Researchers have uncovered a new factor that could contribute to Alzheimer’s disease development.

A study by Harvard Medical School has identified low lithium levels in the brain as a possible trigger for the common dementia.

Lithium is known to have many functions in the brain, including balancing mood-regulating chemicals, protecting neurons and managing emotional processing. It has also been used to treat bipolar disorder and depression.

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Now, new findings show that the metal could be a "missing link" in Alzheimer’s risk, according to a Harvard press release.

The researchers tested lithium’s effects in mice, as well as human brain tissue and blood samples.

The human brain samples were obtained in partnership with the Rush Memory and Aging Project in Chicago, which maintains post-mortem brain tissue from thousands of donors. 

The samples represented the full spectrum of cognitive health, ranging from no sign of disease to mild cognitive impairment to advanced Alzheimer’s, the release stated.

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They discovered that lithium levels became lower as signs of the disease increased, showing as "greatly diminished" in advanced Alzheimer’s patients.

As toxic amyloid plaques build up in the brain — a hallmark of Alzheimer's — they begin to attach to lithium, keeping it from performing its protective functions.

When the mice were fed a "lithium-restricted diet," their brains' lithium levels decreased, causing accelerated aging, formation of amyloid-beta plaques, greater inflammation, memory loss and cognitive decline.

"Lithium turns out to be like other nutrients we get from the environment, such as iron and vitamin C," said senior author Bruce Yankner, professor of genetics and neurology in the Blavatnik Institute at Harvard Medical School, in the release.

"It’s the first time anyone’s shown that lithium exists at a natural level that’s biologically meaningful without giving it as a drug."

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The researchers also discovered a new type of lithium compound — lithium orotate — that did not bind to amyloid. When mice drank water containing this compound, it helped to restore memory and reverse brain damage, even for those who had advanced signs of disease.

The findings were published in the journal Nature.

"What impresses me the most about lithium is the widespread effect it has on the various manifestations of Alzheimer’s," said Yanker. "I really have not seen anything quite like it in all my years of working on this disease."

"The idea that lithium deficiency could be a cause of Alzheimer’s disease is new and suggests a different therapeutic approach."

While the study did suggest that the amount of lithium in the brain could be related to amyloid beta buildup, it did have some obvious limitations, according to Ozama Ismail, Ph.D., director of scientific programs for the Alzheimer’s Association in Chicago.

"Animal models do not directly replicate Alzheimer’s in humans; rather, they can provide some insights into the biology of disease progression and development," Ismail, who was not involved in the study, told Fox News Digital.

"The mouse models have been modified to accumulate amyloid beta, a hallmark protein that builds up in the brains of people with Alzheimer’s."

While studies in mouse models are a "vital early step" in therapeutic research, Ismail emphasized that much more research is needed to understand the health effects of lithium levels in the brain.

"Understanding if lithium can be therapeutic for Alzheimer's requires large clinical trials in representative populations," he said.

Much like other major diseases, it is likely that Alzheimer's treatment will require multiple approaches combining medication and lifestyle changes, Ismail predicted.

The researchers agreed that more research in human clinical trials is needed.

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"You have to be careful about extrapolating from mouse models, and you never know until you try it in a controlled human clinical trial," Yankner noted. "But so far, the results are very encouraging."

If future studies confirm these findings, the scientists say that routine blood tests could potentially screen for lithium levels and identify people at risk.

In the meantime, Yankner cautioned against people taking lithium compounds "on their own."

"My hope is that lithium will do something more fundamental than anti-amyloid or anti-tau therapies, not just lessening but reversing cognitive decline and improving patients’ lives," he said.

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The study was supported by the National Institutes of Health, the Ludwig Family Foundation, the Glenn Foundation for Medical Research and the Aging Mind Foundation.

James van der Beek has revealed the first warning sign of his colon cancer — and it’s one that did not seem alarming at the time.

The "Dawson’s Creek" actor, 48, who announced his colorectal cancer diagnosis in November 2024, recently told Healthline that "there wasn’t any red flag or something glaring."

"I was healthy. I was doing the cold plunge," he said. "I was in amazing cardiovascular shape, and I had stage 3 cancer, and I had no idea."

