Healio News

Mucus plugs revealed via imaging correlate with airflow obstruction, eosinophilia

WASHINGTON — Providers can measure mucus plugs directly with computer tomography and indirectly with MRI imaging, according to data presented at the American Thoracic Society International Conference.Also, mucus scores based on CT imaging correlate with changes in airflow obstruction and eosinophilia over time, Eleanor Dunican, MB, BCH, BAO, PhD (ED), consultant respiratory physician, St.

Vincent’s University Hospital, said during her presentation.“Analysis of standard CT scans using computational fluid dynamics shows that even in normal lungs, there is heterogeneity in

1 year 10 months ago

Health Archives - Barbados Today

CARPHA urges youth to stay clear of tobacco as region observes No Tobacco Day on Tuesday



Tobacco use remains a major public health concern in the Caribbean Region. There is no safe level of exposure to tobacco smoke. The use of tobacco products in any form harms nearly every organ of the body, irrespective of whether it is smoked, smokeless, or electronic. Of all the forms of tobacco use, most common in the Caribbean region is cigarette smoking. Cigarette smoking is the number one risk factor for lung cancer. Using other tobacco products such as cigars or pipes also increases the risk for this disease.

Second-hand smoke exposure causes stroke, lung cancer, and coronary heart disease in adults; and acute respiratory infections and severe asthma in children. It is a preventable risk factor for noncommunicable diseases (NCDs), which are the leading cause of death, disease and disability among Caribbean people. 

This year, World No Tobacco Day focuses on Grow Food, Not Tobacco. This campaign advocates for ending tobacco cultivation and switching to more sustainable crops that improve food security and nutrition. The campaign observed annually on 31 May, also informs the public on the dangers of direct use, and exposure to tobacco.

In the Caribbean Region, non-communicable diseases (NCDs) are the leading cause of death and disability – 76.8 per cent of the total deaths (non-Latin Caribbean, excluding Haiti) were due to NCDs in 2016. Cardiovascular diseases 30.8 per cent and cancer 17.2 per cent are the leading causes of death due to NCD, both linked to tobacco use. Many of these persons die in the prime of their lives before the age of 70 years old. The prevalence of smokers for overall tobacco products ranged from 57.2 per cent prevalence (95 per cent CI 48.4 to 65.4 percent ) to 16.2 per cent (95 percent CI 11.2 to 23.0 per cent ). 

According to the Report on Tobacco Control in the Region of the Americas (2018) Caribbean countries have the highest levels of tobacco experimentation before the age of 10.

Dr. Joy St. John, Executive Director at the Caribbean Public Health Agency (CARPHA) warned: “Smokeless does not mean harmless. Nicotine in e-cigarettes is a highly addictive drug and can damage children’s developing brains. Children and adolescents who use e-cigarettes at least double their chance of smoking cigarettes later in life. Preventing tobacco product use among youth is therefore critical. It is important that we educate children and adolescents about the harms of nicotine and tobacco product use. We must work to prevent future generations from seeing such products as ‘normal.’”

In 2008, the Caribbean Community (CARICOM) endorsed the recommendation to ban smoking in public spaces. Later, in 2012, CARICOM regulated a standard for labelling retail packages of tobacco products with health warnings. Caribbean civil society organisations (CSOs), working in collaboration with local governments and international partners, have led the charge in fighting for significant gains in tobacco control in the Caribbean region.

Dr Heather Armstrong, Head, Chronic Disease and Injury said: “At CARPHA, we believe that reducing the harm caused by tobacco use requires a collective approach, where government, civil society, and the individual play a critical role. CARPHA promotes the prevention of tobacco use in all forms and commitment to the WHO FCTC. The focus on tobacco control deals with the youth of the Region. Children and adolescents who use e-cigarettes at least double their chance of smoking cigarettes later in life.”

The Chronic Diseases and Injury Department of CARPHA provides leadership, strategic direction, coordinates and implements technical cooperation activities directed towards the prevention and control of NCDs in CARPHA Member States. CARPHA’s message for prevention of tobacco product use has spread across its Member States.

In 2018, CARPHA in partnership with the University of the West Indies (UWI), Global Health Diplomacy Program at the University of Toronto, the Pan American Health Organization (PAHO), and the Healthy Caribbean Coalition evaluated the Port of Spain Declaration to learn which mandates helped to prevent and control NCDs. Taxation, smoke-free public places mandate, and mandatory labelling of tobacco products are some of the leading policies making the biggest impact on reduction of tobacco use in the Caribbean regions.

CARPHA urges Member States to work together to prevent and reduce the use of all forms of tobacco products, and scale-up efforts to implement their commitments under the WHO Framework Convention on Tobacco Control (FCTC). By doing so, the negative impact of smoking and its consequences on the health of our people, especially the younger generation, and the tremendous burden on the economies of the countries in our Region, will greatly be reduced. (CARPHA) 

The post CARPHA urges youth to stay clear of tobacco as region observes No Tobacco Day on Tuesday appeared first on Barbados Today.

