Health Archives - Barbados Today
Experts warn bird flu virus changing rapidly in largest ever outbreak
(AFP) — The virus causing record cases of avian influenza in birds across the world is changing rapidly, experts have warned, as calls increase for countries to vaccinate their poultry.
While emphasising that the risk to humans remains low, the experts who spoke to AFP said that the surging number of bird flu cases in mammals was a cause for concern.
Since first emerging in 1996, the H5N1 avian influenza virus had previously been confined to mostly seasonal outbreaks.
But “something happened” in mid-2021 that made the group of viruses much more infectious, according to Richard Webby, the head of a World Health Organization collaborating centre studying influenza in animals.
Since then, outbreaks have lasted all year round, spreading to new areas and leading to mass deaths among wild birds and tens of millions of poultry being culled.
Webby, who is a researcher at St Jude Children’s Research Hospital in the US city of Memphis, told AFP it was “absolutely” the largest outbreak of avian influenza the world had seen.
He led research, published this week in the journal Nature Communications, showing how the virus rapidly evolved as it spread from Europe into North America.
The study said the virus increased in virulence, which means it causes more dangerous disease, when in arrived in North America.
The researchers also infected a ferret with one of the new strains of bird flu.
The found an unexpectedly “huge” amount of the virus in its brain, Webby said, indicating it had caused more serious disease than previous strains.
Emphasising that the risk in humans was still low, he said that “this virus is not being static, it’s changing”.
“That does increase the potential that even just by chance” the virus could “pick up genetic traits that allow it to be more of a human virus,” he said.
In rare cases, humans have contracted the sometimes deadly virus, usually after coming in close contact with infected birds.
– ‘Scares us’ –
The virus has also been detected in a soaring number of mammals, which Webby described as a “really, really troubling sign”.
Last week Chile said that nearly 9,000 sea lions, penguins, otters, porpoises and dolphins have died from bird flu along its north coast since the start of the year.
Most mammals are believed to have contracted the virus by eating an infected bird.
But Webby said that what “scares us the most” are indications from a Spanish mink farm, or among sea lions off South America, that the virus could be transmitting between mammals.
Ian Brown, virology head at the UK’s Animal and Plant Health Agency, said there has not yet been “clear evidence that this virus is easily sustaining in mammals.”
While the virus is changing to become “more efficient and more effective in birds,” it remains “unadapted to humans,” Brown told AFP.
Avian viruses bind to different receptors on the host cell than human viruses, Webby said.
It would take “two or three minor changes in one protein of the viruses” to become more adapted to humans, he said.
“That is what we’re really looking out for.”
– Vaccinating poultry –
One way to bring down the number of total bird flu cases, and therefore reduce the risk to humans, would be for countries to vaccinate their poultry, Webby said.
A few nations including China, Egypt and Vietnam have already held vaccination campaigns for poultry.
But many other countries have been reluctant due to import restrictions in some areas, and fears vaccinated birds that nonetheless get infected could slip through the net.
In April, the United States started testing several vaccine candidates for potential use on birds.
France recently said it hopes to start vaccinating poultry as early as autumn this year.
Christine Middlemiss, the UK’s chief veterinary officer, said that vaccinating poultry was not “a silver bullet because the virus changes constantly”.
But traditionally reluctant countries should consider vaccinating poultry more often, Middlemiss told AFP at an event at the UK’s embassy in Paris last week.
World Organisation for Animal Health director general Monique Eloit said that the issue of vaccinating poultry should be “on the table”.
After all, “everyone now knows that a pandemic is not just a fantasy — it could be a reality,” she added.
The post Experts warn bird flu virus changing rapidly in largest ever outbreak appeared first on Barbados Today.
1 year 10 months ago
A Slider, Health, World
Health Archives - Barbados Today
Drug Service Director explains supply challenges
Director of the Barbados Drug Service (BDS), Maryam Karga-Hinds, has provided an update regarding some of the drugs which have been affected by recent supply challenges.
Karga-Hinds stated that with respect to the steroid Prednisolone, which is used to treat several conditions, including asthma and Long-COVID, there have been a number of delays in shipment from the contracted supplier, causing the need for a second supplier to be contracted. The shipment of this drug is now scheduled to arrive in two to three weeks. The Drug Service is also currently searching for stock that is readily available.
Additionally, she said there has been an issue with the drug Androcur (Cyproterone), which is used to treat prostate cancer, where the manufacturers have been experiencing shortages with obtaining the raw materials. This has resulted in rationing, leading to buyers not receiving the amounts ordered from the suppliers.
Karga-Hinds noted that the Barbados Drug Service contracted a generic supplier to fill the need, but the product has to be manufactured and the generic is not expected to be ready before the end of June. There is a limited supply on island.
She further stated that in the past few months, there have been significant challenges with Epilim which is used to treat epilepsy. She pointed out that this is not a product which can be easily interchanged.
The local agent has indicated that small quantities of the 300 mg and 500 mg have been shipped, however, the 300 mg strength is scheduled for discontinuation by year-end. The Drug Service is actively looking for a replacement product.
The Director indicated that the supplier of Ibuprofen, an anti-inflammatory drug, has advised that a limited supply is available on island and should be ready for sale shortly.
She also shared that a shipment of Ventolin liquid, which is used to treat asthma, is on its way to the island adding that, recently, a quantity of this drug expired and had to be destroyed because of the lack of demand. Ventolin tablet is no longer on the Barbados national drug formulary.
Karga-Hinds expressed regret over any challenges experienced by the public as it relates to availability of medication. She stated that the management and staff of the Barbados Drug Service will continue to do all in their capacity to re-establish supply of the items that are out of stock.
The Ministry of Health and Wellness is committed to updating the public with relevant information as it becomes available.
The post Drug Service Director explains supply challenges appeared first on Barbados Today.
1 year 10 months ago
A Slider, Health, Local News
Call to resume use of face masks due to Covid-19 is considered exaggerated
The Dominican Society of Pneumology and Thoracic Surgery recently asked the population to resume using masks due to the increase in positive cases of Covid-19 and other respiratory diseases.
This call was considered by the medical advisor of the Executive Power, Jorge Marte Baez, as exaggerated because the data available to the authorities do not represent a situation that is cause for alarm.
“There is no doubt that there is an increase in cases, but this is not the first time that there are increases in passing cases in the last two months and that increase lasts for days and fades away. We cannot predict that this time it will be the same, but what we can know is that the number of cases requiring hospital admission remains the same,” said Marte Baez to Diario Libre.
The pneumologist explains that the slight increases in the infections could be due to the sub-variant of Omicron, called XBB.1.5, about which the World Health Organization (WHO) has alerted, which causes mild symptoms and which does not put the life of the patients at risk.
“It is not that we are not concerned, but it seems to me that some people and some entities have perhaps exaggerated this danger a little and are reflected above all in that, in a call to resume the use of masks,” said the doctor when affirming that the State health organizations are alert to any situation that requires a change in the recommendations that up to now have been given to the population.
The also medical director of the Centers for Diagnostic and Advanced Medicine and Medical Conferences and Telemedicine (Cedimat) said that a sign of the low danger so far of the new Covid-19 infections is that, in this center, one of the ones that have treated more patients with this disease, exceeding 26,000 in the last month and a half, only two patients have been admitted. The main reason has been that they have chronic conditions.
Pneumologists ask to resume using masks due to the increase of Covid-19 and other respiratory diseases.
HEALTH
Pneumologists ask to resume using masks due to the increase of Covid-19 and other respiratory diseases.
The Dominican Society of Pneumology and Thoracic Surgery bases its call for using masks on the reports issued by pneumologists from this guild, who warn of an increase in Covid-19 infections.
“In recent weeks, the pulmonologists of the society at the national level, we have observed with concern the increase in the number of patients in consultations who are testing positive to Covid 19 influenza, pneumonia and other viral respiratory processes,” says the entity’s statement.
“It is time for our older adults, pregnant women and people suffering from diseases to start protecting themselves again,” said the pulmonologists’ society when reminding that even though the WHO declared the end of the health emergency due to Covid-19, it does not mean that it has ceased to be a threat to world health.
Public Health on alert
The Minister of Public Health, Daniel Rivera, called on the population not to be alarmed by the alert issued by the Dominican Society of Pneumology and Thoracic Surgery about an increase in positive cases of Covid-19 in the country and assured that the situation is under control.
Rivera warned that Covid-19 is already an endemic disease and that permanent and timely monitoring is maintained by the Epidemiological Surveillance System of this institution that, allows the identification of health events and the taking of appropriate and effective decisions.
“It is not necessary to be alarmed; the Ministry has a permanent monitoring of the disease and has always offered the precise details and in case the data varies, the information will also be offered in a transparent manner, and if it is necessary to retake some measures, it would also be officially informed,” said Rivera when asking the citizenship not to be carried of rumors in networks.
Divided population
Citizens consulted by this media about the return of the use of masks reacted in favor and against this recommendation. Still, they indicated that if ordered, they would put them on again.
In this respect, Dionicio Jiménez says he is not currently using them because he does not consider it necessary. However, he is vigilant if the possibility of doing it again arises.
Others like Felix Caset say that they have never stopped using masks and will continue to use them indefinitely regardless of what the authorities say about it.
Meanwhile, owners of establishments with closed spaces said they would follow the rules established by the authorities in their businesses to help prevent contagion, if necessary.
While in the streets, some people are seen walking with their masks on.
The mandatory use of masks in workplaces and different public spaces was established by resolution 000016 of the Ministry of Public Health on June 22, 2020, and lifted on February 16, 2022; however, its optional use was recommended at that time.
1 year 10 months ago
Health
Border alert after possible cholera outbreak in Juana Mendez, Haiti
Dominican authorities in the northern part of the country have shown concern after a possible cholera outbreak was reported in the community of Juana Mendez. This town borders the province of Dajabon.
With thousands of Haitians entering the country on Mondays and Fridays to participate in the Dajabón border market, Mayor Santiago Riveron alerted the population and, in the next few hours, will meet with Public Health authorities to prevent possible infected people from entering the trade fair.
So far, the Haitian authorities have not officially announced a cholera outbreak, and according to the information received, they have not taken the necessary sanitary measures.
Public Health authorities will meet to discuss the issue EXTERNAL SOURCE
WHAT IS CHOLERA?
Cholera is an acute diarrheal infection caused by ingesting contaminated food or water. People with reduced immunity, such as malnourished children, are at a higher risk of dying if infected.
1 year 10 months ago
Health
Many cases of hypertension and overweight
The province of Hermanas Mirabal has high blood pressure indicators of 45.5% in its adult population, 47% overweight, and 19% with high glycemia levels. The data correspond to the study of Overweight, Obesity, Hypertension, and Diabetes (Sodhip) by the Ministry of Health experts.
For this reason, the Ministry took this weekend to this demarcation of the -Ruta de la Salud- (Health Route).
The participating doctors measured glycosylated hemoglobin to determine blood sugar levels more accurately, thanks to the advanced technology glucometers they obtained.
The day
This was the twenty-third version of the -Health Route: change your lifestyle- where municipalities benefited from more than 35 health services and used advanced technology glucometers that contribute with greater precision to detect blood sugar levels and maintain control in people with diabetes.