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The one symptom that he did experience was a change in bowel movements, which the actor chalked up to an effect of his coffee consumption.

"Before my diagnosis, I didn’t know much about colorectal cancer," van der Beek said. "I didn’t even realize the screening age [had] dropped to 45; I thought it was still 50."

He ultimately underwent a colonoscopy, which revealed that the actor had stage 3 colon cancer.

Professor Eitan Friedman, M.D., Ph.D., an oncologist and founder of The Suzanne Levy-Gertner Oncogenetics Unit at the Sheba Medical Center in Israel, confirmed that changes in bowel habits is the primary red flag that should raise the suspicion of colorectal cancer.

Others include fatigue as a result of anemia, blood in stool, weight loss, loss of appetite and abdominal discomfort, Friedman, who has not treated van der Beek, told Fox News Digital.

Dr. Erica Barnell, M.D., Ph.D., a physician-scientist at Washington University School of Medicine — and co-founder and chief medical officer at Geneoscopy — noted that van der Beek’s experience of having no "glaring" signs is common.

"Many colorectal cancers develop silently, without obvious symptoms," Barnell, who also did not treat the actor, told Fox News Digital. "By the time symptoms appear, the disease may already be advanced."

Symptoms are "especially worrisome" for those 45 and older who have at least one first-degree relative with colon cancer or other GI malignancies, and those with active inflammatory bowel disease, such as ulcerative colitis or Crohn’s disease, added Friedman, who is also an advisory board member at SpotitEarly, a startup that offers an at-home breath test to detect early-stage cancer signals.

The overall chance of an average-risk person getting colorectal cancer over a lifetime is 4% to 5%, according to Friedman.

"Colonoscopy at age 45 onwards, at five- to 10-year intervals, has been shown to lead to early detection of polyps that have the potential to become malignant, and to allow for their removal as an effective means of minimizing the risk of malignant transformation," he said. 

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Unfortunately, Barnell noted, "screening compliance in the U.S. remains below national targets, and gaps are widest in rural, low-income and minority communities."

To help close those gaps, she called for greater access to "accurate, noninvasive screening technologies," along with efforts to increase public awareness.

"Most people don’t like talking about bowel habits, but paying attention to changes can save your life," Barnell said. "Screening gives us the chance to find problems early — often before you feel sick — and that can make all the difference."

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Fox News Digital reached out to van der Beek’s representative for comment.

A man with the deadliest form of brain cancer has no signs of the disease after taking an experimental drug.

Ben Trotman was 40 when he was diagnosed in 2022 with glioblastoma, the most aggressive cancerous brain tumor. Patients typically live an average of 15 months after diagnosis, and the five-year survival rate is just 6.9%.

Trotman was referred to The National Hospital for Neurology and Neurosurgery at University College London Hospitals (UCLH), where he was treated by consultant UCLH medical oncologist Dr. Paul Mulholland, as detailed in a press release.

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As the only person enrolled in a trial that ultimately closed due to lack of patients, Trotman received a medication called ipilimumab, a targeted immunotherapy treatment.

Ipilimumab is an antibody that binds to a protein on immune cells (T cells). It keeps cancer cells from suppressing the immune system so it can then attack and kill the cancer, according to the National Cancer Institute.

Trotman also received radiation and chemotherapy. 

More than two years later, his quarterly scans show no signs of cancer.

"It is very unusual to have a clear scan with glioblastoma, especially when he didn’t have the follow-up surgery that had been planned to remove all of the tumor that was initially visible on scans," his oncologist, Mulholland, said in the release. 

"We hope that the immunotherapy and follow-up treatment Ben has had will hold his tumor at bay — and it has so far, which we are delighted to see."

Two months after receiving the ipilimumab, Trotman married his wife, Emily. In April 2025, they welcomed their daughter, Mabel.

"Getting this diagnosis was the most traumatic experience — we were grappling with the fact that Ben had gone from being apparently perfectly healthy to having months to live," Emily Trotman said in the release. 

"Had we not met Dr. Mulholland, that would have been it for us. We felt we had a lucky break in an otherwise devastating situation."

Ben Trotman added, "We obviously don’t know what the future holds, but having had the immunotherapy treatment and getting these encouraging scan results has given [us] a bit of hope."

