Health News Today on Fox News

Los Angeles County reports dengue fever cluster acquired from local mosquitoes

Health officials in Los Angeles County on Wednesday warned of an "unprecedented" rise in dengue fever among residents who have not traveled out of the country.

Health officials in Los Angeles County on Wednesday warned of an "unprecedented" rise in dengue fever among residents who have not traveled out of the country.

At least three cases of dengue have been reported in residents in the Baldwin Park neighborhood east of downtown Los Angeles after they were bitten by local mosquitoes, Los Angeles County public health officials said.

"This is an unprecedented cluster of locally acquired dengue for a region where dengue has not previously been transmitted by mosquitoes," said Barbara Ferrer, director of the Los Angeles County Department of Public Health.

Dengue is typically acquired after traveling abroad to a country where dengue is commonly spread. The first locally acquired case in California was reported a year ago.

CDC WARNS OF MOSQUITO-DRIVEN VIRUS AS CASES SPIKE

Dengue spread from mosquito bites within the U.S. has been reported this year in Florida, the U.S. Virgin Islands and Puerto Rico, where officials have declared a dengue epidemic.

There have been 3,085 such cases in the U.S. this year, of which 96% were in Puerto Rico, according to the U.S. Centers for Disease Control and Prevention.

Symptoms of dengue fever can include high fever, severe headache, pain behind the eyes, joint and muscle pain, rash and mild bleeding, according to public health officials. 

NORTHEASTERN TOWNS ISSUE VOLUNTARY LOCKDOWN TO PREVENT SPREAD OF MOSQUITO-BORNE DISEASE

Symptoms may mimic other viruses such as the flu, though officials say the most serious cases can result in shock, severe bleeding and severe organ impairment which require immediate medical attention.

Los Angeles County Public Health said it is working with other agencies and the city of Baldwin Park to go door-to-door and speak to residents about the risk of dengue and mosquito bite prevention.

Meanwhile, officials are increasing mosquito trapping to identify and test mosquitoes to reduce the risk of any additional spread in the neighborhood.

The Associated Press contributed to this report.

7 months 2 days ago

california, viruses, Health, us

PAHO/WHO | Pan American Health Organization

PAHO and MSD launch project to improve maternal health in Latin America

PAHO and MSD launch project to improve maternal health in Latin America

Cristina Mitchell

19 Sep 2024

PAHO and MSD launch project to improve maternal health in Latin America

Cristina Mitchell

19 Sep 2024

7 months 2 days ago

The Medical News

High altitude linked to increased congenital heart disease in women

The global prevalence of congenital heart disease is higher among women who live in high altitudes, according to a new study being presented at ACC Latin America 2024 in Punta Cana, Dominican Republic.

The global prevalence of congenital heart disease is higher among women who live in high altitudes, according to a new study being presented at ACC Latin America 2024 in Punta Cana, Dominican Republic.

7 months 3 days ago

Health News Today on Fox News

Is suicide contagious? Mental health experts warn of very real risk

This story discusses suicide. If you or someone you know is having thoughts of suicide, please contact the Suicide & Crisis Lifeline at 988 or 1-800-273-TALK (8255).

Suicide is a leading cause of death in the U.S., with over 49,000 people taking their own lives in 2022, according to the Centers for Disease Control and Prevention (CDC).

This story discusses suicide. If you or someone you know is having thoughts of suicide, please contact the Suicide & Crisis Lifeline at 988 or 1-800-273-TALK (8255).

Suicide is a leading cause of death in the U.S., with over 49,000 people taking their own lives in 2022, according to the Centers for Disease Control and Prevention (CDC).

Although most suicides stem from mental health disorders, statistics show that the behavior can sometimes be "contagious," leading to "suicide clusters."

Suicide clusters are defined as "a group of suicides or suicide attempts that occur closer together in time, space or both than would normally be expected in a community," the CDC states.

ON WORLD SUICIDE PREVENTION DAY, NEW REPORT IDENTIFIES THREE TOP FACTORS DRIVING SUICIDE RATES

Dr. Caroline Fenkel, a licensed clinical social worker in Pennsylvania and the chief clinical officer at Charlie Health, confirmed that the act can have a contagion effect — particularly among young people.

"When individuals hear about a suicide, especially someone close to their age or in their community, it can feel more accessible as an option in moments of distress," she told Fox News Digital. 

"The more the details are shared, especially in sensational ways, the greater the risk."

Up to 5% of youth suicides can be attributed to contagion, according to Jennifer Kelman, a licensed clinical care social worker in Florida who works with JustAnswer, an expert help on-demand platform.