1 year 10 months ago

A Slider, Health, Local News

PAHO/WHO | Pan American Health Organization

La asamblea anual de la OMS concluye con un acuerdo sobre financiación y un amplio abanico de temas de salud

WHO’s annual assembly ends with agreement on funding, and array of health topics

Cristina Mitchell

31 May 2023

WHO’s annual assembly ends with agreement on funding, and array of health topics

Cristina Mitchell

31 May 2023

1 year 10 months ago

Health

How to cure asthma naturally

ASTHMA IS a chronic lung disease affecting people of all ages. It is caused by inflammation and muscle tightening around the airways, which makes it harder to breathe. The symptoms can include coughing, wheezing, shortness of breath, and chest...

ASTHMA IS a chronic lung disease affecting people of all ages. It is caused by inflammation and muscle tightening around the airways, which makes it harder to breathe. The symptoms can include coughing, wheezing, shortness of breath, and chest...

1 year 10 months ago

Health

‘The stove is outdated!’

WE LEARNED long ago that cooking before eating would protect us from bacteria and parasites. This practice of cooking has grown to include all types of foods and is now considered an art. The average meal generally does not include many raw...

WE LEARNED long ago that cooking before eating would protect us from bacteria and parasites. This practice of cooking has grown to include all types of foods and is now considered an art. The average meal generally does not include many raw...

1 year 10 months ago

Health – Demerara Waves Online News- Guyana

Mahdia fire: Burnt student undergoes first surgery in New York, recovery expected

The Mahdia Secondary School student, who was badly burnt in last week’s dormitory fire, has undergone her first of many surgeries in a New York hospital, Health Minister Dr Frank Anthony said Tursday. He said the 13-year old girl, who was flown out of Guyana aboard an air ambulance on Saturday, successfully underwent surgery earlier ...

The Mahdia Secondary School student, who was badly burnt in last week’s dormitory fire, has undergone her first of many surgeries in a New York hospital, Health Minister Dr Frank Anthony said Tursday. He said the 13-year old girl, who was flown out of Guyana aboard an air ambulance on Saturday, successfully underwent surgery earlier ...

1 year 10 months ago

Crime, Education, Health, News

Healio News

Arthritis groups seek osteoarthritis therapy funding in ‘Shark Tank’ event on Capitol Hill

Researchers and CEOs alike presented data recently at a “Shark Tank”-like session with lawmakers on Capitol Hill to discuss, and seek federal funding for, potential therapies for osteoarthritis.“Part of our foundation’s mission is obviously finding a cure and treatment options and investing in osteoarthritis research grants and fellowships,” Steve Taylor, president and CEO of the Arthritis Foun

dation, said during the event, which was held on May 11 at the Rayburn House Office Building, in Washington, D.C. “Despite the exciting advancements that have been

1 year 10 months ago

Healio News

Low-dose colchicine lowers incidence of knee and hip replacements, study finds

A 0.5 mg daily dose of colchicine was linked to a 31% lower incidence of total knee and total hip replacement in patients with chronic coronary artery disease compared with placebo, according to an exploratory analysis of the LoDoCo2 trial.Previous evidence has suggested that short-term use of colchicine may be beneficial in patients with osteoarthritis and clinical features of joint inflammati

on; however, the treatment is not currently recommended for the disease, Michelle W.J. Heijman, MSc, of the department of research at Sint Maartenskliniek hospital in the Netherlands, and colleagues

1 year 10 months ago

Health – Dominican Today

Cases of children with diabetes rise from 150 to 250 new records per year in the Dominican Republic

Santo Domingo.- According to Elbi Morla, the former president of the Dominican Society of Pediatric Endocrinology, there are currently between 1,500 to 2,000 children under the age of 18 in the Dominican Republic who have been diagnosed with diabetes mellitus, a chronic disease characterized by high blood sugar levels.

Santo Domingo.- According to Elbi Morla, the former president of the Dominican Society of Pediatric Endocrinology, there are currently between 1,500 to 2,000 children under the age of 18 in the Dominican Republic who have been diagnosed with diabetes mellitus, a chronic disease characterized by high blood sugar levels.

Morla stated that the number of children diagnosed with diabetes has increased since the arrival of the COVID-19 pandemic. The average annual diagnosis rate has risen from 150 to approximately 250 cases per year.

If left uncontrolled, diabetes can lead to various complications such as blindness, kidney failure, heart attacks, strokes, and lower limb amputations.