"We are focused on rebuilding the life we thought we had lost and enjoying being parents."

Mulholland and his team have now opened another clinical trial for patients who have been newly diagnosed with glioblastoma.

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Sixteen patients will be recruited for the trial, which is sponsored by UCL. 

The treatment will be administered at the NIHR UCLH’s Clinical Research Facility and the National Hospital for Neurology and Neurosurgery, according to the press release.

The patients will receive ipilimumab before proceeding to standard treatments that may include surgery, radiotherapy and chemotherapy.

"The crucial element of this trial is that patients will have their immune system boosted by the drug before they have any other treatment, when they are fit and well enough to tolerate the immunotherapy," Mulholland said in the release.

The Win-Glio trial — nicknamed "Margaret’s Trial" — is funded by the efforts of Dame Siobhain McDonagh, sister of Margaret McDonagh, a London woman who died of glioblastoma in 2023 and was treated by Mulholland.

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Ben Trotman said he is "delighted" that the new trial is moving forward with the same immunotherapy drug he received. 

"It will give people newly diagnosed with glioblastoma some hope."

Reducing the risk of Alzheimer’s could be as simple as eating the right food.

A new study by researchers in Boston, Chicago and Washington, D.C., found that eating foods high in choline could lower the risk of developing the common dementia.

Choline is an essential micronutrient found in various foods, including poultry, dairy products (such as milk, yogurt and eggs), cruciferous vegetables like broccoli and Brussels sprouts, beans and some fish, according to the USDA.

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Dietary choline intake has been associated with a lower risk of cognitive function and reduced risk of dementia, the researchers concluded.

In the study, participants averaging 81 years of age who did not have Alzheimer's completed dietary questionnaires and underwent annual neurological exams.

After an eight-year follow-up, researchers determined that consuming about 350 milligrams of choline per day was associated with the lowest risk of clinical Alzheimer’s diagnoses in older adults.

Los Angeles-based registered dietitian nutritionist Ilana Muhlstein has also backed the impact of choline on brain health, citing a 2024 China-based study that found intake improves cognitive function, especially among women.

"This is the study that inspired me to start supplementing choline," she said. "My memory has gotten worse over the years. I first wrote it off as ‘pregnancy brain,’ then ‘mommy brain,’ but eventually realized I should do my best to help it." 

"I already sleep well, exercise regularly, play mahjong and limit my alcohol, so choline was the next obvious tool worth trying." 

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Muhlstein shared that more than 90% of the choline in eggs comes from the yolk. For those who choose to eat egg whites for dietary reasons, taking a choline supplement may be a better option.

Choline intake should be tailored to each person's individual needs, the nutritionist noted, referencing guidance from the Harvard School of Public Health.

"Premenopausal women may have lower requirements for dietary choline, because higher estrogen levels stimulate the creation of choline in the body," the university wrote.

In a separate interview with Fox News Digital, Dr. Daniel Amen, a psychiatrist, brain imaging doctor and founder of Amen Clinics in California, emphasized the importance of eating the right foods for brain health.

"Your brain uses 20% to 30% of the calories you consume," he said. "So, nutrition is critical to help your brain or hurt your brain." 

Walnuts are one of Amen’s favorite brain-healthy food options, as they contain choline as well as omega-3 fatty acids.

He also recommends including wild salmon as a dietary staple, as it's high in omega-3s and healthy protein, as well as organic blueberries and green, leafy vegetables.

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"If you had a salad every day, and you put blueberries and salmon and walnuts on it with a little lemon and olive oil, that would be a perfect brain-boosting lunch," he said.

The doctor also suggested considering certain supplements to foster better brain health, including vitamin D, omega-3 or fish oil, or a daily multi-vitamin.

For more Health articles, visit www.foxnews.com/health.

"Nearly two-thirds of the American population is low in vitamin D," he said. "And if it's low, it's a universal risk factor for every bad thing related to your brain, but also to your body, including obesity and cancer … Know and optimize your vitamin D level."

Fox News Digital reached out to the study researchers for comment.

Research developments in Alzheimer’s disease, including newly approved blood tests for early detection, have helped patients get diagnosed sooner.