Detection
The aim is to identify the major chronic diseases, such as hypertension, diabetes, and obesity, to apply preventive measures comprehensively and thus guarantee people access to quality, free, and humanized health services.
Dr. Daniel Rivera insisted that the incidence of diseases can be reversed with healthy lifestyles that include healthy eating, exercise, and reducing salt, saturated fats, alcoholic beverages, and sugar.
Health education
Dr. Rivera said one of the elements of interest in the Ruta de la Salud is that it can guide thousands of people and serve as multipliers in their communities.
Likewise, he said that diabetes and hypertension can be detected since many people have these ailments but are unaware of their condition. “We need 10,000 steps a day to reduce weight because this leads to hypertension, and here in Salcedo, we have the ideal agricultural production for a healthy diet,” said the doctor. However, he insisted that he wants people to be healthy and that it is unnecessary to go to health centers because there is enough health.
He said that digital glucose meters are high-tech devices that measure glycosylated hemoglobin in diabetic patients or for those who wish to monitor their glucose levels. They are part of a significant donation from the Central American Bank for Economic Integration through the Strengthening Project.
1 year 10 months ago
Health
Medical News, Health News Latest, Medical News Today - Medical Dialogues |
Eye drops slow nearsightedness progression in kids, study finds
The results of a new clinical trial suggest that the first drug therapy to slow the progression of nearsightedness in kids could be on the horizon.
The three-year study found that a daily drop in each eye of a low dose of atropine, a drug used to dilate pupils, was better than a placebo at limiting eyeglass prescription changes and inhibiting elongation of the eye in nearsighted children aged 6 to 10.
That elongation leads to myopia, or nearsightedness, which starts in young kids and continues to get worse into the teen years before leveling off in most people. In addition to requiring life-long vision correction, nearsightedness increases the risk for retinal detachment, macular degeneration, cataracts and glaucoma later in life – and most corrective lenses don’t do anything to stop myopia progression.
“The idea of keeping eyeballs smaller isn’t just so people’s glasses are thinner-it would also be so that in their 70s they don’t suffer visual impairment,” said lead study author Karla Zadnik, professor and dean of the College of Optometry at The Ohio State University.
“This is exciting work for the myopia research community, which I’ve been part of for 35 years. We’ve talked about treatment and control for decades,” she said. “And it’s exciting to think that there could be options in the future for millions of children we know are going to be myopic.”
The results of the CHAMP (Childhood Atropine for Myopia Progression) trial are published today (June 1, 2023) in JAMA Ophthalmology.
About one in three adults worldwide is nearsighted, and the global prevalence of myopia is predicted to increase to 50% by 2050. Though one federally approved contact lens can slow progression of nearsightedness, no pharmaceutical products are approved in the United States or Europe to treat myopia.
Animal studies years ago hinted at atropine’s ability to slow the growth of the eye, but the full-strength drug’s interference with near vision and concerns about pupil dilation hindered early considerations of its potential as a human therapy for myopia. More recent research has suggested a low dose of atropine might be the ticket.
This new double-masked, randomized phase 3 trial assessed the safety and effectiveness of two low-dose solutions, with atropine concentrations of either .01% or .02%, versus placebo. Treatment for each of the 489 children aged 6 to 10 assessed for the drug’s effectiveness consisted of one daily drop per eye at bedtime, which minimized the disruption of any blurring effects atropine might have on vision.
Researchers were a bit surprised to find that the most significant improvements at all time points compared to placebo resulted from the solution containing .01% of atropine. Though the .02% atropine formulation was also better at slowing progression of myopia than placebo, the results were less consistent.
“The .01% story is clearer and more obvious in terms of significantly slowing both the growth of the eye as well as then resulting in a lower glasses prescription,” Zadnik said.
Including a measure of the eye’s growth was a key component of the study because “the field is actually moving toward axial elongation being as important as, or more important than, the glasses prescription in terms of the most meaningful outcome,” she said. “If we’re trying to slow eye growth to prevent bad outcomes for people in their 80s, measuring the eye growth directly is really important.”
The drugs’ safety was assessed in a larger sample of 573 participants that also included children as young as 3 and up to age 16. Both low-dose formulations were safe and well tolerated. The most common side effects were sensitivity to light, allergic conjunctivitis, eye irritation, dilated pupils and blurred vision, although reports of these side effects were few.
The CHAMP trial was the first study of low-dose atropine to include placebo controls for three years and to involve a large, diverse population recruited from 26 clinical sites in North America and five countries in Europe. In a second section of the trial, researchers are evaluating how the eyes respond when the treatment is over.
The experimental drug is made without preservatives and, if federally approved as a therapy, would be distributed in single-use packaging for convenience and to prevent contamination. Off-label low-dose atropine that can currently be obtained at compounding pharmacies may contain preservatives that can lead to dry eye and corneal irritation, researchers noted.
Reference:
Zadnik K, Schulman E, Flitcroft I, et al. Efficacy and Safety of 0.01% and 0.02% Atropine for the Treatment of Pediatric Myopia Progression Over 3 Years: A Randomized Clinical Trial. JAMA Ophthalmol. Published online June 01, 2023. doi:10.1001/jamaophthalmol.2023.2097.
1 year 10 months ago
Ophthalmology,Pediatrics and Neonatology,Ophthalmology News,Pediatrics and Neonatology News,Top Medical News
Officials on lookout for signs of bird flu in wild and domestic flocks - Milwaukee Journal Sentinel
- Officials on lookout for signs of bird flu in wild and domestic flocks Milwaukee Journal Sentinel
- Experts warn of rapidly spreading avian virus, risk of next human pandemic | Mint Mint
- Bird flu outbreak more virulent than ever recorded - study The Jerusalem Post
- Experts warn bird flu virus changing rapidly in largest ever outbreak Jamaica Observer
- Genetic changes power H5N1 virus spread, severity in animals The Hindu
- View Full Coverage on Google News
1 year 10 months ago
The mind: a powerful tool
PEOPLE with mental health ailments are oftentimes stigmatised, classed poorly, and made to feel as if they don't hold a place in society.
Dr Rochelle Allison Bailey says it is not a situation where one can tell an individual who suffers from depression or anxiety, to name a few, to just 'snap out of it.'
PEOPLE with mental health ailments are oftentimes stigmatised, classed poorly, and made to feel as if they don't hold a place in society.
Dr Rochelle Allison Bailey says it is not a situation where one can tell an individual who suffers from depression or anxiety, to name a few, to just 'snap out of it.'
"The mind is a powerful tool. The World Health Organization [WHO] estimates that 20 per cent of the Jamaican population suffers from some form of mental health issue. We all feel anxious or downtrodden from time-to-time, but only a selective few develop a mental illness," Bailey told the Jamaica Observer.
Bailey said a mental illness is a mental health condition that gets in the way of thinking, relating to others, and day-to-day function.
"It is a physical illness of the brain that causes disturbances in thinking, behaviour, energy or emotion that makes it difficult to cope with the ordinary demands of life. The 2017 Global Burden of Disease database shows that depression and anxiety disorders are among the most common mental health concerns facing the population of Jamaica. Around three per cent of Jamaicans have a depressive disorder and 4.1 per cent have an anxiety disorder," she said.
Bailey said women are at a 'disproportionate" risk for both disorders, as 3.7 per cent have depression, and 4.3 per cent have anxiety, compared to just 2.3 per cent of men for each disorder.
"The mind has the ability to break you or mend you, to bring you peace or to allow your thoughts to roam a million miles per hour. Sometimes we simply have no control over the thoughts that flood our minds. Oftentimes it can become so overwhelming, distressing, depressing, you reach to a point where you begin to ask 'why me?'
"You are called psychotic, insane, mad man or mad woman; you are made to feel as if you too don't matter all because your mind simply has a mind of its own."
Bailey zoomed in on psychosis, explaining that it is a mental health condition that manifests as hallucinations, erratic social behaviour, and delusions – all of which may occur during psychotic episodes when an individual's perception of reality is disrupted.
She said disorders such as schizophrenia, bipolar disorder, and severe depression or anxiety can cause psychosis.
"Substance abuse or general medical conditions such as Alzheimer's disease can also trigger psychotic episodes. The incidence of psychosis in Jamaica has been estimated at 2.09 per 10,000 people, and psychosis and schizophrenia together account for 80 per cent of mental illness related public clinic visits nationwide," Bailey told Your Health Your Wealth, noting that most new cases of anxiety disorders appear in Jamaicans in the 20-34 and 35-59 age groups.
"More than 18 per cent of adults each year struggle with some type of anxiety disorder, including post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (panic attacks), generalised anxiety disorder and specific phobias."
Bailey added that in Jamaica, psychosis was responsible for 106,674 visits to public health clinics for mental illness in 2016, accounting for more than 80 per cent of mental illness related public clinic visits nationwide.
"Only half of those affected receive treatment, often because of the stigma attached to mental health. Untreated, mental illness can contribute to higher medical expenses, poorer performance at school and work, fewer employment opportunities and increased risk of suicide," she told Your Health Your Wealth.
"Studies show that stigma against mental illness is still powerful, largely due to media stereotypes and lack of education and that people tend to attach negative stigmas to mental health conditions at a far higher rate than to other diseases and disabilities, such as cancer, diabetes or heart disease."
Bailey highlighted common symptoms associated with mental illness:
• feeling down for a while
• extreme swings in mood
• withdrawing from family, friends, or activities
• low energy or problems sleeping
• often feeling angry, hostile, or violent
• feeling paranoid, hearing voices, or having hallucinations
• often thinking about death or suicide.
1 year 10 months ago
Effects of heat on the body
We
have been experiencing some really hot days in Jamaica, and the cry on many lips is that it is not yet summer!
We
have been experiencing some really hot days in Jamaica, and the cry on many lips is that it is not yet summer!
The healthy human body maintains its internal temperature at around 37°C. Variations, usually of less than 1°C, occur with the time of the day, level of physical activity or emotional state. A change of body temperature of more than 1°C occurs only during illness or when environmental conditions are more than the body's ability to cope with extreme heat.
As the environment "warms-up", the body tends to do the same. The body's internal "thermostat" maintains a constant inner body temperature by pumping more blood to the skin and by increasing sweat production. By doing so, the body increases the rate of heat loss to balance the heat burden. In a very hot environment, the rate of "heat gain" is more than the rate of "heat loss" and the body temperature begins to rise. A rise in the body temperature results in heat illnesses, which can have serious effects on the body.
Evaporation of sweat from the skin cools the body.
What are the effects of heat on the body?
When the air temperature or humidity rises above the range for comfort, problems can occur.
As the temperature increases, persons may experience:
• Increased irritability
• Loss of concentration and ability to do mental tasks
• Loss of ability to do skilled tasks or heavy work
In moderately hot environments, the body "goes to work" to get rid of excess heat so it can maintain its normal body temperature. The heart rate increases to pump more blood through outer body parts and skin so that excess heat is lost to the environment, and sweating occurs. These changes place additional demands on the body. Changes in blood flow and excessive sweating reduce a person's ability to do physical and mental work. Manual work creates additional metabolic heat and adds to the body heat burden.
The risk of heat-related illness varies from person to person. A person's general health influences how well he/she adapts to heat (and cold).
