Health facilities damaged in Carriacou and Petite Martinique
“During a press briefing at the National Disaster Management Agency on Wednesday evening, Dr Charles said the priority is assisting patients with emergency needs”
View the full post Health facilities damaged in Carriacou and Petite Martinique on NOW Grenada.
9 months 2 weeks ago
Carriacou & Petite Martinique, Health, PRESS RELEASE, hillsborough health centre, hurricane beryl, nadma, national disaster management agency, princess royal hospital, shawn charles
CEDIMAT becomes first certified stroke center in Santo Domingo
Santo Domingo.- The Centers for Diagnostics and Advanced Medicine and Medical Conferences and Telemedicine (CEDIMAT) has become the first hospital in Santo Domingo to receive the prestigious Stroke Centers of Latin America certification from the WSO/SIECV.
Santo Domingo.- The Centers for Diagnostics and Advanced Medicine and Medical Conferences and Telemedicine (CEDIMAT) has become the first hospital in Santo Domingo to receive the prestigious Stroke Centers of Latin America certification from the WSO/SIECV.
This certification verifies that CEDIMAT adheres to international standards for managing and caring for patients with vascular events, as explained by Drs. Francisco Méndez, emergency manager, and Luis Eduardo Suazo, neurosurgeon and coordinator of the Neurosurgery service and stroke unit at CEDIMAT.
CEDIMAT was the pioneer in applying thrombolysis and mechanical thrombectomy treatments for patients with ischemic vascular conditions, crucial interventions that can be life-saving. This certification places CEDIMAT at the top of the quality scale, ensuring superior care for stroke patients compared to 90% of other countries. Thrombolysis, effective within the first 4 to 5 hours of an ischemic event, and thrombectomy, which can reverse mobility loss within the first 24 hours, are key treatments provided by the trained emergency staff at CEDIMAT.
The certification was granted after a thorough evaluation by the Certification Program of the Stroke Centers of Latin America and the Caribbean, involving representatives from the World Stroke Organization, the Ibero-American Society of Cerebrovascular Diseases, the Certification Program Coordinator, and local delegations.
9 months 2 weeks ago
Health
Medical News, Health News Latest, Medical News Today - Medical Dialogues |
London HC decision fuels continued legal battle between Pfizer, Moderna over COVID vaccine patents
London: Pfizer and Moderna's legal dispute over their competing COVID-19 vaccines is poised to persist following a mixed ruling from London's High Court regarding two of Moderna's patents, likely prompting a flurry of appeals in the London leg of the litigation.
In September 2022, Pfizer and its German partner BioNTech initiated legal action against Moderna, seeking the invalidation of two patents held by Moderna. In response, Moderna swiftly countered, alleging infringement of its patents just days later.
The competing lawsuits over the companies' two vaccines, which helped save millions of lives and made the companies billions of dollars, are just one strand of ongoing litigation around the world focusing on messenger RNA (mRNA) technology.Moderna had argued Pfizer and BioNTech copied mRNA advances it had pioneered and patented well before the COVID-19 pandemic began in late 2019.U.S.-based Moderna was seeking damages for alleged infringement of its patents by Pfizer and BioNTech's Comirnaty shot on sales since March 2022.Pfizer made $11.2 billion in sales from Comirnaty last year, while Moderna earned $6.7 billion from its vaccine Spikevax, illustrating the potentially huge sums at stake.Pfizer and BioNTech, however, asked the High Court to revoke Moderna's patents, arguing that Moderna's developments of mRNA technology were obvious improvements on previous work.According to Reuters, the High Court ruled on Tuesday that one of Moderna's two patents relating to mRNA technology was invalid, but that another similar patent was valid and that Pfizer and BioNTech's Comirnaty vaccine had infringed it.LIKELY APPEALSAll three companies said they disagreed with the parts of the court's decision on which they lost, and it is expected that all parties will seek permission to appeal.Pfizer and BioNTech said in a statement: "These proceedings have no bearing on the safety and efficacy profile of our vaccine, as established by regulators worldwide."Irrespective of the outcome of this legal matter, we will continue to manufacture and supply the Pfizer-BioNTech COVID-19 vaccine in line with our agreements and established supply schedules."A spokesperson for Moderna said the company was pleased the court "recognized the innovation of Moderna scientists by confirming the validity and infringement" of one of its patents.Pfizer, BioNTech and Moderna are also involved in parallel proceedings in Germany, the Netherlands, Belgium and the United States, much of which has been put on hold, as well as at the European Patent Office.The London ruling comes at a time of financial strain for Moderna, whose shares have plummeted by more than 70% since the peak of the pandemic as demand and sales for Spikevax have fallen. Shares of Pfizer, meanwhile, are down about 29% since mid-2021.Read also: COVID vaccine: Moderna wins patent case in Europe against Pfizer, BioNTech
9 months 2 weeks ago
News,Industry,Pharma News,Latest Industry News
STAT+: New federal rule proposed to protect 36 million workers from extreme heat
WASHINGTON — President Joe Biden on Tuesday proposed a new rule to address excessive heat in the workplace, warning — as tens of millions of people in the U.S.