With dementia on the rise among younger individuals, the spotlight is on ways to prevent or slow the disease.

Dr. Daniel Amen, a psychiatrist, brain imaging doctor and founder of Amen Clinics in California, spoke with Fox News Digital in an interview about Alzheimer’s risk and management. (See the video at the top of this article.) 

FIRST BLOOD TEST FOR ALZHEIMER'S DIAGNOSIS CLEARED BY FDA

"Alzheimer's starts in your brain decades before you have any symptoms," he said. "So, a 59-year-old woman I diagnosed with Alzheimer's disease likely had negative changes in her brain in her 20s."

He added, "It's really never too early to think about protecting your brain and your mind."

Amen, author of the book "Change Your Brain Every Day," confirmed that half of Alzheimer’s cases are preventable, according to recent findings.

This can be done through nurturing brain health and treating the 11 major risk factors that "steal your mind," he said.

To remember the factors that can help ward off Alzheimer's, Amen created the acronym "BRIGHTMINDS" as follows.

Low blood flow is the No. 1 brain imaging predictor of Alzheimer’s disease, according to the doctor.

Alcohol, marijuana, caffeine, nicotine, sedentary behavior and excess weight or obesity can all decrease blood flow, thus should be avoided.

To promote blood flow, Amen suggests "walking like you’re late," which could entail walking 30 minutes a day — alternating between three minutes of normal walking and three minutes of fast walking.

"Do that five times for 30 minutes, and it increases blood flow to your brain," he said. 

Along with retirement and aging can come a slowdown in learning and cognitive activity, leading to a higher Alzheimer’s risk, Amen said.

'I'M A NEUROLOGIST — HERE'S WHY DEMENTIA IS RISING AND HOW TO REDUCE YOUR RISK’

He encourages retirees to learn something new every day to keep the brain active and healthy.

Inflammation is a "major cause" of psychiatric issues, Amen revealed, as well as conditions like cancer, arthritis and heart disease.

Flossing is an easy way to reduce inflammation in the gums and help prevent gum disease, which is a gateway to brain disease, according to the doctor.

"Genes aren't a death sentence," Amen said. "What they should be is a wake-up call."

The doctor said everyone should take steps to discover which diseases run in the family and then follow a daily prevention program.

STROKE, DEMENTIA AND DEPRESSION SHARE THESE 17 PREVENTABLE RISK FACTORS

"I have heart disease and obesity in my family," he said. "I don't have heart disease, and I'm not overweight. Why? Because I'm on an obesity heart disease prevention program every day of my life."

Concussions and head trauma are a "major cause" of psychiatric problems, Amen described, and should be avoided.

"Don't text and drive," he warned.

Some well-known toxins like alcohol, marijuana and other drugs are known to have negative impacts on overall health.

But some not-so-obvious toxins can include lead, mold, mercury from fish, and even general anesthesia, Amen cautioned.

"You always want to support your organs in detoxification," he said. "Drink more water, as it helps flush things through your kidneys … eat more fiber for your gut, and hold the alcohol."

Amen also suggested eating brassicas, which include vegetables in the cabbage family, as they have a detoxifying effect.

The expert also highlighted the benefits of sauna use as a detox tool.

"The people who take the most saunas have the lowest incidence of Alzheimer's disease," he stated.

A healthy mental state will help support a healthier brain, experts agree.

"Stop believing every stupid thing you think," Amen advised.

Keeping your body healthy and immune from infections is key to overall health, according to Amen.

The doctor suggested optimizing vitamin D intake, which can help support the brain and immune system.

The brain specialist recommends having a hormone balance check done every year, as any imbalances can interfere with the brain and increase Alzheimer’s risk.

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER

"Diabesity," a term referring to the parallel occurrence of obesity and type 2 diabetes, can be a major threat to overall health, the doctor warned.

"You really want to care about your weight," Amen said.

Weight and diet play an important role in brain health, as Amen's research has shown that as weight increases, the size and function of the brain decreases.

"Being overweight, you automatically have 10 of the 11 risk factors, because being overweight lowers blood flow, accelerates aging, increases inflammation and changes your hormones in a negative way," he said.

"Be mindful of only loving food that loves you back."