Persons who are overweight or obese often have trouble in hot environments as the body has difficulty maintaining good heat balance. Age, poor general health, and a low level of physical fitness can also make people more susceptible to feeling the extremes of heat.
Medical conditions such as heart disease, high blood pressure, respiratory disease and uncontrolled diabetes may contribute to challenges of increased heat and individuals affected with these conditions need to take special precautions. Additionally, those individuals with skin diseases and rashes may be more susceptible to heat. Substances — prescription or otherwise — can also have an impact on how people react to heat.
What are the illnesses caused by heat exposure?
1. Heat oedema is swelling which generally occurs among people who are not acclimatised to working in hot conditions. Swelling is often most noticeable in the ankles.
2. A heat rash is a cluster of small itchy, pimple-looking red blisters that appear on the skin – usually on the neck, groin, chest or in the elbow creases. In most cases heat rash will disappear when the affected person returns to a cooler environment.
WHAT TO DO
• Stay in a cool, dry place.
• Keep the rash dry.
• Use powder to soothe the rash.
3. Sunburns are caused by damage to the skin by ultraviolet rays. The skin appears red, warm, and tender and occasionally itchy. The skin will begin to flake and peel after a few days.
WHAT TO DO
• Stay out of the sun until the sunburn heals.
• Put cool cloths on sunburned areas or take a cool bath to help relieve the pain.
• Put moisturising lotion on sunburned areas.
• Do not break blisters.
• Drink extra water.
4. Heat cramps are sharp pains in the muscles that may occur alone or combined with one of the other illnesses caused by heat. These cramps occur during or after intense exercise and sweating in high heat. Sweating depletes the levels of salt and water in the body. The low salt levels in the muscles cause painful cramps. Inadequate fluid intake often contributes to this problem.
WHAT TO DO
• Stop physical activity and move to a cool place.
• Drink water or a sports drink.
• Wait for cramps to go away before engaging in any more physical activity.
Urgent medical attention is needed if:
• Cramps last longer than one hour
• Affected person is on low-sodium diet or has a heart condition
5. Heat exhaustion is caused by loss of body water and salt through excessive sweating. It is most likely to affect the elderly, people with high blood pressure and those who work in hot environments.
Symptoms of heat exhaustion may start suddenly, and include: nausea , irritability, headache, dizziness, fatigue, thirst, heavy sweating, decreased urine output, and elevated body temperature
WHAT TO DO
• Get medical aid.
• Move to a cooler, shaded location.
• Remove as many clothes as possible (including socks and shoes).
• Apply cool, wet cloths or ice to head, face, or neck. Spray the body with cool water.
• Drink water, clear juice, or a sports drink.
Heat exhaustion can lead to heat stroke if left untreated.
6. Heat syncope is heat-induced dizziness and fainting that usually occurs when someone stands for too long or gets up suddenly after sitting or lying down. This is caused by temporarily insufficient flow of blood to the brain. It can also be caused by vigorous physical activity for two or more hours before fainting happens. It is caused by the loss of body fluids through sweating, and by lowered blood pressure due to pooling of blood in the legs. Heat syncope occurs mostly among unacclimatised people. Recovery is rapid after resting in a cool area.
7. Heat stroke is the most serious type of heat illness and is a medical emergency.
• Symptoms of heat stroke include hot, dry skin or profuse sweating, very high body temperature, confusion, loss of consciousness and seizures.
First aid for heat stroke includes:
• Get the person to hospital immediately.
• Stay with the person until help arrives.
• Move him/her to a cooler, shaded location.
• Remove as many items of clothes as possible (including socks and shoes).
• Wet the person's skin and clothing with cool water.
• Apply cold, wet cloths or ice to head, face, neck, armpits, and groin.
• Do not try to force the person to drink liquids.
Delayed treatment may result in death.
Dr Jacqueline E Campbell is a family physician and radio show host. She is the author of the book A patient's guide to the treatment of diabetes mellitus. Email: drjcampbell14@yahoo.com IG: dr.jcampbell
1 year 10 months ago
Tips to prevent dental cavities in children
MAINTAINING good oral health is crucial for our overall well-being, and dental cavities are among the most common oral health issues people face. Dental cavities or tooth decay can have significant consequences if left untreated.
Dental cavities are caused from a combination of factors, including bacteria in the mouth, lots of sugary and starchy foods, and poor oral (or mouth) hygiene. When foods containing carbohydrates such as candy, cookies, soda, milk, cake, fruit juices, and bread are left behind on the teeth, the bacteria that normally live in your mouth interacts with these foods to make an acid. The bacteria plus the food, the acid and saliva combine to form plaque which gets stuck on the teeth. Over time, the acids can eventually cause the enamel (the outer layer of your tooth) to weaken and erode, causing cavities. Other factors that can contribute to cavity formation are inadequate fluoride exposure and conditions affecting saliva production.
If left untreated, dental cavities can lead to serious health conditions. When cavities worsen, they can reach deep into the tooth causing pain, teeth sensitivity and tooth loss. Not only do cavities look unpleasant, but they can also cause bad breath. Cavities can also lead to abscess formation in the mouth, and damage to the bones of your jaw.
The bacteria in the mouth may travel from the mouth, enter the blood stream and cause an infection in other parts of the body.
Dental cavities can hinder medical procedures, especially surgeries. If cavities are present, there is an increased risk of complications like infections in the heart and blood stream.
In fact, if your child has a heart condition which requires a cardiac procedure or surgery, we cannot perform the procedure unless all dental cavities are sorted. I have seen many children waiting on cardiac procedures because they have dental cavities. There have been cases of young children with underlying heart conditions ending up in the ICU (Intensive Care Unit), needing to be attached to a machine to help them breathe because of complications from dental cavities.
Dental cavities increase the risk of developing infective endocarditis, which is a serious infection affecting the lining of the heart, sometimes causing small growths inside the heart. If your child develops this condition, they will have to be admitted and treated in the hospital with antibiotics given in their vein for six weeks! They may even need surgery to remove the growths inside the heart. Children with underlying heart conditions may need to take antibiotics before dental procedures to help prevent this heart infection.
So, parents and guardians, take care of your children's teeth with these tips:
- For young babies, clean baby's gums with a clean wet rag. This introduces them to teeth brushing in their near future.
- Start brushing teeth once baby's first tooth erupts using a soft, small toothbrush
- Use non-fluoride toothpaste to brush baby's teeth (they can't spit out the toothpaste; fluoride toothpaste shouldn't be swallowed)
- For children younger than three, use a tiny amount of fluoride toothpaste.
- Once they understand how to spit out the toothpaste and won't swallow, use a pea sized amount
- Brush teeth for 2 minutes, making sure to clean all teeth and surfaces including gums
(I know they may be challenging, but they'll get used to it eventually. You can make it fun by singing a tooth brushing song, and allowing them to "help" brush their teeth. There are also electrical toothbrushes that have a 2 minute timer)
- Brush teeth twice a day
- Floss teeth regularly after age two
- Brush the tongue as well, or get a tongue scraper
- After brushing teeth before bed, nothing to eat or drink except water- including babies who have a bottle at bedtime
- Supervise children brushing teeth until about age eight
- Limit sugary snacks and drinks!! Ensure children eat a well-balanced diet
-First visit to the dentist should be once a tooth erupts.
What can you look for to check if your child is developing or has tooth decay?
The teeth may start to develop white spots or brownish areas. As the cavity worsens, the brown colour becomes darker. Your child may complain of teeth sensitivity to certain foods like sweets, or can't tolerate hot or cold foods, pain in the mouth or the jaw, or no symptoms at all.
If the dentist suspects dental cavities, they will do X-rays of the affected tooth to determine how to treat the cavity. Cavities can be treated with fillings, or they need to be extracted (or pulled out).
Dr Tal's Tidbit
Dental cavities are a common and preventable health condition and may result in serious complications if left untreated. Prevention starts with good dental hygiene, and early detection and treatment to prevent further damage. A well-balanced diet including limiting sugary and starchy food can help to prevent tooth decay.
Dr Taleya Girvan has over a decade's experience treating children at the Bustamante Hospital for Children, working in the Accident and Emergency Department and Paediatric Cardiology Department. Her goal is to use the knowledge she has gained to improve the lives of patients by increasing knowledge about the health-care system in Jamaica. Dr Tal's Tidbits is a series in which she speaks to patients and caregivers, providing practical advice that will improve health care for the general population. Email: dr.talstidbits@gmail.com IG @dr.tals_tidbits
1 year 10 months ago
A new way to treat an old problem
THE most common irregular heart rhythm — atrial fibrillation (A. fib) — is increasing in prevalence from age 50-60 and affecting one in four adults by the time they reach 80 years old.
This irregular heart rhythm occurs when the upper chambers of the heart (the atrium), instead of contracting as one unit, vibrates with multiple segments doing their own contraction. A. fib can cause a number of problems.
One problem is an irregular heartbeat akin to a child sitting behind a set of drums — unpredictable and with no set timing. It can cause the heartbeat to vary in speed, between slow and very fast (palpitations). In some cases this tachycardia (heart rate over 100 beats per minute) is so fast that it prevents the heart from filling properly. This reduces the amount of blood that leaves the heart and can cause hypoperfusion (decrease blood flow) to the brain, which leads to a person feeling faintish or even blacking out (syncopy). Rarely this can cause death.
A second problem is that it can lead to decreased cardiac function (heart failure). Persons with prolonged A. fib can see a slow decline in their heart function, especially if the heart is beating fast.
The third and most common and devastating effect of A. fib is that it causes strokes. One in every five strokes is due to atrial fibrillation. As the atrium is not contracting properly, blood can settle in the chamber and then form clots. These clots can then get loose, travel to the brain and cause a stroke. For this reason many persons with A. fib are on blood thinners and anyone who has had a stroke should be investigated for A. fib.
With these potential effects it becomes very important to detect and treat the condition. Treatment usually involves medication to control the heart rate, blood thinners (anticoagulants), and medication to try and maintain a normal rhythm. The latter has about a 50 per cent success rate.
Today, more effective therapy is available for patients who have paroxysmal (intermittent) A. fib.
On May 27, at Partners Interventional Centre of Jamaica (PICJ), a therapy called cryo-ablation was performed for the first time in Jamaica. This involved a specialised team involving Dr Nordia Clare-Pasco, cardiac electrophysiologist; Dr Lisa Hurlock, cardiologist specialist in transoesophageal echocardiogram; Dr Cleopatra Patterson, anesthesiologist; plus nursing and technical staff.
Cryo-ablation has an 80 per cent success rate in keeping persons with paroxysmal or persistent — two types of intermittent A. fib — in normal rhythm, hence reducing their risk for syncopy, heart failure, and having a stroke. It does not work, however, for persons with permanent A. fib. This emphasises the importance of treating paroxysmal A. fib before it becomes permanent.
Cryo-ablation involves passing a special catheter through a vein in the groin, up to the heart, and entering the left atrium. A balloon is then applied to the base of the four pulmonary veins which are responsible for providing blood to the left atrium. The balloon is then filled with liquid nitrogen which drops the temperature to between -40 to -60 degrees Fahrenheit. This provides a cold burn to the tissues where the electrical activity for A. fib originates, blocking them from causing the atrium to fibrillate.
This procedure is part of the comprehensive stroke programme that is being developed at PICJ.