Morla explains in his book, “My son has diabetes. What should I do?”, that diabetes can be present from birth in some children, but it is more commonly diagnosed between the ages of 5-7 and 10-14. Children with diabetic relatives are more prone to developing the condition, with a 5% risk when one parent is diabetic and a 15-20% risk when both parents are.

The specialist notes that the most common form of diabetes in children is type 1 diabetes, which requires insulin treatment. However, the frequency of diagnoses of type 2 diabetes, which is typically associated with adults, is increasing in obese children and adolescents.

Morla emphasizes five essential aspects of diabetes management in children and adolescents: diabetes education for the patient and their family, a proper dietary plan, insulin administration, exercise, and mental health care.

Clemente Terrero, the director of Robert Reid Cabral Hospital, mentioned an increase in cases of diagnosed diabetes in children. He noted that these children often require hospitalization due to their decompensated condition upon arrival at the hospital. Although he did not provide specific numbers, Terrero stated that diagnoses have become more frequent after the COVID-19 pandemic.

A similar situation was observed at Hugo Mendoza Hospital, where Dhamelisse Then, the hospital’s director, described the number of children arriving at the hospital with ketoacidosis (diabetic coma) as “alarming.” Ketoacidosis occurs when the body lacks sufficient insulin to allow blood sugar to enter cells for energy use.

During a recent colloquium with medical societies and public health authorities, Then stated that the Pediatric Intensive Care Unit (ICU) has been admitting three to four patients per week due to decompensation resulting from ketoacidosis.

1 year 10 months ago

Health

KFF Health News

¿Mamografías a los 40? Nueva pauta para la detección del cáncer de seno genera debate

Si bien los médicos mayormente aplaudieron la recomendación de un panel designado por el gobierno de que las mujeres comenzaran sus mamografías de rutina para detectar cáncer de mama a partir de los 40 años, en lugar de a los 50, no todos la aprueban.

Algunos médicos e investigadores que están interesados en un enfoque más individualizado para encontrar tumores problemáticos se muestran escépticos y plantean preguntas sobre los datos y el razonamiento detrás del cambio radical del Grupo de Trabajo de Servicios Preventivos de Estados Unidos con respecto a sus pautas de 2016.

“La evidencia para que todas comiencen a los 40 no es convincente”, dijo Jeffrey Tice, profesor de medicina en la Universidad de California-San Francisco.

Tice es parte del equipo de investigación del estudio WISDOM, que tiene como objetivo, en palabras de Laura Esserman, cirujana de cáncer de seno y líder del equipo, “hacer pruebas de manera más inteligente, no probar más”. Esserman lanzó el estudio en curso en 2016 con el objetivo de adaptar las pruebas de detección al riesgo de una mujer, y poner fin al debate sobre cuándo iniciar las mamografías.

Los defensores de un enfoque personalizado enfatizan los costos de la detección universal a los 40, no en dólares, sino en resultados falsos positivos, biopsias innecesarias, sobretratamiento y ansiedad.

Las pautas provienen del Grupo de Trabajo de Servicios Preventivos de Estados Unidos, parte del Departamento de Salud y Servicios Humanos (HHS) federal, un panel independiente de 16 expertos médicos voluntarios que se encargan de ayudar a guiar a los médicos, aseguradoras de salud y legisladores.

En 2009, y de nuevo en 2016, el grupo presentó el aviso actual, que elevó la edad para comenzar la mamografía de rutina de 40 a 50 años e instó a las mujeres de 50 a 74 a hacérselas cada dos años.

Las mujeres de 40 a 49 años que “le otorgan un mayor valor al beneficio potencial que a los daños potenciales” también deberían someterse al procedimiento de detección, dijo el grupo de trabajo.

Ahora, el grupo ha publicado un borrador de una actualización de sus directrices, recomendando la detección para todas las mujeres a partir de los 40 años.

“Esta nueva recomendación ayudará a salvar vidas y evitará que más mujeres mueran debido al cáncer de mama”, dijo Carol Mangione, profesora de medicina y salud pública en UCLA, quien presidió el panel.

Pero la evidencia no es clara. Karla Kerlikowske, profesora de la UCSF que ha estado investigando la mamografía desde la década de 1990, dijo que no vio una diferencia en los datos que justificara el cambio. Dijo que la única forma en que podía explicar las nuevas pautas era un cambio en el panel.

“Son diferentes miembros del grupo de trabajo”, dijo. “Interpretaron los beneficios y los daños de manera diferente”.

Sin embargo, Mangione citó dos puntos de datos como impulsores cruciales de las nuevas recomendaciones: el aumento de la incidencia de cáncer de mama en mujeres más jóvenes, y modelos que muestran la cantidad de vidas que podrían salvar las pruebas de detección, especialmente entre las mujeres negras.