WASHINGTON — President Joe Biden on Tuesday proposed a new rule to address excessive heat in the workplace, warning — as tens of millions of people in the U.S. are under heat advisories — that high temperatures are the country’s leading weather-related killer.
If finalized, the measure would protect an estimated 36 million U.S. workers from injuries related to heat exposure on the job — establishing the first major federal safety standard of its kind. Those affected by excessive heat in the workplace include farmworkers, delivery and construction workers, landscapers and indoor workers in warehouses, factories and kitchens.
Biden highlighted the proposed rule as one of five steps his Democratic administration is taking to address extreme weather as Hurricane Beryl is already ripping through the Caribbean in an ominous sign for the summer.
9 months 2 weeks ago
Politics, climate change
PAHO/WHO | Pan American Health Organization
PAHO supports emergency response following flooding in Rio Grande do Sul, Brazil
PAHO supports emergency response following flooding in Rio Grande do Sul, Brazil
Cristina Mitchell
3 Jul 2024
PAHO supports emergency response following flooding in Rio Grande do Sul, Brazil
Cristina Mitchell
3 Jul 2024
9 months 2 weeks ago
As bird flu spreads among U.S. cattle, veterinarians find themselves in a familiar position: the frontlines
When, in April, the federal government began requiring some cows to be tested for a strain of avian flu before their herds could be moved across state lines, it seemed like an obvious step to try to track and slow the virus that had started spreading among U.S. dairy cattle.
When, in April, the federal government began requiring some cows to be tested for a strain of avian flu before their herds could be moved across state lines, it seemed like an obvious step to try to track and slow the virus that had started spreading among U.S. dairy cattle.
But Joe Armstrong, a veterinarian at the University of Minnesota extension school, feared the U.S. Department of Agriculture rule could lead to potential problems for his colleagues, who were in effect being deputized to implement it.
9 months 2 weeks ago
Health, H5N1 Bird Flu, infectious disease, Public Health
Hurricane preparedness tips for seniors
AS HURRICANE Beryl nears Jamaica, it is essential for everyone, especially our senior citizens, to be well prepared. The effects of a hurricane can be devastating, but with careful planning and preparation, you can ensure your safety and well-being...
AS HURRICANE Beryl nears Jamaica, it is essential for everyone, especially our senior citizens, to be well prepared. The effects of a hurricane can be devastating, but with careful planning and preparation, you can ensure your safety and well-being...
9 months 2 weeks ago
The importance of self-care
SELF-CARE DOES not have to cost anything. It is just doing things you enjoy and many of the things we enjoy or feel fulfilled from cost nothing. Stepping outside and taking a deep breath, for example, might be the greatest act of self-care. Even if...
SELF-CARE DOES not have to cost anything. It is just doing things you enjoy and many of the things we enjoy or feel fulfilled from cost nothing. Stepping outside and taking a deep breath, for example, might be the greatest act of self-care. Even if...
9 months 2 weeks ago
Breaking stereotypes in self-care
SELF-CARE IS not synonymous with self-indulgence or being selfish. Self-care means taking care of yourself so that you can be healthy, you can be well, you can do your job, you can help and care for others, and you can do all the things you need to...
SELF-CARE IS not synonymous with self-indulgence or being selfish. Self-care means taking care of yourself so that you can be healthy, you can be well, you can do your job, you can help and care for others, and you can do all the things you need to...
9 months 2 weeks ago
Health Archives - Barbados Today
All services resume at QEH
All services have resumed at the island’s public hospital following the passage of Hurricane Beryl yesterday.
Corporate Communications Specialist at the Queen Elizabeth Hospital Shane Sealy told Barbados TODAY that operations had resumed as usual yesterday evening as there had been “very, very minor damage” at the Martindales Road facility and most had already been addressed.
“Once the national shutdown was discontinued and the all-clear was given, we resumed normal services and visiting hours from six o’clock. Meanwhile, our clinics will open as normal (today) as well as our pharmacies,” he said.
