. However, we would continue to point to late 2028 as the most likely timeframe for biosimilar entry into the market," Merck said in a statement.DO PATIENTS PREFER SHOTS?Getting doctors and hospitals to adopt the new formulation before biosimilar competition arrives could help Merck protect more of its Keytruda revenue for longer but is not certain, analysts said. On average, they expect Keytruda revenues to top $30 billion in 2026 and $35 billion by 2028, according to Refinitiv data. "Theoretically, in the US, they could transition all of the market," Mizuho analyst Mara Goldstein said, "depending on how quickly they can get it to market."However, BMO Capital's Evan Seigerman said that private insurers in the U.S. might balk at paying for the more expensive branded product and prefer a biosimilar infusion version. Still, he believes the new formulation could allow the company to hold onto as much as 20 percent of its Keytruda revenue into the 2030s.Two doctors interviewed by Reuters said they were not convinced that the new route of administration represents a significant enough clinical improvement over IV infusions to justify the additional system-wide healthcare costs that might be a product of Merck receiving a new patent."I don't think it's going to improve the safety or the effectiveness of the drug," said Dr. Shailender Bhatia, an oncologist at the Fred Hutchinson Cancer Center in Seattle.Merck's Barr said the easier-to-use formulation of the drug could help patients' health by keeping them on Keytruda and on schedule, and could keep high-risk cancer patients from spending long times in hospital settings where they could be exposed to other diseases."From a quality of life and patient perspective, it's for sure going to be helpful," Barr said.That view is backed by clinical studies that have found that patients prefer subcutaneous injections to intravenous administration which can be time-consuming and invasive.How much hospitals and doctors embrace the method could reflect how they will be impacted by the change financially.Hospitals are typically paid less to administer an injection than a long infusion. That could be offset somewhat if the drug's price is higher, since providers receive a percentage fee for physician-administered drugs, according to Lisa Mulloy, chief pharmacy officer for New York's Northwell Health hospital system.Merck said it would not speculate on the expected price of pipeline products. The infusion's list price is about $185,000 per year, though the drug may cost less with company discounts.Northwell's Mulloy said moving patients to subcutaneous versions of drugs also opens up spots in infusion centers for additional patients.
Read also: Merck lifts full-year forecast as cancer immunotherapy Keytruda sales soar
2 years 4 months ago
News,Industry,Pharma News,Latest Industry News
Medical News, Health News Latest, Medical News Today - Medical Dialogues |
Propylene Glycol and Hydroxypropyl Guar Nanoemulsion - Safe and Effective in Management of Dry Eye Disease
Dry eye disease (DED) is a chronic condition impacting >30 million people in the United States and >344 million people globally. It is a multifactorial disease of ocular surface characterized by a loss of tear film homeostasis, and accompanied by ocular symptoms such as eye discomfort and visual disturbances.
DED can be classified as aqueous deficient dry eye (ADDE),
evaporative dry eye (EDE), and mixed DED. ADDE is due to tear underproduction
by the lacrimal glands. EDE can occur due to causes related to either lid
(meibomian gland dysfunction [MGD] or blink-related) or ocular surface (mucin
deficiency and contact lens wear), resulting in abnormal lipid secretion, tear
film instability, and excessive evaporation of tears. Although EDE is considered
a leading cause of DED, ADDE can occur without obvious signs of EDE and vice
versa.
Further, iatrogenic DED could be caused by topical or
systemic drugs, contact lens wear, and ophthalmic surgical/non-surgical
procedures. Goblet cells, which produce mucins and contribute to the stability
of the tear film and immune defenses, are extremely sensitive to
toxic/inflammatory stress and are reduced in density after exposure to
iatrogenic factors. Owing to the multifactorial nature of DED, medications that
can target multiple underlying pathologies simultaneously are desirable.