No hay evidencia directa de que evaluar a mujeres de 40 años salve vidas, dijo. La cantidad de mujeres que murieron de cáncer de mama disminuyó de manera constante desde 1992 hasta 2020, debido en parte a una detección más temprana y a mejores tratamientos.

Pero los modelos predictivos que construyó el grupo de trabajo, basados en varias suposiciones en lugar de datos reales, encontraron que expandir la mamografía a mujeres de 40 años podría evitar 1.3 muertes adicionales por cada 1,000 en esa cohorte, dijo Mangione. Lo más crítico, agregó, es que un nuevo modelo que incluye solo mujeres negras mostró que se podría salvar 1.8 por 1,000.

Un aumento anual del 2% en la cantidad de personas de 40 a 49 años diagnosticadas con cáncer de mama en el país entre 2016 y 2019 alertó al grupo de trabajo sobre una tendencia preocupante, dijo.

Mangione lo llamó un “salto realmente considerable”. Pero Kerlikowske lo llamó “bastante pequeño” y Tice lo llamó “muy modesto”: percepciones contradictorias que subrayan cuánta subjetividad está involucrada en la ciencia de las pautas de salud preventiva.

A los miembros del grupo de trabajo los designa la Agencia para la Investigación y la Calidad de la Atención Médica del HHS, y cumplen mandatos de cuatro años. El nuevo borrador de las pautas está abierto para comentarios públicos hasta el 5 de junio. Después de incorporar los comentarios, el grupo de trabajo planea publicar su recomendación final en JAMA, la revista de la Asociación Médica Estadounidense.

Cerca de 300,000 mujeres serán diagnosticadas con cáncer de mama en el país este año, y morirán más de 43,000 por este mal, según proyecciones del Instituto Nacional del Cáncer. Muchos consideran que expandir la detección para incluir a mujeres más jóvenes es una forma obvia de detectar el cáncer antes y salvar vidas.

Pero los críticos de las nuevas pautas argumentan que hay verdaderas concesiones.

“¿Por qué no empezar al nacer?”, ironizó Steven Woloshin, profesor del Instituto de Políticas de Salud y Práctica Clínica de Dartmouth. “¿Por qué no todos los días?”.

“Si no hubiera inconvenientes, eso podría ser razonable”, dijo. “El problema son los falsos positivos, que dan mucho miedo. El otro problema es el sobrediagnóstico”. Algunos tumores de mama son inofensivos y el tratamiento puede ser peor que la enfermedad, enfatizó.

Tice estuvo de acuerdo en que el sobretratamiento es un problema subestimado.

“Estos cánceres nunca causarían síntomas”, dijo, refiriéndose a ciertos tipos de tumores. “Algunos simplemente retroceden, se encogen y desaparecen, son de crecimiento tan lento que una mujer muere de otra cosa antes de que causen problemas”.

Las pruebas de detección tienden a encontrar cánceres de crecimiento lento que tienen menos probabilidades de causar síntomas, dijo. Por el contrario, las mujeres a veces descubren cánceres letales de crecimiento rápido poco después de haberse realizado mamografías que salieron normales.

“Nuestro fuerte sentimiento es que una sola talla no sirve para todos y que debe personalizarse”, dijo Tice.

WISDOM, que significa “Mujeres informadas para evaluar según las medidas de riesgo”, evalúa el riesgo de las participantes a los 40 mediante la revisión de los antecedentes familiares y la secuenciación de nueve genes. La idea es comenzar con mamografías periódicas de inmediato para las mujeres de alto riesgo mientras que esperar para las de menos.

Las mujeres negras no hispanas tienen más probabilidades de hacerse mamografías de detección que las mujeres blancas no hispanas. Sin embargo, tienen un 40% más de probabilidades de morir de cáncer de seno y de que les diagnostiquen cánceres mortales a edades más tempranas.

El grupo de trabajo espera que las mujeres negras se beneficien más de la detección temprana, dijo Mangione.

No está claro por qué las mujeres negras tienen más probabilidades de sufrir cánceres de mama más letales, pero las investigaciones apuntan a disparidades en el tratamiento.

“Las mujeres negras no obtienen un seguimiento de las mamografías tan rápido ni un tratamiento adecuado tan rápido”, dijo Tice. “Eso es lo que realmente impulsa las discrepancias en la mortalidad”.

También continúa el debate sobre la detección en mujeres de 75 a 79 años. El grupo de trabajo optó por no pedir pruebas de detección de rutina en el grupo de mayor edad porque un estudio observacional no mostró ningún beneficio, dijo Mangione. Pero el panel emitió un llamado urgente para investigar si las mujeres de 75 años o más deberían hacerse una mamografía de rutina.

Los modelos sugieren que evaluar a las mujeres mayores podría evitar 2,5 muertes por cada 1,000 mujeres en ese grupo de edad, más de las que se salvarían al expandir la evaluación a las mujeres más jóvenes, apuntó Kerlikowske.