Sealy also advised those patients whose surgeries or appointments were postponed due to the passage of the weather system to contact the hospital’s Patient Advice and Liaison Service at 536-4800 to be rescheduled.
“We are getting things back on track and we want them to reach out to us so we could let them know what to do,” he added.
The post All services resume at QEH appeared first on Barbados Today.
9 months 2 weeks ago
Health, Local News, News
PAHO/WHO | Pan American Health Organization
WHO releases first-ever clinical treatment guideline for tobacco cessation in adults
WHO releases first-ever clinical treatment guideline for tobacco cessation in adults
Cristina Mitchell
2 Jul 2024
WHO releases first-ever clinical treatment guideline for tobacco cessation in adults
Cristina Mitchell
2 Jul 2024
9 months 2 weeks ago
Pain Doesn’t Belong on a Scale of Zero to 10
Over the past two years, a simple but baffling request has preceded most of my encounters with medical professionals: “Rate your pain on a scale of zero to 10.”
I trained as a physician and have asked patients the very same question thousands of times, so I think hard about how to quantify the sum of the sore hips, the prickly thighs, and the numbing, itchy pain near my left shoulder blade. I pause and then, mostly arbitrarily, choose a number. “Three or four?” I venture, knowing the real answer is long, complicated, and not measurable in this one-dimensional way.
Pain is a squirrely thing. It’s sometimes burning, sometimes drilling, sometimes a deep-in-the-muscles clenching ache. Mine can depend on my mood or how much attention I afford it and can recede nearly entirely if I’m engrossed in a film or a task. Pain can also be disabling enough to cancel vacations, or so overwhelming that it leads people to opioid addiction. Even 10+ pain can be bearable when it’s endured for good reason, like giving birth to a child. But what’s the purpose of the pains I have now, the lingering effects of a head injury?
The concept of reducing these shades of pain to a single number dates to the 1970s. But the zero-to-10 scale is ubiquitous today because of what was called a “pain revolution” in the ’90s, when intense new attention to addressing pain — primarily with opioids — was framed as progress. Doctors today have a fuller understanding of treating pain, as well as the terrible consequences of prescribing opioids so readily. What they are learning only now is how to better measure pain and treat its many forms.
About 30 years ago, physicians who championed the use of opioids gave robust new life to what had been a niche specialty: pain management. They started pushing the idea that pain should be measured at every appointment as a “fifth vital sign.” The American Pain Society went as far as copyrighting the phrase. But unlike the other vital signs — blood pressure, temperature, heart rate, and breathing rate — pain had no objective scale. How to measure the unmeasurable? The society encouraged doctors and nurses to use the zero-to-10 rating system. Around that time, the FDA approved OxyContin, a slow-release opioid painkiller made by Purdue Pharma. The drugmaker itself encouraged doctors to routinely record and treat pain, and aggressively marketed opioids as an obvious solution.
To be fair, in an era when pain was too often ignored or undertreated, the zero-to-10 rating system could be regarded as an advance. Morphine pumps were not available for those cancer patients I saw in the ’80s, even those in agonizing pain from cancer in their bones; doctors regarded pain as an inevitable part of disease. In the emergency room where I practiced in the early ’90s, prescribing even a few opioid pills was a hassle: It required asking the head nurse to unlock a special prescription pad and making a copy for the state agency that tracked prescribing patterns. Regulators (rightly) worried that handing out narcotics would lead to addiction. As a result, some patients in need of relief likely went without.
After pain doctors and opioid manufacturers campaigned for broader use of opioids — claiming that newer forms were not addictive, or much less so than previous incarnations — prescribing the drugs became far easier and were promoted for all kinds of pain, whether from knee arthritis or back problems. As a young doctor joining the “pain revolution,” I probably asked patients thousands of times to rate their pain on a scale of zero to 10 and wrote many scripts each week for pain medication, as monitoring “the fifth vital sign” quickly became routine in the medical system. In time, a zero-to-10 pain measurement became a necessary box to fill in electronic medical records. The Joint Commission on the Accreditation of Healthcare Organizations made regularly assessing pain a prerequisite for medical centers receiving federal health care dollars. Medical groups added treatment of pain to their list of patient rights, and satisfaction with pain treatment became a component of post-visit patient surveys. (A poor showing could mean lower reimbursement from some insurers.)
But this approach to pain management had clear drawbacks. Studies accumulated showing that measuring patients’ pain didn’t result in better pain control. Doctors showed little interest in or didn’t know how to respond to the recorded answer. And patients’ satisfaction with their doctors’ discussion of pain didn’t necessarily mean they got adequate treatment. At the same time, the drugs were fueling the growing opioid epidemic. Research showed that an estimated 3% to 19% of people who received a prescription for pain medication from a doctor developed an addiction.
