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Treatment of miscarriage in first trimester with Misoprostol effective with few side effects: Study

Researchers have defined that first-trimester medical treatment of early miscarriage with Misoprostol has a high success rate and few side effects. Recently, one such study was published in Archives of Gynecology and Obstetrics by Meister L. and colleagues.

In this retrospective study carried out at the Otto von Guericke University Women's Hospital, predictive parameters for successful Misoprostol therapy were investigated. This study was aimed at assessing if various clinical factors, including endometrial stripe thickness, could indicate the need for further intervention in the form of curettage. The conclusion reached was that evaluation of endometrial stripe thickness after a patient has completed the second cycle of Misoprostol may turn out to be a good marker for treatment success.

Miscarriage in the first trimester is a common problem in clinical practice, which is mainly managed medicinally. Misoprostol is one of the most commonly used prostaglandin E1 analogues for this condition due to its effectiveness and safety profile. However, the dosage regimen has not been standardized yet, and it is unknown whether previous pregnancies, deliveries, or their modes have an effect on the outcome. A better understanding of parameters that might predict the success or failure of such treatment would potentially improve treatment protocols for these women.

This was a retrospective study done at the Otto von Guericke University Women's Hospital from 2018 to 2021, whereby the records of women who had an early miscarriage and had been treated using Misoprostol were reviewed.For the purpose of this study, the need for curettage following treatment was taken to be an indicator of failure of the treatment. Double endometrial stripe thickness measured by TVUS after the second cycle of Misoprostol was evaluated for its predictive value in this study.

All statistical analyses were done using the Statistical Package for the Social Sciences, Version 28.0. All tests were two-sided, with the level of significance set at p < 0.050.

Key Findings

  1. In this study, 86% (n = 114) of women treated for medication abortion with Misoprostol succeeded in therapy and did not need curettage. Only 14% (n = 20) of the patients needed additional surgical intervention.

  2. Mild side effects were observed in 16% of participants; nausea was the most common, affecting 9.2% of the study population. This confirms the safety and tolerability of misoprostol for the management of early miscarriage.

  3. This study demonstrated that there was a significant association between endometrial stripe thickness after the second Misoprostol cycle and the need for curettage: p = 0.035. Using Receiver Operating Characteristic analysis, a cutoff value of 8.8 mm with thicker measurements was determined for a higher likelihood of treatment failure.

  4. This would allow clinicians to use the thickness of the endometrial stripe as a predictor of outcome following treatment, so intervention in a timely fashion would obviate the need for unnecessary procedures.

The findings of the study provide supporting evidence for the usage of misoprostol in treating early miscarriage, with a success rate of 86%. Data also indicate the usefulness of endometrial stripe thickness measurement as a possible marker for prognosis in regard to the outcome of the treatment. Patients with thicker endometrial stripes after two cycles of misoprostol may benefit from closer monitoring and early consideration for other treatments like curettage.

This study shows that the measurement of endometrial stripe thickness by transvaginal ultrasound after the second cycle of misoprostol can be used as a predictive marker of successful treatment of miscarriage. Data will also show that such an approach may guide clinical decision-making and potentially decrease additional surgical procedures. Although the effectiveness of Misoprostol in the treatment of early miscarriage was 86%, with a low rate of complications, this drug still remains effective and safe; however, individualized treatment according to endometrial thickness might bring even better outcomes.

Reference:

Meister, L., Künnemann, I., Fettke, F., Lux, A., & Ignatov, A. (2024). Medical treatment of miscarriage using misoprostol—a retrospective study. Archives of Gynecology and Obstetrics. https://doi.org/10.1007/s00404-024-07628-6

6 months 3 weeks ago

Obstetrics and Gynaecology,Obstetrics and Gynaecology News,Top Medical News,Latest Medical News

MedCity News

How AI Humanizes Mental Healthcare

The integration of AI into mental healthcare is more advanced than many realize because it’s not always obvious; frequently, it’s providing support to free up clinicians to spend more time with their patients or to get more patients into treatment. 