“Siempre decimos que las mujeres mayores de 75 años deberían decidir junto con sus médicos si se hacen mamografías, según sus preferencias, valores, historial familiar y de salud”, dijo Mangione.

Tice, Kerlikowske y Woloshin argumentan que lo mismo es cierto para las mujeres de 40 años.

Esta historia fue producida por KFF Health News, que publica California Healthline, un servicio editorialmente independiente de la California Health Care Foundation.

KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

USE OUR CONTENT

This story can be republished for free (details).

1 year 10 months ago

Aging, Noticias En Español, Race and Health, States, Cancer, HHS, Preventive Services, Preventive Services Task Force, Women's Health

Healio News

Lp(a) level varies widely among Hispanic US adults

Median lipoprotein(a) levels vary widely among Hispanic or Latino U.S.

adults, with the highest median values seen among those self-identifying as Cuban, Dominican or Puerto Rican, researchers reported.“There is significant heterogeneity across ancestral groups, with median Lp(a) levels ranging in order from highest to lowest among African, South Asian, white, Hispanic, and East Asian individuals,” Parag H. Joshi, MD, MHS, assistant professor of medicine at the University of Texas Southwestern Medical Center, and colleagues wrote in JAMA Cardiology. “The distribution of

1 year 10 months ago

KFF Health News

Mammograms at 40? Breast Cancer Screening Guidelines Spark Fresh Debate

While physicians mostly applauded a government-appointed panel’s recommendation that women get routine mammography screening for breast cancer starting at age 40, down from 50, not everyone approves.

Some doctors and researchers who are invested in a more individualized approach to finding troublesome tumors are skeptical, raising questions about the data and the reasoning behind the U.S. Preventive Services Task Force’s about-face from its 2016 guidelines.

“The evidence isn’t compelling to start everyone at 40,” said Jeffrey Tice, a professor of medicine at the University of California-San Francisco.

Tice is part of the WISDOM study research team, which aims, in the words of breast cancer surgeon and team leader Laura Esserman, “to test smarter, not test more.” She launched the ongoing study in 2016 with the goal of tailoring screening to a woman’s risk and putting an end to the debate over when to get mammograms.

Advocates of a personalized approach stress the costs of universal screening at 40 — not in dollars, but rather in false-positive results, unnecessary biopsies, overtreatment, and anxiety.

The guidelines come from the federal Department of Health and Human Services’ U.S. Preventive Services Task Force, an independent panel of 16 volunteer medical experts who are charged with helping guide doctors, health insurers, and policymakers. In 2009 and again in 2016, the group put forward the current advisory, which raised the age to start routine mammography from 40 to 50 and urged women from 50 to 74 to get mammograms every two years. Women from 40 to 49 who “place a higher value on the potential benefit than the potential harms” might also seek screening, the task force said.

Now the task force has issued a draft of an update to its guidelines, recommending the screening for all women beginning at age 40.

“This new recommendation will help save lives and prevent more women from dying due to breast cancer,” said Carol Mangione, a professor of medicine and public health at UCLA, who chaired the panel.

But the evidence isn’t clear-cut. Karla Kerlikowske, a professor at UCSF who has been researching mammography since the 1990s, said she didn’t see a difference in the data that would warrant the change. The only way she could explain the new guidelines, she said, was a change in the panel.

“It’s different task force members,” she said. “They interpreted the benefits and harms differently.”

Mangione, however, cited two data points as crucial drivers of the new recommendations: rising breast cancer incidence in younger women and models showing the number of lives screening might save, especially among Black women.

There is no direct evidence that screening women in their 40s will save lives, she said. The number of women who died of breast cancer declined steadily from 1992 to 2020, due in part to earlier detection and better treatment.

But the predictive models the task force built, based on various assumptions rather than actual data, found that expanding mammography to women in their 40s might avert an additional 1.3 deaths per 1,000 in that cohort, Mangione said. Most critically, she said, a new model including only Black women showed 1.8 per 1,000 could be saved.

A 2% annual increase in the number of 40- to 49-year-olds diagnosed with breast cancer in the U.S. from 2016 through 2019 alerted the task force to a concerning trend, she said.

Mangione called that a “really sizable jump.” But Kerlikowske called it “pretty small,” and Tice called it “very modest” — conflicting perceptions that underscore just how much art is involved in the science of preventive health guidelines.

Task force members are appointed by HHS’ Agency for Healthcare Research and Quality and serve four-year terms. The new draft guidelines are open for public comment until June 5. After incorporating feedback, the task force plans to publish its final recommendation in JAMA, the Journal of the American Medical Association.