Treatment goal for DED is to restore ocular surface and tear
film homeostasis. Current treatment options in the management of DED include
artificial tears or ocular lubricants, nutraceuticals, anti-inflammatory
agents, tear stimulants, autologous serum, antibiotics, and other therapies
(eg, physical treatments such as warm compresses, complementary medicines such
as herbal products, punctal occlusion, and surgical approaches).
Artificial Tears
Artificial tears, which substitute or supplement the natural
tear film, are the first line option in the management of DED. Artificial tears
improve symptoms (burning, irritation, and/or discomfort), and provide
temporary relief of dryness of the eye, but have not been shown to treat
pathophysiology of DED. Ideal artificial tears should spread uniformly and
evenly, minimize friction during blinks, have minimal visual disturbance upon
instillation, be safe/ convenient to use, and effectively improve the
signs/symptoms of DED.
Artificial tears are formulated with polymeric lubricants,
demulcents, buffering agents (compatible with ocular pH of approximately 7.5),
electrolytes, osmolality adjusting excipients, and surfactants, with/without
preservatives. Most of artificial tears are formulated to supplement either
lipid layer or aqueous layer of the tear film. However, some eye drops are
formulated as emulsions, which contain aqueous lubricants (such as
hydroxypropyl guar [HPG], polyethylene glycol [PEG], and propylene glycol [PG])
and lipid ingredients (such as phospholipid and mineral oil). Lipid-based
artificial tears have been shown to stabilize the tear film lipid layer, reduce
tear evaporation, and improve the signs of MGD and EDE.
One of the major challenges with eye drops is low retention
time. To increase the retention time, viscosity enhancing agents such as
hyaluronic acid (HA) and carboxymethyl cellulose (CMC) are incorporated in eye
drops; these agents also exhibit muco-mimetic properties and reduce desiccation
by forming a protective layer on the ocular surface. However, eye drops with
high viscosity may cause transient visual disturbances (blurred vision) and
also result in debris, leading to intolerance and non-compliance. Thus, to
overcome low ocular retention, in situ gelling chemistry is used; this is
achieved through HPG, a natural polysaccharide, that forms a viscoelastic gel
at ocular pH through cross-linking.
HPG forms the backbone in artificial tears of the SystaneTM
family (Alcon Laboratories, Inc., Fort Worth, TX, USA), which are indicated for
the temporary relief of dry eye symptoms (such as burning and irritation) and
ocular surface protection in patients with DED. Artificial tears of the
SystaneTM family include nonlipid-based (PEG/PG-HPG lubricant eye drop
[SystaneTM Original], PEG/PG-HPG-sorbitol lubricant eye drop [SystaneTM Ultra]
and PEG/PG-HPG/sodium hyaluronate (HA)-sorbitol lubricant eye drop [SystaneTM
Hydration]) as well as lipid-based (PG-HPG microemulsion lubricant eye drop
[SystaneTM Balance] and PG-HPG nanoemulsion lubricant eye drop [SystaneTM
Complete]) formulations.
In this review, Srinivasan and Williams presented the
formulation components, mechanisms of action, and the summary of literature
evidence of PG-HPG nanoemulsion lubricant eye drop (SystaneTM Complete, Alcon
Laboratories, Inc., Fort Worth, TX, USA) that is indicated for temporary relief
of symptoms of burning and irritation in DED.
PG-HPG Nanoemulsion Lubricant Eye Drops
Craig et al demonstrated the treatment of DED according to
disease subtype and severity. In a multicenter, double-masked, parallel group,
randomized controlled trial, 99 participants (mean age, 44±16 years; 64%
female) with DED were enrolled. Participants instilled either lipid-based
PG-HPG nanoemulsion drops (SystaneTM Complete) or nonlipid-based aqueous drops
(SystaneTM Ultra) ≥4 times daily for 6 months; dry eye symptomology, and tear
film and ocular surface characteristics were assessed.49 Both treatments
demonstrated sustained reduction in DED symptoms (Ocular Surface Disease Index
[OSDI], Dry Eye Questionnaire-5 [DEQ-5], and Symptom Assessment Questionnaire
iN Dry Eye [SANDE] scores) from Day 30 onwards (all p≤0.01) and decreased
superior lid wiper epitheliopathy grades from Day 60 onwards (all p≤0.01).