Doctors who wanted to treat pain had few other options, though. “We had a good sense that these drugs weren’t the only way to manage pain,” Linda Porter, director of the National Institutes of Health’s Office of Pain Policy and Planning, told me. “But we didn’t have a good understanding of the complexity or alternatives.” The enthusiasm for narcotics left many varietals of pain underexplored and undertreated for years. Only in 2018, a year when nearly 50,000 Americans died of an overdose, did Congress start funding a program — the Early Phase Pain Investigation Clinical Network, or EPPIC-Net — designed to explore types of pain and find better solutions. The network connects specialists at 12 academic specialized clinical centers and is meant to jump-start new research in the field and find bespoke solutions for different kinds of pain.
A zero-to-10 scale may make sense in certain situations, such as when a nurse uses it to adjust a medication dose for a patient hospitalized after surgery or an accident. And researchers and pain specialists have tried to create better rating tools — dozens, in fact, none of which was adequate to capture pain’s complexity, a European panel of experts concluded. The Veterans Health Administration, for instance, created one that had supplemental questions and visual prompts: A rating of 5 correlated with a frown and a pain level that “interrupts some activities.” The survey took much longer to administer and produced results that were no better than the zero-to-10 system. By the 2010s, many medical organizations, including the American Medical Association and the American Academy of Family Physicians, were rejecting not just the zero-to-10 scale but the entire notion that pain could be meaningfully self-reported numerically by a patient.
In the years that opioids had dominated pain remedies, a few drugs — such as gabapentin and pregabalin for neuropathy, and lidocaine patches and creams for musculoskeletal aches — had become available. “There was a growing awareness of the incredible complexity of pain — that you would have to find the right drugs for the right patients,” Rebecca Hommer, EPPIC-Net’s interim director, told me. Researchers are now looking for biomarkers associated with different kinds of pain so that drug studies can use more objective measures to assess the medications’ effect. A better understanding of the neural pathways and neurotransmitters that create different types of pain could also help researchers design drugs to interrupt and tame them.
Any treatments that come out of this research are unlikely to be blockbusters like opioids; by design, they will be useful to fewer people. That also makes them less appealing prospects to drug companies. So EPPIC-Net is helping small drug companies, academics, and even individual doctors design and conduct early-stage trials to test the safety and efficacy of promising pain-taming molecules. That information will be handed over to drug manufacturers for late-stage trials, all with the aim of getting new drugs approved by the FDA more quickly.
The first EPPIC-Net trials are just getting underway. Finding better treatments will be no easy task, because the nervous system is a largely unexplored universe of molecules, cells, and electronic connections that interact in countless ways. The 2021 Nobel Prize in Physiology or Medicine went to scientists who discovered the mechanisms that allow us to feel the most basic sensations: cold and hot. In comparison, pain is a hydra. A simple number might feel definitive. But it’s not helping anyone make the pain go away.
KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.
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This story can be republished for free (details).
9 months 2 weeks ago
Health Care Reform, Health Industry, Opioids
El dolor ya no se puede medir en una escala de cero a 10
En los últimos dos años, una solicitud simple pero desconcertante ha precedido la mayoría de mis encuentros con profesionales médicos: “Califique su dolor en una escala del cero al 10”.
Me formé como médica y he hecho esta misma pregunta a los pacientes miles de veces, así que pienso mucho en cómo cuantificar la suma de caderas doloridas, muslos punzantes y el dolor adormecedor cerca de mi omóplato izquierdo. Hago una pausa y luego, generalmente de manera arbitraria, elijo un número. “¿Tres o cuatro?”, aventuro, sabiendo que la respuesta real es larga, complicada e imposible de medir de esta manera unidimensional.
El dolor es algo escurridizo. A veces es ardiente, a veces perforante, a veces oprime profundo en los músculos. El mío puede depender de mi estado de ánimo o de cuánto le preste atención, y puede “desaparecer” casi por completo si estoy concentrada en una película o tarea.
El dolor también puede ser lo suficientemente incapacitante como para cancelar vacaciones, o tan abrumador que vuelve a las personas adictas a los opioides. Incluso el dolor de 10+ puede ser soportable cuando se tolera por una buena razón, como dar a luz.
Pero, ¿cuál es el propósito de los dolores que tengo ahora, efectos persistentes de una lesión en la cabeza?