The integration of AI into mental healthcare is more advanced than many realize because it’s not always obvious; frequently, it’s providing support to free up clinicians to spend more time with their patients or to get more patients into treatment. 

The post How AI Humanizes Mental Healthcare appeared first on MedCity News.

6 months 3 weeks ago

Artificial Intelligence, Daily, MedCity Influencers, AI, caregiver burnout, Mental Health, personalized treatment

Health – Dominican Today

President Abinader and Health Minister deny rise in HIV cases

Santo Domingo.- President Luis Abinader and Minister of Public Health Víctor Atallah, during a press event in New York, refuted false claims circulating on social media about an alleged rise in HIV and AIDS cases in the Dominican Republic. They emphasized that the situation is under control, with patients receiving proper monitoring and treatment.

Santo Domingo.- President Luis Abinader and Minister of Public Health Víctor Atallah, during a press event in New York, refuted false claims circulating on social media about an alleged rise in HIV and AIDS cases in the Dominican Republic. They emphasized that the situation is under control, with patients receiving proper monitoring and treatment.

Minister Atallah stated that the country’s comprehensive program includes diagnosis, follow-up, and free treatment for HIV patients. He highlighted that the Dominican Republic uses advanced diagnostic techniques to track treatment resistance, ensuring effective care.

Additionally, the National Council for HIV and AIDS (Conavihsida) dismissed rumors of a supposed doubling of HIV cases in La Altagracia province. Technical Manager Melvin Brioso clarified that new positive cases in the region account for just 45%, contradicting the misleading figures. Brioso also noted the progress made through over 80 comprehensive care centers across the country, emphasizing that being HIV positive is no longer a death sentence due to advances in medication and treatment.

6 months 3 weeks ago

Health

Health – Dominican Today

U.S. and Dominican Republic partner to co-chair Economic and Health Dialogue of the Americas

Santo Domingo.- The United States and the Dominican Republic have partnered to co-chair the Economic and Health Dialogue of the Americas (EHA). This partnership was formalized during a meeting between President Luis Abinader and José W. Fernández, U.S. Undersecretary for Economic Growth, Energy, and Environment.

Santo Domingo.- The United States and the Dominican Republic have partnered to co-chair the Economic and Health Dialogue of the Americas (EHA). This partnership was formalized during a meeting between President Luis Abinader and José W. Fernández, U.S. Undersecretary for Economic Growth, Energy, and Environment.

The EHA, an initiative launched by U.S. Secretary of State Antony Blinken during the Ninth Summit of the Americas in June 2022, focuses on strengthening the supply chains for medical devices and pharmaceutical products. It also aims to identify best practices in these sectors, emphasizing the links between health industries and economic growth.

The Dominican Republic, represented by the Ministry of Industry, Commerce, and MSMEs (MICM), led by Víctor -Ito- Bisonó, will co-chair the EHA. This role solidifies the country’s position as a regional leader in exporting medical devices and expanding pharmaceutical production.

 

6 months 3 weeks ago

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KFF Health News

Aumentan los casos de hipertensión mortal durante el embarazo

Sara McGinnis tenía nueve meses de embarazo de su segundo hijo y algo no iba bien. Su cuerpo estaba hinchado. Estaba cansada y mareada.

Su esposo, Bradley McGinnis, dijo que ella le había informado a su doctor y enfermeras sobre sus síntomas e incluso había ido a la sala de emergencias cuando empeoraron. Pero, según Bradley, lo que le dijeron a su esposa fue: “‘Es verano y estás embarazada’. Eso me atormenta”.

Dos días después, Sara sufrió un derrame cerebral masivo seguido de una convulsión. Sucedió de camino al hospital, a donde iba nuevamente por un dolor de cabeza insoportable.

Sara, de Kalispell, Montana, nunca conoció a su hijo, Owen, quien sobrevivió gracias a una cesárea de emergencia y tiene sus mismos ojos ovalados y su espeso cabello oscuro. La mujer murió al día siguiente del nacimiento.