Further, non-invasive tear film breakup time (NITBUT), and sodium fluorescein
and lissamine green staining scores consistently improved from Day 120 onwards
in both groups (all p<0.05).49 Tear film lipid layer grades increased only with PG-HPG nanoemulsion eye drops (from Day 90 onwards); with significantly greater improvement in patients with low lipid layer thickness at baseline (lipid layer grade ≤3; p=0.01).49 Hence, both lipid-based and non-lipid-based artificial tears provided symptom relief within a month.49 Improvements in the tear film stability and ocular surface characteristics were slower than the symptomatic improvements.49 Further, both formulations showed long-term efficacy and a good tolerability profile across DED subtypes; however, improvement in tear film lipid layer grade was observed only with PG-HPG nanoemulsion drops; particularly in subgroup of patients with evaporative DED due to tear lipid insufficiency (with baseline lipid layer grade ><0.05).
Tear film lipid layer grades increased only with PG-HPG
nanoemulsion eye drops (from Day 90 onwards); with significantly greater
improvement in patients with low lipid layer thickness at baseline (lipid layer
grade ≤3; p=0.01). Hence, both lipid-based and non-lipid-based artificial tears
provided symptom relief within a month. Improvements in the tear film stability
and ocular surface characteristics were slower than the symptomatic
improvements. Further, both formulations showed long-term efficacy and a good
tolerability profile across DED subtypes; however, improvement in tear film
lipid layer grade was observed only with PG-HPG nanoemulsion drops; particularly
in subgroup of patients with evaporative DED due to tear lipid insufficiency
(with baseline lipid layer grade ≤3).
In a Phase IV, openlabel, single-arm,
multicenter trial, patients with DED (N=134; 56.6±14.8 years; 75.4% female)
instilled one drop of PGHPG nanoemulsion in each eye, twice daily for 28 days.
The instillation of PG-HPG nanoemulsion eye drops increased tear film break-up
time (TFBUT) by 1.5±2.8 seconds at 14 days; and the improvement remained consistent
through 28 days. It also improved (decreased) ocular discomfort at 14 days
(mean±SD change in visual analog scale [VAS] score, −17.3±24.80). Moreover,
subgroup analysis of patients with ADDE, EDE, and mixed DED indicated that
PG-HPG nanoemulsion was effective and well tolerated in all three types of DED.
PG-HPG nanoemulsion improved tear film stability, and signs and symptoms of DED
DED is a multifactorial condition with ADDE, EDE, and mixed
etiologies. Artificial tears are the backbone in the management of DED.
Lipid-based lubricant eye drops with viscoelastic characteristics are
beneficial in providing temporary relief of dry eye symptoms.
PG-HPG and borate components in PG-HPG nanoemulsion
lubricant eye drops form a thin viscoelastic layer that prolongs retention of
demulcent; thus, provides long-term surface hydration and moisture retention,
and ocular surface protection by improving cell barrier functions and cell
recovery, and temporary relief of symptoms in DED. Moreover, it provides tear
film stability between and during blinks owing to viscoelastic properties of
HPG. Further, PG-HPG nanoemulsion formulation helps to optimize ocular surface
coverage of lipids that is beneficial in replenishing the tear film lipid
layer. Additionally, PG-HPG nanoemulsion lubricant eye drops in the form of
multidose preservative-free system (with Novelia® bottles) is effective,
convenient, and well tolerated in DED patients who have intolerance to
preservatives with long-term eye drop use.