For more Health articles, visit www.foxnews.com/health

Sleep is crucial for a high-functioning mind, as an adequate night’s slumber "washes" the brain every night, Amen noted.

Better sleep translates to improved memory, energy, blood flow and decision-making, the doctor said, and should be a priority when working to prevent Alzheimer’s. 

Research developments in Alzheimer’s disease, including newly approved blood tests for early detection, have helped patients get diagnosed sooner.

As the common dementia has been on the rise among younger individuals, the spotlight is on ways to prevent or slow the disease.

Dr. Daniel Amen, a psychiatrist, brain imaging doctor and founder of Amen Clinics in California, spoke with Fox News Digital in an interview about Alzheimer’s risk and management.

FIRST BLOOD TEST FOR ALZHEIMER'S DIAGNOSIS CLEARED BY FDA

"Alzheimer's starts in your brain decades before you have any symptoms," he said. "So, a 59-year-old woman I diagnosed with Alzheimer's disease likely had negative changes in her brain in her 20s."

"It's really never too early to think about protecting your brain and your mind."

Amen, who also authored the book "Preventing Alzheimer’s," confirmed that half of Alzheimer’s cases are preventable, according to recent findings.

This can be done through nurturing brain health and treating the 11 major risk factors that "steal your mind," he said.

To remember the factors that can help ward off Alzheimer's, Amen created the acronym "BRIGHTMINDS" as follows.

Low blood flow is the No. 1 brain imaging predictor of Alzheimer’s disease, according to the doctor.

Alcohol, marijuana, caffeine, nicotine, sedentary behavior and excess weight or obesity can all decrease blood flow, thus should be avoided.

To promote blood flow, Amen suggests "walking like you’re late," which could entail walking 30 minutes a day — alternating between three minutes of normal walking and three minutes of fast walking.

"Do that five times for 30 minutes, and it increases blood flow to your brain," he said. 

Along with retirement and aging can come a slowdown in learning and cognitive activity, leading to a higher Alzheimer’s risk, Amen said.

'I'M A NEUROLOGIST — HERE'S WHY DEMENTIA IS RISING AND HOW TO REDUCE YOUR RISK’

He encourages retirees to learn something new every day to keep the brain active and healthy.

Inflammation is a "major cause" of psychiatric issues, Amen revealed, as well as conditions like cancer, arthritis and heart disease.

Flossing is an easy way to reduce inflammation in the gums and help prevent gum disease, which is a gateway to brain disease, according to the doctor.

"Genes aren't a death sentence," Amen said. "What they should be is a wake-up call."

The doctor said everyone should take steps to discover which diseases run in the family and then follow a daily prevention program.

STROKE, DEMENTIA AND DEPRESSION SHARE THESE 17 PREVENTABLE RISK FACTORS

"I have heart disease and obesity in my family," he said. "I don't have heart disease, and I'm not overweight. Why? Because I'm on an obesity heart disease prevention program every day of my life."

Concussions and head trauma are a "major cause" of psychiatric problems, Amen described, and should be avoided.

"Don't text and drive," he warned.

Some well-known toxins like alcohol, marijuana and other drugs are known to have negative impacts on overall health.

But some not-so-obvious toxins can include lead, mold, mercury from fish, and even general anesthesia, Amen cautioned.

"You always want to support your organs in detoxification," he said. "Drink more water, as it helps flush things through your kidneys … eat more fiber for your gut, and hold the alcohol."

Amen also suggested eating brassicas, which include vegetables in the cabbage family, as they have a detoxifying effect.

The expert also highlighted the benefits of sauna use as a detox tool.

"The people who take the most saunas have the lowest incidence of Alzheimer's disease," he stated.

A healthy mental state will help support a healthier brain, experts agree.

"Stop believing every stupid thing you think," Amen advised.

Keeping your body healthy and immune from infections is key to overall health, according to Amen.

The doctor suggested optimizing vitamin D intake, which can help support the brain and immune system.

The brain specialist recommends having a hormone balance check done every year, as any imbalances can interfere with the brain and increase Alzheimer’s risk.

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER

"Diabesity," a term referring to the parallel occurrence of obesity and type 2 diabetes, can be a major threat to overall health, the doctor warned.

"You really want to care about your weight," Amen said.