AMERICAN VETERANS WHO COMMIT SUICIDE ARE 95% MALE, CRISIS OFTEN DRIVEN BY FAMILY DISPUTES, SAY EXPERTS

"It doesn’t necessarily increase for everyone in that community, but rather for those who are struggling as well — with depression, anxiety and other feelings that may be overwhelming," she told Fox News Digital. 

Dr. Deborah Gilman, owner and chief licensed psychologist at Fox Chapel Psychological Services in Pennsylvania, shared the following four factors that could contribute to suicide clusters. 

When people hear about suicides, it can normalize the idea of using it as a way to deal with problems, according to Gilman.

"People often look to others for cues on how to behave," she told Fox News Digital. 

"If they see that many others are choosing suicide, they may believe that it is the socially acceptable or ‘correct’ thing to do."

"Some individuals may feel a sense of connection or empathy with the person who died and may imitate their actions," Gilman said.

"In close-knit communities, schools or social groups, the suicide of one member can lead to others in the same environment feeling similar distress or engaging in similar behaviors."

Some individuals may imitate the behavior of someone who has died by suicide, especially if they are already struggling with their own mental health, she said. 

"This can be due to a sense of hopelessness or a desire to escape their own pain."

People may believe that if others are choosing suicide, it must be a valid option for them as well, according to Gilman. 

"From social learning theory, if the observed behavior — in this case, suicide — is seen as a positive outcome or a solution to problems, it may be reinforced and more likely to be imitated."

‘SLEEP DISORDER DROVE MY SON TO SUICIDE,’ NEW YORK MOTHER SAYS: ‘BROKE MY HEART’

This risk can escalate when a celebrity or widely admired person dies by suicide, she added, as it can have a disproportionate impact on those who look up to that individual.

"Individuals who are already struggling with mental health issues — especially depression and anxiety — may be more likely to experience suicidal thoughts or behaviors," Gilman warned. 

Those experiencing difficult life circumstances — such as job loss, divorce or financial struggles — may be more susceptible, she added.

"People tend to overestimate the likelihood of events that are easily recalled," Gilman said. 

"If a recent suicide has been widely publicized, it may make the idea of suicide more accessible and salient in people's minds."

For those impacted by suicide, experts agreed that it's important to watch for signs of deep distress, including the following.

"Experiencing recurring or intensifying thoughts of suicide is a critical warning sign that immediate professional help is necessary," Gilman advised. 

"For instance, the survivor may start having more frequent thoughts about ending their own life or making plans for it."

NEW YORK TEEN STARTS NONPROFIT FOR SUICIDE PREVENTION THROUGH BASKETBALL TOURNAMENTS: 'WANTED TO HELP'

They may also express feelings of being overwhelmed to the point where they believe suicide is the only option, she said.

People saying they feel like a burden is a "major red flag," according to Thomas Banta, a clinical mental health counselor in Jeffersonville, Indiana.

"Many people who try to end their lives feel they are doing the people around them a favor," he told Fox News Digital.

"When we hear that type of language, intervention is essential."

"Difficulty managing daily responsibilities or activities can indicate that the emotional burden is too great to handle without professional support," Gilman said. 

The survivor may struggle to maintain a job, manage household duties or care for themselves due to their emotional state.

Engaging in unsafe or self-harming actions is a serious sign that mental health treatment is needed, experts agree.

"For example, the survivor may start harming themselves physically, such as cutting or burning, as a means of dealing with their emotional pain," said Gilman.

"Or they may engage in dangerous activities, like reckless driving, promiscuous sex or substance abuse, which puts their health and safety at risk."

Significant changes in behavior or mood that affect a survivor’s ability to function in everyday life can be a sign that they need help, according to Gilman.

This might involve the survivor becoming unusually aggressive, withdrawn or apathetic, or displaying behavior that is significantly different from their "normal" demeanor.

"Pulling away from friends, family or support groups can indicate that the survivor is struggling more than they can manage on their own," Gilman warned. 

The person might avoid social interactions, decline invitations or isolate themselves from people who usually offer support.

The signs aren’t always obvious, however, Banta noted.

"We also see the opposite end of the spectrum, where somebody will make a plan, and their mood lifts because they feel like they have found an escape," he said.

Experts offered the following tips to help reduce the risk of "clusters" following a suicide.

"It’s important to be cautious about how we discuss suicide publicly," Fenkel said.

The best way to prevent contagion is through responsible communication, she advised.

"This includes limiting the specifics around the method of suicide and focusing on the impact of the loss," she said. 

Offering access to crisis resources can help vulnerable individuals feel connected and supported, Fenkel said.

"It's crucial to highlight help and hope, encouraging those who are struggling to seek support," she said, noting that many schools and communities provide mental health services to help those who are grieving.

Banta agreed, noting that intervention and higher levels of care can stabilize people and help them develop a robust support system. 