Clinically, PG-HPG nanoemulsion lubricant eye drops have
been shown to improve dry eye symptoms, enhance tear film stability, and lipid
layer thickness; hence, they help to restore eye surface health and provide
symptom relief in patients with DED, regardless of subtypes. Moreover, PG-HPG
nanoemulsion relieves ocular dryness and discomfort associated with daily
contact lens wear, and in prophylactic treatment of dry eye against adverse
environmental conditions.
Conversely, other lipid-based and/or liposome-based
lubricant eye drops, shown to mimic tear film composition, provide ocular surface
benefits and improve signs of dry eye; however, large-scale controlled clinical
studies are required to obtain more robust evidence on the efficacy. With over
a demi-decade of usage, PG-HPG nanoemulsion lubricant eye drops are effective,
convenient to use, and well tolerated in DED, regardless of its subtypes.
Source: Srinivasan and Williams; Clinical Ophthalmology
2022:16 https://doi.org/10.2147/OPTH.S377960
2 years 4 months ago
Ophthalmology,Ophthalmology News,Top Medical News
Medical News, Health News Latest, Medical News Today - Medical Dialogues |
Heart transplantation's newest breakthrough: donation after circulatory death
Heart transplantation is limited by organ availability. Transplant programs involve marginal donors with risk characteristics include older age, size mismatch, left ventricular hypertrophy, poor ejection fraction, and extended donor ischemia durations. Brain death or circulatory death is required for deceased organ donation . All brain functions stop after brain death.
Cold solution flushing stops organ function during DBD donor organ assessment and procurement. Circulatory death donors have irreparable damage and cannot be saved. After treatment is discontinued, the donor dies of circulatory failure (no blood pressure, pulse, or heartbeat). Before organ harvesting, circulatory death is certified after a 5-minute standoff.
Ischemic damage threatens all donor organs. Ischemic damage destroys pump and electrical performance in DCD hearts. Recent breakthroughs in machine perfusion (MP) have permitted resuscitation of DCD hearts and successful transplant. DCD hearts may boost donor numbers by 50%.
DCD Heart Recovery
Direct procurement and ex situ perfusion (DPP) and normothermic regional in situ perfusion (NRP) are DCD heart procurement methods.
DPP uses ex situ MP. After circulatory death is confirmed, the heart is flushed with cold crystalloid cardioplegia, obtained, back table instrumentation, and reperfused with normothermic blood. Only TransMedics Organ Care System (OCSTM) (Andover, MA, USA) is FDA-approved for ex situ perfusion of DCD hearts. OCS machine priming before cardiac recovery takes 1100 mL donor blood. Cannulated aorta and pulmonary arteries and LV vent avoid distension. The OCS system keeps the heart normothermic and beating throughout resuscitation and transfer . Lactate metabolism, physical examination, and coronary flow predict heart function and organ viability. Before implant, cardioplegia freezes the heart.
NRP uses open cardiopulmonary bypass (CPB). Death declaration and standoff follow DCD protocol. The donor right atrium and ascending aorta are cannulated for CPB. Before CPB thoraco-abdominal organ reperfusion, the aortic arch arteries are constricted to isolate brain circulation. Venting the innominate artery prevents brain circulation. Heart function recovers after 45–60 minutes. Weaning CPB allows cardiac function testing. After cardioplegia, the heart is carried in cold static storage, normothermic, or hypothermic MP storage.
DCD Heart Transplantation Evolution
DCD hearts are not new. Dr. Christiaan Barnard used NRP to accomplish the first DCD donor heart transplant in 1967. DCD was abandoned due to brain death criteria and ischemia heart damage concerns. Denver Children's Hospital transplanted three pediatric DCD hearts in 2004. Ten years later, Sydney's St. Vincent's Hospital launched a DCD program using DPP In 2015, Papworth Hospital in Cambridge, UK completed NRP DCD heart transplants.