"Treating persons with paroxysmal A. fib — knowing that you are improving their heart function and reducing their stroke risk — is exciting, and to introduce this new procedure to Jamaica is a dream come true" said Dr Elliott, managing director of PICJ.
1 year 10 months ago
1,800 cases of dengue fever registered so far this year
Although official reports indicate that this year there has been a reduction in dengue cases compared to the same period last year, the presence of this endemic disease in the country remains latent, with the threat of an increase after the rainy season, as is currently the case.
According to official data, so far this year, there have been 1,837 cases of dengue fever, a disease transmitted by the bite of the Aedes aegypti mosquito that breeds in clean water, especially in the water that accumulates in or around homes.
The highest number of cases reported up to epidemiological week 20, when 1,341 cases had been registered, was in Greater Santo Domingo, with 523 cases, followed by Santiago with 290 and Monte Cristi with 112 reports in the surveillance system. In the province of Puerto Plata, 83 cases of dengue had been reported up to that date; in Barahona, 65; in La Altagracia and Maria Trinidad Sanchez, 61, respectively; in San Cristobal, 60 cases; in La Romana, 58 and Sanchez Ramirez, 58 cases of dengue. Luis Rosario, director of the Regional and Provincial Health Directorates, assured that dengue, malaria, and other epidemiological surveillance diseases had registered a decrease so far this year.
1 year 10 months ago
Health, Local
Medical News, Health News Latest, Medical News Today - Medical Dialogues |
Pfizer announces positive results from phase 3 studies of novel antibiotic combination aztreonam-avibactam in treating serious bacterial infections
New York: Pfizer Inc.
has announced positive results from the Phase 3 program comprising the REVISIT and ASSEMBLE studies evaluating the efficacy, safety, and tolerability of the novel investigational antibiotic combination aztreonam-avibactam (ATM-AVI) in treating serious bacterial infections due to Gram-negative bacteria, including metallo-β-lactamase (MBL)-producing multidrug-resistant pathogens for which there are limited or no treatment options. Data support that ATM-AVI is effective and well-tolerated, with no new safety findings and a similar safety profile to aztreonam alone.
“We believe these data demonstrate that ATM-AVI, if approved, could be an important treatment option for patients with life-threatening bacterial infections that are resistant to almost all currently available antibiotics,” said James Rusnak, Senior Vice President and Chief Development Officer, Internal Medicine, Anti-Infectives and Hospital, Pfizer. “We are committed to meeting this critical need and helping to address the global health threat of antimicrobial resistance.”
The REVISIT study compared ATM-AVI ± metronidazole (MTZ) with meropenem (MER) ± colistin (COL) for the treatment of complicated intra-abdominal infections (cIAI), hospital-acquired pneumonia (HAP), and ventilator-associated pneumonia (VAP). Key results include:
- For patients with cIAI, cure rate in the intention to treat (ITT) analysis set was 76.4% (95% confidence interval (CI) [70.3, 81.8]) for the ATM-AVI ± MTZ treatment arm vs 74.0% (95% CI [65.0, 81.7]) for the MER ± COL treatment arm, with a treatment difference of 2.4% (95% CI [-12.4, 19.1]). In the clinically evaluable (CE) analysis set, cure rate was 85.1% (95% CI [79.2, 89.9]) for ATM-AVI ± MTZ versus 79.5% (95% CI [69.9, 87.1]) for MER ± COL.
- For patients with HAP/VAP, cure rate in the ITT analysis set was 45.9% (95% CI [34.9, 57.3]) for ATM-AVI ± MTZ versus 41.7% (95% CI [26.7, 57.9]) for MER ± COL, with a treatment difference of 4.3% (95% CI [-25.6, 32.2]). In the CE analysis set, cure rate was 46.7% (95% CI [32.7, 61.1]) for ATM-AVI ± MTZ vs 54.5% (95% CI [34.3, 73.7]) for MER ± COL.
- All-cause 28-day mortality rates were 4/208 (1.9%) for ATM-AVI ± MTZ versus 3/104 (2.9%) for MER ± COL in cIAI, and 8/74 (10.8%) for ATM-AVI ± MTZ versus 7/36 (19.4%) for MER ± COL in HAP/VAP.
- ATM-AVI ± MTZ was well-tolerated, with an overall observed pattern of treatment-emergent adverse events (TEAEs) in line with that described for aztreonam alone. The incidence of serious adverse events (SAEs) was similar between treatment groups (53 [19.3%] patients in the ATM-AVI ± MTZ group and 25 [18.2%] patients in the MER ± COL group). No patient treated with ATM-AVI ± MTZ experienced a treatment-related SAE.
These results are further supported by the ASSEMBLE study, which found that 5/12 (41.7%) of the ATM-AVI ± MTZ patients with infections due to confirmed MBL-producing Gram-negative bacteria were cured at TOC versus 0/3 (0%) of those on best available therapy (BAT). ATM-AVI patients experienced TEAEs that were in line with those of aztreonam alone. No patient treated with ATM-AVI experienced a treatment-related SAE.
Antimicrobial resistance (AMR), particularly in Gram-negative bacteria, is widely recognized as one of the biggest threats to global health and developing new treatments for infections caused by these bacteria has been highlighted as a critical area of need by the World Health Organization (WHO). An estimated 1.27 million deaths globally were caused by bacterial AMR in 2019 alone. Without solutions, a continued rise of AMR could make routine medical procedures too risky to perform.
“These clinical findings show that ATM-AVI, if approved, could help provide coverage against Gram-negative bacteria without compromising on efficacy or safety,” said Yehuda Carmeli, Head, National Institute for Antibiotic Resistance and Infection Control, Tel Aviv Medical Center, Tel Aviv, Israel. “These data are particularly promising given the complexities of managing cIAI and HAP/VAP infections in these hospitalized, critically ill patients, and the challenges of real-world patient recruitment within this population.”
Full results from the studies will be submitted for scientific publication. Data from the REVISIT and ASSEMBLE studies are expected to form the basis for planned regulatory filings in the European Union, United Kingdom, China, and the U.S. in the second half of 2023. Pfizer holds the global rights to commercialize ATM-AVI outside of the U.S. and Canada, where the rights are held by its development partner AbbVie.
These studies were sponsored by Pfizer and funded in whole or part with federal funds from the U.S. Department of Health and Human Services; Administration for Strategic Preparedness and Response; Biomedical Advanced Research and Development Authority, under OTA number HHSO100201500029C. The research leading to these results has received support from the Innovative Medicines Initiative Joint Undertaking under grant agreement 115620, resources of which are composed of financial contribution from the European Union Seventh Framework Programme (FP7/2007-2013) and EFPIA companies in kind contribution.
Read also: Pfizer bags USFDA nod for RSV vaccine Abrysvo for older adults
1 year 10 months ago
News,Industry,Pharma News
Weight loss surgeries on the rise among kids and teens, study finds: ‘Altering the anatomy’
A growing number of kids and teens are turning to weight loss surgery amid rising rates of pediatric obesity, according to a new study published in JAMA Pediatrics.
Between 2020 and 2021, there was a nearly 19% increase in weight loss surgeries among U.S. youths aged 10 to 19 years, as discovered by researchers from the University of Texas, University of Miami Miller School of Medicine, and University at Buffalo School of Medicine and Biomedical Sciences.
The researchers were particularly interested in looking at these trends after the American Academy of Pediatrics (AAP) released a statement in late 2019 endorsing increased access to bariatric surgery for teens, said lead study author Sarah Messiah, PhD, professor and pediatric obesity researcher at UTHealth Houston School of Public Health.
KIDS AND OBESITY: NEW GUIDELINES RELEASED TO EVALUATE AND TREAT CHILDHOOD, ADOLESCENT WEIGHT ISSUES
The study drew on data from across six years from the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program, which accredits bariatric surgery centers in the U.S. and Canada.
"Historically, research shows pediatricians have been hesitant to refer their patients with severe obesity to bariatric surgery," Messiah told Fox News Digital in an email.
"Our findings show a steady increase in usage in the two years after the release of this AAP statement."
The increase was particularly high for racial and ethnic minority groups. That includes Hispanic/Latino, non-Hispanic Black/African American and others, possibly because they are "disproportionately impacted by cardiometabolic disease risk factors versus non-Hispanic Whites," Messiah said.
These risk factors include elevated blood pressure, lipids, insulin, glucose and waist circumference — all of which are risk factors for type 2 diabetes and cardiovascular disease as well as some types of cancer, she added.
MEDICAL EXPERTS FACE BACKLASH OVER 'BARBARIC' CALLS TO TREAT OBESE KIDS WITH DRUGS, SURGERIES
The new study did have some limitations, Messiah said.
"We are always limited to the data we are analyzing in that it does not include the entire universe of all adolescents who have ever completed bariatric surgery in the U.S. during the analytical time period," she said.
BARIATRIC SURGERY PATIENTS LIVE LONGER BUT FACE A HIGHER SUICIDE RISK, SAYS STUDY
"However, this dataset does include all adolescent patients who completed their surgery at a U.S. accredited center, which is the gold standard," the doctor also said.
In January 2023, the AAP released its new pediatric obesity treatment guidelines, officially endorsing bariatric surgery and weight loss prescriptions for the first time.
"Teens age 13 and older with severe obesity (BMI ≥120% of the 95th percentile for age and sex) should be evaluated for metabolic and bariatric surgery," the guidelines stated.
There are four main types of bariatric surgery, according to the Cleveland Clinic: gastric bypass, sleeve gastrectomy, gastric band and duodenal switch.
There was a lot of resistance to the AAP’s recommendation, Messiah pointed out.
TENNESSEE MAN EATS ONLY MCDONALD'S FOOD FOR 100 DAYS STRAIGHT: HERE'S WHAT HAPPENED
"However, our analysis would suggest that families are following their own path in terms of deciding to move forward with surgery for their adolescent," she said.
"It will be important that we support these families moving forward to ensure the best health outcomes for their adolescents as they age into adulthood."
Children’s Mercy Hospital in Kansas City, Missouri, offers a laparoscopic sleeve gastrectomy.
Billed as a minimally invasive procedure, it involves removing a large portion of the stomach to suppress hunger, according to its website.
The hospital recommends exploring weight loss surgery for children who are at least 5 years old, have a BMI of at least 40 (or above 35 with other medical conditions) and have had at least six months of "supervised medical weight loss therapy."
Cincinnati Children’s Hospital in Ohio also has a bariatric surgery program, but its website states that it’s for "severely obese adolescents who haven’t had success with behavioral and nutritional approaches to weight loss."
Nationwide Children’s Hospital in Columbus, Ohio, offers two types of bariatric surgery: gastric bypass and gastric sleeve.
The website doesn’t specify a minimum age requirement, but patients must be at least 100 pounds over their "ideal body weight."
Patients and physicians have gone online to share experiences and opinions on pediatric weight loss surgery.
These run the gamut from success stories to cautionary tales.
One bariatric surgeon on Reddit voiced concern about misconceptions of the procedure.
OZEMPIC, WEGOVY AND PREGNANCY RISK: WHAT YOU NEED TO KNOW ABOUT THE ISSUE
"People see it as ‘the easy way out,’ but it's honestly the only way out for 95% of people who are morbidly obese," the doctor wrote.