Sara tuvo eclampsia, una complicación del embarazo a veces mortal causada por presión arterial alta persistente, también conocida como hipertensión.

Sara murió en 2018. Hoy en día, más embarazadas reciben diagnósticos de presión arterial peligrosamente alta, un hallazgo que podría salvar vidas. Estudios recientes muestran que las tasas de nuevos casos y de hipertensión materna crónica casi se han duplicado desde 2007. Investigadores dicen que el aumento en los casos se debe en parte a más pruebas que detectan la afección.

Pero esa no es toda la historia. Los datos muestran que la tasa general de mortalidad materna en el país también está aumentando, siendo la hipertensión una de las principales causas.

Expertos médicos están tratando de frenar esta tendencia. En 2022, el Colegio Americano de Obstetras y Ginecólogos bajó el umbral sobre cuándo los médicos deben comenzar a tratar a pacientes embarazadas y en posparto por hipertensión.

Y las agencias federales ofrecen capacitación en mejores prácticas para la detección y atención. Los datos federales muestran que las muertes maternas por hipertensión disminuyeron en Alaska y West Virginia después de la implementación de esas pautas.

Pero aplicar esos estándares en la atención diaria lleva tiempo, y los hospitales aún están trabajando para incorporar prácticas que podrían haber salvado la vida de Sara.

En Montana, que el año pasado se convirtió en uno de los 35 estados en implementar las pautas federales de seguridad para pacientes, más de dos tercios de los hospitales brindaron atención oportuna a los pacientes, dijo Annie Glover, científica investigadora senior del Montana Perinatal Quality Collaborative. Desde 2022, poco más de la mitad de los hospitales alcanzaron ese umbral.

“Toma un tiempo implementar un cambio en un hospital”, dijo Glover.

La hipertensión puede dañar los ojos, pulmones, riñones o corazón de una persona, con consecuencias que duran mucho más allá del embarazo. La preeclampsia —hipertensión persistente en el embarazo— también puede causar un ataque cardíaco.

El problema puede desarrollarse por factores hereditarios o de estilo de vida: por ejemplo, tener sobrepeso predispone a las personas a la hipertensión. Lo mismo ocurre con la edad avanzada, y cada vez más personas tienen hijos en una etapa posterior de la vida.

Las personas negras e indígenas son mucho más propensas a desarrollar y morir por hipertensión en el embarazo que la población en general.

“El embarazo es una prueba de estrés natural”, dijo Natalie Cameron, médica y epidemióloga de la Escuela de Medicina Feinberg de la Universidad Northwestern, quien ha estudiado el aumento en los diagnósticos de hipertensión. “Está desenmascarando este riesgo que siempre estuvo presente”.

Pero las mujeres embarazadas que no encajan en el perfil de riesgo típico también se están enfermando, y Cameron dijo que se necesita más investigación para entender por qué.

Mary Collins, de 31 años, de Helena, Montana, desarrolló hipertensión durante su embarazo este año. A mitad de la gestación, Collins aún hacía senderismo y asistía a clases de entrenamiento de fuerza. Sin embargo, se sentía lenta y estaba ganando peso demasiado rápido mientras el crecimiento de su bebé disminuía drásticamente.

Collins dijo que le diagnosticaron preeclampsia después de preguntarle a un obstetra sobre sus síntomas. Justo antes de eso, dijo, el doctor había dicho que todo iba bien mientras revisaba el desarrollo de su bebé.

“Revisó mis lecturas de presión arterial, hizo una evaluación física y simplemente me miró”, dijo Collins. “Él dijo: ‘En realidad, me retracto de lo que dije. Puedo garantizar fácilmente que serás diagnosticada con preeclampsia durante este embarazo, y deberías comprar un seguro para bajar los costos de transporte de emergencia (life flight insurance)”.

Así fue. Collins fue trasladada por aire a Missoula, Montana, para el parto, y su hija, Rory, nació dos meses antes. El bebé tuvo que pasar 45 días en la unidad de cuidados intensivos neonatales. Tanto Rory, que ahora tiene unos 3 meses, como Collins, aún se están recuperando.