In 2019, the first adult DCD heart transplant was conducted in the US as part of a randomized controlled experiment comparing OCS to DBD cold storage. NYU conducted the first adult DCD NRP heart transplant in 2020. DCD heart transplants boost donor organ yield. Thoraco-abdominal NRP improves DCD liver and kidney transplant survival.
Results -
International studies reveal a 30-48% donor pool increase with DBD heart transplant results. Messer and colleagues analyzed DCD and DBD cardiac transplants. DCD 92% and DBD 96% had similar 90-day and 1-year survival. There was no significant difference in primary graft malfunction requiring extracorporeal membrane oxygenation (ECMO) (DCD 15% vs. DBD 6%, p = 0.12) or intra-aortic balloon pump (IABP) (DCD 32% vs. DBD 23%, p=0.28). There was also no significant difference in intensive care unit (ICU) or hospital durations of stay. 57 DCD transplant hearts were DPP and 22 NRP with OCS perfusion. Survival was comparable, but NRP transplants needed fewer ventilator days, dialysis, and hospital stays. US DCD heart multicenter trials randomized 180 patients to 90 OCS and 90 DBD hearts. Six- and 12-month post-transplant survival were similar. DCD hearts used 89%.
Ethics -
DCD heart transplant raises ethical issues. Circulatory death is irreversible cardiopulmonary failure. The phrase "irreversible" raises worries of breaking the deceased donor rule by restoring circulation to the thoraco-abdominal organs using NRP. Before intervention, the donor fulfilled requirements and was proclaimed dead. The obligatory standoff time indicates no autoresuscitation. NRP does not revive the patient or restore pre-withdrawal non-life-sustaining damage.
Before bypass, the head vessels are blocked and ventilated to address concerns about NRP resuming neurologic function.
It is vital to highlight that if the duration from removal of life support to death exceeds the permissible f-WIT for solid organ donation, donors stay on hospice and the process to death continues. In this situation, the donor may still be able to give additional tissue for transplant or study.
Summary of findings
Widespread use of DCD heart transplant has been hindered by ischemia damage. However, success of employing DPP and NRP procedures has led in exponential increase of DCD heart transplant in recent years. MP also allows the study of innovative therapies like gene therapy and mitochondrial transplant, which might repair and reimplant failing hearts.
Many advantages of DCD heart transplant encourage its broader spread adoption: enlarging the donor pool, shortening waiting periods, enhancing organ quality, boosting total organ yield per donor are among them.
References –
Schroder JN, Shah A, Pretorius V, et al. Expanding heart transplants from donors after circulatory death (DCD) – results of the first randomized controlled trial using the organ care system (OCSTM) Heart – (OCS DCD Heart Trial)J Heart Lung Transplant 2022;41:S72.
Smith DE, Kon ZN, Carillo JA, et al. Early experience with donation after circulatory death heart transplantation using normothermic regional perfusion in the United States. J Thorac Cardiovasc Surg 2022;164:557-568.e1.
Mohite PN, Umakumar K, Garcia-Saez, et al. Heart transplantation utilizing organs following donation after circulatory death (DCD). J Heart Lung Transplant 2022;41:S175-176.
2 years 4 months ago
Anesthesia,Cardiology-CTVS,Surgery,Anesthesia News,Cardiology & CTVS News,Surgery News,Top Medical News
News Archives - Healthy Caribbean Coalition
7th Caribbean Alcohol Reduction Day (CARD) 2022
7th Caribbean Alcohol Reduction Day (CARD) 2022.
The Healthy Caribbean Coalition (HCC) continued it’s annual Caribbean Alcohol Reduction Day (CARD) webinar series with a webinar entitled The WHO Global Alcohol Action Plan 2022-2030 – Priorities for the Caribbean. Panelists shared global and regional updates reflecting on the challenges and opportunities to build momentum around Caribbean alcohol policy within the framework of the Global Alcohol Action Plan.