Nearly 300,000 women will be diagnosed with breast cancer in the U.S. this year, and it will kill more than 43,000, according to National Cancer Institute projections. Expanding screening to include younger women is seen by many as an obvious way to detect cancer earlier and save lives.

But critics of the new guidelines argue there are real trade-offs.

“Why not start at birth?” Steven Woloshin, a professor at the Dartmouth Institute for Health Policy and Clinical Practice, asked rhetorically. “Why not every day?”

“If there were no downsides, that might be reasonable,” he said. “The problem is false positives, which are very scary. The other problem is overdiagnosis.” Some breast tumors are harmless, and the treatment can be worse than the disease, he said.

Tice agreed that overtreatment is an underappreciated problem.

“These cancers would never cause symptoms,” he said, referring to certain kinds of tumors. “Some just regress, shrink, and go away, are just so slow-growing that a woman dies of something else before it causes problems.”

Screening tends to find slow-growing cancers that are less likely to cause symptoms, he said. Conversely, women sometimes discover fast-growing lethal cancers soon after they’ve had clean mammograms.

“Our strong feeling is that one size does not fit all, and that it needs to be personalized,” Tice said.

WISDOM, which stands for “Women Informed to Screen Depending On Measures of risk,” assesses participants’ risk at 40 by reviewing family history and sequencing nine genes. The idea is to start regular mammography immediately for high-risk women while waiting for those at lower risk.

Black women are more likely to get screening mammograms than white women. Yet they are 40% more likely to die of breast cancer and are more likely to be diagnosed with deadly cancers at younger ages.

The task force expects Black women to benefit most from earlier screening, Mangione said.

It’s unclear why Black women are more likely to get the most lethal breast cancers, but research points to disparities in cancer management.

“Black women don’t get follow-up from mammograms as rapidly or appropriate treatment as quickly,” Tice said. “That’s what really drives the discrepancies in mortality.”

Debate also continues on screening for women 75 to 79 years old. The task force chose not to call for routine screening in the older age group because one observational study showed no benefit, Mangione said. But the panel issued an urgent call for research about whether women 75 and older should receive routine mammography.

Modeling suggests screening older women could avert 2.5 deaths per 1,000 women in that age group, more than those saved by expanding screening to younger women, Kerlikowske noted.

“We always say women over 75 should decide together with their clinicians whether to have mammograms based on their preferences, their values, their health history, and their family history,” Mangione said.

Tice, Kerlikowske, and Woloshin argue the same holds true for women in their 40s.

This article was produced by KFF Health News, which publishes California Healthline, an editorially independent service of the California Health Care Foundation. 

KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

USE OUR CONTENT

This story can be republished for free (details).

1 year 10 months ago

Aging, california, Race and Health, States, Cancer, HHS, Preventive Services, Preventive Services Task Force, Women's Health

PAHO/WHO | Pan American Health Organization

Countries agree to prioritize initiatives to improve the health of Indigenous populations

Countries agree to prioritize initiatives to improve the health of Indigenous populations

Cristina Mitchell

29 May 2023

Countries agree to prioritize initiatives to improve the health of Indigenous populations

Cristina Mitchell

29 May 2023

1 year 10 months ago

PAHO/WHO | Pan American Health Organization

Novel products, misleading information threaten to undo decades of gains against tobacco use

Novel products, misleading information threaten to undo decades of gains against tobacco use

Cristina Mitchell

29 May 2023

Novel products, misleading information threaten to undo decades of gains against tobacco use

Cristina Mitchell

29 May 2023

1 year 10 months ago

Medical News, Health News Latest, Medical News Today - Medical Dialogues |

Vitamin D deficiency adversely impacts neuronal growth and dopamine function in brain

Australia: A recent study published in the Journal of Neurochemistry has shown how vitamin D deficiency impacts neurons' development, contributing to disorders such as schizophrenia.

Australia: A recent study published in the Journal of Neurochemistry has shown how vitamin D deficiency impacts neurons' development, contributing to disorders such as schizophrenia.

Using innovative technology, neuroscientists discovered that a lack of vitamin D changes neuron growth and affects the brain's dopamine release mechanism. They found that in the cells grown in the presence of vitamin D, dopamine release was enhanced.

"Our findings show the importance of vitamin D in the structural differentiation of dopaminergic neurons and suggest that maternal vitamin D deficiency might alter how early dopaminergic circuits form," Darryl Eyles, University of Queensland, Saint Lucia, Queensland, Australia, and colleagues wrote in their study.

Previous studies have shown vitamin D to be a critical factor in dopaminergic neurogenesis and differentiation. Also, developmental vitamin D (DVD) deficiency has been associated with disorders of abnormal dopamine signalling with a neurodevelopmental basis, such as schizophrenia. Schizophrenia is linked with several developmental risk factors, both environmental and genetic. There is no precise information on the neurological causes of the disorder, but it is known that schizophrenia is associated with a change in how the brain uses dopamine.