"Your metabolic rate will slow down significantly if you try to diet and lose weight, and your progress will slow down — and weight regain is almost inevitable. Bariatric surgery doesn't do that, and something like the gastric bypass hardwires in a malabsorptive component that can't be overridden."
"Do I think we should do bariatric surgery in teenagers? I won't be doing it any time soon, but I think that in a controlled setting with IRB approval, it is appropriate," the surgeon continued, referring to Institutional Review Boards.
"We have an entire demographic of teenagers with type 2 diabetes, obstructive sleep apnea and serious joint pains because of their weight," the surgeon also wrote. "It would be ignorant to overlook an obvious treatment for those conditions."
Another poster, however, shared that her friend opted for the bypass procedure at 16 years old and did not have a good experience.
"She’s now 26 and has gained all the weight back and more," she wrote.
"Her brain wasn’t done developing and she wasn’t mature enough to understand the consequences of such major surgery and to stick to the guidelines and deal with her disordered eating."
Meanwhile, a surgery intern in a private hospital posted that the facility had performed an "astonishingly high number of bariatric cases" and recalled seeing many complications — even when very skilled surgeons did the procedures.
Dr. Sue Decotiis, a triple board-certified weight loss physician in New York City, warned of the potential dangers of these surgeries in children and teens, given their "irreversible nature."
She told Fox News Digital, "With bariatric surgery, you're altering the anatomy of the GI tract, and that anatomy — if it's a bypass — can never be returned [to its original state]."
She added, "That means the individual is never going to be able to eat regular meals because the anatomy of the stomach has changed."
Another potential problem is that after the anatomy of the stomach is altered, Decotiis said, the person won’t be able to eat as much high-nutrition and high-fiber food because they will feel full immediately.
"This can make them gravitate toward processed foods because those are a lot easier to get down," she said.
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Before going the surgery route for a child or teen, Decotiis recommends first making dietary changes, such as cutting out sodas and sugary foods and slowly introducing more nutritious fare.
And in the case of teens with severe obesity, the doctor pointed out that if they start with some of the newer weight loss medications that are available, surgery might not be necessary.
"All the medical options need to be exhausted before they consider surgery, because surgery is irreversible," Decotiis said.
The only exception, she said, is if the child or teen is "morbidly obese" (now known as Class III obesity, which is when a person has a BMI of 40 or higher, or 35 or higher along with obesity-related health conditions, per the Cleveland Clinic).
"Otherwise, it's not worth it because they will likely gain the weight back — and since their anatomy has been disturbed, getting proper nutrients will be difficult in the future."
1 year 10 months ago
Health, weight-loss, childrens-health, medical-research, Surgery, lifestyle, Obesity
Coherus to launch adalimumab biosimilar in US at 85% discount
Coherus BioSciences’ adalimumab biosimilar, Yusimry, will make its debut in the U.S.
marketplace this summer at an 85% discount compared with the originator Humira, according to the manufacturer.In a company press release, Coherus announced that it plans to launch Yusimry (adalimumab-aqvh) in July 2023 at a list price of $995 per carton — each containing two 40 mg/0.8 mL autoinjectors — representing a substantial discount relative to the current $6,922 price tag for a carton of Humira (adalimumab, AbbVie).“Our Yusimry list price is a clear response to the challenges
1 year 10 months ago
Pulmonologists ask to resume the use of a mask due to the increase in Covid-19 and other respiratory diseases
Santo Domingo.- The Dominican Society of Pulmonology and Thoracic Surgery has issued a warning to the Dominican population and healthcare professionals regarding the rising number of positive Covid-19 cases and other respiratory illnesses.
Santo Domingo.- The Dominican Society of Pulmonology and Thoracic Surgery has issued a warning to the Dominican population and healthcare professionals regarding the rising number of positive Covid-19 cases and other respiratory illnesses. Pulmonologists belonging to the society have reported a significant increase in patients testing positive for Covid-19, influenza, pneumonia, and other viral respiratory conditions in recent weeks.
While the World Health Organization has declared the end of the health emergency for Covid-19, society emphasized that this does not mean that the virus is no longer a global health threat. They urged the public to understand that the risk from Covid-19 persists and advised against letting their guard down.
Society emphasized the possibility of new variants emerging despite the current low indicators. They recommended the resumption of mask usage, particularly in enclosed spaces and areas with large gatherings. They highlighted the importance of protecting vulnerable populations, such as seniors, pregnant women, and individuals with underlying health conditions.
Society encouraged individuals experiencing symptoms resembling a common cold or flu to seek medical attention for proper diagnosis and appropriate treatment. They strongly advised against self-medication or following treatments intended for others.
Furthermore, society called upon healthcare professionals to take necessary precautions in their practices, including not admitting patients without masks. Vigilance towards new variants, their effects, and the potential for resurgence was emphasized as a crucial aspect of maintaining public health.
The statement serves as a reminder to remain cautious and proactive in the face of the ongoing Covid-19 pandemic, prioritizing the well-being and safety of individuals and the community at large.
1 year 10 months ago
Health
Medical News, Health News Latest, Medical News Today - Medical Dialogues |
AstraZeneca discontinues brazikumab inflammatory bowel disease development programme
Cambridge: AstraZeneca has announced the discontinuation of the brazikumab inflammatory bowel disease (IBD) development programme, an anti-IL-23 monoclonal antibody, being investigated for the treatment of Crohn’s disease (CD) and ulcerative colitis (UC).
The IBD development programme for brazikumab included the Phase IIb/III INTREPID trial in CD and the Phase II EXPEDITION trial in UC, and their respective open-label extension trials.
The decision to discontinue brazikumab’s IBD development follows a recent review of brazikumab’s development timeline and the context of a competitive landscape that has continued to evolve. The timeline was impacted by delays that could not be mitigated following global events. No safety concerns were identified for patients in these trials.
Under an agreement from 2020, AbbVie contributed to ongoing funding of the development programme, but this funding will now cease.
Brazikumab is a monoclonal antibody that binds to IL23, thus preventing its interaction with its receptor, and was in development for CD and UC.
AstraZeneca is a global, science-led biopharmaceutical company that focuses on the discovery, development, and commercialisation of prescription medicines in Oncology, Rare Diseases, and BioPharmaceuticals, including Cardiovascular, Renal & Metabolism, and Respiratory & Immunology. Based in Cambridge, UK, AstraZeneca operates in over 100 countries.
Read also: CDSCO nod to AstraZeneca cancer drug Tremelimumab
1 year 10 months ago
News,Industry,Pharma News,Latest Industry News
Our 300th Episode!
The Host
Julie Rovner
KFF Health News
Julie Rovner is chief Washington correspondent and host of KFF Health News’ weekly health policy news podcast, “What the Health?” A noted expert on health policy issues, Julie is the author of the critically praised reference book “Health Care Politics and Policy A to Z,” now in its third edition.
This week, KFF Health News’ weekly policy news podcast — “What the Health?” — celebrates its 300th episode with a wide-ranging discussion of what’s happened in health policy since it launched in 2017 and what may happen in the next decade.
For this special conversation, host and chief Washington correspondent Julie Rovner is joined by three prominent “big thinkers” in health policy: Ezekiel Emanuel of the University of Pennsylvania; Jeff Goldsmith, president of Health Futures; and Farzad Mostashari, CEO of Aledade.
Among the takeaways from this week’s episode:
- Since 2017, dissatisfaction has permeated the U.S. health care system. The frustrations of providers, patients, and others in the field point to a variety of structural problems — many of which are challenging to address through policymaking due to the strength of interest-group politics. The emergence of the huge, profitable “SuperMed” firm UnitedHealth Group and the rise of urgent virtual care have also transformed health care in recent years.
- As high costs and big profits dominate the national conversation, lawmakers and policymakers have delivered surprises, including the beginnings of regulation of drug prices. Even the Trump administration, with its dedication to undermining the Affordable Care Act, demonstrated interest in encouraging competition. Meanwhile, on the clinical side, a number of pharmaceuticals are proving especially effective at reducing hospitalizations.
- Looking forward, the face of insurance is changing. Commercial insurance is seeing profits evaporate, private Medicare Advantage plans are draining taxpayer dollars, and employers are making expensive, short-sighted coverage decisions. Some stakeholders see a critical need to reconsider how to be more efficient and effective at delivering care in the United States.
- The deterioration of the patient’s experience signals a major disconnect between the organizational problems providing care and the everyday dedication of individual providers: The local hospital may provide excellent service to a patient experiencing a heart attack, yet Medicare will not pay for patients to have blood pressure cuffs at home, for instance. Low reimbursements for primary care providers exacerbate these problems.
Plus, our experts — drawing on extensive experience making government and private-sector policy and even practicing medicine — name their top candidates for attainable improvements that would make a big difference in the health care system.
Further reading by the panelists from this week’s episode:
- Health Affairs’ “Nine Health Care Megatrends, Part 1: System and Payment Reform,” by Ezekiel J. Emanuel.
- Health Affairs’ “We Have a National Strategy for Accountable Care, So What’s Next?” by Sean Cavanaugh, Mandy K. Cohen, and Farzad Mostashari.
- The Health Care Blog’s “What Can We Learn From the Envision Bankruptcy?” by Jeff Goldsmith.
Click to open the transcript
Transcript: Our 300th Episode!
KFF Health News’ ‘What the Health?’
Episode Title: Our 300th Episode!
Episode Number: 300
Published: June 1, 2023
[Editor’s note: This transcript, generated using transcription software, has been edited for style and clarity.]
Julie Rovner: Hello and welcome back to “What the Health?” I’m Julie Rovner, chief Washington correspondent at KFF Health News. Usually I’m joined by some of the best and smartest health reporters in Washington. But today is our 300th episode, and we have something special planned. Instead of our usual news panel, I’ve invited some of my very favorite health policy thinkers, to cast the net a little wider, and talk about what’s happened to the health care system since we began the podcast in 2017 and what the future of health care might look like for the next, I don’t know, decade or so. So let me introduce our panel. We will put their full bios in the show notes. Otherwise, it would take our entire episode to talk about all that they have done. But it’s safe to say that these are not just some of the smartest people in health care, but also among the most accomplished, with experience making government health policy, private health policy, and, in two of the three cases, also practicing medicine. First up, we have Zeke Emanuel. He’s currently the vice provost for global initiatives and the co-director of the Healthcare Transformation Institute at the University of Pennsylvania. Hi, Zeke. Thanks for joining us.
Ezekiel Emanuel: Great. Wonderful to be here.
Rovner: Next, we have Jeff Goldsmith. He’s president of Health Futures, a health industry consulting firm and a longtime thinker, writer, and lecturer on all things health care — and, I must confess, one of the people who’s implanted many things in my head about what I think about health care. Thanks for joining us, Jeff.
Jeff Goldsmith: It’s a pleasure.
Rovner: Finally, we have Farzad Mostashari, who’s the founder and CEO of Aledade, a company that works with primary care physician practices that he modestly describes on his LinkedIn page as, quote, “helping independent practices save American health care. Thanks for coming, Farzad.
Mostashari: Pleasure to be here, Julie.