El concepto de reducir estos matices del dolor a un solo número data de la década de 1970. Pero hoy en día la escala del cero a 10 parece vetusta debido a lo que se llamó una “revolución del dolor” en los años 90, cuando la nueva forma de abordar el dolor —principalmente con opioides— se presentó como un progreso.
Los médicos de hoy tienen una comprensión más completa del tratamiento del dolor, así como de las terribles consecuencias de recetar opioides con liviandad. Lo que están aprendiendo ahora es cómo medir mejor el dolor y tratar sus muchas formas.
Hace unos 30 años, los médicos que defendían el uso de opioides dieron nueva vida a lo que había sido hasta el momento una especialidad marginal: la gestión del dolor. Comenzaron a promover la idea de que el dolor debería medirse en cada cita como un “quinto signo vital”. La Sociedad Americana del Dolor llegó a registrar la frase. Pero a diferencia de los otros signos vitales —presión arterial, temperatura, frecuencia cardíaca y frecuencia respiratoria— el dolor no tenía una escala objetiva.
¿Cómo medir lo inmensurable?
La sociedad alentó a los médicos y enfermeras a usar el sistema de calificación de cero a 10. Alrededor de esa época, la Administración de Drogas y Alimentos (FDA) aprobó OxyContin, un analgésico opioide de liberación lenta fabricado por Purdue Pharma.
El propio fabricante de medicamentos instó a los médicos a registrar y tratar el dolor de manera rutinaria, y promovió agresivamente los opioides como una solución obvia. Para ser justos, en una época en la que el dolor a menudo se ignoraba o se trataba de manera insuficiente, el sistema de calificación de cero a 10 podría considerarse un avance.
Las bombas de morfina no estaban disponibles para aquellos pacientes con cáncer que vi en los años 80, incluso aquellos con un dolor agonizante por cáncer en los huesos; los médicos consideraban el dolor como una parte inevitable de la enfermedad. En la sala de emergencias donde trabajé a principios de los 90, recetar incluso unas pocas píldoras de opioides era un inconveniente: requería pedirle a la enfermera jefe que desbloqueara un recetario especial y hacer una copia para la agencia estatal que rastreaba los patrones de prescripción.
Los reguladores (con razón) se preocupaban de que repartir narcóticos llevara a la adicción. Como resultado, algunos pacientes necesitados de alivio probablemente se quedaron sin él.
Después que los médicos del dolor y los fabricantes de opioides hicieran campaña para un uso más amplio de estas drogas — alegando que las formas más nuevas no eran adictivas, o mucho menos que las formulaciones anteriores — recetar los medicamentos se volvió mucho más fácil y se promovieron para todo tipo de dolor, ya sea una artritis de rodilla o problemas de espalda.
Como joven médica que se unía a la “revolución del dolor”, probablemente les pregunté a los pacientes miles de veces que calificaran su dolor en una escala de cero a 10 y escribí muchas recetas cada semana para medicamentos para el dolor, ya que monitorear “el quinto signo vital” se volvió rápidamente rutinario en el sistema médico.
Con el tiempo, la medición del dolor de cero a 10 se convirtió en caja necesaria para llenar en los registros médicos electrónicos. La Commission on the Accreditation of Healthcare Organizations hizo que evaluar el dolor regularmente fuera un requisito previo para que los centros médicos recibieran dólares federales de atención médica.
Los grupos médicos agregaron el tratamiento del dolor a su lista de derechos de los pacientes, y la satisfacción con el tratamiento del dolor se convirtió en un componente de las encuestas de pacientes posteriores a la cita médica. (Una mala calificación podría significar un menor reembolso por parte de algunos aseguradoras).
Pero este enfoque para la gestión del dolor tenía claros inconvenientes. Estudios revelaban que medir el dolor de los pacientes no resultaba en un mejor control del dolor. Los médicos mostraban poco interés en, o no sabían cómo responder a la respuesta registrada. Y que los pacientes estuvieran satisfechos con discutir su dolor con el médico no significaba necesariamente que recibieran un tratamiento adecuado.
Al mismo tiempo, los medicamentos estaban alimentando la creciente epidemia de opioides. La investigación mostró que se estimaba que entre el 3% y el 19% de las personas que recibían una receta de medicamentos para el dolor desarrollaban una adicción.
Sin embargo, los médicos que querían tratar el dolor tenían pocas otras opciones. “Teníamos un buen sentido de que estos medicamentos no eran la única forma de manejar el dolor”, me dijo Linda Porter, directora de la Oficina de Políticas y Planificación del Dolor de los Institutos Nacionales de Salud. “Pero no teníamos una buena comprensión de la complejidad o las alternativas”.