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"In terms of public health communication, we must let people know that treatment works and that there is effective help out there," he said. 

"Stigma can lead to feelings of isolation and loneliness, which can contribute to suicidal ideation," Gilman warned.

When people feel comfortable discussing their mental health concerns without fear of judgment, they are more likely to seek help from professionals, she noted. 

Fenkel agreed, encouraging people to talk openly and compassionately about mental health.

"Anyone experiencing thoughts of suicide should know that there is help available, and reaching out for support is a sign of strength, not weakness," she said.

Suicide is a "fleeting state of mind," Banta pointed out. 

For more Health articles, visit www.foxnews.com/health

"I have worked with many people who felt hopeless and that their lives would never improve, but then they did," he said.

"So if you are struggling and reading this, there is help. Don't give up."

7 months 3 days ago

Health, mental-health, depression, stress-and-anxiety, lifestyle

Medical News, Health News Latest, Medical News Today - Medical Dialogues |

Wockhardt Chairman Dr Habil Khorakiwala conferred with BIRAC Innovator Award 2024

Mumbai: Biotechnology Industry Research Assistance Council (BIRAC), a Government of India enterprise, conferred the "BIRAC Innovator Award 2024" to Wockhardt's Chairman, Dr. Habil Khorakiwala.

On
his behalf, the award was received by the inventor, Dr. Mahesh Patel (Chief Scientific Officer - Drug
Discovery Research) during “Global Bio – India 2024” event held in New Delhi.
The award is in recognition of the highest level of innovation and research that led to successful
development of Nafithromycin (Miqnaf), which is the multi-drug resistant pathogen
active respiratory antibiotic for the treatment of Community-Acquired Bacterial Pneumonia.

Miqnaf(Nafithromycin) fulfils major unmet medical need as existing treatment based on
Azithromycin and Amoxicillin + Clavulanic acid have either developed resistance in contemporary
respiratory pathogens or lack the coverage of entire range of respiratory pathogens involved in Community-Acquired Bacterial Pneumonia.

As a result, many of these patients need to be
hospitalized due to limitations of current treatment options. With once-a-day, ultra-short, 3 daycourse of oral treatment, Miqnaf (Nafithromycin) would obviate the need of hospitalization for
many such patients.
Discovery and development of Nafithromycin at Wockhardt spanned over 12 years and involved
several Phase 1 and Phase 2 clinical studies which were conducted in USA and Europe.

Nafithromycin has successfully completed Phase III clinical trial in India and is awaiting DCGI
approval.
Globally, for the 1st time in 33 years, a new macrolide drug in the form of Miqnaf (Nafithromycin)
has been developed to treat millions of community respiratory infections through a convenient
home-based oral monotherapy.

Community Acquired Bacterial Pneumonia is one of the highest disease burden globally and in India,
responsible for high mortality, morbidity and hospitalization, particularly in children and older agepatients. India accounts for 23% of the global burden of pneumonia. The annual incidence of
Community-Acquired Bacterial Pneumonia in India is estimated to be 8-10 million infections. The
currently available drugs to treat Community acquired bacterial pneumonia majorly are
Azithromycin (>60% resistance) and Amoxicillin + Clavulanic which does not cover atypical
respiratory pathogens. Notably, atypical respiratory pathogens are implicated in >30% of
Community-Acquired Bacterial Pneumonia infections.

Read also: CDSCO Panel Approves Wockhardt's Protocol Amendment Proposal for antimicrobial drug Cefepime plus Zidebactam

7 months 3 days ago

News,Industry,Pharma News,Latest Industry News

Health

From barbecue fun days to running 5Ks

IN THE recent past, fish fries, bake sales, and school barbecue fun days were fundraisers of choice for schools, churches, civic organisations, and charitable bodies. Costly, exclusive fundraising galas and cocktail parties worked for corporate...

IN THE recent past, fish fries, bake sales, and school barbecue fun days were fundraisers of choice for schools, churches, civic organisations, and charitable bodies. Costly, exclusive fundraising galas and cocktail parties worked for corporate...

7 months 3 days ago

Health

Tips on how to maintain a balanced lifestyle as a senior citizen

A BALANCED lifestyle refers to having a sense of control and well-being in all areas of life. According to an article published by Physio West, written by Bec Clare (2020), balanced living involves achieving optimal health in various aspects,...

A BALANCED lifestyle refers to having a sense of control and well-being in all areas of life. According to an article published by Physio West, written by Bec Clare (2020), balanced living involves achieving optimal health in various aspects,...

7 months 3 days ago

Health

Healthy eating made easy

ADOPTING A sustainable diet can offer numerous environmental, social, and health benefits. But when shifting to a sustainable way of eating, it is also important to plan ahead and choose foods that are both good for your body and the environment....