Rovner: So I want to divide this conversation into two main parts, roughly titled “Where We’ve Been” and “Where We’re Going,” and where we’ve been in this case means things that have happened since 2017, when the podcast began. For those of you who don’t remember, that was the first year of the Trump presidency, in the middle of the ultimately unsuccessful Republican effort to repeal and replace “Obamacare” and President Trump’s various executive decisions to try to undermine the Affordable Care Act in other ways. Anybody remember that fight over cost-sharing reductions? Let us please not recap that. So let us start not with cost sharing, but with the state of health care in 2017. I want to go around. What does each of you think is the biggest change in the health care system since 2017? Zeke, why don’t you start?
Emanuel: I think probably the biggest change is the growing dissatisfaction by every player in the system. I often say that if you remember back to 2010 — Farzad and I certainly remember, because of passage of the ACA — a lot of people were dissatisfied with the system. But frankly, the upper-middle-class hospitals were not dissatisfied with the system. And mostly the upper middle class could still call — get, you know, VIP care and make sure that they got their needs met. I don’t know anyone — anyone — in 2023 who is happy with the system; maybe there are a few people in the insurance industry who are for this very moment because their profits are higher. But everyone else, including every upper-middle-class and rich person I know, is pissed off and doesn’t think they’re getting good care and is just — doesn’t like the system. And I think that bespeaks very deep structural problems with our system. Different parts are actually doing fantastic, if you want to know the truth, in my opinion, like Farzad’s company giving great primary care, but the whole system sucks. And that I think is probably the biggest change. And again, it bespeaks burnout, it bespeaks payment problems, it bespeaks lots of other underlying problems.
Rovner: I feel like I know that that was growing leading up to the Affordable Care Act, how much the industry and everybody else just didn’t think the system was working, but I think it’s turning into anger. Jeff, what do you think is the biggest change since 2017?
Goldsmith: Well you know, for me, I guess the biggest surprise for me would be we finally got a “SuperMed.” You remember … [unintelligible] … thing about how we’re going to have 10 health systems that — you know, the entire country will be divided into 10 health systems. I think the biggest change has been the arrival of our first SuperMed, which is UnitedHealth Group. It’s doubled in size since 2016. It’s closing in on 3 billion a month in cash flow. So, I mean, I think we may not get another one, but we’ve certainly got one. And it’s on its way to being 10% of health care.
Rovner: And it’s very much — I mean, for people who don’t know — it’s very much more than an insurance company now.
Goldsmith: Yeah, it is. The insurance company is kind of a drag on earnings compared to several other pieces.
Rovner: Farzad, what do you think has changed most since 2017?
Mostashari: I remember in 2017, it really felt like UnitedHealth Group, what they were doing with Optum, was like a secret almost, and it certainly is not anymore. I think I would say covid happened, and one of the main things that has absolutely changed as a result of that is the availability of urgent virtual care. And pretty much all of us now — my mom, through her health system portal; my daughter, through her college portal; me, through my health plan portal — have access to basically hit a button and pretty quickly be able to see someone, usually a nurse practitioner, within a short amount of time. The consequences of that are going to be really interesting. I think, net, it is one of the few things that I think Zeke would agree is pleaser for people to be able to do that. But on the flip side of that, which is to be able to see a primary care doctor, for my parents, is three months out, and they’re 86 and they need to do it. So I think we’re seeing on the one hand, kind of a tale of two cities — like urgent, convenient care with someone who has no idea who you are is more available than ever, and longitudinal primary care with someone who has a long-term relationship with you is getting squeezed.
Rovner: I want to go around again. What’s the most unexpected change? And you don’t get to say the pandemic this time. Jeff, why don’t you start.
Goldsmith: Well, certainly the most unpleasant, unexpected change was the sudden flameout of Geisinger. That’s a really ominous development.
Rovner: Which we haven’t — we haven’t even talked about on the podcast yet. So you better give that a sentence or two.
Goldsmith: Well, Geisinger is — was — one of the elite multi-specialty clinics in the country. It was a follow-on to Mayo, 110-year-old, absolutely superb quality, and done everything in the integrated delivery system playbook. They had a large health plan. They had a widely distributed primary care network. They lost $840 million last year and were losing 20 million a month on operations — that’s arterial bleeding — and about six weeks ago announced a combination of some kind — don’t call it a merger — with Kaiser. It’s still not clear to me what they’ve done. But the big surprise to me was a $7 billion system that did everything you’re supposed to do ended up not being able to remain independent. That’s really scary to me.
Rovner: Yeah. Zeke, what surprised you the most?
Emanuel: I would say two things have surprised me the most. The first one was the fact that we got drug price regulation. Even that little bit we got, I think, very, very surprising. And I have to give credit to the administration. They’re using the small camel’s nose under the tent to really push it as big as they can, jawboning on insulin prices, etc. It’s far from ideal. You know, I’ve been as critical as anyone about the kind of compromises we had to make. But I think that we got something, and I think that’s really changed the psychology. So that would be one thing. The other thing, and here I may be attacked, is we’re still at 18% of GDP for health care spending. Predictions in 2010, even predictions in 2017, were to go over 20%. And we have actually — and it’s not because the economy has gone haywire on us; we’ve been growing at about 2% of GDP. Something is out there that is not as macro that has kept it — some of it’s high deductible, multifactorial. I do think that we also, you know, some of the things that Farzad mentioned, we’ve got virtual that is lower-cost. We do more home care. You know, hospital admissions continue to go down. Anyway, I do think that’s still a surprise. Now, people are feeling it because of high deductibles, because employers are transferring a lot more cost. Nonetheless, as a percent of GDP, it has remained flat for a decade.
Goldsmith: Right. It’ll be lower in ’22 than it was in ’21 when we finally get the numbers out.
Rovner: Farzad.
Mostashari: I want to continue on a little bit. It’s so easy to be pessimistic in health care and health policy. But again, some things that were a little bit — if you are so jaded and so scarred that you have very low expectations, even small victories, like Zeke said, end up being surprises to the upside. So I was surprised to the upside that the Trump administration, despite a lot of — you mentioned, a lot of efforts to undo the Affordable Care Act — were actually pretty good on value-based care and pretty good on turning attention to administrative simplification and to site-neutral payments and thinking about competition in health care markets. And those are obviously, all three of those, are things that the current administration’s support and is also continuing to push. So that was a pleasant surprise, I guess, to the to the upside.
Rovner: Also price transparency, right?
Mostashari: Yeah, I put that in the competition category. The other surprise is, for a long time — I spoke at a pharma group once, a bunch of CEOs, and I said, “Name me the drug that if I use more of it, there will be fewer hospitalizations.” And they kind of drew a blank, and they were like, “Well, vaccines?” And I was like, “OK, that’s pretty sad, right?” But now we actually have SGLT-2s, we have GLP-1s, like there’s actually a bunch of drugs that are going to be, I think, rightfully blockbusters that actually are making a big difference. And I think, in particular, the SGLT-2s I’m really excited about. They’re massively underutilized and I think —
Rovner: What are the SGLT-2s?
Mostashari: Zeke, you want to take this?
Emanuel: No, no, that’s you.
Mostashari: It’s a drug class that has proven to be pretty effective at reducing hospitalizations for people with congestive heart failure, with diabetes. And the more it’s studied, like — there’s a trend in pharma, right, or really anything, that, not what’s the first study with a second randomized trial, but what’s the fifth and sixth and seventh? Do they end up making the evidence stronger or reverting to the mean? And with these drug classes, they seem to be getting stronger and stronger and stronger and more and more generalized in terms of the potential benefit that they can bring. They’re expensive. But I remember a time when a lot of the drugs that are now generic were expensive. So if we take the long arc on this, I think this is going to be very good for health care.
Emanuel: Well, also, to the extent that they preempt hospitalizations, their cost-effectiveness — I don’t know what it is; I haven’t looked it up recently — but the cost-effectiveness is more reasonable, let us put it, than many other drugs that we get, particularly cancer drugs … [unintelligible].
Goldsmith: You know, there’s an even bigger one lurking out there if you’re talking about reducing hospitalizations, and that is the likelihood that we’ll have a dialysis-like solution for sepsis. There are a whole bunch of companies in this space. They’re attaching different molecules to the fibers. But we began seeing during covid, using some of these tools to take virus out of the blood, sepsis is a huge chunk of hospital utilization. It’s a huge chunk of expensive hospital utilization. And what, a third of the deaths, at least — if we could dialyze someone out of sepsis, I mean, it would be an enormous plus, both for health spending and for people’s lives.
Emanuel: I was just going to add one political element to what Farzad said first about the Trump administration, and this gets to how policy is made and the importance of personalities and people. There’s a whole school of history that people don’t matter, the blah, blah, blah. But the Trump administration’s interest in these various things, like price transparency, competition, site-neutral payments, and such, occurred only after they fired Secretary [of Health and Human Services Tom] Price. Secretary Price was sort of a health policy Neanderthal in that he wanted to go back to the 1950s. Many of your listeners will remember he greatly reduced their bundled payment experiments and randomized controlled trial by chopping it in, I think, half, or getting rid of a lot of places. He was totally for the old fee-for-service system, as an orthopedic surgeon, and I think once they got rid of him, actually the focus on, you know, how can we make this a better marketplace, which brings you, you know, not everything liberals can agree on that because many of the things go in, regulate prices and regulate access. And it’s an interesting thing. He had to be moved out for that change to actually happen.
Mostashari: But I’ll also say, though, putting political philosophy back in, not just personality, you look at what’s happening in Indiana, of all places, Zeke, where the legislature have been, I think, pretty forward on on some really great health policy stuff around, again, competition policy, noncompetes for doctors, certificate of need — like a whole bunch of stuff that have been anti-competitive, hospital price increasers they have taken square aim at. And I think that it aligns with like, if we’re going to have a market, like either we’re going to regulate really heavily, or we’re going to have a market-based approach that actually works, and you can’t have a market-based approach that works even a little if you have basically anti-competitive behaviors. So I think it actually does make sense.
Rovner: While we are on the subject of politics, the thing that I think most surprised me in the last seven years is that the pandemic did not convince everybody of the need for everybody to have some kind of health coverage. At the beginning, I thought, well, this is what’s going to get us to a national health plan, because everybody can get sick. And that didn’t happen. In fact, it feels like things got even more polarized. Did that surprise any of you guys or am I just being naive?
Goldsmith: We did get to a 91-million-person Medicaid program and a significant expansion of the exchanges. So it’s not like there wasn’t a realization that covering people had a salutary effect on the overall health of the population. It’s not clear that it lasted. I heard Sarah Huckabee Sanders on the radio the other day saying that throwing a bunch of people off of Medicaid was going to be liberating them from dependency. That was one of the most amazing Orwellian statements I’ve ever heard in my life. But it’s —
Emanuel: She thought if we got rid of her health insurance, it would liberate her from dependency?
Goldsmith: Oh, absolutely.
Mostashari: I do think that one of the things that took away that stink, though, Julie, was really pretty expansive and brave government action that made tests free, that made vaccines free, that made treatment, including monoclonals, free. If the concern was specifically the driver around covid, these programs that — 100% paid, regardless of your ability to pay, just like covered it at all, right? — I do think took away some of the drive that you were describing.