El entusiasmo por los narcóticos dejó muchas variedades de dolor sin explorar y sin tratar durante años.
Solo en 2018, un año en que casi 50,000 estadounidenses murieron por una sobredosis, el Congreso comenzó a financiar un programa —la Red de Investigación Clínica de la Fase Temprana del Dolor, o EPPIC-Net— diseñado para explorar tipos de dolor y encontrar mejores soluciones. La red conecta especialistas en 12 centros clínicos académicos especializados y está destinada a iniciar nuevas investigaciones en este campo y encontrar soluciones a medida para diferentes tipos de dolor.
Una escala de cero a 10 puede tener sentido en ciertas situaciones, como cuando una enfermera la usa para ajustar la dosis de medicación para un paciente hospitalizado después de una cirugía o un accidente. Y los investigadores y especialistas en dolor han intentado crear mejores herramientas de calificación — docenas, de hecho, ninguna de las cuales fue adecuada para capturar la complejidad del dolor, concluyó un panel de expertos europeos.
Por ejemplo, la Administración de Salud de Veteranos creó una que tenía preguntas adicionales e indicaciones visuales: una calificación de 5 se correlacionaba con un ceño fruncido y un nivel de dolor que “interrumpe algunas actividades”. La encuesta tardaba mucho más y producía resultados que no eran mejores que el sistema de cero a 10.
Para la década de 2010, muchas organizaciones médicas, incluida la Asociación Médica Estadounidense y la Academia Estadounidense de Médicos de Familia, estaban rechazando no solo la escala de cero a 10, sino toda la noción de que un paciente podía informar su dolor de manera numérica y significativa.
En los años en que los opioides habían dominado los remedios para el dolor, algunos medicamentos — como la gabapentina y la pregabalina para la neuropatía, y los parches y cremas de lidocaína para los dolores musculoesqueléticos — estaban disponibles.
“Había una creciente conciencia de la increíble complejidad del dolor, y de que tendrías que encontrar los medicamentos adecuados para los pacientes adecuados”, me dijo Rebecca Hommer, directora interina de EPPIC-Net.
Los investigadores ahora están buscando biomarcadores asociados con diferentes tipos de dolor para que los estudios de medicamentos puedan usar medidas más objetivas para evaluar sus efectos. Una mejor comprensión de las vías neurales y los neurotransmisores que crean diferentes tipos de dolor también podría ayudar a los investigadores a diseñar medicamentos para interrumpirlos y domesticarlos.
Es poco probable que cualquier tratamiento que surja de esta investigación sea un éxito de taquilla como los opioides; por diseño, serán útiles para menos personas. Eso también los hace prospectos menos atractivos para las compañías farmacéuticas.
Así que EPPIC-Net está ayudando a pequeños laboratorios, académicos e incluso a médicos individuales a diseñar y realizar ensayos en etapa temprana para probar la seguridad y eficacia de moléculas prometedoras para aliviar el dolor.
Esa información se entregará a las farmacéuticas para ensayos en etapa tardía, todo con el objetivo de obtener nuevos medicamentos aprobados por la FDA más rápidamente. Los primeros ensayos de EPPIC-Net están comenzando. Encontrar mejores tratamientos no será una tarea fácil, porque el sistema nervioso es un universo en gran parte inexplorado de moléculas, células y conexiones eléctricas.
El Premio Nobel de Fisiología o Medicina 2021 fue para los científicos que descubrieron los mecanismos que nos permiten sentir las sensaciones más básicas: el frío y el calor. En comparación, el dolor es una hidra, un monstruo de muchas cabezas. Un simple número puede parecer definitivo. Pero no ayuda a nadie a que el dolor desaparezca.
KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.
USE OUR CONTENT
This story can be republished for free (details).
9 months 2 weeks ago
Health Care Reform, Health Industry, Noticias En Español, Opioids
STAT+: After months of warnings, FTC opens investigation into Teva over ‘improper’ patents
The Federal Trade Commission is formally investigating Teva Pharmaceuticals after the company refused to remove approximately two dozen patents for asthma and COPD inhalers from a key federal registry.
The agency sent a civil investigative demand requiring Teva to provide information related to the patents listed in the so-called Orange Book, which is maintained by the Food and Drug Administration. The move comes after the FTC late last year began warning Teva and several other companies that they should remove hundreds of “improperly or inaccurately” listed patents or face further action.