The HCC and partners have held an annual Caribbean Alcohol Reduction Day for the past 6 years, under the themes and titles: The Misuse of Alcohol (2016); Drink less, Reduce Cancer (2017); Youth: Let’s talk about alcohol (2018); Women and Alcohol (2019), Alcohol and COVID-19 (2020) and Live Better, Drink Less: Challenges and Opportunities in the Caribbean (2021) .
This year’s webinar was entitled The WHO Global Alcohol Action Plan 2022-2030 – Priorities for the Caribbean.
The objectives of the 7th Caribbean Alcohol Reduction Day webinar were:
- To provide an overview of the WHO Global Alcohol Action Plan 2022-2030 and implications for key stakeholders globally and regionally.
- To provide an update on regional progress in alcohol policy development and implementation including discussion of barriers and opportunities.
- To discuss regional priorities for alcohol policy action within the framework of the Global Alcohol Action Plan 2022-2030 in order to inform a civil society position paper targeting the region’s policymakers entitled: The WHO Global Alcohol Action Plan 2022-2030 – Priorities for the Caribbean.
The webinar took the form of a series of brief presentations followed by a panel discussion.
- Introduction: Maisha Hutton HCC Executive Director, Professor Rohan Maharaj, HCC Alcohol Policy Advisor, Professor of Family Medicine of University of the West Indies
- Presentations: Moderator, Maisha Hutton
- ‘WHO Global Alcohol Action Plan 2022-2030 – Perspectives from the Region of the Americas’ including a look at PAHO’so #LiveBetterTakeAction campaign and Pahola, PAHOs first digital specialist on alcohol use – Dr. Maristela Monteiro, Senior Advisor on Alcohol and Substance Abuse, Non-Communicable Diseases and Mental Health, PAHO
- Global Perspectives on the WHO Alcohol Action Plan 2022 – 2030 – Mr. Øystein Bakke, Global Alcohol Policy Alliance (GAPA); Senior Adviser, Alcohol, Drugs and Development FORUT, Campaign for Development and Solidarity
- Alcohol Policy in the Caribbean Update – Professor Rohan Maharaj, HCC Alcohol Policy Advisor, Professor of Family Medicine of University of the West Indies
- Jamaica National Alcohol Policy – Michael A . Tucker, Executive Director, National Council on Drug Abuse, Jamaica
- Presentation of Priorities – Maisha Hutton HCC Executive Director
- Panel Discussion: Regional priorities for alcohol policy action within the framework of the Action Plan 2022-2030: Moderator – Maisha Hutton
- Closing & Thanks: Maisha Hutton and Professor Rohan Maharaj
Maisha Hutton
HCC Executive Director
Professor Rohan Maharaj
HCC Alcohol Policy Advisor, Professor of Family Medicine of University of the West Indies
Dr. Maristela Monteiro
Senior Advisor on Alcohol and Substance Abuse, Non-Communicable Diseases and Mental Health, PAHO
Mr. Øystein Bakke
Department of Institutional Research, Northern Caribbean University, Mandeville, Manchester, Jamaica, West Indies
Michael A . Tucker
Executive Director, National Council on Drug Abuse, Jamaica
View the flyer here
The HCC and partners have held an annual Caribbean Alcohol Reduction Days (CARD) since 2016 you can find details of the other CARD days here.
The post 7th Caribbean Alcohol Reduction Day (CARD) 2022 appeared first on Healthy Caribbean Coalition.
2 years 4 months ago
Alcohol Advocacy, CARD, News, Slider, Webinars
Ministry of Health continues to offer free HIV testing and other services during the Christmas season
The content originally appeared on: News Americas Now
Black Immigrant Daily News
The content originally appeared on: NBC SVG
The content originally appeared on: News Americas Now
Black Immigrant Daily News
The content originally appeared on: NBC SVG
The Ministry of Health Wellness and the Environment will continue to offer free HIV testing and other services during the Christmas season.