El tratamiento típico para la preeclampsia es el parto. Los medicamentos pueden ayudar a prevenir convulsiones y acelerar el crecimiento del bebé para acortar el tiempo del embarazo si la salud de la madre o el feto lo necesitan. En raros casos, la preeclampsia puede desarrollarse poco después del parto, una condición que los investigadores aún no comprenden completamente.

Wanda Nicholson, presidenta del Grupo de Trabajo de Servicios Preventivos de EE. UU., un panel independiente de expertos en prevención de enfermedades, dijo que se necesita un monitoreo constante durante y después del embarazo para proteger verdaderamente a los pacientes. La presión arterial “puede cambiar en cuestión de días, o en un período de 24 horas”, dijo Nicholson.

Y los síntomas no siempre son claros.

Ese fue el caso de Emma Trotter. Días después de tener a su primer hijo en 2020 en San Francisco, sintió que su ritmo cardíaco disminuía. Trotter dijo que llamó a su médico y a una línea de ayuda para enfermeras, y ambos le dijeron que podría ir a la sala de emergencias si estaba preocupada, pero le aconsejaron que no. Así que se quedó en casa.

En 2022, unos cuatro días después de dar a luz a su segundo hijo, su corazón volvió a latir despacio. Esta vez, el equipo médico en su nuevo hogar en Missoula revisó sus signos vitales. Su presión arterial era tan alta que la enfermera pensó que el monitor estaba roto.

“‘Podrías tener un derrame cerebral en un segundo’”, recordó Trotter que le dijo su partera antes de enviarla al hospital.

Trotter estaba por tener a su tercer hijo en septiembre, y sus médicos planearon enviarla a casa con el nuevo bebé con un monitor de presión arterial.

Stephanie Leonard, epidemióloga de la Escuela de Medicina de la Universidad de Stanford que estudia la hipertensión en el embarazo, dijo que más monitoreo podría ayudar con problemas complejos de salud materna.

“La presión arterial es un componente en el que realmente podríamos tener un impacto”, dijo. “Es medible. Es tratable”.

El monitoreo ha sido durante mucho tiempo el objetivo. En 2015, la Administración de Recursos y Servicios de Salud federal trabajó con el Colegio Americano de Obstetras y Ginecólogos para implementar las mejores prácticas para hacer que el parto sea más seguro, incluyendo una guía específica para detectar y tratar la hipertensión.

El año pasado, el gobierno federal aumentó el financiamiento para estos esfuerzos para expandir la implementación de las guías.

“Gran parte de la disparidad en este ámbito se debe a que no se escucha las voces de las mujeres”, dijo Carole Johnson, jefa de la agencia de recursos de salud.

El Montana Perinatal Quality Collaborative pasó un año proporcionando esa capacitación sobre hipertensión a los hospitales de todo el estado. Al hacerlo, Melissa Wolf, jefa de servicios para mujeres en Bozeman Health, dijo que su sistema hospitalario aprendió que el uso por parte de los médicos de su plan de tratamiento para la hipertensión en el embarazo era “inconsistente”.

Incluso la forma en que las enfermeras medían la presión arterial de las pacientes embarazadas variaba. “Simplemente asumimos que todos sabían cómo tomar la presión arterial”, dijo Wolf.

Ahora, Bozeman Health está monitoreando el tratamiento con el objetivo de que cualquier embarazada con hipertensión reciba atención adecuada en el plazo de una hora. Carteles decoran las paredes de las clínicas y las puertas de los baños de los hospitales, enumerando los signos de advertencia de la preeclampsia. Se da de alta a los pacientes con una lista de señales de alerta para que estén atentas.

Katlin Tonkin es una de las enfermeras que capacita a los proveedores médicos de Montana sobre cómo hacer que el parto sea más seguro. Sabe lo importante que es por experiencia: en 2018, cuando estaba de 36 semanas, a Tonkin la diagnosticaron con preeclampsia severa, semanas después de haber desarrollado síntomas. Su parto de emergencia llegó demasiado tarde y su hijo Dawson, quien no había estado recibiendo suficiente oxígeno, murió poco después del nacimiento.