The FTC has argued Teva and these other companies listed patents in the Orange Book without properly claiming certain key information, such as a drug substance or method for using a drug. Industry critics say the tactic makes it harder for generic companies to sell lower-cost alternatives to Americans and has been blamed by several congressional lawmakers for keeping prices high.
9 months 3 weeks ago
Pharmalot, drug patents, Pharmaceuticals, STAT+
PAHO/WHO | Pan American Health Organization
PAHO and World Bank launch PROTECT project to strengthen pandemic response in South America
PAHO and World Bank launch PROTECT project to strengthen pandemic response in South America
Cristina Mitchell
1 Jul 2024
PAHO and World Bank launch PROTECT project to strengthen pandemic response in South America
Cristina Mitchell
1 Jul 2024
9 months 3 weeks ago
Health Archives - Barbados Today
All at QEH safe, no major damage – hospital CEO
CEO of the Queen Elizabeth Hospital (QEH) Neil Clark has assured that patients and staff at the public hospital are safe amid the passage of Hurricane Beryl.
Speaking on CBC a short while ago, he said the QEH had survived the worst of the Category 3 hurricane, with only a few minor leaks reported.
CEO of the Queen Elizabeth Hospital (QEH) Neil Clark has assured that patients and staff at the public hospital are safe amid the passage of Hurricane Beryl.
Speaking on CBC a short while ago, he said the QEH had survived the worst of the Category 3 hurricane, with only a few minor leaks reported.
“I’ve walked around last night, I’ve walked around the different departments and units; it feels very calm and the wind has been quite kind to us so far. It’s been a little bit rougher now this morning, it’s picking up a little bit. We’ve had a few minor leaks but no major damage or no major incident at all. We’re keeping the patients safe, we’re keeping the staff safe, we’re feeding everybody and we’re looking after everybody,” he assured.
“So if you’re at home and you’re worried about your patients or your family members who might be staff, please be assured everything is calm and under control at the hospital.”
Clark confirmed that clinics and theatres for elective surgery remain closed today. He said the aim is to have those reopen from tomorrow.
“As soon as we get the all clear, we’ll review the facilities and the aim would be to allow the outpatient clinics and the theatres to recommence tomorrow. But we’ll have to check the facilities. It will be dependent on the all clear time and we’ll be communicating later on today if that’s the plan that we’ll be bringing the patients back in for clinics and theatres on Tuesday,” the hospital CEO said.
According to Clark, a few patients had turned up at the Accident and Emergency Department during the passage of Hurricane Beryl but the department was “quite calm”.
“I’ve have been down to meet the team. It’s a nice change for them to have that calmness, to catch up with the patients who were in the department before the hurricane started and to move through those patients and to prepare us, I suppose, for after the lockdown is [discontinued] and the patients maybe want to come back out. We should be ready to receive any patients as soon as there’s a need to do that,” he said.
The post All at QEH safe, no major damage – hospital CEO appeared first on Barbados Today.
9 months 3 weeks ago
Health, Local News, News
AbbVie Expands IBD Drug Pipeline Again With $250M Celsius Therapeutics Acquisition
AbbVie has acquired Celsius Therapeutics, a startup whose lead program is in early clinical development for inflammatory bowel disease. It’s the latest in a series of AbbVie business deals that broaden the pharma company’s scope in the gastrointestinal condition.
The post AbbVie Expands IBD Drug Pipeline Again With $250M Celsius Therapeutics Acquisition appeared first on MedCity News.
9 months 3 weeks ago
BioPharma, Daily, Pharma, AbbVie, Acquisitions, biopharma nl, Celsius Therapeutics, deals, inflammatory bowel disease, Startups
Doctors express concern about Biden’s apparent cognitive issues during debate: 'Troubling indicators'
The first presidential debate of 2024 left many Americans and even some traditional Democratic allies wondering about President Biden’s mental fitness for office based on what appeared to be his unclear train of thought at times and his raspy voice on Thursday night.
The first presidential debate of 2024 left many Americans and even some traditional Democratic allies wondering about President Biden’s mental fitness for office based on what appeared to be his unclear train of thought at times and his raspy voice on Thursday night.
The White House responded to these concerns, claiming that the president, who is 81, was fighting a cold, but some doctors said they perceive the health issues go beyond the sniffles — with one noting that "it is an issue of fitness, not of age."
Dr. Brett Osborn, a Florida neurosurgeon who specializes in cognitive function, told Fox News Digital on Friday about his concerns.
"President Biden's performance in [Thursday] night’s debate reignited longstanding discussions about his cognitive abilities and his overall leadership capacity," Osborn told Fox News Digital.