That is according to Chief Health Promotion Officer Shanika John while speaking at a health fair hosted by the ministry yesterday as part of activities to observe World Aids Day.
Ms. John said there is no better Christmas gift than the gift of health.
https://www.nbcsvg.com/wp-content/uploads/2022/12/MORE-TESTING.mp3
Meanwhile, Director of the Health Security Unit in the Ministry of Health Wellness and the Environment Donna Bascombe also spoke of some of the other activities expected to continue over the next few weeks.
https://www.nbcsvg.com/wp-content/uploads/2022/12/DONNA-PROGRAMS.mp3
Related
NewsAmericasNow.com
2 years 4 months ago
Caribbean News
PAHO/WHO | Pan American Health Organization
Carissa F. Etienne on PAHO's 120th Anniversary: solidarity can help build a healthier and more hopeful future for all
Carissa F. Etienne on PAHO's 120th Anniversary: solidarity can help build a healthier and more hopeful future for all
Cristina Mitchell
2 Dec 2022
Carissa F. Etienne on PAHO's 120th Anniversary: solidarity can help build a healthier and more hopeful future for all
Cristina Mitchell
2 Dec 2022
2 years 4 months ago
Health Archives - Barbados Today
CAIPO shares HIV/AIDS awareness message
In recognition of World AIDS Day on December 1, the Corporate Affairs and Intellectual Property Office (CAIPO in Warrens, hosted a special display hoping to raise the level of education about the disease among its clientele.
Speaking to the press on Thursday, Deputy Registrar at CAIPO, Joyann Catwell, said the department wanted to share important and relevant information with all its “shareholders”.
“These are persons who have come to incorporate companies and to register businesses names, we are here to tell them a little bit about AIDS, and in addition to that, we are also here to inform them about beneficial ownership as per our international obligations.”
She explained, “Today at corporate affairs we have our information booth corner, we have a table with leaflets on HIV/AIDS, we also have our condom corner and throughout the day there will prizes and giveaways.”
CAIPO is responsible for the administration of Barbados’ Intellectual Property Rights and advises the Ministry of International Business and Industry on the technical and policy issues which underlie Barbados’ Intellectual Property Rights regime.
(SB)
The post CAIPO shares HIV/AIDS awareness message appeared first on Barbados Today.
2 years 4 months ago
A Slider, Feature, Health
Herbicide causes poisoning at the Montecristi school
Herbicide would have been the cause of nine teachers being intoxicated with poisoning symptoms at the basic level school “Aurora Tavares Ballard” in the municipality of San Lorenzo de Guayubn, in the province of Montecristi, yesterday.
As a result, the National Police launched an extensive investigation into the poisoning suffered by the educators, prompting the educational district 13-02 to suspend classes until next Monday to disinfect the facility and environment, according to the center’s director. Isabel Veras is an educator.
The Ministry of Public Health was able to determine that the cause of the poisoning was herbicide, which occurred after the teachers inhaled a highly toxic substance sprayed on the campus. “We were able to contact a person who lives in front of the school, and he showed us the container in which the herbicide was supplied, which is a burner for cleaning a patio,” a source close to the investigation said.
A woman who lives near the school would have sprayed this liquid to kill the herbs in her yard, but according to the epidemiologist in charge of the Montecristi health province, she sprayed more than the recommended amount, and with the arrival of the wind, the substance entered the school and caused the poisoning. So far, 15 people, including teachers and children, have been taken to the hospital with poisoning symptoms.
The National Police are expected to look into the situation further so that the person responsible can be brought to justice if necessary.
2 years 4 months ago
Health, Local
Medscape Medical News Headlines
Canada Contributes $15 Million to PAHO Vaccine Initiative
The funding will strengthen vaccine production capacities in Latin America and the Caribbean. Medscape Medical News
The funding will strengthen vaccine production capacities in Latin America and the Caribbean. Medscape Medical News
2 years 4 months ago
Infectious Diseases, News