Rovner: And yet we’re peeling them all back one by one, you know, including —
Emanuel: Well, they were all emergency. I mean, all they have expansion was emergency. And, you know, that has to do with the way Washington budgets and all of that. I do think if we’re going to get to universal coverage, we’re going to have to get it in a way that keeps the costs under control. My own interpretation is we’ve reached the limit, and 18% is the limit. And if you want to get to 100% universal coverage, I can’t —
Mostashari: Oh, God, I can’t believe he just jinxed us like that.
Emanuel: I think that’s what the political economy says.
Rovner: You mean 18% of GDP?
Emanuel: Yeah. Yeah.
Goldsmith: But, Zeke, people are saying that when we got to 8, we were going to hit the wall. OK, you have a long enough memory, I mean —
Emanuel: I do, I do have that memory. But I do think you have seen more drastic action, as when things have gone up by employers to make it look less and less like insurance, frankly. And I do think that tells you where the limit is. And I think we’re going to have to think within that. And one of the things we have to do is be much more serious about areas where we have good evidence about cost savings. And we just haven’t done that. And for the last decade, every hospital — and I always talk about cost — but it’s a lot easier to negotiate higher rates from commercial than it is to actually be more efficient. And so what do they do? Focus on negotiating higher rates and have much more brains focusing on that than doing the time-motion studies to get efficient. Until they are forced, they’re not going to do that kind of efficiency. And that’s the thing. And you can’t do it on a dime. That’s the other thing, I think, partially that the Geisinger says: You can’t do the efficiency on a dime.
Goldsmith: Isn’t losing $20 million a month sort of a goad to action? I mean —
Emanuel: Well, Jeff, Jeff, here’s the question. I agree. But it couldn’t induce Geisinger to change fast enough. I mean, they didn’t have enough runway. If they were losing, that’s the first thing. And whether other hospitals and health systems are going to say, “Well, we have to get serious today,” I don’t know. I’m not privileged to their internal deliberations. I will say that, over the last decade, they’ve just continued the old playbook, as I’ve argued.
Mostashari: But I think that’s right, Zeke. But that’s what doesn’t give me hope in terms of your 18% political economy ceiling, because who’s going to make it, you know, like — and I don’t see the employers. I’d say if there’s one thing where there hasn’t been much change has been the employers continue to disappoint.
Rovner: Actually, Farzad, you’ve walked right into my next question, because I want to pivot to what’s going to happen, which is, who’s going to drive the health care train for the next decade?
Emanuel: I think employers are brain-dead on this. They are the worst part of the legion because they control all the profit and they have been terrible. They have chased very short-term profits or very short-term savings. What? Yeah, I know, I, well no, but —
Rovner: Farzad, Farzad’s making air quotes.
Emanuel: Farzad’s making the quotes, but absolutely it’s not been savings, but they’ve been listening to consultants who sold them a bill of goods and they haven’t been serious. And you know, to be honest, when you get something like Haven and you’ve got companies like J.P. Morgan and Amazon and Berkshire Hathaway making a hash of it, “What could I do?” is I think the response, and what they have to do is they have to get together and get out of health care in a responsible way, and that they are — they just, they can’t focus enough mind share on it.
Rovner: Even with, what was it, Amazon and J.P. Morgan? And I forget what the third one was.
Goldsmith: But Zeke, you know, right now the most profitable service line for those insurers isn’t commercial insurance; it’s Medicare Advantage
Emanuel: Yeah.
Goldsmith: And if I were to be a forecasting person, which I tend to do sometimes —
Emanuel: You are?
Goldsmith: I think, I think the profit is rapidly disappearing from commercial insurance, not only because more and more insurers are self-funded, or employers are self-funded and taking themselves out of the equation, but because the government can’t say no to its contractors — state governments, federal government. So I’m actually very concerned about the disappearance of the lever that commercial insurance represented in the emergence of a kind of a rent-seeking health insurance system.
Mostashari: That underscores the need, if more and more employers are self-insured, then they’re going to need to act. They can’t rely on the insurer; they need to demand something different than what they’ve been demanding from the TPAs [third-party administrators]. And I think that’s the opportunity, if I was going to be an optimist. I think that’s the opportunity. To Zeke’s point, from the beginning, everyone is unhappy. And if someone did come up with a TPA that promised cost corridors, as an example, more predictability, free stop loss, you know, like those kind of things and actually delivered slower trend, guaranteed lower trend on your rates. I think there’s room for that, but as Zeke said, not if they just keep listening to the same consultants.
Goldsmith: But Farzad, what seems to me has held them back is that their interest in health benefits cost is cyclical. When they’re awash in cash, they’re mainly interested in more cash; they’re not interested in tuning their health benefit and chasing away scarce workers. And right now, that scarcity of workers is one of the things that’s holding employers back from tightening down or fundamentally changing the logic of their health coverage — is that they are competing, particularly in the skilled part of our economy, for workers that they’re really having trouble getting. And to walk in the door and saying, “Well, we’re going to place all these conditions on, and we’re going to make you do X, Y, and Z,” they’re not going to do it.
Mostashari: I think the TPA 2.0, though — I agree with you that there’s typically been a zero-sum game around this between the employer and employee when it comes to less benefits, higher copays, higher deductibles, like, you’re taking something away from them. But you mentioned Medicare Advantage. What I think the promise has been there is you get more; the member gets more access to primary care or more benefits but for the same cost. And I agree with your facial expression there that our —
Goldsmith: I’m on Medicare Advantage. I mean, it’s just been a great big whoop. The main user experience has been robocalls, and I get about one every two months to send a nurse to my house to upcode me. That’s my Medicare Advantage experience. Big whoop.
Emanuel: So let me just say two things, one of which is I think the fact is that employers don’t have to go down the punitive route to have lower costs; they could focus on the provider and reorganize that system. And the problem of everyone in the system is just thinking about how do I screw the other provider, right? You know, how do I make doctors go through all this prior authorization so they won’t order that drug or they won’t order that MRI? That’s not a way to improve the system. That’s a way to make everyone pissed off.
Rovner: It’s doing a very good job at that.
Emanuel: Yeah, including the patient. Everyone hates it, and no one’s willing to get rid of it. I think Farzad is right; you need a total reconceptualization of how you’re going to deliver care so the answer is yes, not no. And what you get is better thinking so we’re more efficient and we get rid of the unnecessary stuff so that we can actually devote our time and attention and resources to people who need it. The second thing I would say, Jeff, is I think the wallowing and, and getting all the cream from Medicare Advantage is going to come to an end. I think the administration has sort of — you know, when you’re over 50% of the people and there’s all these articles coming out over and over again, you — I mean one of the things they haven’t realized — you end up in Washington putting a big target on your face. And Washington likes nothing more than, “These people are ripping off the government, and now we’re going to penalize them.” And I will say, you know, personally, we’ve started a very large project to try to fix the risk adjustment mechanism. We also need a large project, in my humble opinion, on fixing the fee structure, which is totally perverted.
Rovner: The fee structure for everybody or the fee structure for Medicare?
Emanuel: Well, if you fix it for Medicare, you’re going to fix it for everyone since they take Medicare prices and just inflate ’em. But I think those two things are going to happen, actually, if I had to say, over the next decade, and I do think the days of just getting tons of profit from Medicare Advantage are numbered.
Goldsmith: Well, but the way that’s going to work is, to sustain the 5% and to prevent their stock prices from falling, they’re going to come after providers hammer and tongs.
Rovner: They [being] the insurers, the Medicare Advantage companies.
Goldsmith: They’re just going to cut the rates. They’re not going to really, fundamentally — they’re not going to shift risks, Zeke. They’re not going to capitate them; they’re just going to cut the rates. So I think part of the dynamic there is you’re going to have the hospital folks kind of behind the scenes going, “Don’t cut Medicare Advantage, because we’re the people that are eventually going to bleed for it.” So I think the politics of doing this is actually a whole lot more complicated. You’re dead right; the mask is dropped. There’s a lot of games being played. But fixing it is going to be really hard politically.
Emanuel: Jeff, I agree with you. I think one of the major issues hospitals have to do — look, during covid, one of the tragedies is the government handed out $70 billion to hospitals and asked nothing in return. There was no, “Change this,” “focus on —”
Goldsmith: They asked them to stay open, Zeke They asked them to stay open 24/7 and to, you know, have their emergency room burn out and to suspend their elective care. What do you mean they didn’t ask them to do anything? They had to do those things to respond to the, the pandemic. Now, you’re saying you didn’t attach additional conditions about efficiency. Dead right, they didn’t.
Emanuel: Yeah.
Goldsmith: You’re right.
Emanuel: There was no structural change. $70 billion is a whole lot of money. And we ask no structural change for it. So we’re actually in a worse situation with hospitals today than we were before. And $70 went out the window.
Rovner: 70 billion.
Mostashari: Zeke and I first met when I was at the White House, the NEC [National Economic Council] or something, and we were arguing about $28 billion to take health care from paper and pen to electronic health records. And it seemed like a lot of money, 28 billion, to digitize American health care and, as Zeke is saying, 70 billion went out the door.
Goldsmith: Well, but, but remember what was going on. There was an authentic, bottomless national emergency. And we ended up throwing $6 trillion, $6 trillion, forget about 70 billion. We ended up throwing $6 trillion worth of money that we borrowed from our grandkids at that bottomless problem — not only covid, but the economic catastrophe that covid produced, the flash depression that the shutdowns produced. So there wasn’t a lot of time for fine-tuning the policy message here; it was shovel it out the door and pray.
Emanuel: Jeff, I agree. We had to rescue a very desperate situation. But it’s not as if the last decade hadn’t given us plenty of things that we could have asked the hospitals to do. Unlike —look, look, in 2009, when we were crafting the Affordable Care Act, I called around to everyone. I said, “All right, we got to change off fee-for-service to … [unintelligible]. What’s the best method to get doctors to do the right thing, to get standardized care, to reduce the inefficiencies,” blah, blah, blah. We hadn’t tried anything. 2021, 2020, we had actually better ideas about how we could implement change and actually make the system better. And we implemented … [unintelligible]. And that, I think, was a missed major opportunity.
Rovner: And actually that is sort of my next question. I want to bring this back to the patient. Zeke, you referred to this; the patient experience has gotten worse. We’ve heard it from everybody here. The more we can do to help people and cure them and treat their ailments, the more differentiated and diverse the system becomes and the much harder it is to navigate. I mean, is there any hope of doing something to improve the patient experience over maybe the next decade?
Goldsmith: Well, I’ll tell you. You asked Zeke; I got sick during 2015 to 2017. So after being a big expert on our health care system for 40 years, I actually used it: five major surgeries in 29 months. And my experience was very different than the picture you guys have been painting. Only three of the people that touched me were over the age of 40. That was a big difference. Getting rid of the boomers might help a lot, but I was astonished by the level of commitment and the team-based care that I got. They were all over it. It was really encouraging to me, scared to death though I was, that the level of service that I got — and I’m not an elite patient. I mean, in a couple of those instances, it was my local community hospital; it wasn’t the University of Chicago that was taking care of me. I was really pleasantly surprised by the level of teamwork and the commitment of the care teams that took care of me. It gave me hope that I didn’t have before.