"Throughout the evening, Biden struggled to maintain a coherent narrative, often losing his train of thought mid-sentence, and providing vague, rambling and undecipherable answers to highly critical questions," said Osborn, expressing his professional opinion.
"His frequent pauses, stumbling over words and reliance on notes underscored concerns about his mental acuity," Osborn added.
These seeming signs of cognitive decline highlight a "growing inability" to manage the complexities required by the job of the presidency, according to the neurosurgeon.
"His difficulty in articulating clear, concise responses and his apparent disorientation during the debate were seen by many – including his own constituents – as very troubling indicators of his overall health and an obvious decline in his cognitive function," Osborn said.
"President Biden lacks the mental sharpness required for the highest office in the land … especially amid [today's] current national and international crises."
The neurosurgeon, who has not treated Biden personally, also mentioned the 46th president has undergone multiple surgeries for brain aneurysms.
EXPERIMENTAL ALZHEIMER’S DRUG GETS FDA ADVISORY PANEL'S THUMBS-UP: ‘PROGRESS IS HAPPENING’
There is a famous saying in neurosurgery, Osborn noted: "When the air hits your brain, you’re never the same."
The surgeon surmised, "The odds have been stacked against him for years, long before his presidency."
Dr. Marc Siegel, physician, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, also spoke with Fox News Digital about concerns from his end.
"The debate is, in a way, a psychiatric or cognitive stress test," he told Fox News Digital.
Although Biden was able to respond to questions and seemed to be spatially aware, according to Siegel, the president did display "frequent disorientation" and had "problems with spontaneity or redirecting," the doctor said.
He has not personally examined Biden.
Siegel described Biden’s speech as "meandering," noting that he ended sentences in different places than intended, and "often mixed up ‘trillions’ and ‘billions’ and ‘millions.’"
Siegel confirmed that a physical illness, even with a cold, can bring out cognitive issues "even more."
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"Even so, it's hard to believe this is all from a cold," Siegel told Fox News Digital. "Either way, we need someone who is sharp despite a cold."
The NYU Langone physician noted that cognitive issues "wax and wane," so they won’t always present the same way.
While the age of both candidates has been raised as a concern, Siegel countered that what’s important is a president's physical and mental fitness.
"It is an issue of fitness, not of age," he said. "It is an issue of mental acuity, which is especially important if there is a crisis."
While Biden is 81 (he turns 82 in November), Trump is 78 years old.
During an appearance on "Fox & Friends" on Friday morning, Siegel also spoke about the possibility of cold medications impacting Biden's performance.
"None of the medications that he would be taking for a cold, except something that might make him drowsy, would be relevant here," he said.
"And I don't think they would give him something that would make him drowsy before a debate," he said.
He added, "We've been watching this a long time. This is something progressive."
Fox News Digital reached out to the Biden campaign and to the White House press office for comment.
Earlier this year, concerns emerged about Biden’s age and memory after the release of a special counsel’s report. The report described the Democrat’s memory as "hazy," "fuzzy," "faulty," "poor" and having "significant limitations," the Associated Press noted at the time.
The report indicated that Biden could not recall certain milestones in his own life, such as the date his own son Beau died of brain cancer, as Fox News Digital reported at the time. (Beau Biden passed away on May 30, 2015.)
"My memory is fine," Biden responded afterward from the White House.
The New York Times editorial board and others have called on Biden to step out of the race after his debate performance.
Vice President Kamala Harris acknowledged that Biden had a "slow start" to the debate, but she defended his performance overall and his record during his time in the White House.
For more Health articles, visit www.foxnews/health
Said Dr. Siegel in a New York Post opinion piece that ran in the publication on Saturday morning, "This isn't a question of age. Cognition varies widely with age, and it isn't fair to say that executive function is automatically impaired at a certain point in life. But it's a sad medical fact that a person with growing problems of memory and judgment is frequently the last to acknowledge it."
9 months 3 weeks ago
Health, joe-biden, presidential, presidential-debate, donald-trump, health-care, mental-health, Elections
Canada provides CAN$80,000 to GrenCHAP and GRENCODA
“The projects in Grenada underpin key foreign policy priorities for Canada in the Eastern Caribbean, including advancing gender equality, addressing sexual and gender-based violence, and promoting and protecting human rights”
View the full post Canada provides CAN$80,000 to GrenCHAP and GRENCODA on NOW Grenada.
9 months 3 weeks ago
Business, Community, Health, PRESS RELEASE, canada fund for local initiatives, cfli, grenada community development agency, grenchap, grencoda, high commission of canada, lilian chatterjee, sexual and gender-based violence, sgbv