ADOPTING A sustainable diet can offer numerous environmental, social, and health benefits. But when shifting to a sustainable way of eating, it is also important to plan ahead and choose foods that are both good for your body and the environment....

7 months 3 days ago

Health – Dominican Today

Over 600 runners to compete in ninth edition of Bayahibe 10K

Bayahibe.- The ninth edition of the Bayahíbe race, set for September 22, will see at least 600 participants competing to support the Solca Foundation, which promotes social and educational projects for vulnerable youth.

Bayahibe.- The ninth edition of the Bayahíbe race, set for September 22, will see at least 600 participants competing to support the Solca Foundation, which promotes social and educational projects for vulnerable youth. The event is organized by the La Romana Bayahíbe Hotel Association (AHRB) and the La Romana Bayahibe Tourism Cluster (CTRB), with support from the Bayahíbe Municipal District.

The race will begin at 7:00 am from La Punta de Bayahíbe. Over 70 personnel from various security and emergency services, including the Tourist Police and the National Emergency System (911), will ensure runner safety. This year’s race, notable for its mixed asphalt and sand course, is described by Ana García-Sotoca of AHRB and CTRB as a milestone for integrating sports and offering a unique experience.

The event, supported by Santo Domingo Corre, expects 38% female participants, particularly between 30 and 50 years old. It is designed for runners aiming to complete the 10 kilometers in 40 to 55 minutes. Participants will receive medals, with prizes awarded to the top finishers in several categories. The event will also feature entertainment such as Zumba, a foam party, live DJs, and various raffles. Major sponsors include Mitur, Banreservas, and various local businesses and resorts.

7 months 4 days ago

Health, Local, Sports

STAT

STAT+: Pharmalittle: We’re reading about an Express Scripts lawsuit against FTC, AMR deaths, and more

Top of the morning to you, and a fine one it is, despite the gray skies hovering over the Pharmalot campus.

We are doing our best to maintain sunny spirits, though, because once again, we recall some helpful wisdom from the Morning Mayor, who taught us that “every new day should be unwrapped like a precious gift.” To celebrate the notion, we are brewing still more cups of stimulation and inviting you to join us. Our choice today is orange cream, for those tracking our habits. Meanwhile, here are a few items of interest. Hope you have a meaningful and productive day and, of course, do stay in touch. …

Express Scripts, which is one of the largest pharmacy benefit managers in the U.S., filed a lawsuit demanding that a recent Federal Trade Commission report accusing the industry middlemen of raising drug prices should be vacated, STAT tells us. In scathing language, the company argued the report was “seventy-four pages of unsupported innuendo leveled … under a false and defamatory headline.” The lawsuit also alleged the FTC “followed prejudice and politics, not evidence or sound economics, and wrongly concluded that PBMs inflate drug costs and harm independent pharmacies.” FTC Chair Lina Khan was also accused of “anti-PBM bias.”

Antimicrobial-resistant bacterial infections directly caused more than 1 million deaths worldwide annually from 1990 to 2021, and that number is projected to increase by almost 70% over the next 25 years, MedPage Today writes, citing an analysis in The Lancet. In 2021, 1.14 million deaths that were attributable to bacterial antimicrobial resistance occurred across the globe, slightly higher than the 1.06 million AMR-attributable deaths in 1990. Bacterial AMR was also associated with an estimated 4.71 million deaths in 2021, about the same as in 1990. By 2050, the researchers forecast that an estimated 1.91 million AMR-attributable deaths and 8.22 million AMR-associated deaths could occur every year worldwide. From 2025 to 2050, a cumulative 39.1 million deaths attributable to AMR could occur.

Continue to STAT+ to read the full story…

7 months 4 days ago

Pharma, Pharmalot, pharmalittle, STAT+

KFF Health News

Historic Numbers of Americans Live by Themselves as They Age

Gerri Norington, 78, never wanted to be on her own as she grew old.

But her first marriage ended in divorce, and her second husband died more than 30 years ago. When a five-year relationship came to a close in 2006, she found herself alone — a situation that has lasted since.

Gerri Norington, 78, never wanted to be on her own as she grew old.

But her first marriage ended in divorce, and her second husband died more than 30 years ago. When a five-year relationship came to a close in 2006, she found herself alone — a situation that has lasted since.

“I miss having a companion who I can talk to and ask ‘How was your day?’ or ‘What do you think of what’s going on in the world?’” said Norington, who lives in an apartment building for seniors on the South Side of Chicago. Although she has a loving daughter in the city, “I don’t want to be a burden to her,” she said.

Norington is part of a large but often overlooked group: the more than 16 million Americans living alone while growing old. Surprisingly little is known about their experiences.