Mostashari: And I think we always get into this when we start talking about organizations versus people, and the people — and there’s no one like the people in medicine, and they would do anything for their patients, they love their patients, and they’re trying to work against a system that structurally is against doing the right thing for the patient, that we know can help the patient. And there’s no doubt that once someone has a stroke, we spring into action. The question is, did that person have to have a stroke? How well are we doing at controlling blood pressure, Jeff? We suck at controlling blood pressure: 65% control rates. And we know that that’s going to prevent heart attacks and strokes. Once we — once someone has a heart attack, like, we will deliver excellent customer service to the person with a heart attack, and they will be grateful and they will say, “Doc, you saved my life,” but we won’t invest in allowing people to have Medicare to pay for blood pressure cuffs at home, right? Like, that’s what we are grappling with in health care and medicine, is that disjunct between the organizational incentives and delivery system that follows from it versus the dedication and the compassion of the people in it every day.
Emanuel: So, Julie, one of the things I would say over the next decade that we have to do, and here you have a specialist bowing to Farzad, which is we have to pay more for primary care. Right now, the system pays something like 7%. And in some markets like mine, in Philadelphia, it’s under 5%. It’s outrageously bad, that amount. We have to give primary care doctors more and expect more out of them. What do we have to expect? Chronic care coordination. The primary care doc ought to be your navigator, and we need to have them or someone in their practice, is the first line for mental health and behavioral health services, right? That kind of package, including, you know — and we could go on — extended office hours, etc., etc. That has to happen. And us specialists, my kind of folk, we need to be less. And I think that has got to be one of the shifts we make that will make the patient experience better; I think it’ll make the management of these chronic illnesses like hypertension — I’m completely on board with Farzad; that should be focus, focus, focus. I think that’s a critical change. And what gives me hope — again, I’m by nature a very optimistic person — what gives me hope is Farzad’s company and the 20 others in that space that are doing a bang-up job of primary care and showing that it can be done and it can be done well and cost-effectively and better for patients, and I think we have to embrace that. And one of the things that’s going to be critical is more value-based payments, changing the physician fee schedule, and things like that.
Goldsmith: Well, not to disagree at all that there’s an absurd pay gradient between primary care physicians and specialists, but think about why we have so many specialists in the first place and why they have so much political power and influence in our health policy environment. A lot of the young people that are coming out of medical training today are carrying 3 or 400 grand in debt. That is very different than Europe, where we’re not expecting people to bear this huge burden in going into medicine. Wouldn’t it be easier for people to go into primary care if they didn’t have to worry about the fact that if they go into primary care, they’re going to be 65 and on Medicare before those debts are paid off, and maybe not at all. So we’ve created some of this by how expensive medical education is, by how expensive general education is, for that matter. And we’re not going to do anything about that.
Emanuel: And the solution to that is trivial, right? It might be a $30 billion solution, which would be, you know, whatever — .07% tax on every dollar poured into a fund to fund education. It’s idiocy.
Goldsmith: But politically, Zeke, what you’re doing is giving $30 billion to the wealthiest professional group in the country. That’s the way it’s going to play politically. How are those folks in Alabama, you know, that are, they’re on Medicaid, going to view taking $30 billion and giving it to your kids or grandkids that want to be doctors?
Emanuel: I totally agree with you. It needs to be … [unintelligible].
Mostashari: I don’t disagree that there’s a big difference in cost of medical education here versus other countries. I do wonder, though, in that hypothetical where we make medical education free, if you still have the kind of disparities in pay between the anesthesiology and the surgeon and the primary care doc. I still think we’re — we would be in a place where primary care slots went unfilled this year.
Goldsmith: Not surprising.
Mostashari: Right.
Goldsmith: Not surprising at all.
Mostashari: And we have a big shortage. And, you know, we have urologists who employ 17 nurses and other people to increase the throughput of the practice, right? And a primary care capacity, a lot of that could be augmented. You don’t need necessarily to wait until we graduate a whole new crop of doctors. We could actually supplement our primary care capacity if there was more money in primary care. And as Zeke says, I don’t mean just increasing the fee schedule or just paying more, although that would be nice, but tying it to outcomes that actually make it so that we can pay more for primary care in a way that’s budget-neutral.
Emanuel: But it’s a crazy thing because all we would have to do is spend 3% more of total medical spending on primary care. And guess what? You’d increase their revenue 50%. And that would, Farzad’s — that would make — that would be transformative. And you could get that 3%, you know, 1½ from hospitals, from specialists, from other, and they would barely — well, … [unintelligible] … hospitals might notice. But in general, it wouldn’t be a tragedy to any other part of the system. And that’s the insanity of where we’re at. And as Jeff, I think correctly, points out, is, you know, the political optics of this and the political power of these various different groups going to marshal against it — I mean, you could take 1% of it from pharma, easy, maybe even 2% from pharma, easy. The thing which makes me pessimistic now — I was optimistic, now pessimistic — the thing which makes me pessimistic is the sclerosis which makes these kind of structural changes impossible, and that’s basically interest group politics. And it doesn’t cost much. That’s what’s crazy. You know, United can spend $1 billion a year running ads against various congresspeople to keep its position, and its profit margin wouldn’t be affected.
Rovner: All right. We can go on all day. I would love to go on all day, but I know you guys have places to get, so I want to ask one last question of each of you. If there’s one piece of low-hanging fruit that we could accomplish to, I won’t say fix the health care system, but to make it better over the next decade, what would it be? If you could wave a wand and just change one small part of the system?
Goldsmith: We need a Medicare formulary. I’m sorry, we need a Medicare formulary, and we need to basically put a bullet in the PBM [pharmacy benefit manager] business on the way to doing it. That would be mine. And that would free up tens of billions of dollars that we could use to finance some of the stuff that Zeke and Farzad have been talking about.
Rovner: I think that may be the one thing that Congress is actively looking at, so —
Goldsmith: We’ll see how far they get.
Rovner: Yeah. Farzad.
Mostashari: I think we talked about it: competition. I think there’s a — there needs to be a coordinated government regulatory, DOJ [Department of Justice], [Department of] Commerce, CMS [Centers for Medicare & Medicaid Services] response to competition policy — FTC [Federal Trade Commission], obviously — that looks at all the different issues: the payment policies that are digging the hole deeper, like site-neutral payments. I think you need to look at the nonprofit hospitals and which jurisdiction applies to them. I think you need to look at transparency. I think you need to look at transparency around ownership of physician practices. I think there needs to be noncompetes. I think there needs to be a whole set of things that tilt the field towards more competition in health care markets, because if you are big and have, you know, the will to use that market power to say all-or-none contracting, no tiering, no steering, no — none of that, right — then there’s just no purchase for any health care payment or delivery reforms, because you’re big and fat and happy and you don’t care.
Rovner: And you’re making your shareholders happy. Zeke.
Emanuel: Let me give one clinical and one that’s more policy. So the clinical is, Farzad already mentioned it, if we would focus on controlling blood pressure well in this country. We’ve got more than a hundred guidelines, you’ve got cheap, 200 drugs for this. It would both improve longevity, decrease morbidity, and reduce disparities, that single thing. And Farzad is the one who turned me on. I know exactly the place on our walks that he put the bug in my ear about it. We should be focused on that because, among other things, it’s a huge producer of disparities between Blacks and whites in terms of renal failure, blah, blah, blah. The one policy thing I think is we know we spend a trillion dollars on administration. It’s a ludicrous amount of money. We know what the solutions are, and a lot of them don’t require that much policy. What we need is someone in the federal government whose job it is to wake up every day and get that money going. Now, the federal government wouldn’t make that much of it, by the way. That’s one of the reasons the federal government hasn’t taken this on, because they do have standardized billing and blah, blah, blah. But everyone agrees that’s a ridiculous amount of money and it’s producing no health benefit. If anything, it’s producing stress, which is not a good thing. And I think the conservative estimates by David Cutler and Nikhil [Sahni] are, you know, we’re talking $250 billion. I mean, that’s real, real money. And it’s no health benefit, and no one likes that stuff. And a lot of it’s about gaming. And so I think that’s a place — and you’d, again, have to put some serious government backbone, including threats, behind it. But I think that’s free money.
Rovner: Well, we will see if any of this happens. I could go on all afternoon, but I promised I would let you all get back to your day jobs. As always, if you enjoy the podcast, you can subscribe wherever you get your podcasts. We’d appreciate it if you left us a review; that helps other people find us, too. Special thanks, as always, to our ever-patient producer, Francis Ying, for helping gather all of this together. As always, you can email us your comments or questions. We’re at whatthehealth@kff.org. Or you can tweet me. I’m @jrovner. We will be back in your feed next week. Until then, be healthy.
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1 year 10 months ago
Health Care Costs, Health Industry, Insurance, Multimedia, KFF Health News' 'What The Health?', Podcasts
STAT+: Pharmalittle: Coherus undercuts AbbVie with discounted Humira; FDA approves second RSV vaccine
Good morning, everyone. Damian Garde here, filling in for Ed Silverman on the back half of what is, at least in this part of the world, a shortened work week. Temperatures are climbing and with them the number of out-of-office email replies from colleagues who’ve thought better of working while it’s nice out. May you join them soon.
In the meantime, here as always are some tidbits to get your day started. If you hear anything interesting out there, do let us know. …
Coherus BioSciences plans to sell a biosimilar version of Humira at a steep discount, STAT reports, and the company will work with Mark Cuban’s generic drug company to make the medicine available directly to consumers for even less. Coherus’ version of Humira, one of the world’s best-selling medicines, will carry a $995 list price for a carton of two autoinjectors, which is an 85% discount from the $6,922 that AbbVie charges for the branded product. Coherus will also sell its drug at a discount to the Mark Cuban Cost Plus Drug company, which will market the treatment for about $579.
The U.S. Food and Drug Administration approved a second vaccine to protect older adults against RSV, STAT tells us, licensing Pfizer’s Abrysvo for adults 60 and older. The decision comes about a month after the agency approved GSK’s Arexvy, the first-ever vaccine against respiratory syncytial virus, or RSV. Neither vaccine is currently available for use. The Centers for Disease Control and Prevention must recommend the vaccines before they can be sold, a process expected to conclude later this month.
1 year 10 months ago
Pharma, Pharmalot, pharmalittle, STAT+
STAT+: Coherus works with Mark Cuban to sell biosimilar Humira at steep discounts
In a bold move, Coherus BioSciences plans to sell a biosimilar version of Humira — one of the world’s best-selling medicines — at a steep discount, and will work with Mark Cuban’s generic drug company to make the medicine available directly to consumers for even less.
In a bold move, Coherus BioSciences plans to sell a biosimilar version of Humira — one of the world’s best-selling medicines — at a steep discount, and will work with Mark Cuban’s generic drug company to make the medicine available directly to consumers for even less.
Specifically, the Coherus medicine will carry a $995 list price for a carton of two autoinjectors, an 85% discount from the $6,922 that AbbVie charges for Humira, which is used to treat rheumatoid arthritis and other conditions. At the same time, Coherus will sell its drug at a discount to the Mark Cuban Cost Plus Drug Company, which will market the treatment for about $579.
The lowball pricing for the drug, which will become available in July, has the potential to alter one of the most closely watched product rollouts by pharmaceutical companies in many years. After enjoying a monopoly that yielded billions of dollars in annual sales, AbbVie is expected to face at least eight biosimilar rivals to Humira by the end of the year.
1 year 10 months ago
Pharma, Pharmalot, Biosimilars, finance, Pharmaceuticals, STAT+