Desde entonces, Tonkin ha tenido dos hijos más, ambos nacieron sanos, y mantiene fotos de Dawson, tomadas durante su corta vida.

“Ojalá hubiera sabido entonces lo que sé ahora”, dijo Tonkin. “Tenemos las prácticas actuales basadas en evidencia. Solo necesitamos asegurarnos de que estén en funcionamiento”.

KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

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6 months 3 weeks ago

Noticias En Español, Public Health, Children's Health, Montana, Women's Health

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Opinion: What happened when my mother became the first 2024 West Nile patient in Manhattan

What was that mosquito thinking as the six needles of its proboscis mouth bit into my mother’s skin? Had it taken a long, unplanned journey in a bag as a tourist traveled north from a tropical Caribbean island? Or was it an old-time New York mosquito that had feasted the night before on the sweaty skin of a feverish traveler from the south?

My mother would remain incredulous at her bad luck: Why did this mosquito choose her arm to snack upon? She is nearly 90 years old woman and has lived a quiet life that involves walking her curly-haired Jack Russell, Millie, to and from Central Park.

Read the rest…

6 months 3 weeks ago

First Opinion, infectious disease

PAHO/WHO | Pan American Health Organization

PAHO and CEPI to advance regulatory harmonization and response to health emergencies in the Americas

PAHO and CEPI to advance regulatory harmonization and response to health emergencies in the Americas

Cristina Mitchell

23 Sep 2024

PAHO and CEPI to advance regulatory harmonization and response to health emergencies in the Americas

Cristina Mitchell

23 Sep 2024

6 months 3 weeks ago

Healio News

BLOG: Cornea could become the new glaucoma

Megatrends happen in ophthalmology when new technology addresses existing patient needs and is met with physician acceptance.

There’s no better example of this than the current landscape in glaucoma.A prevalent and vision-threatening condition that was traditionally treated best with eye drops, glaucoma is now best approached by initial treatment with selective laser trabeculoplasty followed shortly by other interventional measures like drug delivery platforms. These include Durysta (bimatoprost intracameral implant) from AbbVie and iDose (travoprost intracameral implant) from Glaukos,

6 months 3 weeks ago

Medical News, Health News Latest, Medical News Today - Medical Dialogues |

High-altitude environments linked to congenital heart disease prevalence, finds research

The global prevalence of congenital heart disease is higher among women who live in high altitudes, according to a new study being presented at ACC Latin America 2024 in Punta Cana, Dominican Republic. However, congenital heart disease in these regions is underestimated and underdiagnosed because of poor access to health care and health systems that lack essential tools.

It is crucial to implement cardiovascular public health policies to ensure these communities receive effective care, maternal detection, early intervention and improved survival rates related to congenital heart disease.

“There is an underdiagnosed prevalence of congenital heart disease because not all high-altitude regions have the health resources for its evaluation, management and follow-up,” said lead author Jean Pierre Eduardo Zila-Velasque, MD, a medical doctor at the Red Latinoamericana de Medicina en la Altitud e Investigación (REDLAMAI).

Congenital heart disease refers to an issue with the heart’s structure that’s present at birth and prevents the blood from flowing normally. Recent reports have shown that in Latin America and the Caribbean, congenital heart disease is 60% more prevalent than cancer and occurs in eight to 13 cases per every 1,000 births in these nations. Hypoxia is a condition where there is insufficient oxygen in the tissues to sustain bodily functions, which can also impact the development of an embryo or the process of forming organs during the embryonic period of human development, including the heart. As altitude increases, barometric pressure decreases, and the risk of hypoxia is heightened. This study sought to evaluate the impact of high-altitude environments on the prevalence of congenital heart disease.

The authors conducted a systematic analysis of cross-sectional studies on the prevalence of congenital heart disease in people living in regions that are greater than 1,500 meters above sea level. The analysis included 1,180,544 participants from eight countries: Bolivia, China, Turkey, Colombia, Ecuador, Ethiopia, the United States and Mexico. The participants were 52.4% male and 47.6% female, and ages ranged from birth to 20 years old. The study was conducted over the span of seven months.