This slice of the older population has significant health issues: Nearly 4 in 10 seniors living alone have vision or hearing loss, difficulty caring for themselves and living independently, problems with cognition, or other disabilities, according to a KFF analysis of 2022 census data.

If help at home isn’t available when needed — an altogether too common problem — being alone can magnify these difficulties and contribute to worsening health.

Studies find that seniors on their own are at higher risk of becoming isolated, depressed, and inactive, having accidents, and neglecting to care for themselves. As a result, they tend to be hospitalized more often and suffer earlier-than-expected deaths.

Getting medical services can be a problem, especially if older adults living alone reside in rural areas or don’t drive. Too often, experts observe, health care providers don’t ask about older adults’ living situations and are unaware of the challenges they face.

***

During the past six months, I’ve spoken to dozens of older adults who live alone either by choice or by circumstance — most commonly, a spouse’s death. Some have adult children or other close relatives who are involved in their lives; many don’t.

In lengthy conversations, these seniors expressed several common concerns: How did I end up alone at this time of life? Am I OK with that? Who can I call on for help? Who can make decisions on my behalf if I’m unable to? How long will I be able to take care of myself, and what will happen when I can’t?

This “gray revolution” in Americans’ living arrangements is fueled by longer life spans, rising rates of divorce and childlessness, smaller families, the geographic dispersion of family members, an emphasis on aging in place, and a preference for what Eric Klinenberg, a professor of sociology at New York University, calls “intimacy at a distance” — being close to family, but not too close.

The most reliable, up-to-date data about older adults who live alone comes from the U.S. Census Bureau. According to its 2023 Current Population Survey, about 28% of people 65 and older live by themselves, including slightly fewer than 6 million men and slightly more than 10 million women. (The figure doesn’t include seniors living in institutions, primarily assisted living and nursing homes.)

By contrast, 1 in 10 older Americans lived on their own in 1950.

This is, first and foremost, an older women’s issue, because women outlive men and because they’re less likely to remarry after being widowed or divorcing. Twenty-seven percent of women ages 65 to 74 live alone, compared with 21% of men. After age 75, an astonishing 43% of women live alone, compared with only 24% for men.

The majority — 80% — of people who live alone after age 65 are divorced or widowed, twice the rate of the general population, according to KFF’s analysis of 2022 census data. More than 20% have incomes below $13,590, the federal poverty line in 2022, while 27% make between that and $27,180, twice the poverty level.

***

Of course, their experiences vary considerably. How older adults living alone are faring depends on their financial status, their housing, their networks of friends and family members, and resources in the communities where they live.

Attitudes can make a difference. Many older adults relish being independent, while others feel abandoned. It’s common for loneliness to come and go, even among people who have caring friends and family members.

“I like being alone better than I like being in relationships,” said Janice Chavez of Denver, who said she’s in her 70s. “I don’t have to ask anybody for anything. If I want to sleep late, I sleep late. If I want to stay up and watch TV, I can. I do whatever I want to do. I love the independence and the freedom.”

Chavez is twice divorced and has been on her own since 1985. As a girl, she wanted to be married and have lots of kids, but “I picked jerks,” she said. She talks to her daughter, Tracy, every day, and is close to several neighbors. She lives in the home she grew up in, inherited from her mother in 1991. Her only sibling, a brother, died a dozen years ago.

In Chicago, Norington is wondering whether to stay in her senior building or move to the suburbs after her car was vandalized this year. “Since the pandemic, fear has almost paralyzed me from getting out as much as I would like,” she told me.

She’s a take-charge person who has been deeply involved in her community. In 2016, Norington started an organization for single Black seniors in Chicago that sponsored speed dating events and monthly socials for several years. She volunteered with a local medical center doing outreach to seniors and brought health and wellness classes to her building. She organized cruises for friends and acquaintances to the Caribbean and Hawaii in 2022 and 2023.

Now, every morning, Norington sends a spiritual text message to 40 people, who often respond with messages of their own. “It helps me to feel less alone, to feel a sense of inclusion,” she said.

In Maine, Ken Elliott, 77, a retired psychology professor, lives by himself in a house in Mount Vernon, a town of 1,700 people 20 miles northwest of the state capital. He never married and doesn’t have children. His only living relative is an 80-year-old brother in California.

For several years, Elliott has tried to raise the profile of solo agers among Maine policymakers and senior organizations. This began when Elliott started inquiring about resources available to older adults living by themselves, like him. How were they getting to doctor appointments? Who was helping when they came home from the hospital and needed assistance? What if they needed extra help in the home but couldn’t afford it?

To Elliott’s surprise, he found this group wasn’t on anyone’s radar, and he began advocating on solo agers’ behalf.

Now, Elliott is thinking about how to put together a team of people who can help him as he ages in place — and how to build a stronger sense of community. “Aging without a mythic family support system — which everyone assumes people have — is tough for everybody,” Elliott said.