Weight and diet play an important role in brain health, as Amen's research has shown that as weight increases, the size and function of the brain decreases.

"Being overweight, you automatically have 10 of the 11 risk factors, because being overweight lowers blood flow, accelerates aging, increases inflammation and changes your hormones in a negative way," he said.

"Be mindful of only loving food that loves you back."

For more Health articles, visit www.foxnews.com/health

Sleep is crucial for a high-functioning mind, as an adequate night’s slumber "washes" the brain every night, Amen noted.

Better sleep translates to improved memory, energy, blood flow and decision-making, the doctor said, and should be a priority when working to prevent Alzheimer’s. 

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A popular diet trend may have its origins in the Bible.

Intermittent fasting, a pattern of eating based on time limits, is intended to assist with weight loss and other health benefits, according to Mayo Clinic.

There are several types of intermittent fasting, but they all follow the same concept of alternating between fasting and eating — a practice that is often mentioned in biblical scripture.

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With a time-restricted approach to intermittent fasting, the dieter only eats during a certain window. For example, with the 16/8 method, the person fasts for 16 hours and then can eat within an eight-hour span, between 10 a.m. and 6 p.m. 

Other versions involve fasting for a full 24 hours once or twice per week — or only consuming limited calories on fasting days.

"The idea is that intermittent fasting causes the body’s cells to change how they work," states Mayo Clinic's website. "Timed eating may push cells to focus on repair, energy use and balancing body-wide functions."

Religious fasting is practiced in many faiths, including Christianity, Islam, Buddhism and Jainism, as well as Hinduism, Judaism and Taoism, research shows.

Around 21% of Americans report that they fast for certain periods of time for religious reasons, according to a 2024 survey from the Pew Research Center.

Some view intermittent fasting as a modern-day form of biblical fasting. 

Fasting is mentioned in the Bible as a way to be closer to God. 

In Matthew 6:16-18, for example, Jesus instructs his followers on how to fast.

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"When you fast, do not look somber as the hypocrites do, for they disfigure their faces to show others they are fasting. Truly I tell you, they have received their reward in full. Specifically, when you fast, put oil on your head and wash your face. So, that it will not be obvious to others that you are fasting, but only to your Father, who is unseen; and your Father, who sees what is done in secret, will reward you."

Fasting is also mentioned in Joel 2:12, when the Lord declares, "Yet even now, return to me with all your heart, with fasting, with weeping, and with mourning."

Various religions teach that fasting improves self-control, increases spiritual awareness and even fosters empathy for the less fortunate, according to Pew.

While religious fasting is for spiritual purposes, intermittent fasting may also have physical and mental benefits that go beyond the primary goal of weight loss.

Studies have shown that the practice may have positive impacts on blood pressure, cardiovascular health, cognitive function and other health factors — but the long-term effects aren’t as clear.

"When changes occur with this metabolic switch, it affects the body and brain," Johns Hopkins neuroscientist Mark Mattson, who has studied intermittent fasting for 25 years, states on the hospital's website.

Mattson's research has confirmed multiple health benefits associated with fasting, including greater longevity, a leaner physique and a sharper mind.

"Many things happen during intermittent fasting that can protect organs against chronic diseases like type 2 diabetes, heart disease, age-related neurodegenerative disorders, even inflammatory bowel disease and many cancers," he said.

However, Fox News Digital previously reported on a 2024 study that linked time-restricted eating to a significantly higher risk of cardiovascular death.

"Intermittent fasting is not appropriate for people with a history of disordered eating or active eating disorders, those with hypoglycemia or type 1 diabetes on insulin, children under 18, pregnant or breastfeeding women, and more," New Jersey-based registered dietitian Lauren Harris-Pincus told Fox News Digital at the time.

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Ohio-based cardiologist Dr. Lou Vadlamani was not involved in the study, but told Fox News Digital that it would be "a stretch" to conclusively say that fasting has a direct impact on heart attack risk.

"It certainly raises a lot of questions and supports the need for a more comprehensive study, since intermittent fasting has become so common," he said.

For more Health articles, visit www.foxnews.com/health

As with every major lifestyle change, it’s important to check with a doctor before starting intermittent fasting, experts advise.

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