“In relation to the sociodemographic variables, we were able to carry out analysis by place of residence (urban or rural area), type of resident (native or immigrant) and the altitude level in which they reside,” Zila-Velasque said. “Sociodemographic information had a greater impact on the prevalence, unlike gender, where it was evident that the majority of patients with some type of CHD were female.”

Across all high-altitude populations, the prevalence of congenital heart disease was 8.97% overall and more prevalent in women. Broken down by altitude levels, congenital heart disease was prevalent in 6.8% of people living at an altitude of 1500-2500 meters, 14.47% in 2500-3500 meters, 7.26% in 3500-4500 meters and 1.52% in 4500 meters. The most common type of heart defect was atrial septal defect, which occurred in 29.9% of the participants. Congenital heart disease was more prevalent in rural environments, native people and American countries. By comparison, according to the U.S. Centers for Disease Control and Prevention, congenital heart defects affect 1% of births in the United States each year.

“In high-altitude environments, cardiovascular public health policies need to address the unique challenges posed by lower oxygen levels and increased physical strain,” Zila-Velasque said. “This can be achieved through enhanced screening and monitoring. Implementing regular cardiovascular health screenings for residents and workers in high-altitude areas could help us identify and manage hypertension, arrhythmias and other cardiovascular conditions early.”

Public health policies should also focus on access to medical care and the development of new educational programs, Velasque noted. These communities often lack access to specialized medical care, such as cardiologists who are trained in high-altitude medicine, and improving access could help ensure that local facilities are equipped to address altitude-related cardiovascular emergencies. Educational campaigns that highlight the cardiovascular risks associated with high-altitude environments can promote awareness about symptoms and preventive measures.

“Further research is needed on cardiovascular health in high-altitude environments to better understand the specific risks and effective interventions,” Zila-Velasque said.

6 months 3 weeks ago

Cardiology-CTVS,Cardiology & CTVS News,Top Medical News,Latest Medical News

Health – Dominican Today

An aesthetic dream turned into a nightmare: woman denounces malpractice in surgery

Santo Domingo – Iliana Carolina Espinal Marte, 35, says that her desire to improve her physical appearance through surgery ruined her life.

Santo Domingo – Iliana Carolina Espinal Marte, 35, says that her desire to improve her physical appearance through surgery ruined her life.

On June 12, she went to the San Lucas Medical Institute in Santo Domingo to undergo an abdominoplasty performed by surgeon Juan Stanley. However, what followed was a series of complications that have left her health in a critical state.

Espinal relates that after the operation, she was abandoned by the doctor and was left in the care of her sister, who had no medical knowledge. “The doctor left me alone,” she explained.

During the postoperative massages, she began to suffer fainting spells and noticed blisters appearing on her skin, which the surgeon described as “normal.” In addition, she began to see a foul odor coming from her body.

Subsequently, she contracted a bacterium leading to granulomas and four umbilical hernias. “They tore my life apart,” Espinal said, describing the physical and emotional impact of her situation.

“It really was terrible,” she said with tear-filled eyes as she recalled the worst moments. In addition, she complained that when she needed to be operated on again, Dr. Stanley demanded an additional payment. “It was such terrible pain that I thought I was going to have a heart attack,” she added.

Espinal said she has all the evidence of the difficult time.
Added to the health complications are the high costs of the treatments.

Espinal has had to receive blood transfusions and undergo hyperbaric chamber therapies.

In addition, she needs medication every 21 days, the cost of which amounts to 3,500 pesos, a figure she can no longer afford. “I would like to be taken into account, I no longer have the resources to continue to follow up,” she lamented.

Finally, Espinal called on the authorities to investigate the surgeon and the medical center, warning that she did not want other women to suffer the same experience. “I don’t want more women to go through what I have gone through,” she concluded.

6 months 4 weeks ago

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