In Manhattan, Lester Shane, 72, who never married or had children, lives by himself in an 11-by-14-foot studio apartment on the third floor of a building without an elevator. He didn’t make much money during a long career as an actor, a writer, and a theater director, and he’s not sure how he’ll make ends meet once he stops teaching at Pace University.

“There are days when I’m carrying my groceries up three flights of stairs when I think, ‘This is really hard,’” Shane told me. Although his health is pretty good, he knows that won’t last forever.

“I’m on all the lists for senior housing — all lottery situations. Most of the people I’ve talked to said you will probably die before your number comes up,” he said with mordant humor.

Then, Shane turned serious. “I’m old and getting older, and whatever problems I have now are only going to get worse,” he said. As is the case for many older adults who live alone, his friends are getting older and having difficulties of their own.

The prospect of having no one he knows well to turn to is alarming, Shane admitted: “Underneath that is fear.”

Kate Shulamit Fagan, 80, has lived on her own since 1979, after two divorces. “It was never my intention to live alone,” she told me in a lengthy phone conversation. “I expected that I would meet someone and start another relationship and somehow sail off into the rest of my life. It’s been exceedingly hard to give up that expectation.”

When I first spoke to Fagan, in mid-March, she was having difficulty in Philadelphia, where she’d moved two years earlier to be close to one of her sons. “I’ve been really lonely recently,” she told me, describing how difficult it was to adjust to a new life in a new place. Although her son was attentive, Fagan desperately missed the close circle of friends she’d left behind in St. Petersburg, Florida, where she’d lived and worked for 30 years.

Four and a half months later, when I called Fagan again, she’d returned to St. Petersburg and was renting a one-bedroom apartment in a senior building in the center of the city. She’d celebrated her birthday there with 10 close friends and was meeting people in her building. “I’m not completely settled, but I feel fabulous,” she told me.

What accounted for the change? “Here, I know if I want to go out or I need help, quite a few people would be there for me,” Fagan said. “The fear is gone.”

As I explore the lives of older adults living alone in the next several months, I’m eager to hear from people who are in this situation. If you’d like to share your stories, please send them to khn.navigatingaging@gmail.com.

KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

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7 months 4 days ago

Aging, Navigating Aging, Public Health, Colorado, Illinois, Maine, New York, Pennsylvania

Medical News, Health News Latest, Medical News Today - Medical Dialogues |

Once-Weekly Insulin Efsitora Noninferior to Daily Basal Insulin in T2D, reveal QWINT Trials

Eli Lilly and Company today announced positive topline results from the QWINT-1 and QWINT-3 phase 3 clinical trials evaluating once weekly insulin efsitora alfa (efsitora) in adults with type 2 diabetes using basal insulin for the first time (insulin naïve) and in those who have switched from daily basal insulin injections, respectively.

In these long-term treat-to-target trials, efsitora showed non-inferior A1C reduction compared to the most frequently used daily basal insulins globally.

"Once weekly insulins, like efsitora, have the potential to transform diabetes care as we know it," said Jeff Emmick, M.D., Ph.D., senior vice president, product development, Lilly. "Many patients are reluctant to start insulin because of the burden it places on them. With a simple fixed-dose regimen, once-weekly efsitora could make it easier for people with diabetes to start and manage insulin therapy, while reducing the impact it has on their day-to-day lives."

QWINT-1 evaluated the efficacy and safety of once weekly efsitora compared to once daily insulin glargine for 52 weeks. The trial randomized adults with type 2 diabetes who are insulin naïve to receive either efsitora once weekly in a single-use autoinjector or insulin glargine once daily. Efsitora was titrated across four fixed doses at four-week intervals, as needed for blood glucose control. The study's goal was to provide data supporting real-life applications of fixed dose regimens, which have the potential to make it easier for people living with diabetes to start and manage insulin therapy.

The trial met its primary endpoint of non-inferior A1C reduction with efsitora compared to insulin glargine at week 52. For the efficacy estimand, efsitora reduced A1C by 1.31% compared to 1.27% for insulin glargine, resulting in an A1C of 6.92% and 6.96%, respectively4. For the treatment-regimen estimand, efsitora reduced A1C by 1.19% compared to 1.16% for insulin glargine, resulting in an A1C of 7.05% and 7.08%, respectively.

QWINT-3 evaluated the efficacy and safety of once weekly efsitora compared to once daily insulin degludec for 78 weeks in adults with type 2 diabetes currently treated with basal insulin. Participants were randomized 2:1 to receive either efsitora once weekly or insulin degludec once daily.