In the present study, the researchers provided further evidence of the role of vitamin D as a mediator of dopaminergic development by showing that it increases neurite outgrowth, presynaptic protein re-distribution, neurite branching, dopamine production and functional release in various in vitro models of developing dopaminergic cells including primary mesencephalic cultures, SH-SY5Y cells, and mesencephalic/striatal explant co-cultures.

The research team at the Queensland Brain Institute developed dopamine-like cells to replicate the differentiation process into early dopaminergic neurons that usually occur during embryonic development.

They cultured the neurons in the absence and presence of the active vitamin D hormone. They then showed alterations in the distribution of presynaptic proteins responsible for dopamine release within these neurites. In three different model systems, dopamine neurite outgrowth was markedly increased.

Using false fluorescent neurotransmitters, a new visualization tool, the team analyzed the functional changes in presynaptic dopamine uptake and release in the absence and presence of vitamin D. They found that in the cells grown in the presence of the hormone, the dopamine release was enhanced compared to a control.

Key takeaways from the study:

  • For the first time, the study has shown that chronic exposure to the active vitamin D hormone increases the capacity of developing neurons to release dopamine and continues to establish vitamin D as an essential differentiation agent for developing dopamine neurons.
  • This study also has implications for understanding the mechanisms behind the link between DVD deficiency and schizophrenia.
  • Dopamine release was enhanced in cells grown in the presence of the vitamin D hormone compared to a control.

The research team believes that such early alterations to dopamine neuron differentiation and function may be the neurodevelopmental origin of dopamine dysfunction later in adults with schizophrenia.

Reference:

Nedel Pertile, R. A., Brigden, R., Raman, V., Cui, X., Du, Z., & Eyles, D. Vitamin D: A potent regulator of dopaminergic neuron differentiation and function. Journal of Neurochemistry. https://doi.org/10.1111/jnc.15829

1 year 10 months ago

Medicine,Neurology and Neurosurgery,Medicine News,Neurology & Neurosurgery News,Top Medical News

Health | NOW Grenada

Outpatient clinic relocated to General Hospital building Phase 2

Effective Tuesday, 30 May 2023, outpatient clinics will be conducted at the new hospital building (Phase 2)

View the full post Outpatient clinic relocated to General Hospital building Phase 2 on NOW Grenada.

Effective Tuesday, 30 May 2023, outpatient clinics will be conducted at the new hospital building (Phase 2)

View the full post Outpatient clinic relocated to General Hospital building Phase 2 on NOW Grenada.

1 year 10 months ago

Health, PRESS RELEASE, general hospital, gis, Ministry of Health, outpatient clinic

Medical News, Health News Latest, Medical News Today - Medical Dialogues |

Oral dexamethasone effective in treatment of infantile spasms and related Lennox-Gastaut syndrome

Oral dexamethasone is effective in the treatment of infantile spasms and infantile spasms related Lennox-Gastaut syndrome suggests a new study published in the BMC Pediatrics

Treatment with adrenocorticotropic hormone (ACTH) or a corticosteroid is the first choice for infantile spasms (IS), and vigabatrin is the first choice for children with tuberous sclerosis. Although corticosteroids may be also effective against IS and IS-related Lennox–Gastaut syndrome (LGS), the use of dexamethasone (DEX), a kind of corticosteroid, for these diseases has been rarely reported. This retrospective study aimed to evaluate the efficacy and tolerability of DEX for the treatment of IS and IS-related LGS.

Patients diagnosed as having IS (including patients whose condition evolved to LGS after the failure of early treatment) in our hospital between May 2009 and June 2019 were treated with dexamethasone after failure of prednisone treatment. The oral dose of DEX was 0.15–0.3 mg/kg/d. Thereafter, the clinical efficacy, electroencephalogram (EEG) findings, and adverse effects were observed every 4–12 weeks depending on the individual patient’s response. Then, the efficacy and safety of DEX in the treatment of IS and IS-related LGS were retrospectively evaluated.

Results

Among 51 patients (35 cases of IS; 16 cases of IS-related LGS), 35 cases (68.63%) were identified as responders to DEX treatment, comprising 20 cases (39.22%) and 15 cases (29.41%) with complete control and obvious control, respectively. To discuss the syndromes individually, complete control and obvious control were achieved in 14/35 and 9/35 IS cases and in 6/16 and 6/16 IS-related LGS cases, respectively. During DEX withdrawal, 11 of the 20 patients with complete control relapsed (9/14 IS; 2/6 LGS). The duration of dexamethasone treatment (including weaning) in most of the 35 responders was less than 1 year. However, 5 patients were treated with prolonged, low-dose maintenance therapy, which continued for more than 1.5 years. These 5 patients showed complete control, and 3 patients had no recurrence. Except for one child who died of recurrent asthma and epileptic status 3 months after stopping DEX, there were no serious or life-threatening adverse effects during DEX treatment.

Oral DEX is effective and tolerable for IS and IS-related LGS. all LGS patients were evolved from IS in this study. The conclusion may not apply to patients with other etiology and courses of LGS. Even when prednisone or ACTH is failed, DEX may still be considered as a treatment option. For children who respond to DEX but do not show complete control after 6 months of treatment, prolonged treatment with low-dose DEX administered in the morning might be considered.

Reference:

Li, J., Gao, Y., Cao, J. et al. Efficacy analysis of oral dexamethasone in the treatment of infantile spasms and infantile spasms related Lennox–Gastaut syndrome. BMC Pediatr 23, 255 (2023). https://doi.org/10.1186/s12887-023-04062-6

1 year 10 months ago

Pediatrics and Neonatology,Pediatrics and Neonatology News,Top Medical News

Jamaica Observer

The high price of back pain

BACK pain is a common and often debilitating condition that affects millions of people worldwide. Besides the physical discomfort and limitations it imposes on individuals, back pain also comes with significant financial costs. In this article we explore the economic impact of back pain and highlight the importance of selecting an effective management strategy, particularly through the utilisation of physiotherapy.

The economic burden of back pain

Back pain is a leading cause of disability and absenteeism in the workplace, resulting in substantial financial losses for both individuals and society as a whole. The costs associated with back pain can be categorised into direct health-care expenses, indirect costs due to lost productivity, and intangible costs related to reduced quality of life.

1. Direct Health Care Expenses

Back pain patients often seek medical intervention including doctor visits, diagnostic tests, medications, and surgical procedures. These expenses can quickly accumulate, especially for chronic or severe cases. According to a study published in The Journal of the American Medical Association (JAMA), the annual cost of treating back pain in the United States alone exceeds US$100 billion.

2. Indirect Costs and Lost Productivity

Back pain frequently leads to missed workdays, decreased work productivity, and limitations in job performance. The Global Burden of Disease Study estimated that in 2017 low back pain alone accounted for 60.1 million years lived with disability globally. This translates into an enormous economic burden encompassing productivity, increased sick leave, and disability benefits.

3. Intangible Costs

Beyond the measurable financial expenses, back pain also has intangible costs such as reduced quality of life, psychological distress, and decreased overall well-being. The impact on mental health, relationships, and social activities can further contribute to the overall burden experienced by individuals suffering from chronic back pain.

THE ROLE OF PHYSIOTHERAPY IN MANAGING BACK PAIN

Physiotherapy, a specialised branch of health care, offers a conservative, non-invasive approach to managing back pain. It focuses on assessing and treating musculoskeletal conditions, including back pain, through a variety of evidence-based techniques. Physiotherapists are highly trained professionals who utilise manual therapy, exercise prescription, education, and other modalities to improve mobility, reduce pain, and enhance functional ability.

Targeted Treatment

Physiotherapy employs personalised treatment plans tailored to the individual's specific needs. Through a thorough assessment, physiotherapists identify the underlying causes of back pain such as muscle imbalances, joint dysfunction, or poor posture. By addressing these root causes physiotherapy aims to alleviate pain and improve overall function.

Active Rehabilitation

Unlike passive treatment methods such as medications or surgeries, physiotherapy emphasises active rehabilitation. Patients are actively involved in their own recovery process, learning exercises, stretches, and strategies to manage and prevent future episodes of back pain. This empowers individuals to take control of their health, reducing the risk of recurrent pain.

Holistic Approach

Physiotherapy takes a holistic approach to back pain management, considering the whole body and its interconnected systems. This comprehensive perspective allows physiotherapists to address not only the symptoms but also the contributing factors that may exacerbate or perpetuate back pain. By improving overall physical fitness, posture, and body mechanics, physiotherapy promotes long-term pain relief and better spinal health.

The economic burden of back pain is staggering, affecting individuals, employers, and society at large. Choosing an effective management strategy is crucial to mitigate the financial costs associated with back pain. Physiotherapy offers a valuable solution by providing targeted treatment, active rehabilitation, and a holistic approach to back pain management. To access exceptional physiotherapy services that prioritise your back care and alleviate the cost of back pain, consider seeking help from InSync Health Wellness Beauty. With their team of highly trained physiotherapists and commitment to patient-centred, one-on-one care, InSync Health Wellness Beauty is a premier choice for addressing your back pain concerns and improving your overall well-being.

Kimberly Hoffman is a pelvic health therapist and director of InSync Health Wellness Beauty. Follow her on
Instagram:
be.insync or contact her by calling or sending a
WhatsApp
message to 876-804-3665

1 year 10 months ago

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