The QWINT-3 trial met its primary endpoint of non-inferior A1C reduction with efsitora compared to insulin degludec at week 26. For the efficacy estimand, efsitora reduced A1C by 0.86% compared to 0.75% for insulin degludec resulting in an A1C of 6.93% and 7.03%, respectively. For the treatment-regimen estimand, efsitora reduced A1C by 0.81% compared to 0.72% for insulin degludec resulting in an A1C of 6.99% and 7.08%, respectively.

Additionally, participants taking efsitora or insulin degludec spent approximately two hours more time in range (glucose 70-180 mg/dL) per day for weeks 22-26 compared to baseline. For the efficacy estimand, participants taking efsitora spent 62.8% of time in range compared to 61.3% for insulin degludec for weeks 22-26. For the treatment-regimen estimand, participants taking efsitora spent 61.4% of time in range compared to 61% for insulin degludec. Further, for the efficacy estimand, participants taking efsitora spent 38.3% of time in tight range (glucose 70-140 mg/dL) compared to 36.8% for insulin degludec for weeks 22-26.

In both QWINT-1 and QWINT-3, the overall safety and tolerability profile of efsitora was similar to that of daily basal insulin therapies for the treatment of type 2 diabetes. In QWINT-1, estimated combined rates of severe or clinically significant (blood glucose <54 mg/dL) hypoglycemic events per patient-year of exposure from weeks 0-52 were 0.50 with efsitora vs. 0.88 with insulin glargine – approximately 40% lower with efsitora than insulin glargine. In QWINT-3, estimated combined rates of severe or clinically significant (blood glucose <54 mg/dL) hypoglycemic events per patient-year of exposure from weeks 0-78 were 0.84 with efsitora vs. 0.74 with insulin degludec.

Detailed results for QWINT-1 and QWINT-3 will be shared at an upcoming congress and published in a peer-reviewed journal. Additionally, detailed results for QWINT-2 and QWINT-5 will be presented at the European Association for the Study of Diabetes (EASD) Annual Meeting 2024.

About the QWINT clinical trial program

The QWINT phase 3 global clinical development program for insulin efsitora alfa (efsitora) in diabetes began in 2022 and has enrolled more than 4,000 people living with type 1 or type 2 diabetes across five global registration studies.

QWINT-1 (NCT05662332) was a parallel-design, open-label, treat-to-target, randomized controlled clinical trial comparing the efficacy and safety of efsitora as a once weekly basal insulin using a fixed dose to insulin glargine for 52 weeks in insulin-naïve adults with type 2 diabetes. The trial randomized 796 participants across the U.S., Argentina, Mexico and Puerto Rico to receive efsitora once weekly or insulin glargine once daily administered subcutaneously. All participants treated with efsitora received a starting dose of 100 units followed by a fixed dose escalation to achieve a target fasting blood glucose of 80-130 mg/dL. Fasting blood glucose was measured every four weeks and participants escalated to fixed dosages of 150 units, 250 units and 400 units as appropriate. Participants with fasting blood glucose greater than 130 mg/dL on or after 16 weeks were transferred to flexible dosing. The primary objective of the trial was to demonstrate non-inferiority in reducing A1C at week 52 with efsitora compared to insulin glargine.

QWINT-3 (NCT05275400) was a multicenter, randomized, parallel-design, open-label trial comparing the efficacy and safety of efsitora as a once-weekly basal insulin to insulin degludec for 78 weeks after a three-week lead-in period, and followed by a five-week safety follow up period, in adults with type 2 diabetes who are currently treated with basal insulin. The trial randomized 986 participants across the U.S., Argentina, Hungary, Japan, Korea, Poland, Puerto Rico, Slovakia, Spain and Taiwan to receive efsitora once weekly or insulin degludec once daily administered subcutaneously. The primary objective of the study was to demonstrate non-inferiority in reducing A1C at week 26 with efsitora compared to insulin degludec.

About insulin efsitora alfa

Insulin efsitora alfa (efsitora) is a once-weekly basal insulin, a fusion protein that combines a novel single-chain variant of insulin with a human IgG2 Fc domain. It is specifically designed for once-weekly subcutaneous administration, and with its low peak-to-trough ratio, it has the potential to provide more stable glucose levels (less glucose variability) throughout the week. Efsitora is in phase 3 development for adults with type 1 and 2 diabetes.

7 months 4 days ago

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'Vaccine fatigue' blamed as roughly half of people in US will skip COVID and flu shots this year

A growing number of U.S. adults are hesitant to get recommended vaccines this fall, a new survey found.

The poll, which included 1,006 people, found that only 43% of respondents have gotten or plan to get the COVID vaccine.

A growing number of U.S. adults are hesitant to get recommended vaccines this fall, a new survey found.

The poll, which included 1,006 people, found that only 43% of respondents have gotten or plan to get the COVID vaccine.

Only a slight majority (56%) of adults said they have gotten or plan to get the flu shot this fall.

COVID VACCINE DISTRUST GROWING AMONG AMERICANS, SURVEY FINDS: ‘SHOULD BE A PERSONAL CHOICE’

The poll also found that 37% of those who have gotten vaccines in past years plan to skip the shots this season. 

Around one-third of respondents also said they don’t believe they need the vaccines mentioned in the survey — flu, COVID, RSV or pneumococcal pneumonia.

Vaccine hesitancy tends to skew younger, as adults aged 65 and older are the most likely to get the recommended immunizations.

The nationwide survey was conducted by The Ohio State University Wexner Medical Center in mid-August 2024.

NEW COVID VACCINES GET FDA APPROVAL FOR 2024-2025 SEASON

These findings come just weeks after the U.S. Food and Drug Administration (FDA) approved updated COVID-19 vaccines from Moderna and Pfizer for the 2024-2025 season.

"We’re at the start of respiratory virus season, when you have the triple threat of flu, COVID-19 and RSV," said Nora Colburn, MD, medical director of clinical epidemiology at Ohio State’s Richard M. Ross Heart Hospital, in a press release.

"Unfortunately, there is a lot of misinformation about vaccinations, but the reality is that they are safe and highly effective in preventing serious illness and death," she went on.

"Older adults, people with certain chronic medical conditions, and those who are pregnant are especially at risk during respiratory virus season."

Dr. Jacob Glanville, CEO of Centivax, a San Francisco biotechnology company, reacted to the poll’s findings.

"It’s obviously not surprising that 37% of people said they had been vaccinated in the past but weren’t planning to this year," he told Fox News Digital. 

RISKS ASSOCIATED WITH THE COVID VACCINE IDENTIFIED IN STUDY

"We just had a vaccine mandate a couple of years ago, and furthermore, childhood vaccines are very broadly administered, so those 37% are people who wouldn’t be getting a vaccine normally anyway."

The reported rate of 56% for the flu shot is a little above average, Glanville said, as it tends to hover at around 50%.

"Coronavirus vaccination rates are a little lower than for the flu," he noted. 

This could be due to lack of clarity with the public over how COVID should be treated post-pandemic, according to Glanville.

"It’s also fatigue due to the COVID vaccines not being particularly effective at preventing symptoms, which causes people to believe that they are not effective (although they do protect against severe illness)," he added.

Dr. Marc Siegel, senior medical analyst for Fox News and clinical professor of medicine at NYU Langone Medical Center, said he finds the poll’s findings concerning.

"Both vaccines wane over six months, so a yearly booster makes sense for high-risk groups," he told Fox News Digital.

Siegel estimates that this year’s flu season will be similar to last year’s, which was "moderate," with 25,000 deaths and 400,000 hospitalizations. 

"The flu shot decreases severity and number of hospitalizations by about a quarter, and helps to provide community immunity," he added.

FIRST CASE OF HUMAN BIRD FLU DIAGNOSED WITHOUT EXPOSURE TO INFECTED ANIMALS, CDC SAYS

For COVID, Siegel warned that the virus’ activity is still fairly high — "especially in the western U.S."

The doctor also warned of a new variant circulating in Europe, which he expects will soon be in the U.S., known as the XEC subvariant.

"It seems to be more contagious — it causes congestion, cough, loss of smell and appetite, sore throat and body aches," he told Fox News Digital.

"The new vaccine should provide at least some coverage."

Dr. Paul Offit, director of the Vaccine Education Center and an attending physician in the Division of Infectious Diseases at Children's Hospital of Philadelphia, told Siegel that very young children are being hospitalized at a greater rate — "likely because they haven't been vaccinated with the primary series."

"I recommend a yearly booster for the elderly, immunocompromised and those with chronic illness, along with anyone who is at risk for long COVID or has had it previously," Siegel said.

The U.S. Centers for Disease Control and Prevention (CDC) has issued the following vaccine recommendations.

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Flu: Everyone 6 months and older is advised to get vaccinated against influenza.

COVID-19: The latest version of the COVID vaccine is recommended for everyone 6 months and older.

RSV: The respiratory syncytial virus (RSV) vaccine is recommended for everyone aged 75 and older, as well as those aged 60 to 74 who have certain chronic medical conditions, such as lung or heart disease, or who live in nursing homes, as they are at a higher risk of severe disease. Pregnant women are also advised to get the vaccine during weeks 32 through 36 of pregnancy.

Pneumococcal: Everyone younger than 5 years and age 65 and older is advised to get the pneumococcal vaccine, along with those who are at increased risk of severe disease.

For more Health articles, visit www.foxnews.com/health

Fox News Digital reached out to the OSU research team for comment.

7 months 4 days ago

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